Clinical trials: Stroke, Acute, Ischemic
Acute Ischemic Stroke
A PhaseⅡ of Injection for Recombinant Human Tissue Plasminogen Kinase Derivative in Treatment of Acute Ischemic Stroke.
The primary purpose of this trial is to compare the efficacy of different doses of investigator product and comparator product in patients with acute ischemic stroke in 4.5 Hours after stroke onset, and provide a basis of drug…
- Trial name
- NCT04028518
- Testing
- r-PA, Alteplase for Injection
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Angde Biotech Pharmaceutical Co., Ltd.
Ischemic Stroke, Myocardial Ischemia
Coronary Arteriosclerosis in Patients With Acute Ischemic Stroke
The specific objectives of this thesis are in a cohort of patients with an acute ischemic stroke, 1. To establish the degree of coronary arteriosclerosis. 2.
- Conditions
- Ischemic Stroke, Myocardial Ischemia, Coronary Arteriosclerosis
- Trial name
- CORAIS (NCT00701818)
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Vejle Hospital
Ischemic Stroke, Intracranial Hemorrhage
Registry of Acute Stroke Under New Oral Anticoagulants -Pilot (RASUNOA-Pilot)
The registry of acute stroke under new oral anticoagulants (RASUNOA) is a German multicenter, prospective, observational registry performed at about 50 study centers covering about 50.000 acute ischemic strokes and 6000 acute…
- Trial name
- RASUNOA (NCT01850797)
- Where
- Germany
- Volunteers
- 353 people
- Sponsor
- University Hospital Heidelberg
Ischemic Stroke, Acute
Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-D )
To compare the prognosis of patients with hyperacute ischemic stroke (arriving at the emergency department between 4.5-6 hours of symptom onset) managed in a standard stroke unit adherent to guidelines versus managed in Emergency…
- Trial name
- NCT06522282
- Testing
- Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
Study to Assess the Safety and Effectiveness of the Penumbra System
This clinical evaluation is a prospective, single-arm, multi-center trial. The purpose of this clinical evaluation is to assess the safety and effectiveness of the Penumbra System in the revascularization of patients presenting…
- Trial name
- NCT00334061
- Testing
- Penumbra System
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Penumbra Inc.
Acute Ischemic Stroke
Clopidogrel Plus Aspirin in Acute Ischemic Stroke Following Thrombectomy and/or Intravenous Thrombolysis (CoPrime)
Stroke is a common cause of disability. The most common type of stroke, an ischemic stroke, is caused by a blood vessel in the brain getting blocked by a clot.
- Trial name
- CoPrime (NCT06638151)
- Testing
- aspirin + clopidogrel, Aspirin
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of Alberta
Stroke, Practice
Smart-SABI: Digital Phenotyping of Stroke Access Barriers
This study aims to identify and quantify the non-clinical barriers (social, transport, and knowledge-based) that delay patient arrival at the hospital during an Acute Ischemic Stroke.
- Conditions
- Stroke, Practice, Healthcare Disparities, Thrombectomy
- Trial name
- Smart-SABI (NCT07257146)
- Testing
- Targeted Stroke Systems of Care Training (SABI-Guided)
- Where
- Egypt
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Middle East North Africa Stroke and Interventional Neurotherapies Organization
Acute Ischemic Stroke, Cerebrovascular Disorders
Brain, Blood And Clot or Tissue Registry And Collaboration
This is a prospective open enrollment biorepository to collect and evaluate blood and tissue collected during cerebrovascular procedures, which will then be used for the purposes of identifying biological markers, inflammatory…
- Trial name
- BACTRAC (NCT03153683)
- Testing
- Registry
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Justin Fraser
Cerebral Infarction
The Safety and Efficacy of Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ACI) in the Treatment of Acute Cerebral Infarction
The purposes of the study is to determine the safety and efficacy of treating acute ischemic stroke patients with human umbilical cord mesenchymal stem cells (hUC-MSC).
- Trial name
- NCT03186456
- Testing
- Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), Aspirin Tablet
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sclnow Biotechnology Co., Ltd.
Stroke
Activated Protein C in Acute Stroke Trial
The purpose of this research study is to determine the safety and learn more about the dose of Activated Protein C (APC) in reducing the damage from stroke.
