Clinical trials: Stroke, Acute, Ischemic
Ischemic Stroke
Cerebrolysin REGistry Study in Stroke
Investigation of clinical practices, safety and effectiveness of Cerebrolysin in routine treatment of patients with acute ischemic stroke.
- Trial name
- CREGS-S (NCT02541227)
- Testing
- Cerebrolysin
- Where
- Austria
- Volunteers
- 1,823 people
- Sponsor
- Ever Neuro Pharma GmbH
Stroke, Acute
Manipulation of Arterial Pressure in Acute Ischemic Stroke
This is a controlled clinical trial among non thrombolysed acute ischemic stroke patients to determine the effects of three levels of arterial pressure on death and neurological disability.
- Trial name
- MAPAS (NCT00848770)
- Testing
- Esmolol, Sodium Nitroprussiate (NPS) or Norepinephrine (NOR), Esmolol, NPS or NOR, manipulation of SAP
- Where
- Brazil
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acute Ischemic Stroke
Early Administration of Edoxaban After Acute Ischemic Stroke in Patients With Non-valvular Atrial Fibrillation
The investigators hypothesize that earlier initiation of edoxaban in AF-related stroke patients may significantly reduce the early recurrence of ischemic stroke, compared with conventional strategy of anticoagulation following…
- Trial name
- NCT03433235
- Testing
- Edoxaban
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Jong Sung Kim
Brain Ischemia
Cerebral Perfusion Associated With Postural Changes: an ASL MR Perfusion Study
Postural changes are commonly used as therapeutic maneuver to enhance or reduce cerebral perfusion. For instance, in acute stroke, the patient can be positioned in head down tilt position so as to increase perfusion of cerebral…
- Trial name
- PerfIRMAVC (NCT02912546)
- Testing
- MRI
- Where
- Martinique
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University Hospital Center of Martinique
Acute Ischemic Stroke
Construction and Validation of an In-hospital Mortality Risk Prediction Model for Acute Ischemic Stroke Patients
Firstly, the application effect of the existing predictive models, SOAR and GWTG-Stroke, was verified in Guangdong acute ischemic Stroke population, and the clinical application effect of the existing predictive models was…
- Trial name
- NCT04979624
- Volunteers
- 234 people
- Sponsor
- Shenzhen Second People's Hospital
Stroke, Acute
Early Neurological Trajectory and Clinical Outcomes in Brain Acute Ischemic Stroke
Prospective identification of potential responsible blood vessels, provision of intervention targets, prevention of fatal and disabling cerebrovascular diseases, identification of early END patients, determination of clinical…
- Trial name
- NCT06170086
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Ischemic Stroke
Rescues On Reperfusion Damage In Cerebral Infarction by Nelonemdaz
Efficacy and safety of Neu2000, a multi-target drug designed to prevent both NMDA receptor-mediated excitotoxicity and free radical toxicity, will be investigated in acute ischemic stroke patients receiving endovascular treatment…
- Trial name
- RODIN (NCT05041010)
- Testing
- Neu2000KWL group
- Where
- 24 sites in South Korea
- Volunteers
- 496 people
- Sponsor
- GNT Pharma
Acute Ischemic Stroke
Efficacy and Safety of Human Urinary Kallidinogenase Combined With Endovascular Therapy in Acute Ischemic Stroke With Large Vessel Occlusion
The purpose of this study is to evaluate the safety and efficacy of Human Urinary Kallidinogenase combined with endovascular therapy in acute ischemic stroke (AIS) patients with large vessel occlusion.
- Trial name
- HEAL (NCT06211712)
- Testing
- Experimental: Human Urinary Kallidinogenase
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huashan Hospital
Ischemic Stroke
Granulocyte-colony Stimulating Factor for Stem Cells Therapy for Acute Ischemic Stroke
The aim of the study is to investigate treatment with Leukostim (Filgrastim; granulocyte-colony stimulating factor; G-CSF) for acute ischemic stroke.
- Trial name
- STEMTHER (NCT00901381)
- Testing
- Filgrastim
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Clinical Institute of the Brain, Russia
Venous Thrombosis, Pulmonary Embolism
Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)
This prospective cohort study will provide information about: characteristics of Rivaroxaban use in patients who are prescribed Rivaroxaban for the first time compared to patients who are prescribed Warfarin for the first time…
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Acute Coronary Syndrome
- Trial name
- NCT01947998
- Testing
- Rivaroxaban (Xarelto, Bay59-7939), Warfarin, Antiplatelet drugs
- Where
- United Kingdom
- Volunteers
- 50,299 people
- Sponsor
- Bayer
Cerebral Ischemia, Cerebral Infarction
Efficacy of Sovateltide (PMZ-1620) in Patients of Acute Ischemic Stroke
In the present prospective, multicentric, randomized, double-blind, parallel, saline-controlled phase II clinical study; the investigators plan to evaluate the efficacy of sovateltide (IRL-1620 or PMZ-1620) therapy along with…
- Conditions
- Cerebral Ischemia, Cerebral Infarction, Stroke, Acute
- Trial name
- NCT04047563
- Testing
- Normal Saline along with standard treatment, PMZ-1620 (sovateltide) along with standard treatment
- Where
- 11 sites in India
- Volunteers
- 158 people
- Sponsor
- Pharmazz, Inc.
