Clinical trials: Stromal Vascular Fraction
Multiple Sclerosis, Autoimmune
Use of Cellular Stromal Vascular Fraction in Multiple Sclerosis,Autoimmune, Inflammatory, Neurologic Conditions
Purpose of study is to determine safety and efficacy of use of autologous Adipose-Derived cellular Stromal Vascular Fraction (AD-cSVF) suspended in Normal Saline and delivered via intravascular system of quality of life and…
- Trial name
- cSVF (NCT02939859)
- Testing
- Microcannula Harvest Adipose, Centricyte 1000, Sterile Normal Saline IV deployment AD-cSVF
- Where
- 2 sites in United States, Honduras
- Sponsor
- Healeon Medical Inc
Osteoarthritis
Safety and Feasibility Study of Autologous Stromal Vascular Fraction (SVF) Cells for Treatment of Osteoarthritis
Autologous stromal vascular fraction (SVF) injected into joints of 20 patients with grade 2, 3, or 4 radiographic OA severity will be safe and feasible as assessed by lack of treatment associated adverse events.
- Trial name
- NCT01885832
- Testing
- Autologous adipose tissue stromal vascular fraction
- Where
- Panama
- Sponsor
- Translational Biosciences
Osteonecrosis of the Femoral Head
Triple-Modal Therapy in Early-Stage Femoral Head Osteonecrosis (TM-ONFH)
This retrospective observational study evaluates the clinical and radiological outcomes of patients with early-stage osteonecrosis of the femoral head treated with a combination of core decompression, stromal vascular fraction…
- Trial name
- TM-ONFH (NCT07560163)
- Testing
- Core decompression, stromal vascular fraction (SVF), Hyperbaric Oxygen Therapy (HBOT)
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ankara City Hospital Bilkent
Wound Heal, Scar
Scar Tissue Analysis After Intraoperative Application of Stromal Vascular Fraction Cells Into Suture Line
The study will evaluate the effect of intradermal injection of stromal vascular fraction into suture line on wound healing and scarring.
- Conditions
- Wound Heal, Scar, Hypertrophic Scar, Delayed Wound Healing
- Trial name
- NCT04238468
- Testing
- Intradermal stromal vascular fraction injection
- Where
- Slovenia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Katarina Zivec
Tracheoesopharyngeal Fistula, Bronchoesophageal Fistula
Adipose Derived SVF for Aero-digestive & Enterocutaneous Fistulae
Determine safety and feasibility of using institutionally prepared autologous, uncultured SVF on patients with aerodigestive and enterocutaneous fistulae secondary to malignancy, trauma or surgery.
- Conditions
- Tracheoesopharyngeal Fistula, Bronchoesophageal Fistula, Tracheoesophageal Fistula
- Trial name
- NCT03792360
- Testing
- SVF (Stromal Vascular Fraction)
- Sponsor
- Mayo Clinic
Scleroderma, Systemic
Subcutaneous Injection of Autologous Adipose Tissue-derived Stromal Vascular Fraction Into the Fingers of Patients With Systemic Sclerosis
Systemic sclerosis (SSc) is an auto-immune orphan disease mainly characterized by an alteration of the microvascular network, and by cutaneous and visceral fibrosis.
- Trial name
- scleradec2 (NCT02558543)
- Testing
- Stromal Vascular fraction, Ringer lactate
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Osteoarthritis, Joint Disease
Autologous Adipose-Derived Stromal Vascular Fraction Cells for Osteoarthritis Treatment
Adipose-derived stromal vascular fraction cells (SVFs) include regenerative cell populations (hematopoietic cells, pericytes, endothelial cells and progenitors, stromal/stem cells) and thus are potentially important as new…
- Conditions
- Osteoarthritis, Joint Disease, Osteoarthritis,Knee, Arthritis, Degenerative
- Trial name
- NCT02967874
- Testing
- Intra-articular auto-SVFs injection, Hyaluronic Acid
- Where
- Russia
- Volunteers
- 27 people
- Sponsor
- Russian Academy of Medical Sciences
Systemic Sclerosis
Assessment of the Subcutaneous Reinjection of Human Autologous Adipose-derived Stromal Vascular Fraction (Celution® System) in the Hands of Patients Suffering From Systemic Sclerosis
Systemic sclerosis is an autoimmune disease characterized by skin lesions and visceral responsible for significant morbidity. Microcirculatory disorders and tissue fibrosis are excessive severity of the disease.
- Trial name
- NCT01813279
- Testing
- the cell therapy
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Rheumatoid Arthritis
Autologous Adipose Tissue Stromal Vascular Fraction Cells for Rheumatoid Arthritis
Autologous stromal vascular fraction (SVF) injected at 8 and 10 days after extraction is safe and useful procedure in inducing remission of RA in patients resistant to standard DMARD therapy.
- Trial name
- NCT01885819
- Testing
- Autologous stromal vascular fraction cells
- Where
- Panama
- Sponsor
- Translational Biosciences
Perianal Fistula, Perianal Crohn Disease
Regenerative Therapy With Autologous Stromal Vascular Fraction Derived Mesenchymal Stem Cells and Platelet-rich Plasma to Treat Complex Perianal Diseases
Consecutive patients with complex anal fistula were prospectively followed for 12 months. Routine MRI was performed before and at 4 and 12 months after surgery. Continence was assessed likewise using a validated questionnaire.
