Clinical trials: Stroke, Mechanism
Ischemic Stroke, Acute
Clinical Efficacy and Mechanism Research of Getong Tongluo Capsule in Ischemic Stroke
The purpose of this single-center, randomized, double-blind, controlled trial is to clarify the clinical efficacy and safety of Getong Tongluo Capsule in patients with ischemic stroke.
- Trial name
- NCT07690020
- Testing
- Getong Tongluo Capsule, Standard Routine Therapy for Ischemic Stroke
- Volunteers
- 216 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Stroke
Structural Mechanisms of Dual-Target tDCS in Stroke Hemiparetic Hand
This is a single-center, randomized, single-blind study investigating the effects of dual-target transcranial direct current stimulation (tDCS) combined with task-oriented functional electrical stimulation on upper limb recovery…
- Trial name
- NCT07605039
- Testing
- tDCS
- Volunteers
- 56 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Cerebrovascular Accidents
Mechanism and Efficacy of Rehabilitation Approaches
Identify the possible mechanisms and the relative effectiveness of existing rehabilitation approaches that target upper extremity deficits of stroke patients on the ground that these approaches are based on neuroplasticity…
- Trial name
- NCT00564005
- Testing
- Constraint-induced therapy (CIT), Bilateral arm training (BAT), Combined therapy (CT)
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital
Ischemic Stroke
Early Neurovascular Decoupling Trajectories After Revascularization in Acute Ischemic Stroke
Background: Recanalization therapy is the standard treatment for acute ischemic stroke (AIS), yet patient outcomes remain highly heterogeneous. The underlying mechanisms of this variability are not fully understood.
- Trial name
- MAP-END (NCT07405762)
- Testing
- Multimodal Neuromonitoring
- Where
- 2 sites in China
- Volunteers
- 180 people
- Sponsor
- Xijing Hospital
Stroke, Stroke with Hemiparesis
Study of Hemodynamic Markers of Upper Extremity Motor Dysfunction in Stroke Patients Using Functional Near Infrared Spectroscopy (fNIRS)
The aim of the study was to explore potential pathways for recovery and adaptation of the motor cortex by examining cerebral blood flow characteristics and hemodynamic markers analyzed by functional near-infrared spectroscopy…
- Conditions
- Stroke, Stroke with Hemiparesis, Stroke, Ischemic
- Trial name
- NCT06806397
- Testing
- Stimulus response task
- Where
- 2 sites in Russia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Skolkovo Institute of Science and Technology
Heat Stroke
Mechanism Study of G Protein-coupled Receptor 81 in Multiple Organ Dysfunction of Heat Stroke
Heat stroke is one of the common acute and critical conditions in the ICU, characterized by a high incidence and mortality rate, and there is still a lack of effective and precise treatment methods.
- Trial name
- NCT07346443
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Stroke, Walking Impairment
Investigating the Mechanisms of Welwalk Robot in Restoring Motor Function of the Lower Extremities in Stroke Patients
Current evidence and clinical applications of robotic gait training devices for motor function recovery post-stroke are increasingly available.
- Trial name
- NCT07057700
- Testing
- welwalk training, physical therapy
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Ruijin Hospital
Post-Stroke Cognitive Impairment (PSCI)
Efficacy of Vitamin D in Post-Stroke Cognitive Impairment
Post-stroke cognitive impairment (PSCI) is a prevalent and debilitating sequela of stroke, posing a significant burden on patients and healthcare systems.
- Trial name
- ViD-PSCI (NCT07767214)
- Testing
- Vitamin D2 capsules
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Suzhou Municipal Hospital of Anhui Province
Stroke
Neural Changes in Stroke Patients During Challenging Walking Tasks.
For stroke patients, a challenging, unfamiliar, and more difficult task may increase the likelihood of brain activation to stimulate recovery.
