Clinical trials: Sts
Liver Cancer, Ototoxicity
Cisplatin With or Without Sodium Thiosulfate in Treating Young Patients With Stage I, II, or III Childhood Liver Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- SIOPEL6 (NCT00652132)
- Testing
- cisplatin, sodium thiosulfate
- Where
- 16 sites in United Kingdom
- Volunteers
- 116 people
- Sponsor
- University of Birmingham
Renal Failure
The Pharmacologic Profile of Sodium Thiosulfate in Renal Failure and Healthy Volunteers
The pharmacokinetics of sodium thiosulfate in humans with different degrees of renal failure and in healthy volunteers will be after two single shot applications.
- Trial name
- NCT01008631
- Testing
- Sodium thiosulfate
- Where
- Switzerland
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma Adult
A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors
This is a multi-center, single arm, open-label, localized pharmacodynamic biomarker Phase 0 trial designed to study the biological effects within the tumor microenvironment of PBA-0405 when administered intratumorally in…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma Adult, Triple Negative Breast Cancer
- Trial name
- NCT06273852
- Testing
- PBA-0405
- Where
- 4 sites in United States
- Volunteers
- 8 people
- Sponsor
- Pure Biologics S.A.
Soft Tissue Sarcoma, Pulmonary Metastasis
Phase 1b/2 Study of Liposomal Annamycin (L-Annamycin) in Subjects With Previously Treated Soft-Tissue Sarcomas (STS) With Pulmonary Metastases
This study is a multi-centre, open-label, single-arm, 3+3 Phase 1b/ and Phase II. Phase 1b is aimed to determine the maximum-tolerated dose (MTD)/Recommended Phase 2 Dose (RP2D) based on safety reporting.
- Trial name
- ANNA-SARC (NCT05518526)
- Testing
- Liposomal Annamycin (L-Annamycin)
- Where
- Poland
- Volunteers
- 64 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Ototoxic Hearing Loss
Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving Cisplatin Chemotherapy
One common side effect of cisplatin chemotherapy is ototoxicity. The drugs sodium thiosulfate and mannitol may protect against cisplatin-induced hearing loss.
- Trial name
- NCT05129748
- Testing
- Sodium Thiosulfate + Mannitol
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- Sunnybrook Health Sciences Centre
Soft Tissue Sarcoma (STS)
Cirtuvivint in Selected Advanced Soft-Tissue Sarcomas
The study is a Phase 2 clinical trial of the drug cirtuvivint as a second-line treatment for advanced soft tissue sarcomas. The study is being conducted in Spain and is expected to enroll approximately 25 patients in total.
- Trial name
- CIRTUSARC (NCT07032285)
- Testing
- Cirtuvivint
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Asociación Europea y Latinoamericana SELNET para la Investigación en Sarcomas
COVID-19, Virus Diseases
STS Administration on Coronavirus Disease (COVID-19) Patients in Critical Care
The primary purpose is to describe the safety of administration of three doses of STS to critically ill patients with confirmed COVID-19.
- Conditions
- COVID-19, Virus Diseases, Corona Virus Infection
- Trial name
- H4COVID (NCT05277285)
- Testing
- Sodium Thiosulfate 25% Solution for Injection
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Acute Coronary Syndrome
Safety and Tolerability of Sodium Thiosulfate in Patients With an ACS Undergoing CAG Via Trans-radial Approach.
The purpose of this trial is to evaluate the safety and maximum tolerable dose (MTD) of sodium thiosulfate in patients presenting with an acute coronary syndrome and treated with primary percutaneous coronary intervention (PPCI)…
- Trial name
- SAFE-ACS (NCT03017963)
- Testing
- Sodium Thiosulfate Pentahydrate
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- University Medical Center Groningen
Soft Tissue Sarcoma (STS), Soft Tissue Sarcoma Adult
Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma.
The purpose of the study is to study if dose escalated proton radiotherapy can improve local controll for patients with inoperable soft tissue sarcomas. The standard treatment is photon-based radiation.
- Conditions
- Soft Tissue Sarcoma (STS), Soft Tissue Sarcoma Adult, Soft Tissue Sarcoma of the Trunk and Extremities, Synovial Sarcomas
- Trial name
- PROSARC-2 (NCT07173972)
- Testing
- Definitive radiotherapy
- Where
- 2 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Sarcoma, Soft Tissue Sarcoma (STS)
A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Soft Tissue Sarcoma
A study of lifileucel (tumor-infiltrating lymphocytes) in adults with advanced soft tissue sarcoma ('SARATOGA')
- Conditions
- Sarcoma, Soft Tissue Sarcoma (STS), Advanced Soft Tissue Sarcoma, Undifferentiated Pleomorphic Sarcoma (UPS)
- Trial name
- 'SARATOGA' (NCT07741877)
- Testing
- Lifileucel
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Iovance Biotherapeutics, Inc.
