Clinical trials: Stroke, open to volunteers
Stroke
Task-Oriented Upper Limb Training With Focal Vibration in Stroke
This study aims to investigate the effects of task-oriented upper limb training combined with focal vibration on hand function, proprioception, and muscle tone in patients with stroke.
- Trial name
- NCT07558876
- Testing
- Task-oriented upper limb training combined with focal vibration, Active Comparator: Task-Oriented Upper Limb Training Alone
- Where
- 2 sites in South Korea
- Volunteers
- 38 people
- Sponsor
- Jisu Kim
Ulcerative Colitis (UC), Crohn's Diseases
Cardiovascular Risk in Patients With IBD
In this study the Research Hospital San Donato Policlinic ask the participation with the aim to evaluate the risk of cardiovascular complication (i.e. stroke, myocardial infarction) in patients with inflammatory bowel disease.
- Conditions
- Ulcerative Colitis (UC), Crohn's Diseases, Cardiovascular Risk
- Trial name
- DICOM-IBD (NCT07663201)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Moyomoya Disease
Fufang Tongluo Decoction as an Adjunct to Aspirin and Atorvastatin for Ischemic Moyamoya Disease
Ischemic moyamoya disease is the most common subtype of moyamoya disease in adults. This investigator-initiated, multicenter, randomized, double-blind, placebo-controlled trial evaluates the efficacy and safety of Fufang Tongluo…
- Trial name
- NCT07875335
- Testing
- Aspirin, Atorvastatin, Fufang Tongluo Decoction
- Where
- China
- Volunteers
- 128 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Stroke, Acute, Parkinson Disease
Assessment of the Rehabilitative Effects of Curved-walking Training in Stroke, Parkinson and Orthopaedic Populations
The recovery of walking ability is crucial to promote independence in daily living and is one of the major goal of neuromotor rehabilitation.
- Conditions
- Stroke, Acute, Parkinson Disease, Femur Fracture
- Trial name
- NCT03545477
- Testing
- Novel locomotion treatment: curved-walking training, Standard locomotion treatment: straight-walking training, Standard physical therapy
- Where
- Italy
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Stroke
Upper Limb Mirror Therapy With Bilateral Transcutaneous Electrical Nerve Stimulation to Improve Upper Limb Functions in Patients With Stroke
This study compare the effectiveness of 2 rehabilitation programmes that use (1) MT with Bilateral TENS (Bi-TENS), (2) sham-MT with Bi-TENS (Bi-TENS), respectively, in addition to conventional rehabilitation of standardized upper…
- Trial name
- NCT03631628
- Testing
- Bilateral Transcutaneous electrical nerve stimulation (Bi-TENS), Mirror Therapy (MT), Conventional Rehabilitation Program
- Where
- 2 sites in Hong Kong
- Volunteers
- 90 people
- Sponsor
- The Hong Kong Polytechnic University
Occult Cancer
Intensive Cancer Screening After Cryptogenic Stroke
The INCOGNITO Pilot Trial is a single centre pilot prospective randomized open-label blinded endpoint (PROBE) trial to assess the feasibility of a full-scale randomized trial to determine whether an occult cancer screening…
- Trial name
- INCOGNITO (NCT05733416)
- Testing
- FDG PET/CT, Usual Care
- Where
- 3 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Ottawa Hospital Research Institute
Chronic Stroke
Psychometric Study of the Spanish Version of Two Upper Limb Assessment Scales in Chronic Stroke
The purpose of this cross-sectional study is to translate and cross-culturally adapt to Spanish the Motor Evaluation Scale for Upper Extremity in Stroke Patients (MESUPES) and the Stroke Upper Limb Capacity Scale (SULCS) and to…
- Trial name
- NCT05872191
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- University of Valencia
Stroke Recurrence, Myocardial Infarction
Cilostazol for Prevention of Recurrent Stroke Trial
The goal of this clinical study is to learn if adding a medicine called cilostazol to usual treatment can help prevent another stroke, a heart attack, or death in patients who had a stroke caused by a blocked blood vessel, or a…
- Conditions
- Stroke Recurrence, Myocardial Infarction, Vascular Death, Ischemic Stroke
- Trial name
- Clarity (NCT07174414)
- Testing
- Cilostazol 100 mg Tablets
- Where
- 46 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Stanford University
Stroke
Overground Virtual Reality (VR) Gait Rehabilitation for Stroke
The purpose of this study is to evaluate a new virtual reality (VR)-based rehabilitation program designed to help stroke survivors improve their walking abilities in real-world settings.
- Trial name
- NCT07676578
- Testing
- Walk-over-Ground, C-Mill VR+ by Motek
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Acute Ischemic Stroke, Acute Ischemic Stroke (AIS) Related to a Distal Occlusion
FORWARD: Functional Outcomes in Real-World Treatment And Revascularization of Non-dominant and Distal M2 Occlusions
The objective of this study is to collect safety and effectiveness data on the Penumbra System reperfusion catheters in participants with isolated primary non-dominant and distal M2 occlusions who undergo endovascular mechanical…
- Trial name
- NCT07749170
- Testing
- Endovascular Thrombectomy, Medical Management
- Where
- 5 sites in United States
- Volunteers
- 250 people
- Sponsor
- Penumbra Inc.