- Trial name
- NCT06764290
- Testing
- pedal walking, visual occlusion
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Nanjing Medical University
Stroke
The Effect of tDCS on Motor Learning and Neural Network in Stroke Patients
This study is to investigate the effect of transcranial direct current stimulation (tDCS) simulation on motor learning to stroke patients compared to sham stimulation
- Trial name
- NCT04903457
- Testing
- Transcranial Direct Current Stimulation, Motor learning
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- Samsung Medical Center
Stroke
Fatiguing Arm Exercise Following Stroke
This study investigates the effects of sub-maximal exercise to task-failure (e.g., fatigue) with the less involved, or so-called non-paretic hand, in people who have experienced a stroke.
- Trial name
- NCT03194464
- Testing
- submaximal exercise (grip)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- VA Office of Research and Development
Chronic Stroke, Cerebral Palsy
Gondola Mechanism of Action
This study will investigate the clinical, functional and neurophysiological effects of automated mechanical peripheral stimulation (AMPS) via the Gondola device administered to patients with chronic stroke, cerebral palsy and…
- Conditions
- Chronic Stroke, Cerebral Palsy, Parkinson's Disease
- Trial name
- NCT05146648
- Testing
- Gondola AMPS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Stroke
Active Balance and Cardio Care Intervention on Physical and Cardiovascular Health in People With Chronic Stroke
Neurological impairment such as stroke is a leading cause of adult disability. Traditional rehabilitative therapies can help regain motor function and ameliorate disability.
- Trial name
- ABCcare (NCT06060470)
- Testing
- Virtual reality based dance group, Active Comparator: Control
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Illinois Chicago
Post-stroke, Hemiplegic Gait
Evaluation of the Mechanisms of Weight-bearing of the Hemiplegic Limb During Table Tennis Sessions in the Framework of Post-stroke Rehabilitation : Pilot Study
This is an experimental, observational, prospective study designed to develop medical knowledge. The primary objective of the study is to analyze the weight bearing of the hemiplegic side according to the different areas of…
- Conditions
- Post-stroke, Hemiplegic Gait, Rehabilitation
- Trial name
- HEMITENNIS (NCT05857072)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- FondationbHopale
Aphasia, Acquired, Stroke
Neurocognitive Mechanisms of Sentence Production Impairment in Aphasia
The proposed research is relevant to public health because stroke is a leading cause of long-term disability among older adults and communication impairments resulting from stroke have a significant negative impact on quality of…
- Conditions
- Aphasia, Acquired, Stroke, Healthy Aging
- Trial name
- sentence (NCT06405594)
- Testing
- Language Condition
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Stroke
Action Observation, Imagery and Execution for Stroke Rehabilitation
The specific study aims will be: 1. To investigate the short- and long-term treatment effects of action observation, imagery, and execution therapy (AOIE) compared with an action observation therapy (AO) group and a control…
- Trial name
- NCT03246139
- Testing
- Action observation, imagery & execution, Action observation, Control treatment
- Where
- 4 sites in Taiwan
- Volunteers
- 17 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke
fNIRS for Monitoring Cortical Activity in Stroke Recovery
This clinical trial aims to investigate the mechanisms of brain reorganization underlying motor recovery following end-effector (EE) and exoskeleton (Exo) robot-assisted hand training in individuals with stroke.
- Trial name
- NCT07623512
- Testing
- Robot-assisted therapy (EE or EXO system) and functional training
- Where
- Taiwan
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Stroke
The Beneficial Effects of Naps on Motor Learning
Background: Memory consolidation is the process by which memories become stable, long-term representations in the brain. Consolidation of a motor skill is dependent upon sleep.
- Trial name
- NCT04312126
- Testing
- MRI system, MEG system
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Ischemic Stroke, Acute
Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE
A combination therapy proposed to be evaluated in this trial, consisting of three already registered compounds with a validated disease mechanism and with known safety profiles, targets key proteins in the dysregulated signal…
- Trial name
- REPO-STROKE II (NCT05762146)
- Testing
- Riociguat, Propylthiouracil, Perphenazine
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- Maastricht University
Stroke
Potential for Recovery of Voluntary Finger Extension After Stroke
Stroke patients with absent voluntary finger extension (VFE) 6-months after stroke are not expected to recover hand function. However, experience from the Queen Square Upper Limb neurorehabilitation service contradicts this view.
- Trial name
- PROVES (NCT07592247)
- Testing
- Neuromuscular Electrical Stimulation and Home Exercise Programme
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London