Clinical trials: Stroke, Acute, Ischemic
Ischemic Stroke
Safety, Tolerability and Pharmacokinetics of SP-8203
Phase I study in health volunteers to assess the safety, tolerability and pharmacokinetics of escalating single doses and multiple doses of SP-8203
- Trial name
- NCT01757795
- Testing
- SP-8203
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Ischemic Stroke
Serial ECG Versus Holter to Detect Atrial Fibrillation in Elderly Ischemic Stroke Patients
Paroxysmal atrial fibrillation is often undetected because characteristics such as short duration, episodic, and frequently asymptomatic nature make it challenging to diagnose at the bedside, leading to suboptimal secondary…
- Trial name
- NCT02578979
- Testing
- Electrocardiogram, Holter
- Where
- 6 sites in Taiwan
- Volunteers
- 826 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke
Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke
The purpose of this trial is to evaluate if it is safe to use tissue plasminogen activator (tPA) within 6 hours of stroke onset when combined with hypothermia.
- Trial name
- NCT00283088
- Testing
- hypothermia, tissue plasminogen activator
- Where
- 7 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of California, San Diego
Stroke Acute
Study on the Optimal Head Position for Patients With Severe Acute Ischemic Stroke
Stroke is the second leading cause of death and the third leading cause of disability worldwide, with an increasing incidence. Reperfusion therapy after cerebral ischemia is one of the most practical and effective treatments for…
- Trial name
- NCT07507097
- Testing
- head position
- Where
- China
- Volunteers
- 1,508 people
- Sponsor
- West China Hospital
Acute Stroke
Endovascular Revascularization With Solitaire Device Versus Best Medical Therapy in Anterior Circulation Stroke Within 8 Hours
To evaluate the hypothesis that mechanical embolectomy with the Solitaire FR device is superior to medical management alone in achieving favorable outcome in the distribution of the modified Rankin Scale scores at 90 days in…
- Trial name
- REVASCAT (NCT01692379)
- Testing
- Solitaire FR device, Medical treatment
- Where
- 4 sites in Spain
- Volunteers
- 206 people
- Sponsor
- Fundacio Ictus Malaltia Vascular
Stroke, Ischemic
Randomization of Endovascular Treatment in Acute Ischemic Stroke in the Extended Time Window
A phase III, randomized, multi-center, open label clinical trial that will examine whether endovascular treatment is superior to standard medical therapy alone in patients who suffer a large vessel anterior circulation ischemic…
- Trial name
- RESILIENTExt (NCT04256096)
- Testing
- Thrombectomy
- Where
- 14 sites in Brazil
- Volunteers
- 376 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Ischemic Stroke
REMOTE Ischemic Perconditioning Among Acute Ischemic Stroke Patients ( REMOTE-CAT)
Stroke is one of the leading causes of death worldwide and the main cause of incapacity. Currently, the only therapies for acute ischemic stroke (AIS) patients are the administration of recombinant tissue plasminogen activator…
- Trial name
- REMOTE-CAT (NCT03375762)
- Testing
- Remote ischemic perconditioning
- Where
- Spain
- Volunteers
- 572 people
- Sponsor
- Institut de Recerca Biomèdica de Lleida
Stroke, Acute
r-tPA Thrombolytic Therapy in Combination With Remote Ischemic Conditioning for Acute Ischemic Stroke Recovery
to detect the efficiency and safety of intravenous rtPA combined with RIPC in acute ischemic stroke patients
- Trial name
- rtPA-RIC (NCT02886390)
- Testing
- ischemic conditioning
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Comparative Effectiveness of Neuroprotectants on Acute Ischemic Stroke
The primary objective of this study is to compare effectiveness of five different neuroprotectants, including butylphthalide, edaravone, citicoline, cerebrolysin, and piracetam, among patients with acute ischemic stroke.
- Trial name
- CER (NCT01556854)
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- yongjun wang
Acute Stroke, Ischemic Stroke, Acute
Rescue Extracranial Vertebral Stenting in Tandem Occlusions
The acute vertebrobasilar occlusion associated with the poor prognosis, particularly tandem occlusion. However, few data on the efficacy of the endovascular therapy was indicated in this occlusion.
- Conditions
- Acute Stroke, Ischemic Stroke, Acute, Vertebro Basilar Ischemia
- Trial name
- REVET (NCT06365294)
- Testing
- Rescue extracranial stenting
- Where
- Vietnam
- Volunteers
- 9 people
- Sponsor
- Dr. Cuong Tran Chi
Acute Ischemic Stroke
Minocycline Efficacy in Improving Neurological Outcome of Patients Who Undergo Endovascular Revascularization for Acute Ischemic Stroke
The study will be a prospective, randomized, double- blinded placebo, single center pilot clinical trial. Patients with acute ischemic stroke due to large vessel occlusion undergoing endovascular thrombectomy will be included.
