Clinical trials: Strokes
Ischemic Stroke, Thrombolysis
Quantitative Net Water Uptake as a Predictor of Functional Outcomes After Intravenous Thrombolysis in Acute Ischemic Stroke International Multicenter Observational Retrospective Study
While the effectiveness of intravenous thrombolysis (IVT) decreases over time, patients show considerable variability in how quickly their ischemic core progresses.
- Trial name
- NCT07299981
- Testing
- No Interventions
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Sigmund Freud PrivatUniversitat
Stroke
Myoelectric Computer Interface to Reduce Muscle Co-activation After Stroke
This study examines whether in-lab training with a myoelectric-computer interface (MyCI) can reduce abnormal muscle co-activation after stroke.
- Trial name
- NCT03579992
- Testing
- 60-min isometric MyCI training, 90-min isometric MyCI training, 90-min movement MyCI training
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Northwestern University
Acute Cerebrovascular Accident, Vasospasm
Carbonic Anhydrase Antagonism in Subarachnoid Hemorrhage
Subarachnoid Hemorrhage (SAH) can occur commonly in the setting of trauma or brain aneurysm. SAH accounts for 10% of all the strokes.
- Trial name
- NCT02165644
- Testing
- Acetazolamide, Nimodipine
- Sponsor
- University of Florida
Stroke, Ischemic
An Exploratory Study of Ganglioside GM1 in Acute Ischemic Stroke
The purpose of this study was to evaluate the efficacy and safety of higher doses of monosialoganglioside GM1 injection in the treatment of patients with acute ischemic stroke.
- Trial name
- NCT04952064
- Testing
- Monosialoganglioside GM1
- Where
- China
- Volunteers
- 300 people
- Sponsor
- General Hospital of Shenyang Military Region
Stroke, Acute Ischemic, Stroke, Acute
CHemical OptImization of Cerebral Embolectomy 2 (CHOICE 2).
Multi-center, randomized, parallel-group, superiority study to compare the efficacy of adjunct intra-arterial rt-PA versus not adjunct intra-arterial rt-PA in the improvement of the efficacy of mechanical thrombectomy in patients…
- Trial name
- CHOICE2 (NCT05797792)
- Testing
- Intraarterial alteplase
- Where
- 14 sites in Spain
- Volunteers
- 440 people
- Sponsor
- Hospital Clinic of Barcelona
Stroke
A Home-based Intervention to Reduce Sedentary Behaviour and Improve Function After Stroke
The traditional approach to physical activity promotion in people with stroke has always emphasized activities of a moderate-to-vigorous intensity (i.e. moving enough to breathe fast and break a sweat).
- Trial name
- STUFFS (NCT02980744)
- Testing
- Sedentary behaviour intervention
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University of Alberta
Dysphagia
Large-Scale Study of Oro-esophageal Feeding Versus Nasogastric Feeding for Swallowing Function and Airway Protection
This is a randomized controlled trial involving patients with ischemic stroke and dysphagia. The aim of this study is to explore the recovery speed and therapeutic effect of oro-esophageal feeding compared with nasogastric…
- Trial name
- IOEfinal (NCT07386834)
- Testing
- Oro-esophageal Feeding, Nasogastric Feeding, Rehabilitation care
- Volunteers
- 422 people
- Sponsor
- Zeng Changhao
Healthy
Safety,Tolerability, and Pharmacokinetic of KPCXM18 for Injection
to assess the safety,Tolerability, and pharmacokinetic of KPCXM18 for injection in healthy subjects
- Trial name
- NCT04629287
- Testing
- KPCXM18
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Kunming Pharmaceuticals, Inc.
Stroke, CVA (Cerebrovascular Accident)
HEADS: UP Online Psychological Self-management Intervention: Feasibility 2
To test feasibility of online version of HEADS: UP
- Conditions
- Stroke, CVA (Cerebrovascular Accident), Anxiety, Depression
- Trial name
- NCT04567472
- Testing
- Helping Ease Anxiety and Depression following Stroke
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Glasgow Caledonian University
Stroke
Urdu Version of National Institutes of Health Stroke Scale: Reliability and Validity Study
The goal of this study was to translate and culturally adapt NIHSS into Urdu language and to evaluate its reliability and validity in Pakistani stroke population.
