Clinical trials: Sts
Calcific Tendinitis of the Rotator Cuff
Efficacy and Tolerance of Sodium Thiosulfate Injection After Ultrasound-guided Percutaneous Irrigation of Calcific Tendinopathy of the Rotator Cuff
Calcific tendinitis of the rotator cuff is a common cause of chronic pain of the shoulder. US- guided needling and lavage of the calcification is one of the therapeutic options after failure of conservative management with…
- Trial name
- THIOCAL (NCT02538939)
- Testing
- Sodium thiosulfate
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Nantes University Hospital
Soft Tissue Sarcoma (STS)
Sarcoma Care Adherence and Survival in Strasbourg
This retrospective monocentric study evaluates adherence to international clinical practice guidelines for soft tissue sarcoma management in Strasbourg and its impact on overall survival.
- Trial name
- SAGES (NCT07864870)
- Where
- France
- Volunteers
- 900 people
- Sponsor
- University Hospital, Strasbourg, France
Hearing Loss, Metastatic Malignant Germ Cell Tumor
Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors
This phase I trial evaluates whether adding Pedmark to standard of care cisplatin-based chemotherapy reduces drug-induced ear damage (ototoxicity) in men with stage II-III testicular germ cell tumors that have spread from where…
- Conditions
- Hearing Loss, Metastatic Malignant Germ Cell Tumor, Metastatic Malignant Nongerminomatous Germ Cell Tumor, Metastatic Malignant Testicular Non-Seminomatous Germ Cell Tumor
- Trial name
- NCT07218913
- Testing
- Audiometric Test, Cisplatin, Computed Tomography
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- City of Hope Medical Center
Calcinosis
Topical Sodium Thiosulfate and Fractional Carbon Dioxide Laser in Treating Dermatomyositis Associated Calcinosis
Dermatomyositis is an inflammatory muscle disorder that is often associated with many skin findings. One of the skin findings seen in up to 50% of individuals with juvenile dermatomyositis, an early onset form of this condition…
- Trial name
- NCT01572844
- Testing
- Fractionated Carbon Dioxide (FCO2) Laser, Sodium thiosulfate
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Alison Ehrlich
Sarcoma, Soft Tissue
Trabectedin Maintenance Post 1st-line in STS
Maintenance therapy with trabectedin versus observation after first line treatment with doxorubicin of patients with advanced or metastatic soft tissue sarcoma.
- Trial name
- NCT02929394
- Testing
- Trabectedin
- Where
- 14 sites in France, Germany and 4 more
- Volunteers
- 13 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Malignant Soft Tissue Sarcoma
Use of Propranolol Hydrochloride in the Treatment of Metastatic STS
Fifty patients with pathological proof of malignant soft tissue sarcoma will receive Anthracyclin based chemotherapy combined with propranolol 40 mg twice daily.
- Trial name
- NCT03108300
- Testing
- Propranolol Hydrochloride, Doxorubicin
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Anaplastic Oligoastrocytoma, Anaplastic Oligodendroglioma
Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors
This phase I/II trial studies the side effects and best dose of melphalan when given together with carboplatin, etoposide phosphate, mannitol, and sodium thiosulfate and to see how well they work in treating patients with…
- Conditions
- Anaplastic Oligoastrocytoma, Anaplastic Oligodendroglioma, Mixed Glioma, Oligoastrocytoma
- Trial name
- NCT00303849
- Testing
- Carboplatin, Etoposide, Etoposide Phosphate
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- OHSU Knight Cancer Institute
Sodium Thiosulfate, Calcific Tendinitis
Efficacy of Sodium Thiosulfate in Shoulder Pain in Calcific Tendinitis of the Rotator Cuff
Calcific tendinitis of the rotator cuff is one of the most common causes of shoulder pain. Ultrasound guided percutaneous lavage (UGPL or barbotage or irrigation) of calcific tendinopathy is indicated when conservative treatments…
- Conditions
- Sodium Thiosulfate, Calcific Tendinitis, Shoulder Pain
- Trial name
- NCT04251832
- Testing
- Sodium Thiosulfate
- Where
- Portugal
- Volunteers
- 80 people
- Sponsor
- Soraia Azevedo
Calcinosis Cutis
Efficacy of Intralesional Sodium Thiosulfate Versus Intralesional Saline for Dystrophic and Idiopathic Calcinosis Cutis
The purpose of our research is to compare the effectiveness of 125mg/50ml sodium thiosulfate (STS) solution to normal saline (0.9% sodium chloride) when injected intralesionally for the treatment of calcinosis cutis.
