Clinical trials: Stroke, Cerebral
Acute Ischemic Stroke, rhTNK-tPA
Observational Study to Assess the Safety of rhTNK-tPA (Mingfule®) vs. Rt-PA (Actilyse®) in Treating Acute Ischemic Stroke
This is a multicenter, prospective, non-randomized, post-marketing safety surveillance cohort study with rt-PA (Actilyse®) as the control.
- Trial name
- NCT07519889
- Testing
- rhTNK-tPA, rt-PA
- Volunteers
- 4,500 people
- Sponsor
- CSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd.
Stroke, Acute
Optimized C-arm Cone Beam CT for the Endovascular Treatment (EVT) of Acute Stroke
When it comes to acute stroke, everyone deserves the best care. Today, more patients can benefit from endovascular treatment (EVT) in a comprehensive stroke center.
- Trial name
- ASO-AVC (NCT04774510)
- Testing
- Diagnostic Test: optimized C-Arm Cone Beam Computed Tomography
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Ischemic, Healthy
Stochastic Resonance Stimulation in Brain Plasticity and Post Stroke Motor Recovery
This study evaluates the effectiveness of stochastic resonance electric stimulation on neuromuscular control and proprioception in healthy and individuals with stroke.
- Trial name
- NCT03839810
- Testing
- stochastic resonance electrical stimulation
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Stroke
Stroke Survival in Municipalities: Impact of Geographic Proximity to First- and Second-degree Relatives
Our key objective will be to investigate if geographic proximity to first- and second-degree relatives has an influence on post-acute stroke survival and use of health and social services.
- Trial name
- NCT04072120
- Where
- Norway
- Volunteers
- 7,400,000 people
- Sponsor
- University of Oslo
Stroke, Transient Ischemic Attack
SLEep APnea Screening Using Mobile Ambulatory Recorders After TIA/Stroke
Obstructive sleep apnea (OSA) is common after stroke/TIA and, left untreated, is associated with recurrent vascular events, poor functional outcomes, and long-term mortality.
- Conditions
- Stroke, Transient Ischemic Attack, Obstructive Sleep Apnea
- Trial name
- SLEAP SMART (NCT02454023)
- Testing
- Portable sleep monitor (ApneaLink Air), In-laboratory polysomnography
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- Sunnybrook Health Sciences Centre
Brain Ischemia
Cerebral Perfusion Associated With Postural Changes: an ASL MR Perfusion Study
Postural changes are commonly used as therapeutic maneuver to enhance or reduce cerebral perfusion. For instance, in acute stroke, the patient can be positioned in head down tilt position so as to increase perfusion of cerebral…
- Trial name
- PerfIRMAVC (NCT02912546)
- Testing
- MRI
- Where
- Martinique
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University Hospital Center of Martinique
Stroke, Spasticity
Effects of Low-level Laser Therapy on Spasticity and Gait Parameters in Chronic Stroke Patients With Spastic Plantar Flexors
Stroke is one of the leading causes of long-term disability worldwide. Many patients who survive a stroke experience muscle stiffness (called spasticity), especially in the ankle and foot muscles, which makes walking difficult…
- Conditions
- Stroke, Spasticity, Plantar Flexors
- Trial name
- LLLT-STROKE (NCT07273591)
- Testing
- Low Level Laser Therapy, conventional physical therapy
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Montiha Azeem
Multiple Sclerosis, Stroke
A Comprehensive Assessment of Trunk, Scapula and Upper Limb in Neurological Patients. Reliability, Validity and Interrelatedness
The study aimed to provide insights in the coordination between trunk, shoulder and upper limb while reaching. Two main phases are present in this study: In phase A: the psychometric properties of two tests: Clinical Scapular…
- Trial name
- NCT04908891
- Testing
- Clinical Scapular protocol (ClinScaP), the prevalence of trunk, scapula and upper limb impairments., the interaction between trunk, scapula and upper limb impairments.
- Where
- 4 sites in Belgium
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Stroke
Physical Activity Maintenance Intervention for People With Stroke
Most people living with stroke engage in low levels of physical activity putting them at higher risk of having a second stroke and developing a range of chronic health conditions.
- Trial name
- PREP Maintain (NCT07569497)
- Testing
- Physical activity maintenance
- Where
- 2 sites in United Kingdom
- Volunteers
- 34 people
- Sponsor
- University of Ulster
Stroke
Efficacy and Safety of Early Supported Discharge for Post-Acute Stroke Patients in Korea
The study aims to examine the effect of early supported discharge (ESD) service on the functional outcomes and quality of life of acute stroke patients with mild to moderate disability in Korea.
