Clinical trials: Stroke, Mechanism
Stroke
Cognitive Training After Stroke : Effects and Mechanisms
Stroke is a major cause of severe cognitive and physical disability. Despite the high and increasing incidence, and large health, economic, social and personal consequences, studies designed to remedy cognitive impairments and…
- Trial name
- NCT04932304
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- 2 sites in Norway
- Volunteers
- 54 people
- Sponsor
- Oslo University Hospital
Stroke Sequelae
Mechanisms of Balance Disorders in a Seated Position Following a Stroke
One of the causes of disability in stroke patients is postural disturbances that result in postural asymmetry in the standing position, characterized during an evaluation on a force platform by a greater displacement of the…
- Trial name
- HEMISEAT (NCT04152616)
- Testing
- Instrumental evaluation of posture
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Ischemic Stroke
DIRECT-SAFE: A Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis With Endovascular Clot Retrieval
The study will be a multicentre, prospective, randomized, open label, blinded endpoint (PROBE) phase 3 trial (2 arm with 1:1 randomization) in ischemic stroke patients within 4.5 hours of stroke onset.
- Trial name
- NCT03494920
- Testing
- Direct endovascular clot retrieval, Bridging thrombolysis followed by ECR
- Where
- 33 sites in Australia, China and 2 more
- Volunteers
- 295 people
- Sponsor
- Neuroscience Trials Australia
Aphasia
Based on the Spatio-temporal Coding Characteristics of Frontotemporal Network, This Paper Explores the Mechanism of Five-tone Speech Training in Reshaping Language Fluency Function.
To explore the mechanism of five-tone speech training in reshaping language fluency function and the clinical efficacy of aphasia language function, daily communication ability and communication efficiency based on the temporal…
- Trial name
- NCT07329751
- Testing
- Traditional Chinese Medicine Five-Tone Therapy, Melodic Intonation Training, Standard speech therapy; Routine medical treatment; Health education
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fujian University of Traditional Chinese Medicine
Chronic Stroke, Cerebral Palsy
Gondola Mechanism of Action
This study will investigate the clinical, functional and neurophysiological effects of automated mechanical peripheral stimulation (AMPS) via the Gondola device administered to patients with chronic stroke, cerebral palsy and…
- Conditions
- Chronic Stroke, Cerebral Palsy, Parkinson's Disease
- Trial name
- NCT05146648
- Testing
- Gondola AMPS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Dysphagia, Stroke
Study on the Effect Mechanism of Acupuncture Combined With Swallowing Training in Oral Dysphagia of Stroke
Up to 84% of patients after stroke are accompanied by dysphagia, of which 53% are oral dysphagia. The oral phase is the initial phase of swallowing activity and the only stage of swallowing that is completely discretionary.
- Conditions
- Dysphagia, Stroke, Oral Phase
- Trial name
- NCT05982977
- Testing
- Acupuncture, Conventional rehabilitation
- Volunteers
- 56 people
- Sponsor
- Qingqing Zhang
Stroke
The Effect of tDCS on Motor Learning and Neural Network in Stroke Patients
This study is to investigate the effect of transcranial direct current stimulation (tDCS) simulation on motor learning to stroke patients compared to sham stimulation
- Trial name
- NCT04903457
- Testing
- Transcranial Direct Current Stimulation, Motor learning
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- Samsung Medical Center
Chronic Stroke
Paired Vagus Nerve Stimulation Mechanisms
In this mechanistic study, 40 individuals with chronic stroke will be implanted with a small vagus nerve stimulation (VNS) device.
- Trial name
- NCT06716112
- Testing
- Vagus Nerve Stimulation (VNS) Device, Upper Extremity Rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- NYU Langone Health
Stroke, Small Vessel Cerebrovascular Disease
Small Vessel Disease and Cerebral Infarct Healing InErvation Via Limb Distant Adaptation
Cerebral infarction (ischemic stroke) and cerebral small vessel disease (CSVD) represent major global causes of disability, cognitive decline, and mortality.
- Trial name
- SHIELD (NCT07503301)
- Testing
- Medical-grade ischemic preconditioning training instrument, Standard Treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke
Robot-assisted Therapy Combined With Mirror Priming in Upper Limb Training in Stroke
This project will employ the robot-assisted system to assist patients to perform the grasping and releasing movement of both hands simultaneously while mirror priming strategy is applied, and, then, perform intensive and…
- Trial name
- NCT04326140
- Testing
- mirror therapy, robotic-assisted training
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Hemiparesis
Neural Mechanisms of Music Intervention Chronic Arm Hemiparesis Following Stroke: A Single Case Series EEG Study
The aims of the study are to recruit five participants with stroke upper limb hemiparesis and determine the effects on neural reorganisation of a three-week music intervention using electroencephalogram measures.
