Clinical trials: Stroke Prevention
Atrial Fibrillation
Efficacy and Safety of Rivaroxaban for the Prevention of Stroke in Subjects With Non-Valvular Atrial Fibrillation
This is a clinical study evaluating the efficacy and safety of rivaroxaban for stroke prevention in patients with atrial fibrillation (originally described in Japanese).
- Trial name
- NCT00494871
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Warfarin
- Where
- 165 sites in Japan
- Volunteers
- 1,280 people
- Sponsor
- Bayer
Ischemic Stroke, Transient Ischemic Attack
Zastaprazan for the prEvention of Upper GI Bleeding in Ischemic Stroke
The goal of this clinical trial is to learn if zastaprazan can help prevent upper gastrointestinal bleeding in adults who have recently had a transient ischemic attack (TIA) or ischemic stroke and are taking antiplatelet or…
- Trial name
- NCT07730840
- Testing
- Zastaprazan
- Where
- 15 sites in South Korea
- Volunteers
- 984 people
- Sponsor
- Asan Medical Center
Moderate Risk of CVD
A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease
The use of acetylsalicylic acid in the primary prevention of cardiovascular events has been extensively studied but to a lesser extent in patients with moderate levels of cardiovascular risk.
- Trial name
- ARRIVE (NCT00501059)
- Testing
- Aspirin (Acetylsalicylic acid, BAYE4465)
- Where
- 466 sites in United States, Germany and 6 more
- Volunteers
- 12,546 people
- Sponsor
- Bayer
Stroke, Diabetes Mellitus
Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study
The project is a passive follow-up of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort. Originally, this was a large, randomized, double-blind, placebo-controlled, 2x2 factorial primary prevention trial…
- Conditions
- Stroke, Diabetes Mellitus, Heart Disease, Cancer
- Trial name
- NCT00342992
- Where
- Finland
- Volunteers
- 29,133 people
- Sponsor
- National Cancer Institute (NCI)
Ischemic Stroke, TIA
Stroke Card Long-term Follow-Up
We undertook the STROKE-CARD trial (NCT02156778) between 2014 and 2018 with follow-up until 2019 to evaluate the efficacy of the Post-Stroke disease-management program STROKE-CARD care.
- Trial name
- NCT04205006
- Where
- 2 sites in Austria
- Volunteers
- 1,000 people
- Sponsor
- Medical University Innsbruck
Stroke Prevention in Patients With Atrial Fibrillation
Long Term Open Follow-up With H376/95 vs. Warfarin
The purpose of this study is to evaluate tolerability of long-term treatment with ximelagatran compared to standard treatment with warfarin.
- Trial name
- NCT00206063
- Testing
- EXANTA
- Where
- 19 sites in United States, Belgium and 7 more
- Volunteers
- 220 people
- Sponsor
- AstraZeneca
Transient Ischemic Attack, Non-disabling Stroke
Prevention of Ischemic Conditions in Non-disabling Stroke/Transient Ischemic Attack With Remote Ischemic Conditioning
This is a single-arm, open-labeled and phase II futility study. Application of Remote ischemic conditioning (RIC) as an adjunctive therapy to medication were involved in the study.
- Trial name
- PICNIC-ONE (NCT03004820)
- Testing
- Remote Ischemic Conditioning
- Where
- 4 sites in China
- Volunteers
- 167 people
- Sponsor
- Capital Medical University
Non-valvular Atrial Fibrillation (NVAF)
A Study to Evaluate the Safety and Effectiveness of Rivaroxaban (Xarelto) for Prevention of Stroke and Systemic Embolism in Indian Patients With Non-valvular Atrial Fibrillation (NVAF)
This study is planned to collect prospective data and evaluate the safety and effectiveness of rivaroxaban for the prevention of stroke and systemic embolism in Indian patients with NVAF when used in clinical practice under…
- Trial name
- XARIN (NCT03887780)
- Testing
- Rivaroxaban (Xarelto,Bay 59-7939)
- Where
- India
- Volunteers
- 504 people
- Sponsor
- Bayer
Obstructive Sleep Apnea, Hypertension
Antihypertensive and PAP Treatment in Obstructive Sleep Apnea Patients With Hypertension (AHPAP)
The investigators will perform a long term registry based prospective analysis on incidence of major cardiovascular events or death in hypertensive patients with obstructive sleep apnea .
- Conditions
- Obstructive Sleep Apnea, Hypertension, Death, Cardiac, Treatment Compliance
- Trial name
- AHPAP (NCT05115994)
- Testing
- Continous positive airway pressure
- Where
- Sweden
- Volunteers
- 10,000 people
- Sponsor
- Vastra Gotaland Region
Atrial Fibrillation
Satisfaction/Quality of Life With Rivaroxaban in SPAF (Stroke Prevention in Atrial Fibrillation) Indication
National, multicenter, prospective, observational, non-interventional study. The objective is to determine if the switch from Vitamin K antagonists (VKA) to Xarelto in subjects treated with VKA with issues for stroke prevention…
- Trial name
- SAFARI (NCT01805531)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Where
- France
- Volunteers
- 411 people
- Sponsor
- Bayer
Atrial Fibrillation (AF), Atrial Fibrillation (Prevention of Stroke)
Stroke Risk Assessment and Markers of Blood Clotting in Patients With Newly Diagnosed Non-valvular Atrial Fibrillation (NVAF), Who Have Not Received Oral Anticoagulation Therapy (OAC-therapy) Prior to Inclusion
Background: Atrial fibrillation (AF) is the most common heart rhythm disorder worldwide. Globally, there are 37.5 million people with AF.