- Trial name
- KOMPACT (NCT04720820)
- Testing
- Early Supported discharge with home based Rehabilitation, Conventional rehabilitation
- Where
- South Korea
- Volunteers
- 67 people
- Sponsor
- Seoul National University Bundang Hospital
Hemianopia, Hemianopsia
Rehabilitating Visual Deficits Caused by Stroke
This research aims to understand the efficacy of a visual training task to improve visual loss after stroke, also known as hemianopia.
- Conditions
- Hemianopia, Hemianopsia, Quadrantanopia, Stroke Induced Vision Loss
- Trial name
- NCT04878861
- Testing
- Training in the blind field
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Oxford
Stroke, Hemiparesis;Poststroke/CVA
Effectiveness of Paretic Lower Limb Loading During Over-ground Training Among Stroke Survivors
Post-stroke gait deviations contribute to significant functional disability, impaired walking ability and poor quality of life. Prior studies suggest that gait training with paretic lower limb loading may improve gait parameters…
- Trial name
- NCT05097391
- Testing
- Warm-up (5 minutes), Conventional physiotherapy exercise (15 minutes), Over-ground training with lower limb loading (15-25 minutes)
- Where
- Nigeria
- Volunteers
- 48 people
- Sponsor
- Bayero University Kano, Nigeria
Pressure Ulcer Prevention
Nursing Interventions for the Prevention of Pressure Ulcer
this study is aimed to assess the effectiveness of nursing interventions on the prevention of pressure ulcers among immobile stroke patients
- Trial name
- NCT06981962
- Testing
- Pressure ulcer prevention program
- Where
- Iraq
- Volunteers
- 128 people
- Sponsor
- Hawler Medical University
Patent Foramen Ovale
Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO)
Background and hypothesis: The appropriate treatment strategy for secondary stroke prevention in patients with cryptogenic stroke and patent foramen ovale (PFO) remains challenging.
- Trial name
- NCT01550588
- Testing
- Device closure, Standard medical treatment
- Where
- 4 sites in South Korea
- Volunteers
- 210 people
- Sponsor
- Jae-Kwan Song
Stroke
Effect of Robotic Treatments on Motor Functions in Subacute Stroke Patients
We are conducting a three-group comparative study on stroke patients. The treatment is started in a subacute state and completed in the hospital.
- Trial name
- NCT05947773
- Testing
- Learning to walk with a robot, Walking group, Control group
- Where
- Hungary
- Volunteers
- 45 people
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
Stroke Rehabilitation
Dual-task Training During Curved Walking in Stroke Patients
The purpose of this study is to explore the effects of curved walking training under dual-task conditions on the cognitive function and walking ability of stroke patients.
- Trial name
- NCT06898073
- Testing
- cognitive dual-task group, Single-task group
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Fooyin University
Stroke
Ventilation Strategies, Anesthetic Techniques and Cerebral Oxygenation in the Beach Chair Position
The seated or "beach chair" position during surgery and general anesthesia decreases brain oxygen levels and can result in stroke. As such, poor neurological outcome following beach chair positioning is a growing concern.
- Trial name
- NCT01535274
- Testing
- Inspired oxygen fraction / end tidal carbon dioxide
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Michigan
Training
Operant H-reflex Down-conditioning of Rectus Femoris in Post-stroke Stiff Knee Gait
The investigators performed a feasibility trial of operant conditioning of spinal reflex excitability on five healthy individuals and two post-stroke individuals.
- Trial name
- NCT05467774
- Testing
- Operant RF H-reflex conditioning
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Stroke, Acute Ischemic Stroke
Extended Time Window Intravenous Thrombolysis Registry for Acute Ischemic Stroke
The EXTEND-IVT Registry is a prospective, multicenter, observational cohort study designed to evaluate the effectiveness and safety of intravenous thrombolysis administered beyond 4.5 hours after last known well in patients with…
- Trial name
- EXTEND-IVT (NCT07536074)
- Testing
- Intravenous Thrombolysis
- Where
- 2 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Stroke
Low-frequency Transcranial Magnetic Stimulation To Enhance Motor Recovery In The Subacute Phase After Stroke
Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the unaffected hemisphere (UH) transiently improves motor function in patients in the chronic phase after stroke.
- Trial name
- NCT01333579
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Sao Paulo General Hospital
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