- Conditions
- Stroke, Hemiparesis, Home-based
- Trial name
- NCT06223529
- Testing
- Therapeutic Instrumental Music Performance
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Anglia Ruskin University
Stroke
Neuromechanical Mechanisms of Exosuit-assisted Gait Rehabilitation After Stroke
Stroke survivors often experience impaired neuromechanical control that limits walking speed and quality, particularly due to deficits in paretic propulsion.
- Trial name
- NCT07218094
- Testing
- Walking with robotic ankle assistance
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Boston University Charles River Campus
Ischemic Stroke
Molecular Mechanisms of microRNA-494 Involving in Cerebral Ischemia
We and other investigations suggested that the activation of nerve cell cycle following cerebral ischemia led to neuronal apoptosis, glial cell proliferation and the formation of glial scar.The cyclin-dependent kinases (CDKs) and…
- Trial name
- NCT03577093
- Testing
- There is no intervention at all.
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Capital Medical University
Ischemic Stroke
Early Neurovascular Decoupling Trajectories After Revascularization in Acute Ischemic Stroke
Background: Recanalization therapy is the standard treatment for acute ischemic stroke (AIS), yet patient outcomes remain highly heterogeneous. The underlying mechanisms of this variability are not fully understood.
- Trial name
- MAP-END (NCT07405762)
- Testing
- Multimodal Neuromonitoring
- Where
- 2 sites in China
- Volunteers
- 180 people
- Sponsor
- Xijing Hospital
Stroke Sequelae, Movement Disorders
Programmed Flexor-extensor Alternating Electrical Acupiont Stimulation on Limb Functional Reconstruction After Stroke
The purpose of this study is to study the effect mechanism of programmed flexor-extensor alternating electrical acupiont stimulation on upper limb functional reconstruction after stroke.
- Trial name
- NCT05333497
- Testing
- the fourth programmed generation of low-frequency acupoint electric stimulation therapy instrument, the fourth generation of low-frequency acupoint electric stimulation therapy instrument
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Yang Liu
Intracerebral Hemorrhage, Acute Ischemic Stroke
Biologic Mechanisms of Early Exercise After Intracerebral Hemorrhage
This study aims to determine whether in-bed cycle ergometry, early in the hospital course after a brain hemorrhage could balance damaging and reparative inflammation in the brain.
- Trial name
- BEACH (NCT04027049)
- Testing
- Supine cycle ergometry of the lower extremities
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Johns Hopkins University
Cognitive Dysfunction, Stroke
Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project
The goal of this observational study is to determine the feasibility of using integrated Transcranial Doppler Ultrasonography or Near Infrared Spectroscopy to detect changes in cerebral autoregulation and neurovascular coupling…
- Conditions
- Cognitive Dysfunction, Stroke, Dementia, Depression
- Trial name
- VESPAR (NCT05649800)
- Where
- 2 sites in United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Stroke
Investigation of Acceptable Dose of Mobilisation and Tactile Stimulation to Enhance Upper Limb Recovery After Stroke
The purpose of this study is to find which of three doses of mobilisation and tactile stimulation therapy, when given in addition to conventional UK physical therapy, has the most beneficial effect on enhancing motor recovery of…
- Trial name
- NCT00360997
- Testing
- Conventional UK physical therapy, Con UK PT + Mobilisation & tactile stimulation (MTS)
- Where
- 2 sites in United Kingdom
- Volunteers
- 80 people
- Sponsor
- St George's, University of London
Carotid Artery Plaques, Atherosclerosis
Effects of Rosa Roxburghii Tratt Freeze-Dried Powder on Carotid Atherosclerotic Plaques: A Real-World Study
This study aims to evaluate the effectiveness and safety of Rosa roxburghii freeze-dried powder in reducing carotid atherosclerotic plaques.
- Conditions
- Carotid Artery Plaques, Atherosclerosis, Ischemic Stroke
- Trial name
- RRC-AS (NCT07840950)
- Testing
- Rosa Roxburghii Freeze-Dried Powder, Conventional Anti-Atherosclerosis Therapy
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Stroke
Study of the Pathogenesis and Molecular Mechanism of "YURE" in Internal Intractable Diseases
The purpose of this study is to determine whether the Chinese herbs formula is effective in the treatment of hemorrhagic stroke and to find out Chinese pathogeny and pathogenesis in the disease.
- Trial name
- NCT00569088
- Testing
- Chinese herbs formula, Mannitol
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Nanjing University of Traditional Chinese Medicine