Stroke
Telerehabilitation for Post-Stroke Hand Function
This pilot randomized controlled trial will evaluate the feasibility and preliminary effects of a home-based, technology-enabled hand telerehabilitation program for adults with chronic stroke.
- Trial name
- NCT07792655
- Testing
- Technology-Supported Hand Training, Pamphlet-Supported Hand Activity
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Michigan
Stroke, Atrial Fibrillation (AF)
Early Anticoagulation Therapy After Endovascular Treatment for Acute Ischemic Stroke With Atrial Fibrillation
The goal of this clinical trial is to learn whether starting a direct oral anticoagulant (DOAC) early after endovascular treatment works to improve outcomes in patients with ischemic stroke related to atrial fibrillation.
- Trial name
- EATAF (NCT07849777)
- Testing
- Early Initiation of DOAC Therapy, Antiplatelet Bridging Followed by DOAC Therapy
- Where
- 2 sites in China
- Volunteers
- 474 people
- Sponsor
- The Fourth Affiliated Hospital of Soochow University
Insomnia, Ischemic Stroke
Adenosine A2a Receptor-Mediated Neuroinflammation in Remote Ischemic Conditioning for Post-Stroke Sleep Disorders
This is a single-center, prospective, randomized, double-blind, sham-controlled study. It will test whether remote ischemic conditioning (RIC), a non-invasive arm-cuff treatment, can improve insomnia after ischemic stroke and…
- Conditions
- Insomnia, Ischemic Stroke, Sleep Wake Disorders
- Trial name
- RIC-A2AR-SD (NCT07874594)
- Testing
- RIC Intervention Group
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Sichuan Academy of Medical Sciences
Stroke, Brain Computer Interface
Evaluation of an Adaptive Neurotechnology Based on Motor Imagery in Patients Who Suffered a Left Hemisphere Stroke
This randomized clinical trial will evaluate the feasibility and performance of a co-adaptive motor imagery brain-computer interface (BCI) for upper-limb rehabilitation in adults with subacute left-hemisphere stroke.
- Conditions
- Stroke, Brain Computer Interface, Motor Imagery, Neurofeedback
- Trial name
- NCT07875257
- Testing
- BCI sessions with neurofeedback, BCI sessions without neurofeedback
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
Secondary Stroke
A Study to Evaluate Cenvacibart (REGN7508) for Secondary Stroke Prevention in Adult Participants
This study will test an experimental Regeneron drug called cenvacibart (REGN7508) ("study drug") compared with a placebo (a look-alike treatment with no active medicine) on top of background antiplatelet medications.
- Trial name
- ROXI-DAISEN (NCT07876492)
- Testing
- Cenvacibart
- Volunteers
- 6,106 people
- Sponsor
- Regeneron Pharmaceuticals
Stroke
Enabling Bedside Brain Measurement of Motor Outcomes Post Stroke
The goal of this basic neuroscience study is to learn whether visual feedback of brain activity can help improve arm and hand recovery in people who recently had a stroke.
- Trial name
- fNIRS-NFB (NCT07876700)
- Testing
- fNIRS-neurofeedback, Control
- Volunteers
- 60 people
- Sponsor
- Sue Peters
Atrial Fibrillation
The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation
REACT-AF is a multicenter prospective, randomized, open-label, blinded endpoint (PROBE design), controlled trial comparing the current Standard Of Care (SOC) of continuous Direct Oral Anticoagulation (DOAC) use versus…
- Trial name
- REACT-AF (NCT05836987)
- Testing
- AFSW Guided DOAC, Continuous DOAC therapy
- Where
- 93 sites in United States
- Volunteers
- 5,350 people
- Sponsor
- Johns Hopkins University
Cerebral Vascular Accident
Brain Stimulation Enhance Post-stroke Walking Survivors and Healthy Adults
Recent studies showed that a non-invasive, low-intensity brain stimulation called transcranial direct current stimulation (tDCS) can effectively increase motor neuron excitability in the brain and therefore promotes functional…
- Trial name
- NCT06191549
- Testing
- anodal transcranial direct current stimulation (a-tDCS)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Mitochondrial Diseases, Maternally Inherited Diabetes and Deafness (MIDD)
KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases
The KHENERFIN study aims to determine whether the study medicine, sonlicromanol, is able to reduce symptoms of fatigue and the impact of fatigue on daily life, and whether sonlicromanol is able to improve physical abilities of…
- Conditions
- Mitochondrial Diseases, Maternally Inherited Diabetes and Deafness (MIDD), Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS), Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation
- Trial name
- KH176-301 (NCT06451757)
- Testing
- Sonlicromanol
- Where
- 10 sites in United States, Denmark and 5 more
- Volunteers
- 220 people
- Sponsor
- Khondrion BV
Stroke
Explore the Effects of Cortical Priming on Visuomotor Stepping Learning in Persons With Chronic Stroke
This research study aims to understand the relationship between brain stimulation and leg skill learning in both healthy adults and persons with chronic stroke.
- Trial name
- NCT06681207
- Testing
- anodal transcranial direct current stimulation (a-tDCS)
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston