Clinical trials: Stricture
Aortic Valve Stenosis
The SAPIEN 3 Ultra System in Intermediate Risk Patients With Symptomatic, Severe Aortic Stenosis
This study will confirm the procedural safety and performance of the SAPIEN 3 Ultra System in subjects with severe, calcific AS who are at intermediate operative risk for standard aortic valve replacement.
- Trial name
- NCT03471065
- Testing
- SAPIEN 3 Ultra Delivery System with the SAPIEN 3 Ultra THV
- Where
- 6 sites in Canada, United Kingdom
- Volunteers
- 100 people
- Sponsor
- Edwards Lifesciences
Idiopathic Subglottic Tracheal Stenosis
Voice Quality Analysis of Patients With Laryngotracheal Stenosis
The investigators previously demonstrated that voice changes are common in patients with Laryngotracheal Stenosis (LTS), and patients typically report an improvement in voice outcomes following endoscopic dilation.
- Trial name
- NCT06161077
- Testing
- Voice Biomarker Screening Too
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Liver Transplant; Complications, Bile Duct; Stricture, Postoperative
The Effect of the Type of Conduit-duct Anastomosis Technique on the Postoperative Course in Patients Undergoing Liver Transplantation
The main objective of the trial is to compare the effect of two end-to-end duct-to-duct anastomosis surgical techniques using the continuous suture method versus interrupted method (control group) on reducing the risk of bile…
- Conditions
- Liver Transplant; Complications, Bile Duct; Stricture, Postoperative, Bile Leak, Quality of Life
- Trial name
- NCT06533592
- Testing
- Continous suture technique, Interrupted suture technique
- Where
- Poland
- Volunteers
- 284 people
- Sponsor
- Medical University of Warsaw
Hypertrophic Cardiomyopathy
Echocardiographic Perspectives on Transient Mitral Regurgitation After Septal Myectomy
Mitral regurgitation (MR) following septal myectomy for hypertrophic obstructive cardiomyopathy may persist despite relief of systolic anterior motion and left ventricular outflow tract obstruction.
- Trial name
- TMRSM_R (NCT07831811)
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Cardiomyopathy
Evaluate the Efficacy of Disopyramide Therapy in Hypertrophic Obstructive Cardiomyopathy Patients
Population study- patients with obstructive hypertrophic cardiomyopathy that are treated with disopyramide. Tow echo examination, few hours apart, that includes strain rate will be done to each patient.
- Trial name
- NCT02917395
- Testing
- echocardiography
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Esophageal Stricture, Endoscopic Submucosal Dissection
Local Triamcinolone Injection Combined With Fibrin Glue Spray in Preventing Esophageal Stricture After Big-range Endoscopic Submucosal Dissection for Esophageal Early Cancer
Endoscopic submucosal dissection (ESD) is the main treatment for esophageal early cancer. But post-ESD stricture has a serious impact on quality of life.When the lesion range reaches up to 3/4 circumferential mucosal defect or…
- Conditions
- Esophageal Stricture, Endoscopic Submucosal Dissection, Early Esophageal Cancer or Precancerous Lesions Treated With Endoscopic Resection
- Trial name
- NCT06840561
- Testing
- Local triamcinolone injection combined with fibrin glue spray
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-Sen University Cancer Center
Lumbar Spinal Stenosis, Intermittent Claudication
Investigating Superion™ In Spinal Stenosis
The proposed prospective, multi-center, randomized clinical trial is designed to evaluate the safety and effectiveness of the Superion™ ISS compared to the X-STOP® IPD® device in healthy adults suffering from at least 6 months of…
- Trial name
- NCT00692276
- Testing
- Superion™ Interspinous Spacer, X-STOP® IPD® Device
- Where
- 32 sites in United States
- Volunteers
- 391 people
- Sponsor
- Boston Scientific Corporation
Aortic Valve Stenosis, Transcatheter Aortic Valve Implantation
Comparison of Different Vascular Closure Device in TAVI
Femoral artery approach for transcatheter aortic valve implantation (TAVI) is an ideal approach site. However the closure for femoral artery after transfemoral TAVI is challenging.
- Trial name
- NCT05491070
- Testing
- Vascular closure device (Angio-Seal, Progilde)
- Where
- Taiwan
- Volunteers
- 260 people
- Sponsor
- National Taiwan University Hospital
Ventricular Septal Defect, Complete Atrioventricular Canal
Optical Tissue Identification for Myocardial Architecture
The goal of this study is to test the hypothesis that fiberoptic confocal microscopy (FCM) imaging during repair of common congenital heart defects is a useful adjunct for avoidance of conduction abnormalities.
- Conditions
- Ventricular Septal Defect, Complete Atrioventricular Canal, Tetralogy of Fallot With Pulmonary Stenosis
- Trial name
- OPTIMA (NCT04017975)
- Testing
- Fluorescite, Cellvizio 100 Series System with Confocal Miniprobes
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Aditya Kaza
Lumbar Spinal Stenosis
Study Comparing Local/ MAC Anesthesia in Lumbar Decompression
Explore efficacy, complications, and other factors associated with anaesthetic choice- To evaluate the efficacy of local + MAC as an alternative anesthetic to general anesthesia and to analyze patients' outcomes and experiences.