- Trial name
- APCAST (NCT00533546)
- Testing
- Activated Protein C
- Where
- 9 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Rochester
Intravenous, Thrombosis
Intravenous TNK vs TPA for AIS Treatment on MSU,a Prospective Multicenter RCT
Acute ischemic stroke is one of the devastating diseases that increase hospitalization, disabilities, and deaths worldwide. Current treatment with intravenous thrombolytic agent can help reduce disabilities and improve quality of…
- Conditions
- Intravenous, Thrombosis, Acute Ischemic Stroke
- Trial name
- NCT06498323
- Testing
- tenecteplase
- Where
- Thailand
- Volunteers
- 160 people
- Sponsor
- Mahidol University
Acute Ischemic Stroke From Large Vessel Occlusion
The Preliminary Efficacy and Safety of Intra-Arterial Albumin as Adjunct to Mechanical Thrombectomy in Acute Ischemic Stroke
Albumin-assisted therapy has demonstrated good safety and potential neuroprotective effects following mechanical thrombectomy. To further systematically evaluate its efficacy and safety, we are conducting a Phase IIa clinical…
- Trial name
- NCT07294391
- Testing
- Human serum albumin infusion 20%
- Volunteers
- 60 people
- Sponsor
- Tianjin Huanhu Hospital
Acute Ischaemic Stroke
Magnetic Resonance Post-contrast Vascular Hyperintensities at 3 T: a Sensitive Sign of Vascular Occlusion in Acute Ischaemic Stroke
Magnetic resonance imaging (MRI) is the diagnostic cornerstone for precisely identifying acute ischaemic strokes and locating vascular occlusions.
- Trial name
- NCT03971526
- Testing
- MRI images review
- Volunteers
- 130 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Cerebral Infarction
Chinese Assessment for Vinpocetine In Neurology
Trial Title：The treatment of Vinpocetine（Cavinton）in patients with cerebral infarction, an open, randomized, multi-center control study 1.
- Trial name
- CAVIN (NCT01400035)
- Where
- China
- Volunteers
- 610 people
- Sponsor
- Shanghai Rxmidas Pharmaceuticals Co. Ltd.
Ischemic Stroke, Acute, Post-stroke Anxiety
Benson Relaxation for Anxiety, Depression, and Insomnia After Stroke
Stroke is a leading cause of disability worldwide. Many patients experience anxiety, depression, and sleep disturbances in the early recovery phase, which can slow rehabilitation.
- Conditions
- Ischemic Stroke, Acute, Post-stroke Anxiety, Post-stroke Depression, Sleep
- Trial name
- BRT-Stroke (NCT07731282)
- Testing
- Benson Relaxation Technique, Structured Health Education
- Where
- 2 sites in China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Changchun University of Traditional Chinese Medicine
Acute Ischemic Stroke
Combined Use of Contact Aspiration and the Stent Retriever Technique Versus Stent Retriever Alone for Recanalisation in Acute Cerebral Infarction
Mechanical thrombectomy (MT) with a stent retriever (SR) device is now the standard intervention in ischemic stroke with large vessel occlusion. Favorable outcome is strongly associated with the successful reperfusion status.
- Trial name
- ASTER2 (NCT03290885)
- Testing
- Combined contact aspiration/Stent Retriever Technique, Stent retriever technique
- Where
- 11 sites in France
- Volunteers
- 408 people
- Sponsor
- Hopital Foch
Mechanical Ventilator Weaning, Acute Brain Injury
Brain-injured Patients Extubation Readiness Study
The BIPER study is a stepped wedge cluster randomised clinical trial aiming to decrease extubation failure in critically-ill brain-injured patients with residual impaired consciousness using a simple clinical score.
- Conditions
- Mechanical Ventilator Weaning, Acute Brain Injury, Altered Level of Consciousness, Mechanical Ventilation
- Trial name
- Biper (NCT04080440)
- Testing
- Extubation readiness clinical score, Usual Care
- Where
- 21 sites in France
- Volunteers
- 660 people
- Sponsor
- University Hospital, Clermont-Ferrand
Stroke, Ischemic
Prognostic Factors and Mortality in Older Stroke Patients With Mechanical Thrombectomy
The study focus on the elderly patient (older than 80 years of age) who had acute ischemic stroke and received mechanical thrombectomy.
- Trial name
- NCT04672148
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Far Eastern Memorial Hospital
Ischemic Stroke
Identification of Hypoxic Brain Tissues by F-MISO PET in Acute Ischemic Stroke
This study is a French multicenter prospective study including 5 stroke units with available MRI and F-MISO PET for patients with acute ischemic stroke.
- Trial name
- STROKE F-MISO (NCT01866189)
- Testing
- PET and MRI
- Sponsor
- University Hospital, Toulouse
Stroke, Endovascular Treatment
Endovascular treatmenT for Acute Ischemic Stroke in China
This is a retrospective real world registry study, aiming to explore the effectiveness and safety of endovascular treatment of acute ischemic stroke in a Chinese population.
- Trial name
- DETECT-China (NCT04752735)
- Testing
- endovascular treatment
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- General Hospital of Shenyang Military Region
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