Clinical trials: Stroke, Acute, Ischemic
Acute Ischemic Stroke
Safety and Effectiveness of Remote Ischemic Conditioning Combined With Intravenous Thrombolysis in Treating Acute Ischemic Stroke
The purpose of this study is to determine the efficacy and safety of remote ischemic conditioning combined with intravenous thrombolysis in treating acute ischemic stroke.
- Trial name
- SERICT-AIS (NCT04027621)
- Testing
- remote ischemic conditioning
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Yi Yang
Acute Ischemic Stroke
Imaging Guided Patient Selection for Interventional Revascularization Therapy
The primary objective of this clinical evaluation is to determine the safety and effectiveness of the Penumbra System in a stroke cohort who presents within 8 hours from symptom and with a known core infarct volume at admission.
- Trial name
- START (NCT00963989)
- Testing
- Penumbra System
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Penumbra Inc.
Acute Ischemic Stroke
Buyang Huanwu Decoction With Wuling Powder for Acute Ischemic Stroke
Acute ischemic stroke is a common cause of disability. Standard Western medical treatment is widely used, but some patients continue to have neurological impairment and difficulty with daily activities after stroke.
- Trial name
- BYHW-WL (NCT07687043)
- Testing
- Standard Western Medical Treatment, Serum Sample Collection for Metabolomics Only, Buyang Huanwu Decoction Combined With Wuling Powder
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Liaoning University of Traditional Chinese Medicine
Acute Ischemic Stroke
A Multicenter, Three-Arm, Open-Label, Endpoint-Blinded Randomized Controlled Trial to Evaluate the Optimal Duration of Early Tirofiban After Intravenous Thrombolysis in Acute Ischemic Stroke
Acute ischemic stroke is a leading cause of disability and mortality among dults in China. Although intravenous thrombolysis serves as first-line reperfusion therapy, nearly half of patients fail to achieve vascular…
- Trial name
- INSTANT-2 (NCT07842185)
- Testing
- Tirofiban Injection, No Interventions
- Where
- 10 sites in China
- Volunteers
- 1,482 people
- Sponsor
- Xinqiao Hospital of Chongqing
Acute Ischemic Stroke
Remote Ischemic Conditioning for the Treatment of Stroke-related Insomnia
This study intends to further reveal the effect of RIC in stroke-related insomnia and explore its potential mechanisms.
- Trial name
- RIC-SI (NCT05289518)
- Testing
- Remote ischemic conditioning (RIC)
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Ji Xunming,MD,PhD
Stroke, Ischemic
Neuroprotection in Acute Ischemic Stroke
This is a pilot randomized control trial (RCT) to explore the possible beneficial effect of a novel combination therapy consisting of molecular hydrogen H2 plus minocycline ("H2M"), on neurological recovery after acute ischemic…
- Trial name
- H2M (NCT03320018)
- Testing
- Hydrogen, Minocycline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stony Brook University
Ischemic Stroke
A Safety and Effective Study of Ginkgolides Diterpene Lactone Meglumine Injection in the Treatment of Ischemic Stroke.
The aim of this study is to evaluate the safety and effectivity of Ginkgo diterpene lactone meglumine injection tn the treatment of acute ischemic stroke
- Trial name
- NCT02526225
- Testing
- Ginkgo diterpene lactone meglumine injection, Ginkgo diterpene lactone meglumine injection simulation
- Where
- China
- Volunteers
- 3,452 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Acute Coronary Syndrome
Comparative Study of Arterial Properties After an Ischaemic Stroke or an Acute Coronary Syndrome
A pilot, prospective, comparative study. To include both male and female patients who have presented an ischaemic stroke (full stroke or TIA) or an ACS, 5 to 30 days prior to inclusion.
- Conditions
- Ischemic Stroke, Acute Coronary Syndrome, Obstructive Sleep Apnea Syndrome
- Trial name
- AVC/SCA (NCT00926874)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Grenoble
Stroke, Acute Ischemic Stroke
Extended Time Window Intravenous Thrombolysis Registry for Acute Ischemic Stroke
The EXTEND-IVT Registry is a prospective, multicenter, observational cohort study designed to evaluate the effectiveness and safety of intravenous thrombolysis administered beyond 4.5 hours after last known well in patients with…
- Trial name
- EXTEND-IVT (NCT07536074)
- Testing
- Intravenous Thrombolysis
- Where
- 2 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Acute Stroke
Impact of Anesthesia Type on Outcome in Patients With Acute Ischemic Stroke (AIS) Undergoing Endovascular Treatment
Recent observational studies have found an association between general anaesthesia and increased post-operative mortality in acute ischemic stroke patients undergoing endovascular treatment.
