Clinical trials: Stromal Vascular Fraction
Diabetic Foot Ulcer, Diabetes Mellitus
Efficacy of Adipose Tissue Derived Stem Cells for the Treatment of Diabetic Foot Ulcers
The aim of this study is to evaluate the therapeutic efficacy of uncultured adipose derived stromal vascular fraction (SVF) and cultured adipose derived stem cells (ASCs) both supplemented with platelet rich plasma (PRP) to treat…
- Conditions
- Diabetic Foot Ulcer, Diabetes Mellitus, Diabetic Foot, Diabetic Foot Infection
- Trial name
- NCT05610865
- Testing
- Control; Standard-of-care management, Only PRP injection, PRP + SVF injection
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- University of the Punjab
Patellar Tendinitis, Tendinopathy
Stromal Vascular Fraction (SVF) Injection in the Treatment of Patellar Tendinopathy
The aim of the study is the evaluation of clinical and radiological results after the treatment of patellar tendinopathy through the injection of autologous ultrasound-guided, intra- and peri-tendon stromal vascular fraction.
- Conditions
- Patellar Tendinitis, Tendinopathy, Patellar Tendinopathy
- Trial name
- NCT04753853
- Testing
- Stromal Vascular Fraction injection
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Ortopedico Rizzoli
Xerostomia
Safety and Potential Effect of Innovative Cell-based Therapy Using Adipose-derived Stromal Vascular Fraction in Patients With Autoimmune Xerostomia
The main objective of this study is to evaluate the tolerance and safety of autologous adipose-derived stromal vascular fraction injected in accessory salivary glands for treatment of autoimmune xerostomia in terms of adverse…
- Trial name
- XEROCELL (NCT05857358)
- Testing
- lipoaspiration, Injection of the autologous adipose-derived stromal vascular fraction (AD-SVF)
- Volunteers
- 18 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Assessment of the Trophic and Anti-inflammatory Effect of SVF Added With HPL
Evaluation of Enhanced Therapeutic Effect of Adipose Stromal Vascular Fraction Added With Human Platelet Lysate in Treatment of Osteoarthritis
Osteoarthritis (OA) is a highly progressive and debilitating joint disease. Recently, it was demonstrated the existence of an important link between OA inflammation and progression of structural changes.
- Trial name
- NCT04225481
- Testing
- isolation of waste material and culturing with different supplement culture media
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Cell- and Tissue-Based Therapy, Cartilage Injury
Synovial Tissue and Fat Pad Stromal Vascular Fraction Bioengineering in Patients With Knee Articular Cartilage Injury
A phase I/II clinical trial (first in human) to assess the effectiveness and safety of the treatment of cartilage injury with a tissue engineering construct composed of stromal vascular fraction collected from the synovial…
- Conditions
- Cell- and Tissue-Based Therapy, Cartilage Injury, Knee Injuries
- Trial name
- NCT05120700
- Testing
- Synovial Tissue and Fat Pad Stromal Vascular Fraction
- Volunteers
- 10 people
- Sponsor
- University of Sao Paulo General Hospital
Endometrium; Atrophy, Intrauterine Synechiae
AD-SVF Therapy for Refractory Endometrial Infertility
The purpose of this study is to initially explore the efficacy of adipose-derived stromal vascular fraction (AD-SVF) therapy in the treatment of refractory endometrial infertility.
- Trial name
- NCT07230600
- Testing
- AD-SVF
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Rectovaginal Fistula
Autologous Adipose-derived Regenerative Cells Injection for Treatment of Radiation-induced Rectovaginal Fistula
A new strategy for treatment of late radiation damage is to develop methods aimed at stimulating the regenerative capabilities of irradiated tissues.
- Trial name
- NCT03643614
- Testing
- Injection of autologous regenerative cells of adipose tissue
- Where
- Russia
- Volunteers
- 16 people
- Sponsor
- South Ural State Medical University
Inclusion Body Myositis
Cell Therapy for IBM by Muscle Injection of ADSVF
Inclusion Body Myositis is a slowly but disabling myopathy, the most frequent in patients over 50 years old. No treatments (in particular immunosuppressive) are known to be efficient.
- Trial name
- ADSVF-in-IBM (NCT05032131)
- Testing
- ADSVF
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Type 2, Platelet-rich Plasma
Stromal Vascular Fraction and Autologous Activated Platelet-Rich Plasma Combination in Treating Treatment of Type 2 Diabetes
This study was a retrospective study on type 2 diabetes patients that were treated with autologous stromal vascular fraction (SVF) and autologous activated platelet-rich plasma (aaPRP) measuring HbA1c level at baseline, 1-month…
- Conditions
- Diabetes Mellitus, Type 2, Platelet-rich Plasma, Stromal Vascular Fraction
- Trial name
- NCT05925829
- Testing
- SVF and aaPRP
- Where
- Indonesia
- Volunteers
- 39 people
- Sponsor
- Hayandra Peduli Foundation
Scars, Delayed Wound Healing
Nanofat on Wound Healing and Scar Formation
This study will evaluate the effectiveness and safety of intradermal injection of Nanofat on wound healing and scar formation.