- Trial name
- NCT05203081
- Where
- Pakistan
- Volunteers
- 225 people
- Sponsor
- Riphah International University
Stroke
Efficiency Study of Traditional Chinese Medicine (TCM) Versus Western Medicine (WM) on Ischemic Stroke
Complex project of Traditional Chinese Medicine (TCM) with Western Medicine (WM) project under stroke unit mode contrast,assuming that the efficiency of TCM on early rehabilitation and secondary prevention of ischemic stroke is…
- Trial name
- NCT00843765
- Testing
- acupuncture, massage and basic TCM treatment, rehabilitation and WM basic treatment
- Where
- China
- Volunteers
- 1,151 people
- Sponsor
- China Academy of Chinese Medical Sciences
Ischemic Stroke, Stroke
Effective Translation of Endovascular Thrombectomy Trials Into Real-world Practice in the Asia-Pacific
As a major breakthrough of acute stroke treatment over the past decade, endovascular thrombectomy (EVT) drastically improved neurological recovery and survival in patients with large vessel occlusion (LVO) ischemic strokes in…
- Conditions
- Ischemic Stroke, Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- NCT05578300
- Testing
- Thrombus analyses, Imaging assessment
- Where
- 3 sites in China, Hong Kong
- Volunteers
- 350 people
- Sponsor
- Chinese University of Hong Kong
Stroke, Acute Stroke
The Effects of Gait Rehabilitation After Stroke by Treadmill-based Robotics Versus Traditional Gait Training
This multicenter non-randomized controlled trial aims to investigate the effectiveness (an increase of the walking speed in the 10 Meter Walk Test - 10MWT) of the robotic treatment with exoskeleton or end-effector system compared…
- Conditions
- Stroke, Acute Stroke, Chronic Stroke
- Trial name
- TREAD_STROKE (NCT03688165)
- Testing
- Treadmill-based Robotic Gait Training, Traditional Over-ground Gait Training
- Where
- 4 sites in Italy
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Left Atrial Appendage Closure
Oral Anticoagulation Versus Left Atrial Appendage Occlusion Added to Direct Oral Anticoagulation in Patients with Stroke Despite Oral
A total of 380 patients with ischemic stroke despite OAC will be included. Patients will be randomized 1:1 to the best medical treatment (control) or the combination of LAAO and DOAC or OAC.
- Trial name
- ADDLAAO (NCT06869811)
- Testing
- LAA Closurse
- Where
- Spain
- Volunteers
- 380 people
- Sponsor
- Hospital Clinic of Barcelona
Acute Ischemic Stroke From Large Vessel Occlusion
Efficacy and Safety of Intra-Arterial Albumin as Adjunct to Mechanical Thrombectomy in Acute Ischemic Stroke
Stroke remains a predominant global public health challenge, ranking as the third leading cause of death and the fourth leading contributor to disability-adjusted life years (DALYs).
- Trial name
- AMASS2 (NCT07365475)
- Testing
- 20% human serum albumin
- Volunteers
- 306 people
- Sponsor
- Tianjin Huanhu Hospital
Ischemic Stroke
Bridging Thrombolysis Versus Direct Mechanical Thrombectomy in Acute Ischemic Stroke
Intravenous thrombolysis with recombinant tissue-type plasminogen activator (IV t-PA) has been the only proven therapy for acute ischemic stroke (AIS) for almost 20 years.
- Trial name
- SWIFT DIRECT (NCT03192332)
- Testing
- Stent-retriever thrombectomy with revascularization device of the Solitaire™ type, Intravenous thrombolysis with recombinant tissue-type plasminogen activator (IV t-PA)
- Where
- 48 sites in Austria, Canada and 6 more
- Volunteers
- 410 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Stroke
Scapular Training in Stroke Individuals
In recent publications evaluating scapular kinematics after stroke, it is emphasized that scapular muscles, which affect the performance of upper limbs in daily life, should not be ignored.
- Trial name
- NCT04743830
- Testing
- Neurodevelopmental Treatment (Bobath) + Scapular Training, Neurodevelopmental Treatment (Bobath)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Vascular Dementia
The Clinical Trial of Chinese Herbal Medicine SaiLuoTong Capsule
As a traditional Chinese medicine compound, SaiLuoTong capsule is proven to have beneficial effects on learning and memory ability in animal models of vascular dementia (VaD).
- Trial name
- NCT01978730
- Testing
- high dose group of SaiLuoTong capsule, low dose group of SaiLuoTong, the control group
- Where
- 16 sites in China
- Volunteers
- 372 people
- Sponsor
- Shineway Pharmaceutical Co.,Ltd
Aphasia, Non-fluent Aphasia
Combining tDCS and CILT in Non-fluent Aphasia
The long-term goal of this work is to determine if combining a highly intensive, task-specific behavioral language intervention with modulation of the efferent cerebellar-cortical pathway using transcranial direct current…
- Conditions
- Aphasia, Non-fluent Aphasia, Stroke, Brain Injuries
- Trial name
- NCT05561400
- Testing
- tDCS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Minnesota
Hemodynamics Instability, Anesthesia, General
Hemodynamics During Induction of General Anesthesia With High and Low Propofol Dose.
The study objective is to examine if a high propofol dose is non-inferior to a low dose in respect to hemodynamic stability in healthy patients during induction of general anesthesia with propofol and remifentanil.
- Conditions
- Hemodynamics Instability, Anesthesia, General, Anesthesia, Intravenous
- Trial name
- PH (NCT03861364)
- Testing
- Propofol
- Where
- Norway
- Volunteers
- 68 people
- Sponsor
- Helse Fonna
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