Clinical trials: Stroke, Cerebral
Acute Ischemic Stroke, Large Vessel Occlusion
EFfects of Y-6 SUblingual Tablets foR PaTients With AcUte Ischemic StRokE (FUTURE)
This study aims to evaluate the efficacy of Y-6 sublingual tablets in improving microcirculation dysfunction and reducing thrombo-inflammation in patients who had AIS caused by LVO and received reperfusion therapy.
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Reperfusion
- Trial name
- NCT06138834
- Testing
- Low-dose Y-6 sublingual tablets, High-dose Y-6 sublingual tablets, Low-dose Cilostazol
- Volunteers
- 300 people
- Sponsor
- Beijing Tiantan Hospital
Arterial Ischemic Stroke
Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke
Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also…
- Trial name
- DOP-MOBILIZE (NCT07232498)
- Testing
- Doppler-guided early mobilization
- Where
- 7 sites in Croatia, Portugal
- Volunteers
- 1,300 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Multiple Sclerosis, Stroke
Clinical and Instrumental Treatment's Predictors in Subjects With Neurological Diseases Using G-EO Robotic System
The aim of this work is to elaborate a statistical model to predict the effectiveness of robotic treatment in subjects with neurological diseases.
- Conditions
- Multiple Sclerosis, Stroke, Parkinson Disease, Acquired Brain Injury
- Trial name
- NCT05493514
- Testing
- Robotic Assisted Gait Training with G-EO system
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Mitochondrial Diseases, Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation
The KHENEREXT Study
This is an open-label, multi-centre study in subjects with a genetically confirmed mitochondrial deoxyribonucleic acid (DNA) transfer ribonucleic acid (tRNA)Leu(UUR) m.3243A>G mutation who completed study KH176-202.
- Conditions
- Mitochondrial Diseases, Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation, Maternally Inherited Diabetes and Deafness (MIDD), Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke Like Episodes (MELAS)
- Trial name
- NCT04604548
- Testing
- Oral administration of 100 mg KH176 twice daily
- Where
- 4 sites in Denmark, Germany and 2 more
- Volunteers
- 11 people
- Sponsor
- Khondrion BV
Ischemic Stroke, Vertebral Artery Stenosis
Drug Eluting Stents Versus Bare Metal Stents for Treatment of Symptomatic Extracranial Vertebral Artery Stenosis
Stroke is one of the important causes of disability and death in the world, in which more than half were ischemic strokes. About 1/4 of the ischemic stroke occurred in the vertebral basilar artery system, especially when in the…
- Trial name
- NCT03201432
- Testing
- Drug eluting stent (DES), Bare metal stent (BES)
- Volunteers
- 160 people
- Sponsor
- Xiongjing Jiang
Stroke, Ischemic, Intracranial Atherosclerosis
Predictors of Intracranial Atherosclerotic Disease in Posterior Circulation: a Cohort Study
Early identification of intracranial atherosclerotic disease (ICAD) may impact the management of patients undergoing mechanical thrombectomy (MT).
- Conditions
- Stroke, Ischemic, Intracranial Atherosclerosis, Posterior Circulation Brain Infarction
- Trial name
- NCT06453252
- Testing
- we are aiming to develop a Scoring system based on certain variables derived from both groups
- Where
- 2 sites in United States, Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
Stroke
Effects of Early Exercise in Patients With Moderate to Severe Stroke.
Purpose: to investigate the efficacy of early exercise in patients with moderate to severe stroke regarding functional outcome and walking ability.
- Trial name
- NCT04241952
- Testing
- Exercise
- Volunteers
- 52 people
- Sponsor
- Klas Sandberg
Stroke
Action Observation Therapy Versus Mirror Therapy on Upper Limb in Stroke
Stroke is a medical condition which causes the cessation of blood flow to the brain cells and results in cell death and ultimately can lead to motor disorders, perception disorders, language disorders, sensory disturbances.It is…
- Trial name
- NCT05544747
- Testing
- Action Observation Therapy, Mirror Therapy
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Peripheral Vascular Diseases
Screening DIVA - Diffuse Vascular Disease
Primary Objective: To investigate the value of the Edinburgh Claudication Questionnaire (ECQ) against the ankle-brachial index (ABI) in Canadian patients mainly followed in general practice, with documented acute coronary…
- Trial name
- NCT01076738
- Where
- Canada
- Volunteers
- 2,233 people
- Sponsor
- Sanofi
Neurologic Disorder, Paralysis
SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis
The Synchron Motor Neuroprosthesis (MNP) is intended to be used in subjects with severe motor impairment, unresponsive to medical or rehabilitative therapy and a persistent functioning motor cortex.
- Conditions
- Neurologic Disorder, Paralysis, Paralysis; Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- NCT05041114
- Testing
- Motor Neuroprosthesis
- Where
- 3 sites in Australia
- Sponsor
- Synchron Medical, Inc.