- Trial name
- NCT05367362
- Testing
- Minocyclin
- Sponsor
- State University of New York at Buffalo
Stroke, Embolus Cerebral
MAnagement of Systolic Blood Pressure During Thrombectomy by Endovascular Route for Acute Ischaemic STROKE
Stroke is the third most common cause of death in New Zealand and is one of the leading causes of long-term disability at all ages.
- Conditions
- Stroke, Embolus Cerebral, Blood Pressure
- Trial name
- MASTERSTROKE (NCT05645861)
- Testing
- Blood pressure management of Systolic Blood Pressure to maintain target range +/- 10 mmHg
- Where
- 6 sites in Australia, New Zealand
- Volunteers
- 550 people
- Sponsor
- Auckland City Hospital
Ischemic Stroke
Study of Tiprogrel in the Treatment of High-risk Patients with Acute Ischemic Cerebrovascular Events (THRIVE).
This study is designed to evaluate efficacy and safety of tiprogrel in the treatment of patients with acute ischemic cerebrovascular events.
- Trial name
- NCT06601127
- Testing
- Tiprogrel, Clopidogrel
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Tianjin Institute of Pharmaceutical Research Co., Ltd
Stroke, Ischemic
Tenecteplase REperfusion in Acute Ischemic sTroke Registry（TREAT）
The aim of the study was to establish tenecteplase thrombolysis database and to investigate the effectiveness and safety of rhTNK-tPA in acute ischemic stroke patients.
- Trial name
- NCT05724342
- Testing
- rhTNK-tPA Thrombolysis
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Reasons for Prehospital Delay in Patients With Acute Ischemic Stroke
Ischemic stroke is the leading cause of acquired disability among adults, and one of the main causes of death. In Switzerland, the approved time window for stroke treatment with intravenous thrombolysis after symptom onset is 4.5…
- Trial name
- NCT02798770
- Testing
- No Intervention Foreseen
- Where
- Switzerland
- Volunteers
- 337 people
- Sponsor
- University Hospital, Basel, Switzerland
Stroke, Acute
Biological Dating of Cerebral Ischemia With GST-π/PRDX1 to Detect Patients With Stroke of Unknown Onset Within the Therapeutic Window of Thrombolysis
The FLAG1 study will assess the diagnostic performance of biomarkers Glutathion S-Transferase-π (GST-π) and Peroxyredoxin 1 (PRDX1) to identify cerebral infarction of less than 4,5 hours in a population of patients with…
- Trial name
- FLAG1 (NCT03364296)
- Testing
- Blood Samples
- Where
- 5 sites in France
- Volunteers
- 935 people
- Sponsor
- Central Hospital, Nancy, France
Acute Ischemic Stroke, Acute Haemorrhagic Stroke
Role of EEG in Differentiation Between Ischemic and Hemorrhagic Stroke
Searching electrical activity registered by EEG in acute ischemic and hemorrhagic stroke and comparing these parameters to the post-stroke recovery patterns to investigate the role of EEG as a differentiation tool and as a…
- Trial name
- NCT06984965
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Assiut University
Ischemic Stroke
Outcome in Patients Treated with Intraarterial Thrombectomy - OptiMAL Blood Pressure Control (OPTIMAL-BP)
Recent endovascular thrombectomy (EVT) trial have proven the effectiveness of intraarterial revascularization in patients with larger cerebral artery occlusion.
- Trial name
- NCT04205305
- Testing
- conventional blood pressure control (labetalol, nicardipine), intensive blood pressure control (labetalol, nicardipine)
- Where
- South Korea
- Volunteers
- 306 people
- Sponsor
- Yonsei University
Acute Ischemic Stroke
FIrst-Pass Reperfusion With the NeVa Stent-Retriever Trial
This study is designed to compare the safety, performance and efficacy of blood clot (thrombus) removal in subjects presenting with acute ischemic stroke with the NeVa versus the Solitaire stent retrievers.
- Trial name
- FIRST (NCT04072367)
- Testing
- NeVa Stent Retrievers, Solitaire Stent Retrievers
- Sponsor
- Vesalio
Acute Stroke
Cytoflavin in Combination With Reperfusion in Stroke Patients
Evaluation of the efficacy and safety of Cytoflavin®, solution for intravenous administration, (OOO NTFF POLYSAN, Russia) for 10 days, patients with cerebral infarction who receive reperfusion therapy, with the start of treatment…
- Trial name
- NCT05297851
- Testing
- Cytoflavin (succinic acid + inosine + nicotinamide + riboflavin), Control
- Where
- 7 sites in Russia
- Volunteers
- 200 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
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