Clinical trials: Stroke, Acute
Stroke
Exercise and Genotype in Sub-acute Stroke
This study will investigate the impact of cardiovascular exercise on brain plasticity among patients in sub-acute stages after stroke, and whether genotype modulates the response to this intervention.
- Trial name
- NCT05076747
- Testing
- Cardiovascular training, Standard Therapy
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- McGill University
Acute Ischemic Stroke
COOLing of the Ischemic PENumbra in Patients With Acute Ischemic Stroke.
This study will develop and validate a novel, active/conductive combined head and neck cooling system to selectively cool the ischemic penumbra during the acute phase of stroke, reducing neuronal damage and improving stroke…
- Trial name
- PEN-Cool (NCT07844096)
- Testing
- PEN-Cool Conductive Head-and-Neck Cooling System, Standard Reperfusion Therapy / Routine Care
- Where
- 5 sites in India
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Ischemic Stroke, Exercise Therapy
Vivifrail Program on the Degree of Debilitation in Hospitalized Patients After Venous Hemolysis in Acute Ischemic Stroke
Physical exercise is an effective strategy to maintain functional ability and improve debilitating symptoms in the elderly.In addition to functional enhancement, exercise is considered a cornerstone for enhancing cognitive…
- Conditions
- Ischemic Stroke, Exercise Therapy, Frailty
- Trial name
- NCT06391502
- Testing
- Multi-component Exercise Intervention Program
- Where
- China
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nantong University
Stroke
Brain Electrical Stimulation to Enhance Recovery After Stroke
This study will examine whether brain stimulation using transcranial direct current stimulation (tDCS) in stroke patients undergoing rehabilitation therapy can help patients recover strength and motor function more than…
- Trial name
- NCT00085657
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Venous Thromboembolism (VTE), Acute Myocardial Infarction With ST Segment Elevation
Heat Shock Protein 47 in Thrombosis
The goal of this observational study is to learn if the novel biomarker Heat shock protein 47 (HSP47) can be used as a prognostic marker for vascular disease in people with acute venous thromboembolism (VTE), myocardial…
- Conditions
- Venous Thromboembolism (VTE), Acute Myocardial Infarction With ST Segment Elevation, Stroke (in Patients With Atrial Fibrillation)
- Trial name
- NCT06731673
- Where
- 2 sites in Denmark, Germany
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Atherosclerosis, Inflammation
Atherosclerosis and Acute Ischemic Stroke Study
A significant proportion of strokes are thromboembolic in nature, arising from atherosclerotic plaque at the carotid bifurcation. It is now wellknown that inflammation plays a key role in atherogenesis and plaque destabilization.
- Conditions
- Atherosclerosis, Inflammation, Ischemic Stroke
- Trial name
- NCT03685006
- Where
- Norway
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Cerebrovascular Disorders
Identification of microRNAs Involved in Cerebral Collateral Regulation
Patients >18 years of age presenting to Ohio State Wexner Medical Center Emergency department with stroke symptoms, within 6 hours of last know well and found to have acute anterior circulation large vessel occlusion (LVO) will…
- Trial name
- microRNA (NCT03905434)
- Testing
- miRNA sampling
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Acute Ischemic Stroke
DS1040b/Aspirin Drug/Drug Interaction Study
This is a phase 1, open label, single dose study, after 5 days of aspirin treatment, in healthy male and female subjects. It is hypothesized that co-administering DS-1040b with aspirin at steady state will be safe and well…
- Trial name
- NCT02071004
- Testing
- DS-1040b, Aspirin
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Daiichi Sankyo
Ischemic Stroke, Acute
Molecular Network Characteristics of Phlegm-heat Syndrome in Ischemic Stroke Based on Multi-omics Integrated Analysis
The molecular characteristics of ischemic stroke with phlegm-heat syndrome and candidate biomarkers were identified based on multi-omics data.
- Trial name
- NCT05626296
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Dongzhimen Hospital, Beijing
Upper Extremity Paresis, Motor Control
Reach to Grasp Movement of Stroke Patients: Different Heights and Weights
A cross-sectional study of Reach-to-Grasp (RTG) movement of the upper limb of stroke patients vs. healthy controls. 30 stroke patients and 30 healthy controls will take place in a cross-sectional study.
- Trial name
- NCT03655327
- Testing
- reach to grasp a cup
- Where
- Israel
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ben-Gurion University of the Negev
Verticality Perception in Stroke
Verticality Perception in Stroke Patients
The long-term goal of this research is to advance our knowledge of how information from the labyrinth is brought to perception and how adaptation to vestibular imbalance influences spatial orientation.
