Clinical trials: Stroke, Acute, Ischemic
Stroke
Glial Fibrillary Acidic Protein Testing and Handheld Near Infrared Spectroscopy Technology CEREBO in India.
CEREBO is an ICMR award winning point-of-care (POC) adjunct CT scanning device for detecting brain hematomas in patients with head injury.
- Trial name
- NCT07844109
- Testing
- GFAP/D-Dimer Point-of-Care Testing & CEREBO Near-Infrared Spectroscopy (NIRS), CT Head
- Where
- 2 sites in India
- Volunteers
- 232 people
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Cerebrovascular Stroke, Atrial Fibrillation
Prediction and Detection of Occult Atrial Fibrillation in Patients After Acute Cryptogenic Stroke and TIA
PROACTIA is a prospective, event-driven observational study. It aims to propose a composite scoring system in order to evaluate the risk of paroxysmal atrial fibrillation (PAF) in patients after acute cryptogenic stroke and…
- Trial name
- PROACTIA (NCT02725944)
- Testing
- Implantation of ICRM
- Where
- Norway
- Volunteers
- 251 people
- Sponsor
- University Hospital, Akershus
Large Vessel Occlusion, Acute Ischemic Stroke
Intracranial Thrombosis Aspiration Catheter for Recanalization in Acute Ischemic Stroke Therapy (RECOVER)
This study is a prospective, multi-center, open-label, end-point blinded, randomized, parallel positive control, non-inferiority clinical trial, with a purpose to evaluate the safety and efficacy of Hemo Jirui intracranial…
- Conditions
- Large Vessel Occlusion, Acute Ischemic Stroke, Cerebrovascular Disorders
- Trial name
- NCT03753061
- Testing
- Aspiration Catheter, Solitaire FR
- Where
- 23 sites in China
- Volunteers
- 204 people
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
Acute Ischemic Stroke
The Efficacy and Safety of HRS-4029 in Acute Ischemic Stroke Patients
This trial will evaluate the efficacy and safety of HRS-4029 compared with placebo in participants with acute ischemic stroke (AIS).
- Trial name
- NCT07739160
- Testing
- HRS-4029
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Beijing Suncadia Pharmaceuticals Co., Ltd
Acute Ischemic Stroke
Association Between Circulating BDNF Levels and Cardioembolic Strokes in Patients Treated for Ischemic Stroke
Atrial fibrillation (AF) is associated with serious complications, including embolic strokes, heart failure, and mortality. Disruption of normal blood flow in the atrium, particularly in the context of an endocardium predisposed…
- Trial name
- METAPROFIL 1 (NCT07624396)
- Testing
- Circulating BDNF levels measured via blood sample
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Medium Vessel Occlusion Stroke (MeVO), Stroke Acute
SAIL-MEVO: Endovascular Treatment Versus Best Medical Therapy for Distal Vessel Occlusions
Patients with acute ischemic stroke caused by distal or medium vessel occlusions (MeVOs) may experience significant disability despite receiving the current standard medical treatment.
- Conditions
- Medium Vessel Occlusion Stroke (MeVO), Stroke Acute, Acute Ischemic Stroke, Cerebral Artery Occlusion
- Trial name
- SAIL MEVO (NCT07843797)
- Testing
- best medical therapy, Endovascular Treatment
- Where
- Spain
- Volunteers
- 420 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Ischemic Stroke
Repeated Intravenous Thrombolysis for Ischemic Stroke With Medium to Large Vessel Occlusion Presenting Within 4.5 Hours of Onset With Prourokinase
Ischemic cerebrovascular disease is a common neurological disorder with high incidence, mortality, and disability. Early reperfusion to salvage the ischemic penumbra is the cornerstone of acute ischemic stroke (AIS) treatment.
- Trial name
- NCT07550296
- Testing
- prourokinase
- Where
- China
- Volunteers
- 122 people
- Sponsor
- General Hospital of Shenyang Military Region
Stroke, Acute Ischemic
Tirofiban for Successful Endovascular Stroke Thrombectomy
Up to 50% of acute ischemic stroke patients with large vessel occlusion failed to achieve functional independence even after successful reperfusion therapy, a phenomenon that is referred to as "futile recanalization".
- Trial name
- ADJUVANT-2 (NCT06373042)
- Testing
- Intraarterial and intravenous tirofiban
- Volunteers
- 712 people
- Sponsor
- Zhongming Qiu
Ischemic Stroke, Alteplase Adverse Reaction
the Predictors of Hemorrhagic Transformation Subtypes in Acute Embolic Stroke Patients
The investigators evaluated the impact of AF on different subtypes of post-alteplase hemorrhagic transformation of brain infarction.