- Trial name
- NCT04992572
- Testing
- Propofol Injection, Lidocaine Hydrochloride, Injectable
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Renal Artery Stenosis
A Comparison of Coated and Uncoated Stents in Renal Artery Treatment.
The primary objective of this study is to compare the safety and performance of the Palmaz Genesis™ balloon expandable stent, with or without sirolimus coating in the treatment of renal artery stenosis, measured at 6 months…
- Trial name
- GREAT (NCT00235157)
- Testing
- Sirolimus-eluting Palmaz Genesis peripheral stent
- Where
- 3 sites in France, Germany and 1 more
- Volunteers
- 105 people
- Sponsor
- Cordis US Corp.
Aortic Stenosis
Impact of Aortic Annulus Calcification on Long-Term Outcomes Following Transcatheter Aortic Valve Replacement: SAINT-TAVR Calcium Registry
The goal of this observational study is to learn about the long-term effects of aortic valve annular calcification in patients undergoing transcatheter aortic valve replacement (TAVR).
- Trial name
- SAINT-TAVR Ca (NCT06722066)
- Testing
- Transcatheter aortic valve replacement with ballon-expandable or self-expandable valves
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Eunpyeong St. Mary's Hospital
Hypertrophic Cardiomyopathy
New Diagnostic Strategy in Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease characterized by unexplained hypertrophy of the left ventricle, often with predominant involvement of the interventricular septum, and characterized by myocyte…
- Trial name
- HYPERGEN (NCT02520856)
- Testing
- blood sample
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Rectal Cancer, Left Colic Artery Stenosis (Diagnosis)
Robotic-Assisted or Laparoscopic Radical Resection for Rectal Cancer With or Without Left Colic Artery Preservation
Brief Summary Background The preservation of the left colic artery (LCA) during rectal cancer resection remains a topic of controversy, and there is a notable absence of robust evidence regarding the outcomes associated with LCA…
- Conditions
- Rectal Cancer, Left Colic Artery Stenosis (Diagnosis), Robotic Assisted Laparoscopic Surgery
- Trial name
- NCT06376227
- Testing
- with or without Left Colic Artery Preservation
- Where
- China
- Volunteers
- 1,164 people
- Sponsor
- Northern Jiangsu People's Hospital
Chronic Cerebral Ischemia, Intracranial Atherosclerosis
Optimized Remote Ischemic Conditioning (RIC) Treatment for Patients With Chronic Cerebral Ischemia
This prospective, randomized, single-center clinical trial is designed to figure out the most optimal algorithm of remote ischemic conditioning on patients with chronic cerebral ischemia.
- Trial name
- NCT03105141
- Testing
- Remote ischemic conditioning
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Capital Medical University
Williams Syndrome, Angelman Syndrome
Study of Phenotype and Genotype Correlations in Patients With Contiguous Gene Deletion Syndromes
OBJECTIVES: I. Investigate phenotype and genotype correlations in patients with Smith-Magenis syndrome (SMS) associated with del(17p11.2). II.
- Conditions
- Williams Syndrome, Angelman Syndrome, Prader-Willi Syndrome, Shprintzen Syndrome
- Trial name
- NCT00004351
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Coronary Restenosis
Trial of a Novel Paclitaxel-coated Balloon With Citrate Excipient for Restenosis in -Limus Analogue DES
Hypothesis: Angioplasty with a novel paclitaxel-coated balloon (PCB; Agent, Boston Scientific) with citrate-based excipient will be non-inferior to conventional paclitaxel-coated balloon with iopromide excipient (PCB) for the…
- Trial name
- ISAR-DESIRE 3A (NCT02367495)
- Testing
- PCB
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Coronary Artery Disease, Coronary Artery Stenosis
To Evaluate the Performance and Safety of RisoR Crest Everolimus Eluting Coronary Stent System
The study will evaluate the performance and safety of RisoR Crest Everolimus Eluting Coronary Stent System. A total of 2000 participants will be included in the study from India and Italy.
- Conditions
- Coronary Artery Disease, Coronary Artery Stenosis, Percutaneous Coronary Intervention, de Novo Lesions in Native Coronary Arteries
- Trial name
- PACIFIER (NCT07098195)
- Testing
- Coronary Stent
- Volunteers
- 2,000 people
- Sponsor
- Poly Medicure Limited
Ultrasonography, Carotid Stenosis
Prognostic Value of Carotid CEUS in Acute Ischemic Stroke Patients
Contrast-enhanced ultrasound(CEUS) of carotid artery plaque is a novel method that enabled direct visualization of neovessels in the vulnerable plaque.
- Conditions
- Ultrasonography, Carotid Stenosis, Ischemic Stroke
- Trial name
- NCT03283306
- Where
- South Korea
- Volunteers
- 667 people
- Sponsor
- Seoul National University Hospital
Nasal Obstruction, Lumbar Stenosis, Familial
Comparison of Intubation Conditions Between the Gliderite and the S-Guide
Intubation with an unchanneled videolaryngoscope mandates the use of a stylet. The Gliderite is a stylet specially designed for videolaryngoscopes.
- Trial name
- S-Guide (NCT02519647)
- Testing
- Tracheal intubation with Gliderite, Tracheal intubation with S-guide
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
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