Clinical trials: Structure and Function of MRI
Anosognosia, Alzheimer's Disease
Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)
This is a three year fMRI study conducted at the University of Wisconsin (UW) Hospital and the William. S. Middleton VA Hospital.
- Conditions
- Anosognosia, Alzheimer's Disease, Mild Cognitive Impairment
- Trial name
- NCT00908999
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Glycogen Storage Disease Type 2, Dystrophia Myotonica
An MRI Study on Muscular Diseases -Pompe Disease and Dystrophia Myotonica-
The aim of the project is to develop new Magnetic Resonance (MR) imaging techniques for better diagnosis and monitoring of patients with muscular disorders.
- Trial name
- NCT02708784
- Where
- 2 sites in Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Fallopian Tube Cancer, Ovarian Cancer
Structural and Functional Imaging and Cognitive Functions in Ovarian Cancer
The purpose of this study is to learn about possible changes in brain anatomy and function, and in thinking abilities, such as memory skills, in patients with ovarian cancer who receive treatment with chemotherapy.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cancer
- Trial name
- NCT01591772
- Testing
- Neuroimaging & Neuropsychological Evaluation
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Perinatal Hypoxia, Dopamine
Measuring Brain Activity of School Age Children
This observational study will investigate whether differences in birth events and oxygen levels during the newborn period affects the brain activity of children during the middle childhood years.
- Conditions
- Perinatal Hypoxia, Dopamine, Neurobehavioral Manifestations
- Trial name
- NCT03407729
- Testing
- Magnetic Resonance Imaging, Cognitive Performance Testing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Tumor, Brain
Bridging Brain Structure and Function by Correlating Structural Connectivity, Cortico-Cortical Transmission and Direct Electro-Stimulation
Elucidating the structure-function relationship of the brain is one of the main open questions in neuroscience. The capabilities of diffusion MRI-based (dMRI) techniques to quantify the connectivity strength between brain areas…
- Trial name
- NCT03503110
- Testing
- electrocorticography with electrostimulation, dRMI
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Healthy Volunteers
Normative Cardiovascular Magnetic Resonance Values for Measurement of Cardiovascular Structure and Function at MCMR
Cardiovascular magnetic resonance (CMR) imaging is an important clinical and research tool. Measurements of cardiovascular structure and function can vary according to scanner vendor, scanner field strength, imaging sequence and…
- Trial name
- NORMAL MCMR (NCT05066269)
- Where
- United Kingdom
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Infant, Extremely Low Birth Weight, Lung Diseases, Obstructive
Growth, Health and Development in Children Born Extremely Preterm
Background: In a national Norwegian cohort of children born before 28 weeks gestation or with a birth weight less than 1000 g born in 1999 and 2000, 372 survived.
- Conditions
- Infant, Extremely Low Birth Weight, Lung Diseases, Obstructive, Disorder of Bone Density and Structure, Unspecified, Cognition Disorders
- Trial name
- PEP11 (NCT01150071)
- Where
- 2 sites in Norway
- Volunteers
- 232 people
- Sponsor
- University of Bergen
Protracted Bacterial Bronchitis
Lung MRI in Paediatric Lung Disease: MRI in PBB
Protracted bacterial bronchitis (PBB) is a problem in the lungs causing children to have a wet cough for more than 4 weeks. PBB is also known to start before and cause other lung diseases and to affect children's quality of life.
- Trial name
- NCT07545304
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Spinal Cord Injuries
The Impact of Electroacupuncture on Clinical Effect,Brain Structural and Functional Changes on Spinal Cord Injury
Spinal cord injury (SCI) is a kind of severe disease with high morbidity and complications. At present, electroacupuncture has certain advantages in treating motor sensory dysfunction, neuropathologic pain, neurogenic bladder and…
- Trial name
- NCT03909958
- Testing
- Electroacupuncture+Routine rehabilitation training Group, Routine rehabilitation training Group
- Where
- China
- Volunteers
- 84 people
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Genotype, Allelic Frequencies of Genetic Markers
Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers
The purpose of this study is to use brain imaging technology to compare differences in brain structure, chemistry, and functioning in individuals with brain and mental disorders compared to healthy volunteers.
- Conditions
- Genotype, Allelic Frequencies of Genetic Markers, Brain Mapping, Brain Disease
- Trial name
- NCT00001284
- Where
- United States
- Volunteers
- 2,802 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Child Development, Adhd
Reducing Head Motion With Customized Head Mold in Young Children
The purpose of this study is to assess the safety and efficacy of a customized head mold for reducing head motion during MRI scanning in young children.