- Conditions
- Scars, Delayed Wound Healing, Hypertrophic Scar, Post Inflammatory Hyperpigmentation
- Trial name
- NFWHSF (NCT03850119)
- Testing
- Nanofat injection
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Benign Airway Stenosis, Respiratory Tract Fistula
Clinical Study on Autologous Stromal Vascular Fraction(SVF) Treatment for Refractory Benign Airway Stenosis and Respiratory Tract Fistula
Benign airway stenosis and respiratory tract fistula are common types of airway injury. The diseases occurred after endogenous and exogenous stimuli (tuberculosis, tumor, surgery, tracheal intubation) causing damage to the airway…
- Trial name
- NCT05270850
- Testing
- Control group, SVF group
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Systemic Sclerosis
Safety Of Fat Micrografts With Adipose-Derived Stromal Vascular Fraction In Hands Of Patients With Systemic Sclerosis
Systemic sclerosis (SS) causes microvascular alteration in the hand and subsequently pain, skin fibrosis, and osteoarticular deformities.
- Trial name
- NCT04387825
- Testing
- ADSVF application in the right hand
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Systemic Sclerosis
ADMSCs for the Treatment of Systemic Sclerosis
Systemic sclerosis (SSc) is a rare autoimmune disease, mainly characterized by cutaneous and visceral fibrosis. Digital ulcer and sclerosing skin are commonly affected on hands, but the treatment for these manifestations are…
- Trial name
- NCT02975960
- Testing
- injection of autologous stromal vascular fraction
- Where
- South Korea
- Volunteers
- 7 people
- Sponsor
- The Catholic University of Korea
Knee Arthrosis
The Use of Stromal Vascular Fraction for Knee Arthrosis
A trial to investigate the safety and efficacy of SVF for the treatment of knee arthrosis. Patients will undergo a single liposuction to obtain the SVF. The SVF will then be isolated and frozen in our laboratory.
- Trial name
- NCT06171204
- Testing
- Injection of SVF in fat pad of the knee
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Erectile Dysfunction
Adipose-derived SVF for Treatment of Erectile Dysfunction (ED)
This study will examine the safety and feasibility of a single injection of autologous adipose-derived stromal vascular fraction to treat erectile dysfunction.
- Trial name
- NCT03886402
- Testing
- GID SVF-2
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- GID BIO, Inc.
Diminished Ovarian Reserve (DOR)
Application of Autologous Adipose Stromal Vascular Fraction in the Treatment of Diminished Ovarian Reserve
A multi-center, prospective, randomised controlled clinical trial (1:1 treatment ratio), designed to investigate the efficacy and safety of autologous SVF in improving the pregnancy outcome of infertile patients with DOR.
- Trial name
- aSVF-DOR (NCT07901218)
- Testing
- Lower abdominal liposuction and preparation of SVF, Ovarian injection, Conventional ART treatment
- Where
- 4 sites in China
- Volunteers
- 260 people
- Sponsor
- Peking University Third Hospital
Facial Atrophy
Adipose Derived Stem Cells in Facial Fat Grafting
This phase two, randomized, double-blind study is designed to demonstrate the enhanced efficacy of SVF-enriched autologous facial fat grafts, in relation to standard, non-SVF enriched, facial fat grafts by evaluating volumetric…
- Trial name
- SVF (NCT02526576)
- Testing
- Stromal Vasular Fraction, Biopsy
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Antria
GERD (Gastroesophageal Reflux Disease)
Endoscopic Injection of Autologous Fat-Derived Cells (SVF) for Adults With Refractory Gastroesophageal Reflux Disease (GERD). (The GERD-REVIVE Pilot Study)
The purpose of this pilot clinical study is to evaluate the feasibility and safety of an innovative endoscopic treatment for adults with gastroesophageal reflux disease (GERD) that does not respond adequately to standard…
- Trial name
- GERD-REVIVE (NCT07638423)
- Testing
- Autologous Stromal Vascular Fraction (SVF) Endoscopic Injection
- Volunteers
- 15 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Dysphonia
Innovative Treatment for Scarred Vocal Cords by Local Injection of Autologous Stromal Vascular Fraction
Post-operative scarring on vocal cords is responsible for disorders of the vibration of the lining to the original dysphonia can be troublesome for the patient both in his private and professional life.
- Trial name
- NCT02622464
- Testing
- micro injection of SVF in vocal cords
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Osteoarthritis, Knee
SVF Cellular Composition, Secretome, and Responses in Knee Osteoarthritis
This prospective, single-center observational study will enroll 20 adults aged 40 to 75 years with Kellgren-Lawrence grade II or III knee osteoarthritis who have already been scheduled for an intra-articular injection of…
- Trial name
- NCT07898501
- Testing
- Autologous adipose-derived stromal vascular fraction intra-articular injection
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University