Atrial Fibrillation, Atrial Flutter
Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation
The trial seeks to determine if apixaban, an investigational anticoagulant (blood-thinner) is as effective as standard therapy (warfarin) in preventing stroke and systemic embolism in subjects with atrial fibrillation and risk…
- Trial name
- ARISTOTLE (NCT00412984)
- Testing
- warfarin, apixaban
- Where
- 1,111 sites in United States, Argentina and 39 more
- Volunteers
- 20,976 people
- Sponsor
- Bristol-Myers Squibb
Carotid Artery Stenoses
SPI-guided Analgesia During CEA Under RA
The aim of this randomized prospective trial is to assess the utility of Adequacy of Anaesthesia technique (Response Entropy and Surgical Pleth Index) for monitoring pain perception intraoperatively, maintainance of hemodynamic…
- Trial name
- CEA (NCT04500249)
- Testing
- infiltration rescue intraoperative analgesia, rescue IA, rescue antyhypertensive medication
- Where
- Poland
- Volunteers
- 105 people
- Sponsor
- Medical University of Silesia
Acquired Brain Injury Including Stroke
Evaluating a CFT Group for Adults With Acquired Brain Injury
Emotional difficulties such as anxiety and depression are common after experiencing a brain injury. The compassion focused therapy (or CFT) model proposes the importance of developing skills in being able to self-soothe and be…
- Trial name
- NCT06316258
- Testing
- Compassion focused therapy group
- Volunteers
- 12 people
- Sponsor
- King's College London
Stroke
Effect of Robotised Gait Training on Dynamic Balance, Symmetry and Push-off in Persons After Stroke
Rehabilitation robotics is increasingly used because it enables the patients to practice a wide array of movements. Dynamic balance training is essential for gait rehabilitation and robotised devices enhance repeatability…
- Trial name
- BART (NCT03782948)
- Testing
- Standard gait training on BART without pelvic perturbations, Robotised gait training with BART with pelvic perturbations
- Where
- Slovenia
- Volunteers
- 10 people
- Sponsor
- University Rehabilitation Institute, Republic of Slovenia
Atrial Fibrillation
Patient Convenience Study- NIS RELATE
The aim of this non-interventional study is to describe patient's perception of anticoagulant treatment when using Pradaxa® to prevent stroke and systemic embolism while suffering from atrial fibrillation (according to its…
- Trial name
- NCT02849509
- Testing
- Pradaxa (dabigatran), Vitamin K antagonist
- Where
- 50 sites in Indonesia, Malaysia and 3 more
- Volunteers
- 1,313 people
- Sponsor
- Boehringer Ingelheim
Stroke, Hemiparetic Patients After Subacute Stroke
Effects of Locomotion Training With Assistance of a Robot-Driven Gait Orthosis in Hemiparetic Patients After Subacute Stroke
The investigators aimed in this study to investigate the effects of 4 weeks robot-assisted locomotor training on motor recovery of lower extremities and walking ability compared with the conventional gait training in subacute…
- Trial name
- NCT01726998
- Testing
- Robot-assisted gait therapy, conventional gait training
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Yonsei University
Stroke, Acute, Ischemic Stroke, Acute
Endovascular Therapy for Large Core Patients With Uncertain Response to Thrombectomy
The purpose of this study is to assess the safety and efficacy of endovascular thrombectomy in both an early and extended time window in patients with large strokes due to large artery occlusion.
- Trial name
- OUTER LIMITS (NCT06961487)
- Testing
- EndovascularThrombectomy, Endovascular thrombectomy with any FDA-approved device
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Stroke, Movement Disorders
Robot Therapy for Rehabilitation of Hand Movement After Stroke
A study will be performed where individuals with chronic stroke will be randomly assigned to receive 2 different dosages of robotic hand therapy.
- Conditions
- Stroke, Movement Disorders, Hemiparesis
- Trial name
- HEXORR (NCT04536987)
- Testing
- HEXORR
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The Catholic University of America
COVID-19, Chronic Heart Failure
Analysis of Health Status of Сomorbid Adult Patients With COVID-19 Hospitalised in Fourth Wave of SARS-CoV-2 Infection
Depersonalized multi-centered registry initiated to analyze dynamics of non-infectious diseases after SARS-CoV-2 infection in population of Eurasian adult patients.
- Conditions
- COVID-19, Chronic Heart Failure, Diabetes Mellitus, Chronic Kidney Diseases
- Trial name
- ACTIV4 (NCT05226416)
- Where
- Russia
- Volunteers
- 3,554 people
- Sponsor
- Eurasian Association of Therapists
Ischemic Stroke, Large Vessel Occlusion
Direct Intra-arterial Thrombectomy in Order to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals
Background: Intravenous thrombolysis (IVT) combined with mechanical thrombectomy (MT) has been proven safe and effective in patients with acute ischemic stroke (AIS) of anterior circulation large vessel occlusion (LVO).
- Conditions
- Ischemic Stroke, Large Vessel Occlusion, Thrombectomy, Thrombosis
- Trial name
- DIRECT-MT (NCT03469206)
- Testing
- intra-arterial thrombectomy, Intravenous thrombolysis
- Where
- China
- Volunteers
- 656 people
- Sponsor
- Changhai Hospital
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