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation (Prevention of Stroke), Atrial Fibrillation New Onset, Non Valvular Atrial Fibrillation
- Trial name
- BIO-AF (NCT06949319)
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Nedim Tojaga
Atrial Fibrillation
Polish Atrial Fibrillation (POL-AF) Registry
Evaluation of clinical characteristics and pharmacotherapy of hospitalized Polish patients with atrial fibrillation (AF).
- Trial name
- POL-AF (NCT04419012)
- Testing
- observation
- Where
- Poland
- Volunteers
- 4,000 people
- Sponsor
- Jan Kochanowski University
Ischemic Stroke, Hypertension
Home Blood Pressure Study for Recent Stroke Survivors With High Blood Pressure *On Hold Due to Global Pandemic*
The purpose of this pilot study is to assess the feasibility of implementing a home blood pressure self-management program in a population of recent stroke survivors in the Washington, D.C. area.
- Trial name
- HBPS (NCT04226157)
- Testing
- Home Blood Pressure Monitoring Device (Qardio Arm), Primary Care Provider Blood Pressure Management
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- MedStar Georgetown University Hospital
Anemia, Sickle Cell, Sickling Disorder Due to Hemoglobin S
Comparison of Two Methods of Transfusion for Stroke Prevention in Sickle Cell
Chronic blood transfusions are essential supportive care for sickle cell patients at high risk for morbidity and mortality due to stroke. These patients, however, are at risk for iron overload.
- Trial name
- NCT02561312
- Testing
- Rapid manual partial exchange transfusion, Simple Transfusion
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Chattanooga-Hamilton County Hospital Authority
Stroke, Ischemic
Investigating Adherence to Cereneo Tele-service Support After Clinical Disharge in Stroke Patients
This observational, prospective cohort, pilot study aims at investigating usability, operational, and economical factors around 'traditional' and 'technology-supported' approaches to promote a healthy life-style in stroke…
- Trial name
- NCT04733339
- Testing
- Secondary Prevention
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Cereneo AG
Ischemic Stroke, TIA
Personalized Antiplatelet Secondary Stroke PRevenTion
This is a descriptive study designed to evaluate the safety and feasibility of a precision medicine approach to antiplatelet selection for secondary stroke prevention.
- Trial name
- PASSPoRT (NCT03979781)
- Testing
- tailored antiplatelet selection, standard of care
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- State University of New York - Upstate Medical University
Coronary Heart Disease, Ischemic Stroke
Collaborative Quality Improvement (C-QIP) Study
The overarching goal of this study is to develop, implement, and evaluate the effect of a collaborative quality improvement (C-QIP) intervention (consisting of non-physician health workers, text messages for a healthy lifestyle…
- Conditions
- Coronary Heart Disease, Ischemic Stroke, Heart Failure
- Trial name
- C-QIP (NCT05196659)
- Testing
- Integrated comprehensive cardiovascular disease management
- Where
- 4 sites in India
- Volunteers
- 410 people
- Sponsor
- Public Health Foundation of India
Stroke, Stenosis
Abciximab for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic Carotid Stenosis
The purpose of the present prospective, randomized, double-blind, double dummy controlled multicenter pilot study is to investigate whether abciximab, compared with aspirin, is able to reduce the rate of recurrent ischemic…
- Trial name
- NCT00126139
- Testing
- Abciximab
- Where
- 5 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Acute Stroke, Dual Antiplatelet Therapy
Statin and Dual Antiplatelet Therapy to Prevent Early Neurological Deterioration in Branch Atheromatous Disease
Branch atheromatous disease (BAD) has been reported to contribute to small-vessel occlusion and is associated with a higher possibility of early neurological deterioration (END).
- Conditions
- Acute Stroke, Dual Antiplatelet Therapy, Statin
- Trial name
- SATBRAD (NCT04824911)
- Testing
- Clopidogrel, Aspirin, Atorvastatin
- Where
- Taiwan
- Volunteers
- 376 people
- Sponsor
- Chang Gung Memorial Hospital
Atrial Fibrillation (AF), Atrial Fibrillation (Prevention of Stroke)
The Southern-Norway Post-Stroke Atrial Fibrillation Study
This study evaluates whether a procedure using a new wireless heart sensor patch is equal to or better than the standard hospital procedures and equipment at detecting an irregular heartbeat called Atrial Fibrillation (AF) after…
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation (Prevention of Stroke), Ischemic Stroke, Secondary Prevention
- Trial name
- SNAPS (NCT07407790)
- Testing
- Patch ECG, Standard Care (in control arm)
- Where
- Norway
- Volunteers
- 450 people
- Sponsor
- Sorlandet Hospital HF