- Conditions
- Perianal Fistula, Perianal Crohn Disease, Anal Fissure, Rectovaginal Fistula
- Trial name
- NCT05709717
- Testing
- Regenerative therapy with SVF-PRP to supplement perianal surgery
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Kantonsspital Winterthur KSW
Differenciation of Stromal-vascular Fraction Cells
A Study Using Human Abdominal Adipose Tissue Biopsies to Characterize the Role of Endocannabinoids in Adipocyte Differentiation
Abdominal obesity and type 2 diabetes are associated with hyperactivation of the endocannabinoid system. Several animal and human studies indicate that circulating endocannabinoid levels correlate with body fat mass.
- Trial name
- ECTADIF (NCT07567287)
- Testing
- Collection of adipose tissue samples
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Breast Reconstruction, Contour Irregularities
Immunophenotyping of Fresh Stromal Vascular Fraction From Adipose Derived Stem Cells (ADSC) Enriched Fat Grafts
The purpose of this study is to investigate if there is a relationship between the take of fat grafts with and without ADSCs and the presence of specific surface markers on the cells of the stromal vascular fraction.
- Conditions
- Breast Reconstruction, Contour Irregularities, Volume Insufficiency
- Trial name
- NCT01771913
- Testing
- centrifuged fat graft, ADSCs enriched fat graft
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Critical Limb Ischemia, Arteriosclerosis Obliterans
Effectiveness and Safety of Adipose-Derived Regenerative Cells for the Treatment of Critical Lower Limb Ischemia
Adipose-derived regenerative cells (ADRC) will be extracted from lipoaspirate by enzymatic digestion. 10 mL of autologous ADRC suspension injected intramuscularly, close to the site of muscle injury.
- Conditions
- Critical Limb Ischemia, Arteriosclerosis Obliterans, Peripheral Arterial Disease, Thromboangiitis Obliterans
- Trial name
- NCT02864654
- Testing
- ADRC injection, ADRC isolation, Liposuction
- Where
- Russia
- Volunteers
- 9 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Safety Issues
SVF Combined With Functional Self-assembling Peptide Nanofiber Hydrogels in the Treatment of Spinal Cord Injury
Traumatic spinal cord injury (SCI) is a severe medical problem experienced by people worldwide with high mortality and long term morbidity.
- Trial name
- NCT05967325
- Testing
- Stromal Vascular Fraction (SVF) combined with Functional self-assembling peptide nanofiber hydrogels
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Kunming Tongren Hospital
Osteoarthritis, Knee
Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis
This is a pivotal study to evaluate the efficacy and safety of a single injection of autologous adipose-derived SVF produced using the GID SVF-2 device system for treatment of pain with concomitant improvement in function…
- Trial name
- NCT04440189
- Testing
- GID SVF-2 Device System
- Where
- 9 sites in United States
- Volunteers
- 114 people
- Sponsor
- GID BIO, Inc.
Idiopathic Parkinson Disease, Parkinson's Disease and Parkinsonism
Adipose-derived Stromal Vascular Fraction Cells to Treat Parkinson
This is an interventional study to treat 10 patients with a diagnosis of Parkinson's disease with neurological assessment from the Oxford Parkinson's Disease Quotient-39 (PDQ-39) and Movement Disorders Society Universal…
- Trial name
- SVFP1 (NCT05699161)
- Testing
- Adipose-derived stromal vascular fraction cells
- Where
- Nicaragua
- Volunteers
- 10 people
- Sponsor
- Samuel Vilchez, PhD
Keloid, Autologus Adipose Derived Stem Cells
Autologous Adipose Derived Stem Cells Transplantation in the Treatment of Keloids.
Keloids are the most common disfiguring skin disorder affecting colored population with a prevalence of upto 16%. Autologous adipose derived stem cells have been found to have potential therapeutic benefits however limited…
- Conditions
- Keloid, Autologus Adipose Derived Stem Cells, Feasibility, Safety
- Trial name
- NCT04553159
- Testing
- Autologous adipose derived stem cells
- Where
- Uganda
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Makerere University
Knee Chondral Lesion
PRP vs AD-SVF in Addition to Marrow Stimulation for Knee Chondral Lesion
The goal of this clinical trial is to learn if PRP and adipose-derived stem cells (AD-SVF) enhance healing after knee microfracture for chondral lesions. It will also learn about the safety of the procedure.
- Trial name
- NCT07255547
- Testing
- Bone Marrow Stimulation, stromal vascular fraction (SVF), PRP injection
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Università degli Studi dell'Aquila
Lipoatrophy, Aging
Safety Study of Antria Cell Preparation Process to Enhance Facial Fat Grafting With Adipose Derived Stem Cells
The primary purpose of this study is to demonstrate the safety of injecting the Stromal Vascular Fraction (SVF) [containing Adipose Derived Stem Cells (ADSCs)] enriched fat grafts into regions of the face that require…
- Conditions
- Lipoatrophy, Aging, Wrinkles
- Trial name
- NCT01828723
- Testing
- SVF
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Antria
Fistula, Regenerative Medicine
RESTOREGI Study: Regenerative Endoscopic Stromal Therapy: Outcomes and Risk Factor Evaluation in GI Fistulas
RESTOREGI Study Benign gastrointestinal fistulas are abnormal communications between the gastrointestinal tract and adjacent organs or the skin.
- Conditions
- Fistula, Regenerative Medicine, Stromal Vascular Fraction
- Trial name
- RESTORE-GI (NCT07661043)
- Testing
- Endoscopic tSVF-EM Therapy
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Asian Institute of Gastroenterology, India