Stroke, Acute Stroke
Effectiveness of Best Care Practices in Acute Stroke in Conventional Hospitalization (BEST CARE ICTUS_HC)
The goal of this clinical trial is to evaluate whether a multicomponent nurse-led intervention (BEST CARE ICTUS_HC) can reduce stroke-related complications and improve recovery in adults (18 years and older) hospitalized with an…
- Conditions
- Stroke, Acute Stroke, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- BESTCAREICTUS (NCT07627399)
- Testing
- BEST CARE ICTUS_HC BUNDLE
- Where
- 4 sites in Spain
- Volunteers
- 700 people
- Sponsor
- University of Malaga
Stroke, Acute, Stroke, Ischemic
Glenzocimab for REperfusion in the Setting of Endovascular Therapy for Brain infarctioN: GREEN Study
Emergent reperfusion is the main goal for acute ischemic stroke therapy (AIS). Endovascular therapy (EVT) is recommended within 6 hrs of stroke onset, and up to 24 hrs following perfusion imaging criteria.
- Trial name
- GREEN (NCT05559398)
- Testing
- Glenzocimab
- Where
- 12 sites in France
- Volunteers
- 108 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Ischemic Stroke
Study to Assess PK, Safety and Tolerability in Healthy Subjects
The purpose of this study is to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of QHRD106 in Chinese healthy subjects with single and multiple doses.
- Trial name
- NCT06380699
- Testing
- QHRD106 Injection, Human Urinary Kallidinogenase
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Changzhou Qianhong Bio-pharma Co., Ltd.
Acute Ischemic Stroke, Large Vessel Occlusion
Evaluation of the CONDA Stent Retriever in Acute Ischemic Stroke
The goal of this study is to evaluate the safety and performance of the CONDA stent retriever in patients with acute ischemic stroke due to large vessel occlusion, treated within 24 hours of symptom onset.
- Trial name
- ARTEMIS (NCT07174505)
- Testing
- Mechanical Thrombectomy using the CONDA Stent Retriever
- Where
- 2 sites in Hungary, Spain
- Volunteers
- 50 people
- Sponsor
- Anaconda Biomed S.L.
Cognitive Impairment, Stroke
Hypoalbuminemia in Mild Acute Stroke and Cognitive Impariment Post-stroke
This registration enrolled patients with acute ischemic stroke within 72 hours after stroke ictus. Patients was identified as first-ever stroke based on past medical histrory.
- Conditions
- Cognitive Impairment, Stroke, Albumin; Double
- Trial name
- NCT04135872
- Testing
- strengthened nuitritional treatment
- Where
- China
- Volunteers
- 435 people
- Sponsor
- Dongguan People's Hospital
Stroke, Acute Ischemic, Stroke, Acute
CHemical OptImization of Cerebral Embolectomy 2 (CHOICE 2).
Multi-center, randomized, parallel-group, superiority study to compare the efficacy of adjunct intra-arterial rt-PA versus not adjunct intra-arterial rt-PA in the improvement of the efficacy of mechanical thrombectomy in patients…
- Trial name
- CHOICE2 (NCT05797792)
- Testing
- Intraarterial alteplase
- Where
- 14 sites in Spain
- Volunteers
- 440 people
- Sponsor
- Hospital Clinic of Barcelona
Subjects With Acute Ischemic Stroke
The Efficacy and Safety of Edaravone Dexborneol Sequential Therapy in the Treatment of Patients With AIS
SIM0308-302 is a multicenter, randomized, double-blind, placebo-controlled clinical III trial with the primary objective of evaluating the efficacy of Edaravone Dexborneol sequential therapy, consisting of Edaravone Dexborneol…
- Trial name
- NCT06176781
- Testing
- Edaravone Dexborneol Sequential Therapy
- Volunteers
- 880 people
- Sponsor
- Simcere Pharmaceutical Co., Ltd
Ischemic Stroke, Transient Ischemic Attack
Rivaroxaban Versus Warfarin in Acute Ischemic Stroke With Atrial Fibrillation
Rationale Acute ischemic stroke due to atrial fibrillation (AF) carries a high risk for early recurrence. In acute stage, guidelines recommend aspirin, but do not recommend anticoagulation due to the increased risk of…
- Trial name
- TripleAXEL (NCT02042534)
- Testing
- Rivaroxaban, Warfarin
- Where
- South Korea
- Volunteers
- 195 people
- Sponsor
- Asan Medical Center
Stroke, Acute, Stroke, Ischemic
Induced Hypertension in Acute PRogrESsive Perforating Artery Stroke Using Peripheral Dilute noREpinephrine
PRESSURE is a multicenter, prospective, randomized, open, blinded end-point assessed (PROBE) trial, that aims to evaluate the efficacy and safety of drug-induced hypertension using peripheral dilute norepinephrine, in patients…
- Trial name
- PRESSURE (NCT06059144)
- Testing
- Peripheral intravenous norepinephrine
- Where
- France
- Volunteers
- 358 people
- Sponsor
- University Hospital, Bordeaux
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