Endometriosis
PGL2001 Proof of Concept Study in Symptomatic Endometriosis
This is a Phase II, multicentre, randomised, two-arm, parallel group ,double-blind, placebo controlled, study to investigate the efficacy, safety, pharmacokinetics and pharmacodynamics of the steroid sulfatase inhibitor PGL2001…
- Trial name
- AMBER (NCT01631981)
- Testing
- PGL2001 + Primolut-Nor 5
- Where
- 20 sites in Hungary, Poland and 1 more
- Volunteers
- 162 people
- Sponsor
- PregLem SA
Soft Tissue Sarcoma
Study Comparing Negative Pressure Dressing vs Conventional in Patients With Resected STS After Radiotherapy
This is a randomized (1:1 ratio), prospective, comparative, controlled, open-label study. The aim is to compare the efficacy of negative pressure therapy (PREVENA™) versus standard postoperative wound management on the wound…
- Trial name
- TPN-RAD (NCT05944913)
- Testing
- Prevena
- Where
- 15 sites in France
- Volunteers
- 166 people
- Sponsor
- Centre Leon Berard
Hepatoblastoma
A Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT Strategy
A Phase 3 multi-institutional study for treatment of children with newly diagnosed hepatoblastoma using a modified Paediatric Hepatic International Tumour Trial (PHITT) strategy incorporating a randomized assessment of sodium…
- Trial name
- NCT04478292
- Testing
- Sodium Thiosulfate Injection, Primary surgery resection, mono CDDP-Group A2
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Children's Medical Center
Soft Tissue Sarcoma
tTF-NGR Randomized Study - STS
In this phase III open label, controlled clinical trial patients with unresectable or metastatic soft-tissue sarcoma after failure of anthracycline-containing first line therapy or with contraindications to these drugs and CD13…
- Trial name
- TRABTRAP (NCT05597917)
- Testing
- Trabectedin, tTF-NGR
- Where
- 9 sites in Germany
- Volunteers
- 126 people
- Sponsor
- Universität Münster
Metastatic and Locally Advanced Soft Tissue Tumor Patients Unfit to Receive, Standard Chemotherapy
Trabectedin First Line Therapy In Unfit Sarcoma Study
Phase II, non-randomized, two-stage study according to Bryant \& Day The study enroll patients with Metastatic and locally advanced soft tissue sarcoma unfit to receive standard chemotherapy (doxorubicin/epirubicin and/or…
- Trial name
- TR1US (NCT02066675)
- Testing
- Trabectedin
- Where
- 16 sites in Italy
- Volunteers
- 24 people
- Sponsor
- Italian Sarcoma Group
Soft Tissue Sarcoma
Study of Selinexor and Doxorubicin in Advanced Soft Tissue Sarcomas
This is a phase 1b study of investigational drug selinexor in combination with doxorubicin in patients with locally advanced or metastatic soft tissue sarcoma.
- Trial name
- NCT03042819
- Testing
- Selinexor, Doxorubicin
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University Health Network, Toronto
Sarcoma, Soft Tissue
Neoadjuvant Adriamycin and Ifosfamide Plus High-Dose ICE in Patients With Soft Tissue Sarcoma (STS)
Complete resection is still the only curative treatment option in patients with soft tissue sarcoma (STS). Patients with a non-resectable STS have a dismal prognosis even without evidence of metastatic disease.
- Trial name
- NCT00204646
- Testing
- Adriamycin, Ifosfamide, Etoposide
- Where
- Germany
- Sponsor
- University Hospital Tuebingen
Soft Tissue Sarcoma (STS)
A Multicenter, Single-arm, Prospective Phase II Clinical Study of Epalrotokewali Combined With Eribulin, Anlotinib, and Radiotherapy for the Treatment of Patients With Advanced Soft Tissue Sarcoma.
This study intends to enroll patients with advanced soft tissue sarcoma, employing immunotherapy combined with eribulin, anlotinib, and radiotherapy as subsequent-line treatment to preliminarily explore its efficacy and safety.
- Trial name
- NCT07205185
- Testing
- QL1706 + Eribulin + Anlotinib + Radiotherapy
- Volunteers
- 46 people
- Sponsor
- Fudan University
Aortic Valve Stenosis
Society of Thoracic Surgeons and American College of Cardiology Transcatheter Valve Therapy Registry (STS/ACC TVT Registry™): Registry Purpose and Research Objective
The STS/ACC TVT Registry™ (TVT Registry), created by The Society of Thoracic Surgeons (STS) and the American College of Cardiology Foundation (ACCF), is a benchmarking tool designed to assess the prevalence, demographics…
- Trial name
- NCT07908355
- Testing
- Transcatheter Aortic Valve Replacement
- Where
- United States
- Volunteers
- 50,000 people
- Sponsor
- American College of Cardiology
Darier Disease, Hailey-Hailey Disease
National Registry for Ichthyosis and Related Disorders
The ichthyoses are a family of genetic skin diseases characterized by dry, thickened, scaling skin. Dermatologists estimate that there are over twenty varieties of ichthyosis, with a wide range of severity and associated…
- Conditions
- Darier Disease, Hailey-Hailey Disease, Hyperkeratosis, Epidermolytic, Ichthyosis
- Trial name
- NCT00074685
- Where
- United States
- Volunteers
- 610 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)