Clinical trials: Stricture
Degenerative Lumbar Spinal Stenosis
Evaluation of the Efficacy and Safety of the FACET FIXation Implant.
This is a single center, hybrid retrospective and prospective (ambispective) study to evaluate the safety and efficacy of the Facet Fixation implant.
- Trial name
- FACETFIX (NCT05645497)
- Testing
- Surgery with FACET FIXATION implants, Surgery with Pedicle Screw
- Where
- France
- Volunteers
- 116 people
- Sponsor
- SC Medica
Fibrostenotic Crohn's Disease
A Study of PALI-2108 in Healthy Volunteers, Patients With Ulcerative Colitis, and Patients With Fibrostenosing Crohn's Disease
This is a Phase 1b, open-label, exploratory study designed to evaluate the pharmacodynamic effects of PALI-2108, a phosphodiesterase-4 (PDE4) inhibitor, in patients with fibrostenotic Crohn's disease (FSCD).
- Trial name
- NCT07428096
- Testing
- PALI-2108
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Palisade Bio
Hypertrophic Cardiomyopathy (HCM)
The Therapeutic Value of Mavacamten in Hypertrophic Cardiomyopathy With Mid-to-Apical Left Ventricular Obstruction
This study is a prospective interventional cohort study aimed at evaluating the therapeutic efficacy and clinical utility of Mavacamten-a targeted myosin inhibitor specifically developed for obstructive hypertrophic…
- Trial name
- BRAVE-HCM (NCT07103655)
- Testing
- mavacamten, Beta Blocker (BB) - metoprolol, bisoprolol, carvedilol, diltiazem
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Arteriovenous Fistula, Arteriovenous Fistula Stenosis
Randomised Clinical Trial Comparing Drug-coated Balloon to Plain Balloon for All Peripheral AVF Stenosis
To compare the access circuit primary patency after Ranger drug-coated balloon angioplasty of arteriovenous fistula (AVF) stenosis with that after conventional balloon angioplasty
- Conditions
- Arteriovenous Fistula, Arteriovenous Fistula Stenosis, Dialysis Access Malfunction
- Trial name
- RANGER (NCT06553443)
- Testing
- Angioplasty of all peripheral AVF stenosis
- Where
- Singapore
- Volunteers
- 94 people
- Sponsor
- Singapore General Hospital
Coronary Artery Stenosis
Comparison of Fractional Flow Reserve and Intravascular Ultrasound
This study will evaluate the relationship of Fractional Flow Reserve (FFR) and Minimal Lumen Area (MLA) by IntraVascular UltraSound (IVUS) by comparing the results of the both tests which is done as a part of the cardiac…
- Trial name
- NCT01133015
- Testing
- Fractional flow reserve, IVUS
- Where
- South Korea
- Volunteers
- 191 people
- Sponsor
- Seoul National University Hospital
Obstructive Airway Disease
Study of Interventional Pulmonologic Treatment of Benign Central Airway Fibrotic Stricture
The purpose of this study is to evaluate the efficacy and safety of four interventional pulmonology techniques for the treatment of fibrotic central airway stricture.
- Trial name
- NCT02287389
- Testing
- balloon dilation, cryotherapy, spiculiform electrosurgery
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Tang-Du Hospital
Cervical Stenosis
Outpatient Posterior Cervical Fusion: Outcomes of the First 100 Consecutive Cases
Observational study regarding outcomes, complications, and patient acceptance for 100 consecutive patients undergoing outpatient posterior cervical decompression, instrumentation and fusion.
- Trial name
- NCT07242989
- Testing
- Enhanced recovery after surgery protocol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NeuroSpine Center of Wisconsin
Nasal Obstruction, Bilateral
Evaluate the Effectiveness of the Vivaer ARC Stylus for Nasal Breathing
A Prospective, Multicenter, Non-Randomized Study of the Aerin Medical Vivaer ARC Stylus for Nasal Airway Obstruction
- Trial name
- NCT04717791
- Testing
- Vivaer® ARC Stylus
- Where
- 3 sites in Germany
- Volunteers
- 118 people
- Sponsor
- HNO-Praxis Alte Post
Aortic Stenosis
Remote Monitoring for Patients With Aortic Stenosis
Remote-AS aims to develop a remote digital monitoring cohort of people with AS and use these data to establish a digital twin intervention to personalise risks and benefits, and optimise the time of surgical or transcatheter…
- Trial name
- Remote-AS (NCT07690748)
- Volunteers
- 160 people
- Sponsor
- Baker Heart and Diabetes Institute
Coronary Stenosis, Aortic Valve Stenosis
Impact of Fast-rotation Coronary CT in Patients Undergoing Aortic Stenosis Workup
This study aims to evaluate the clinical value of a novel CT gantry supporting a .23 second rotation time and systematically compare it with 0.23 second rotation time, in patients with clinically indicated aortic CTA in the…
- Conditions
- Coronary Stenosis, Aortic Valve Stenosis, Cardiovascular Diseases
- Trial name
- FAST-CCT (NCT05709652)
- Testing
- Aortic CTA, .23s, Aortic CTA, .28s
- Where
- Switzerland
- Volunteers
- 124 people
- Sponsor
- David C. Rotzinger
Brain Ischemia
Magnetic Resonance Imaging to Investigate Silent Strokes During Neck and Skull Angioplasty
This study will use magnetic resonance imaging (MRI) to determine if silent strokes occur during angioplasty of the blood vessels in the neck or skull.