- Trial name
- CANVAS (NCT02677415)
- Testing
- Intravenous anesthetics, local anesthesia, Controlled ventilation
- Where
- China
- Volunteers
- 640 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Albumin for Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Therapy -2
This study is a prospective, multicenter, open-label, randomized controlled clinical trial. The investigators will apply albumin to the reperfusion treatment of patients with acute ischemic stroke in the anterior circulation.
- Trial name
- ARISE-2 (NCT07263308)
- Testing
- Albumin, Endovascular treatment
- Where
- 61 sites in China
- Volunteers
- 1,192 people
- Sponsor
- Capital Medical University
Transcranial Magnetic Stimulation
Effects of Repetitive Transcranial Magnetic Stimulation on Cerebral Autoregulation in Patients With Acute Ischemic Stroke
The purpose of this study was to investigate the effect of repetitive transcranial magnetic stimulation on cerebral autoregulation in patients with acute ischemic stroke.
- Trial name
- NCT05843240
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Yi Yang
Stroke, Stenosis
Abciximab for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic Carotid Stenosis
The purpose of the present prospective, randomized, double-blind, double dummy controlled multicenter pilot study is to investigate whether abciximab, compared with aspirin, is able to reduce the rate of recurrent ischemic…
- Trial name
- NCT00126139
- Testing
- Abciximab
- Where
- 5 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Acute Ischemic Stroke
A Study to Evaluate the Intracranial Arterial Recanalization With Multiple Doses of LT3001 Drug Product in AIS Participant
This is a phase II, open-label, single-arm, exploratory study to evaluate the intracranial arterial recanalization of multiple doses of LT3001 drug product in participant with acute ischemic stroke (AIS)
- Trial name
- NCT07890298
- Testing
- LT3001 Drug Product
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Lumosa Therapeutics Co., Ltd.
Stroke Acute, Endovascular Treatment
Advancing Reperfusion Therapy for Ischemic Stroke: Safety and Efficacy of Anakinra for Futile Reperfusion Following Endovascular Treatment in Patients With Acute Ischemic Stroke
The investigators initiated a multicenter, prospective, randomized, open label, blinded-endpoint (PROBE) controlled trial to explore the safety and efficacy of different dose of Anakinra compared to standard medical care for…
- Trial name
- ARTS-SAFE (NCT07423975)
- Testing
- High-dose Anakinra, Low-dose Anakinra, Standard medical treatment
- Where
- 6 sites in China
- Volunteers
- 159 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke, Diabetes (DM)
CGM in Acute Ischemic Stroke
The goal of this randomized clinical trial is to evaluate whether continuous glucose monitoring (CGM) can be used to guide glucose management in patients with type 2 diabetes who are admitted with an acute ischemic stroke and…
- Conditions
- Acute Ischemic Stroke, Diabetes (DM), Diabetes Type 2, Hyperglycemia
- Trial name
- SENSTROKE (NCT07510919)
- Testing
- Continuous Glucose Monitoring, Point-of-Care Testing
- Volunteers
- 82 people
- Sponsor
- Isala
Acute Ischemic Stroke (AIS)
Tirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized Trial
Acute ischemic stroke caused by blockage of a large artery in the brain is one of the leading causes of death and long-term disability worldwide.
- Trial name
- TOPAZ (NCT07734792)
- Testing
- Tirzepatide, Standard Medical Care (SMC)
- Where
- China
- Volunteers
- 726 people
- Sponsor
- yifang zhu
Acute Ischaemic Stroke
Pragmatic Ischaemic Stroke Thrombectomy Evaluation
Ischaemic strokes (those caused by blockage in an artery in the brain caused by a blood clot) can be treated with very early use of clot-busting (thrombolytic) drugs to attempt to restore the blood supply and limit the damage…
- Trial name
- PISTE (NCT01745692)
- Testing
- Mechanical thrombectomy, Intravenous rtPA
- Where
- United Kingdom
- Volunteers
- 65 people
- Sponsor
- NHS Greater Glasgow and Clyde
Ischemic Stroke
Intravenous Thrombolysis Registry for Acute Ischemic Stroke in China
To analyze the real situation of intravenous thrombolysis in acute ischemic stroke in China
- Trial name
- NCT03997292
- Testing
- Alteplase, Urokinase
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- General Hospital of Shenyang Military Region
Stroke
Contribution of a High-resolution Diffusion Sequence at 3T for the Detection of Acute Punctate Ischemic Brain Lesions
Stroke is a public health issue and a priority for our institution. MRI plays an essential role in the management of stroke, its contribution being diagnostic, etiological and prognostic.
- Trial name
- STROKE_HR (NCT05232500)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Hôpital Saint-Joseph
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