- Trial name
- NCT06653946
- Testing
- Alteplase
- Where
- Egypt
- Volunteers
- 716 people
- Sponsor
- Kafrelsheikh University
Acute Ischemic Stroke
Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-Ⅱ
A Phase Ⅲ, Multicenter, Prospective, Randomized, Open Label, Blinded-endpoint (PROBE) Controlled Trial of Recombinant Human TNK Tissue-type Plasminogen Activator (rhTNK-tPA) for Injection Versus Alteplase for Acute Ischemic…
- Trial name
- TRACEⅡ (NCT04797013)
- Testing
- rt-PA, rhTNK-tPA
- Where
- 61 sites in China
- Volunteers
- 1,430 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, TIA
Cilostazol and Aspirin in Stroke and TIA
This study is a randomized, open-labelled trial. We randomly assigned patients within 24 hours after the onset of minor ischemic stroke or high-risk TIA to combination therapy with cilostazol and aspirin or to clopidogrel plus…
- Trial name
- NCT06522113
- Testing
- Cilostazol, Clopidogrel
- Where
- South Korea
- Volunteers
- 378 people
- Sponsor
- Incheon St.Mary's Hospital
Ischemic Stroke, Acute, Endovascular Thrombectomy
Effects of Transcranial Magnetic Stimulation After Endovascular Treatment for Acute Ischemic Stroke
This is a multicenter, randomized, double-blind, sham-controlled trial, to determine the efficacy and safety of cTBS in treating patients with acute ischemic stroke after endovascular treatment.
- Trial name
- NCT06639360
- Testing
- Transcranial Magnetic Stimulation Active
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Stroke, Acute Ischemic Stroke
Study on Anti-Thrombotic Regimens for Secondary Prevention in Ischemic Stroke Patients With Possible Benefit From Anticoagulation Therapy
To screen ischemic stroke patients likely to benefit from anticoagulation and compare the effectiveness and safety of anticoagulation versus antiplatelet therapy in preventing recurrent ischemic stroke within 3 months.
- Trial name
- NCT07746882
- Testing
- Rivaroxaban, or Edoxaban , or Apixaban , or Dabigatran, Aspirin
- Volunteers
- 680 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Coronary Syndrome
Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome
This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death…
- Trial name
- AEGIS-II (NCT03473223)
- Testing
- Apolipoprotein A-I [human] (apoA-I)
- Where
- 903 sites in United States, Argentina and 47 more
- Volunteers
- 18,226 people
- Sponsor
- CSL Behring
Acute Ischemic Stroke
Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events(TRACE)
To explore the safe and efficacious dose of rhTNK-tPA injection administered within 3 hours after onset of hyperacute ischemic stroke; to provide dose evidence for phase III clinical trial.
- Trial name
- NCT04676659
- Testing
- TNK-tPA
- Where
- 24 sites in China
- Volunteers
- 240 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Acute, Stroke, Ischemic
Carotid Artery Stenting During Endovascular Treatment of Acute Stroke
Rationale: Approximately 20% of the patients with acute ischemic stroke due to an intracranial large vessel occlusion (LVO) has a high-grade stenosis in the ipsilateral cervical carotid artery.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Carotid Stenosis, Carotid Atherosclerosis
- Trial name
- CASES (NCT06511089)
- Testing
- carotid artery stenting during EVT, no carotid artery stenting during EVT
- Where
- Netherlands
- Volunteers
- 600 people
- Sponsor
- University Medical Center Groningen
Acute Ischemic Stroke
Head-of-Bed Positioning in Large Artery Acute Ischemic Stroke
Positioning of the patient with hyperacute large artery ischemic stroke (IS) is an important, yet understudied aspect of care that could impact the course of treatment and ultimately clinical outcome.
- Trial name
- NCT05073159
- Testing
- Allocating head-of-bed position
- Where
- 2 sites in Singapore
- Volunteers
- 182 people
- Sponsor
- National University of Singapore
Stroke, Ischemic, Thrombectomy
Prognostic Value of Isolated and Combined Score Aspects in Acute Ischemic Stroke
This study, called TARGET-ASPECT, looks at patients who had a type of stroke called acute ischemic stroke and were treated with clot-busting medicine and a procedure to remove the clot.
- Conditions
- Stroke, Ischemic, Thrombectomy, Thrombolytic Therapy, Brain Ischemia
- Trial name
- NCT07069452
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Centre Hospitalier de Gonesse
Stroke, Stroke, Acute
BELgian CT-perFUSion Study to Select Acute Stroke Patients for Thrombectomy
The goal of this clinical trial is to test whether perfusion CT can be used as a selection tool in stroke patients with a major anterior circulation occlusion, to exclude patients from thrombectomy because of a predicted…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- BELFUS (NCT05685043)
- Testing
- perfusion CT
- Sponsor
- University Hospital, Ghent
Stroke, Lacunar
The Effect of Aerobic Exercise in Patients With Lacunar Stroke
In a randomized-controlled study the effect of high-intensity training, 5 days a week at home for 12 weeks is tested in patients with lacunar stroke.
- Trial name
- HITPALS (NCT02731235)
- Testing
- High-intensity training, prophylactic stroke medication, Recommendations for lifestyle changes
- Where
- Denmark
- Volunteers
- 71 people
- Sponsor
- Herlev Hospital
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