- Trial name
- NCT00015717
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Aortic Valve Stenosis, Cardiovascular Diseases
Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT)
The aortic valve is located between the left ventricle and the aorta. Patients with symptomatic, severe aortic valve stenosis conventionally have it surgically replaced requiring direct access to the heart through the chest.
- Conditions
- Aortic Valve Stenosis, Cardiovascular Diseases, Heart Valve Diseases, Ventricular Outflow Obstruction
- Trial name
- GALILEO-4D (NCT02833948)
- Testing
- Acetylsalicylic acid, Clopidogrel, Rivaroxaban
- Where
- 25 sites in United States, Canada and 5 more
- Volunteers
- 231 people
- Sponsor
- ECRI bv
Idiopathic Subglottic Tracheal Stenosis
Everolimus Trial in Laryngotracheal Stenosis
Subglottic stenosis (obstructing scar in the larynx and trachea) occurs in patients spontaneously (idiopathic), with autoimmune disease, and after long-term breathing tube placement and can result in communication disability and…
- Trial name
- NCT05153668
- Testing
- Everolimus Oral Tablet
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Johns Hopkins University
Coronary Artery Disease, Aortic Valve Stenosis
Functional Assessment in TAVI: FAITAVI
The aim of this study is to compare the clinical outcome of patients with severe aortic valve stenosis and associated significant coronary artery disease treated with TAVI and a percutaneous myocardial revascularization dictated…
- Trial name
- FAITAVI (NCT03360591)
- Testing
- Physiologically-guided strategy
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- Universita di Verona
Coronary Artery Stenosis
Coronary Laser Atherectomy System for Treatment of Coronary Artery Stenosis (SHINE)
This prospective, multi-center clinical trial evaluates the safety and efficacy of the Coronary Laser Atherectomy System for the pretreatment of coronary artery stenosis.
- Trial name
- SHINE (NCT07697638)
- Testing
- Coronary Laser Atherectomy System, CVX300 Laser System
- Volunteers
- 218 people
- Sponsor
- Shanghai MicroPort Rhythm MedTech Co., Ltd.
Aortic Valve Stenosis, Cardiovascular Diseases
Multicenter Study Evaluating the Efficacy of an Intervention Aimed At Reducing the Length of Stay After Transfemoral Transcatheter Aortic Valve Implantation
Since the first implantation of a percutaneous aortic bioprosthesis (TAVI) in 2002 (Cribier et al. Circulation 2002), TAVI occupies an increasing place in the management of aortic stenosis (AR) .
- Trial name
- FAST-TAVI II (NCT04503655)
- Testing
- Training
- Where
- 20 sites in France
- Volunteers
- 1,842 people
- Sponsor
- University Hospital, Rouen
Atherosclerotic Renal Artery Stenosis
The Evaluation Studies of Curative Effect of Fu-zheng-qu-zhuo Oral Liquid in Treatment of Ischemic Nephropathy
Background: Since evidence show that renal-artery stenting did not confer a significant benefit with respect to the prevention of clinical events when added to comprehensive, multifactorial medical therapy in people with…
- Trial name
- NCT02044835
- Testing
- Fu-zheng-qu-zhuo oral liquid
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Mavacamten Post-marketing Surveillance in Patients With Obstructive Hypertrophic Cardiomyopathy in Japan
The purpose of this study is to assess the real-world effectiveness and safety of mavacamten in patients with obstructive hypertrophic cardiomyopathy (HCM) receiving mavacamten in Japan
- Trial name
- NCT07383025
- Testing
- Mavacamten
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Bristol-Myers Squibb
Cervical Degenerative Disc Disease, Degenerative Spondylolisthesis
Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion
The purpose of this study is to evaluate the safety and preliminary efficacy of NeoFuse in subjects with a diagnosis of degenerative disc disease (DDD) at 2 or more adjacent cervical vertebral levels between C3-C4 to C7-T1.
- Conditions
- Cervical Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT01106417
- Testing
- NeoFuse, MasterGraft Granules
- Where
- 2 sites in Australia
- Volunteers
- 12 people
- Sponsor
- Mesoblast, Ltd.
Spinal Stenosis of Lumbar Region, Spine Degeneration
Proteomic and Histological Analysis of Ligamentum Flavum in Lumbar Stenosis
Background Lumbar spinal stenosis (LSS) is a common condition characterized by spinal canal narrowing, often linked to ligamentum flavum hypertrophy (LFH) and degeneration.
- Trial name
- APIDeLeG (NCT07026552)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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