- Conditions
- Child Development, Adhd, Neuroimag
- Trial name
- NCT04817059
- Testing
- Caseforge headcase
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Alzheimer Disease, Sleep
Sleep, Rhythms and Risk of Alzheimer's Disease
Alterations in sleep and the sleep / wake cycle, which are particularly common in Alzheimer's disease patients, could represent an early biomarker for cognitive decline and onset of dementia .
- Trial name
- AMImage3 (NCT04044495)
- Testing
- Multimodal brain imaging (MRI), Actimetry, Sleep Diary
- Where
- France
- Volunteers
- 47 people
- Sponsor
- University Hospital, Bordeaux
Multiple Sclerosis
Aerobic Training Effects on Motor and Cognitive Performances in MS: an Exploratory Study With Structural and Functional MRI
Aerobic training (AT) induces cardiovascular, metabolic and muscular changes and has been proposed as a promising rehabilitative approach in elderly adults and in neurological patients to improve both motor and cognitive…
- Trial name
- NCT04097418
- Testing
- Aerobic training compared to conventional motor training
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Pituitary Adenoma, Visual Impairment
Clinical Study of Structural and Functional Evaluation of the Visual Pathway
Sellar area tumors such as pituitary adenoma, craniopharyngioma and meningioma, etc, commonly lead to visual impairment symptoms.
- Conditions
- Pituitary Adenoma, Visual Impairment, Sellar Tumor, Neuroimaging
- Trial name
- NCT03591315
- Testing
- resting state fMRI, visual tasking state fMRI, diffusion tensor imaging
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Motivation
TDCS to Improve Motivation and Memory in Elderly (TIME)
Fundamental advancements in understanding successful aging are limited by the lack of causal, rather than just correlational methods to connect age-related changes in memory ability to changes in brain structure and function.
- Trial name
- NCT04268186
- Testing
- Direct tDCS, Indirect tDCS, Personalized tDCS
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Alcohol Addiction
Effects of Frontopolar TMS in Alcohol Craving
The goal of this interventional study is to learn if continuous theta burst stimulation (cTBS) applied over the left frontopolar cortex can reduce psychological, physiological, and neurobiological markers of alcohol craving in…
- Trial name
- TMS-SUD (NCT07064590)
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- 2 sites in Germany
- Volunteers
- 34 people
- Sponsor
- Goethe University
Cardiac Toxicity, Chemotherapeutic Agent Toxicity
Cardiac Magnetic Resonance Imaging in Patients With Non-Hodgkin Lymphoma or Hodgkin Lymphoma Receiving Doxorubicin
RATIONALE: Diagnostic procedures, such as cardiac magnetic resonance imaging, may help doctors detect early changes in the heart caused by chemotherapy.
- Conditions
- Cardiac Toxicity, Chemotherapeutic Agent Toxicity, Lymphoma
- Trial name
- NCT00577798
- Testing
- contrast-enhanced magnetic resonance imaging
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Mood Disorders, Anxiety Disorders
Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders
This study is intended to help develop new MRI imaging techniques for studying mood and anxiety disorders. Researchers believe that depression and anxiety disorders may cause structural and functional changes in the brain.
- Trial name
- NCT00397111
- Testing
- 7T Magnetic Resonance Imaging scanner
- Where
- United States
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Meditation, Brain; Agenesis
Brain Health With Inner Engineering Meditation
This study will explore whether a 21-minute meditation practice called Shambhavi Mahamudra Kriya leads to changes in brain health and explore how it affects cognitive and physiological function.
- Trial name
- BLISS (NCT05455814)
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Group 1: Healthy Controls, Group 2: Stable CF
Assessment of CFTR-Modulator Treatment in Cystic Fibrosis Lung Disease Using Novel Structural and Functional MRI
This is a prospective, longitudinal observational study conducted at The Hospital for Sick Children (SickKids). The purpose of this study is to evaluate the ability of MRI to detect changes in lung structure and function in CF…
- Conditions
- Group 1: Healthy Controls, Group 2: Stable CF, Group 3: CF Participants Anticipated to Receive CFTR-modulator Therapy, Group 4: 4-8 yo CF Participants Starting Triple Combination Modulator Therapy
- Trial name
- NCT04391322
- Where
- Canada
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children