Clinical trials: Stroke, Chronic
Spinal Cord Injuries, Cerebral Palsy
LEAP a New Overground Body Weight Support Robot: Usability Trial
People with central nervous system disorders such as spinal cord injury, stroke, cerebral palsy, Parkinson's disease, multiple sclerosis, etc… often have impaired lower extremity function that limits activities of daily life and…
- Conditions
- Spinal Cord Injuries, Cerebral Palsy, Parkinson Disease, Multiple Sclerosis
- Trial name
- LEAP (NCT03458169)
- Testing
- Therapist LEAP session feedback, Participant LEAP session feedback, LEAP risk control validation
- Where
- Switzerland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Clinique Romande de Readaptation
Spinal Cord Injuries, Nerve Injury
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional…
- Conditions
- Spinal Cord Injuries, Nerve Injury, Pain, Postoperative, Post Herpetic Neuralgia
- Trial name
- NCT04144972
- Testing
- Medtronic Summit RC+S or Percept RC
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Stroke
Amplitude Modulation Frequency Comparison in Kilohertz Transcranial Magnetic Perturbation (kTMP) for Chronic Stroke
Stroke is a leading cause of disability with many patients suffering chronic motor function impairments that affect their day-to-day activities.
- Trial name
- NCT07681102
- Testing
- kTMP
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Magnetic Tides
Stroke
Home-Based Automated Therapy of Arm Function After Stroke Via Tele-Rehabilitation
Constraint-Induced Movement therapy, also known as CI therapy, is an approach to physical rehabilitation derived from basic behavioral and neuroscience research.
- Trial name
- NCT01157195
- Testing
- Tele-AutoCITE, CI therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Unruptured Intracranial Aneurysm, Infarction Cerebral
Chronic Remote Ischemic Conditioning in Small Infarctions Associated with Stent-assisted Coiling of Unruptured Intracranial Aneurysms
1. Disease Description Stent-assisted coiling has become an effective treatment modality for intracranial aneurysms. With continuous advancements in periprocedural antiplatelet regimens, the incidence of symptomatic…
- Trial name
- CRISIS (NCT06826144)
- Testing
- remote ischemic conditioning
- Volunteers
- 84 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Stroke
Cranial Nerve Neuromodulation to Improve Arm Function and Brain Plasticity in Stroke
Following a stroke, persistent residual muscle weakness in the upper limb (UL) drastically impacts the individuals' quality of life and level of independence.
- Trial name
- CN-NINM (NCT06386510)
- Testing
- Strength training, Cranial nerve non-invasive neuromodulation
- Where
- 3 sites in Canada
- Volunteers
- 74 people
- Sponsor
- Université de Sherbrooke
Fall Prevention, Chronic Stroke Patients
Effects of a Health Belief Model-Based Fall Prevention Education Program on Health Literacy and Physical Function in Patients With Chronic Stroke
The goal of this clinical trial is to to evaluate the effects of a health belief model-based fall prevention education program on health literacy and physical function, fall rate, fall risk, fear of fall, and quality of life in…
- Conditions
- Fall Prevention, Chronic Stroke Patients, Health Literacy, Education of Patients
- Trial name
- NCT06833580
- Testing
- The intervention group, who will receive the health belief model-based fall prevention education program
- Where
- Saudi Arabia
- Volunteers
- 44 people
- Sponsor
- King Saud University
Stroke
The Immediate Effects of Intermittent Theta Burst Stimulation on Intracortical Excitability of the Primary Motor Cortex in Patients With Chronic Stroke
This study is to investigate the immediate effects of intermittent theta burst stimulation (iTBS) on intracortical excitatory and inhibitory circuits, neural connectivity, and network properties in patients with chronic stroke…
- Trial name
- NCT05509686
- Testing
- Intermittent theta burst stimulation (iTBS)
- Where
- Hong Kong
- Volunteers
- 21 people
- Sponsor
- The Hong Kong Polytechnic University
Stroke, Dystonia
MyoSense- Automated Muscle Hypertonicity Classification System
It is often difficult to quantify and distinguish aspects of abnormal muscle tone due to neurological injury. This makes it difficult to evaluate therapies that aim to reduce the effects of abnormal muscle tone.
- Conditions
- Stroke, Dystonia, Cerebral Palsy
- Trial name
- NCT02076581
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Stroke, Hemiplegia
The Effect of Robot-Assisted Gait Training With or Without Plantar Pressure Summary Feedback: Impact on Gait Symmetry and Balance in Hemiplegic Patients
The goal of this randomized, single-blind clinical trial is to learn whether a 4-week Lokomat-based gait training program with plantar pressure feedback can improve gait symmetry and balance in adult patients with chronic…
- Trial name
- NCT07336667
- Testing
- Lokomat robot assisted gait training, Plantar pressure summary feedback
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Yeonji Choi
Insomnia, Insomnia Chronic
SHADES Mechanistic Trial
Cardiovascular disease (CVD) is common, deadly, and costly, and adults with insomnia represent a large group of people at elevated risk of developing CVD in the future.