- Trial name
- NCT02184923
- Testing
- presentation of visual vertical
- Where
- Switzerland
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Ischemic Stroke
Safety, Tolerability and Pharmacokinetics of SP-8203
Phase I study in health volunteers to assess the safety, tolerability and pharmacokinetics of escalating single doses and multiple doses of SP-8203
- Trial name
- NCT01757795
- Testing
- SP-8203
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Acute Ischemic Stroke
The Correlation and Mechanistic Study of GGCX Gene With Prognosis in Acute Ischemic Stroke
This observational study aims to investigate the impact of GGCX gene mutations and GGCX levels on stroke prognosis in patients with ischemic stroke, as well as their correlation.
- Trial name
- NCT07269288
- Testing
- Usually, all enrolled patients with acute ischemic stroke will receive routine medication and/or surgical treatment according to clinical diagnosis and treatment protocols.
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Peking University Aerospace Center Hospital
Stroke, Epilepsy
Coronary and Cerebral Microvascular Dysfunction in Neurological Diseases
Neurological and cardiovascular diseases are increasing in relative and absolute terms globally, and pose a major burden in terms of morbidity, mortality, quality of life and healthcare costs.
- Conditions
- Stroke, Epilepsy, Transient Global Amnesia (TGA)
- Trial name
- G-HeBra (NCT07009990)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Stroke, Acute
The Effectiveness of Waiting Room Posters for Stroke Education
The purpose of this study is to determine the effectiveness of posters in improving patient awareness and knowledge of the signs and symptoms of stroke. The control group study will be conducted in the first two weeks.
- Trial name
- NCT03391713
- Testing
- Poster
- Where
- Malaysia
- Volunteers
- 1,064 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Cerebrovascular Stroke, Cerebrovascular Accident, Acute
Effect of Aerobic Exercise Training on Balance, Walking Capacity, and Quality of Life in Sub-acute Stroke.
Stroke is one of the major cause of morbidity and mortality and the leading cause of disability in adults all around the world. Stroke survivors can suffer several neurological impairments and deficits which have an important…
- Conditions
- Cerebrovascular Stroke, Cerebrovascular Accident, Acute, Cerebral Stroke
- Trial name
- NCT04377022
- Testing
- Combined Therapy (Aerobic Exercise in addition to conventional therapy)
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Government College University Faisalabad
Hemorrhagic Stroke, Intracerebral, Acute Ischemic Stroke
Feasibility of a Digital Goals-of-Care Decision Aid for Clinicians and Families of Patients With SABI
The goal is to pilot test a highly accessible, web-based, pragmatic, scalable intervention to overcome ongoing problems with high stakes decision-making by surrogate decision-makers of patients in ICUs with severe acute brain…
- Conditions
- Hemorrhagic Stroke, Intracerebral, Acute Ischemic Stroke, Traumatic Brain Injury
- Trial name
- NCT05671874
- Testing
- Web/mobile/tablet-based digital decision aid + communication (DA+C) tool
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Hemiparesis;Poststroke/CVA
Strengthening in Sub-acute Stroke Survivors: A Randomized Controlled Trial
The goal of this study is to compare between Eccentric training and conventional therapy in sub-acute stroke survivors. The primary objective of this study is to evaluate improvements in gait speed after four months of ET in…
- Trial name
- NCT06140381
- Testing
- Eccentric training, Conventional therapy
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Clinique Du Parc de Belleville
Acute Stroke, Ischemic Stroke
Analysing the Effects of Xingnaojing for Mild-to-severe Acute Ischemic Stroke
The main purpose of this trial is to analyse the Effects of Xingnaojing for Mild-to-severe Acute Ischemic Stroke by Metabonomics, proteomics and clinical parameters.
- Trial name
- NCT04813445
- Testing
- Xingnaojing injection
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Dongzhimen Hospital, Beijing
Acute Ischemic Stroke
Buyang Huanwu Decoction With Wuling Powder for Acute Ischemic Stroke
Acute ischemic stroke is a common cause of disability. Standard Western medical treatment is widely used, but some patients continue to have neurological impairment and difficulty with daily activities after stroke.
- Trial name
- BYHW-WL (NCT07687043)
- Testing
- Standard Western Medical Treatment, Serum Sample Collection for Metabolomics Only, Buyang Huanwu Decoction Combined With Wuling Powder
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Liaoning University of Traditional Chinese Medicine