- Conditions
- Insomnia, Insomnia Chronic, Insomnia, Primary, Sleep Disturbance
- Trial name
- SHADES (NCT06041581)
- Testing
- Sleep Healthy Using The Internet (SHUTi), Telephonic CBT-I, Face-to-Face CBT-I
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
Stroke, Multiple Sclerosis
Design and Validation of Innovative Strategies Based on Dual-Task Approach
People affected by Stroke, Multiple Sclerosis (MS), and Parkinson's disease (PD) share severe and complex disabilities. Widespread neuro-inflammatory processes represent an important pathogenetic component in all three…
- Conditions
- Stroke, Multiple Sclerosis, Parkinson Disease, Dual Task Exercises
- Trial name
- START (NCT07254377)
- Testing
- Dual Task exercise, Physical therapy
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Stroke
Effect of Non-invasive Vagus Nerve Stimulation on Cerebrovascular Reactivity and Cognition in Chronic Stroke Patients
This study will be conducted to assess the effect of non-invasive vagus nerve stimulation on cerebrovascular reactivity and cognition in chronic stroke patients
- Trial name
- NCT07626242
- Testing
- Trans-auricular vagus nerve stimulation, Conventional physical therapy, Computer based cognitive rehabilitation training
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Stroke Syndrome
Treadmill With Biofeedback on Gait Symmetry After Stroke
This study aims to investigate the immediate, accumulated, and maintainable effects of treadmill with biofeedback on gait symmetry in individuals with chronic stroke.
- Trial name
- NCT04441541
- Testing
- Treadmill with auditory feedback, Treadmill with visual feedback, Treadmill with auditory and visual feedback
- Volunteers
- 48 people
- Sponsor
- National Yang Ming Chiao Tung University
Neonatal Seizure, Hypoxic-Ischemic Encephalopathy
Neonatal Seizure Registry - Developmental Functional EValuation
The NSR-DEV study is a longitudinal cohort study of around 280 Neonatal Seizure Registry participants that aims to evaluate childhood outcomes after acute symptomatic neonatal seizures, as well as examine risk factors for…
- Conditions
- Neonatal Seizure, Hypoxic-Ischemic Encephalopathy, Stroke, Intracranial Hemorrhages
- Trial name
- NSR-DEV (NCT04337697)
- Where
- 9 sites in United States
- Volunteers
- 188 people
- Sponsor
- University of California, San Francisco
Stroke, Chronic Stroke
Comparison of EEG-Timed vs. Repetitive Robot Therapy for Chronic Stroke
This clinical trial compares two types of robotic hand rehabilitation-brain wave (EEG)-timed therapy versus simple repetitive therapy-to see which is more effective for recovering hand function in patients with chronic stroke.
- Conditions
- Stroke, Chronic Stroke, Hemiparesis
- Trial name
- NCT07459725
- Testing
- EEG-Timed Robot Operation, Repetitive Robotic System
- Volunteers
- 20 people
- Sponsor
- Seoul National University Bundang Hospital
End Stage Renal Disease, Cardio-Renal Syndrome
Cardio-Renal Registry
Cardiovascular disease is the leading cause of morbidity and mortality among patients with chronic kidney disease (CKD). Even after adjustment for known cardiovascular risk factors, including diabetes and hypertension, mortality…
- Conditions
- End Stage Renal Disease, Cardio-Renal Syndrome, Myocardial Infarction, Cerebrovascular Accident
- Trial name
- BHCRR (NCT06521801)
- Testing
- Observation
- Where
- United Kingdom
- Volunteers
- 60,000 people
- Sponsor
- Queen Mary University of London
Stroke, Muscle Hypertonia
Antagonist Activation Measurement at the Ankle Using High-density and Bipolar Surface EMG in Chronic Hemiparesis
In chronic hemiparesis, abnormal antagonist muscle activation in the paretic lower limb contributes to impair ambulation capacities.
- Conditions
- Stroke, Muscle Hypertonia, Spasticity, Muscle
- Trial name
- CC2017 (NCT06099132)
- Testing
- Electromyographic measurements
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Henri Mondor University Hospital
Stroke, Plegia
Treatment of Chronic Stroke With AMES + EMG Biofeedback
The purpose of this study is to determine if individuals who had a stroke more than one year before entering the study and who remain unable to open their affected hand are better able to sense and move their affected arm after…
- Conditions
- Stroke, Plegia, Paresis, Cerebrovascular Accident
- Trial name
- AMES (NCT01116544)
- Testing
- AMES Therapy (assisted movement and enhanced sensation)
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- AMES Technology
Stroke
Upper Limb Training Modalities in Patients With Stroke
To date, evidence of the effects of robotic training combined with OnabotulinumtoxinA focal treatment for spasticity is limited.
- Trial name
- NCT03590314
- Testing
- Experimental group - robot assisted arm training (Armotion®), Control group - conventional treatment
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
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