- Trial name
- NCT03639779
- Testing
- Sodium Thiosulfate, Saline Solution
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Advanced Soft Tissue Sarcoma, Metastatic Soft Tissue Sarcoma
SAINT:Trabectedin, Ipilimumab and Nivolumab for Previously Treated Advanced Soft Tissue Sarcoma
This is an open label, dose-seeking phase 1/2 study using escalating doses of TRABECTEDIN given intravenously with defined doses of IPILIMUMAB and NIVOLUMAB based on preliminary results of the Checkmate 012 trial for NSCLC…
- Trial name
- NCT03138161
- Testing
- Trabectedin, Ipilimumab, Nivolumab
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Sarcoma Oncology Research Center, LLC
Diagnosis of Soft Tissue Sarcoma (STS)
Improved Management of Soft Tissue Sarcomas Patients With an Optimized and Innovative Sorting Technology for Circulating Tumor Cells
This trial is a monocentric, clinico-biological cohort study with prospective enrollment, aiming to develop a method for detecting and sorting CTCs (circulating tumour cells) from liquid biopsies (fresh blood samples) in patients…
- Trial name
- LIGHT-CTC (NCT07401355)
- Testing
- Collection of tumor and blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Leon Berard
Bone Marrow Suppression, Brain and Central Nervous System Tumors
Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, etoposide phosphate, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Bone Marrow Suppression, Brain and Central Nervous System Tumors, Drug/Agent Toxicity by Tissue/Organ, Long-term Effects Secondary to Cancer Therapy in Children
- Trial name
- NCT00238173
- Testing
- filgrastim, acetylcysteine, carboplatin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- OHSU Knight Cancer Institute
Soft Tissue Sarcoma (STS), Bone Cancer Tumor
Development of a Radiomics Model With MR to Predict the Occurence of a Infiltration of Muscoskeletal Tumor
The goal of this observational study is to evaluate the feasibility and clinical utility of radiomics to diagnose peri-lesion tumour infiltration of tumours in participants with a suspect of Bone Cancer Tumor or Soft Tissue…
- Trial name
- NCT06774729
- Where
- Italy
- Volunteers
- 122 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sarcoma, Bone Sarcoma
Bridging Adolescent and Young Adult Sarcoma Survivors With Personalized Oncology Exercise Service (AYA-ONE): A Pilot Intervention
This study will evaluate strategies to improve physical function and promote exercise and physical activity in adolescents and young adults (AYAs) with sarcoma.
- Conditions
- Sarcoma, Bone Sarcoma, Soft Tissue Sarcoma (STS)
- Trial name
- AYA-ONE (NCT07662239)
- Testing
- Exercise Triage and Personalized Exercise Program
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Dana-Farber Cancer Institute
Head Neck Tumors, Neuroendocrine Tumors
A Phase II Study on Adjuvant Vaccination with Dendritic Cells Loaded with Autologous Tumor Homogenate in Resected Stage IV Rare Cancers.
Single-arm, monocentric trial to assess safety and immunological efficacy of adjuvant vaccination with autologous dendritic cells loaded with autologous tumour homogenate after curative resection for stage IV rare cancers (In…
- Conditions
- Head Neck Tumors, Neuroendocrine Tumors, Soft Tissue Sarcoma, Rare Cancer
- Trial name
- RaC-Ad (NCT04166006)
- Testing
- Autologous DC vaccine, Interleukin-2
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Back Pain, Sciatica
Predictive Value of the Five-repetition Sit-to-stand Test After Lumbar Spine surgerySTS-3 Study.
Sciatica is a disabling condition that affects many people. This condition has an enormous influence on the social functioning of patients.
- Trial name
- 5R-STS-III (NCT04660656)
- Testing
- 5 repetition sit-to-stand test
- Where
- 2 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- Bergman Clinics
Metastatic and Locally Advanced Soft Tissue Tumor Patients Unfit to Receive, Standard Chemotherapy
Trabectedin First Line Therapy In Unfit Sarcoma Study
Phase II, non-randomized, two-stage study according to Bryant \& Day The study enroll patients with Metastatic and locally advanced soft tissue sarcoma unfit to receive standard chemotherapy (doxorubicin/epirubicin and/or…
- Trial name
- TR1US (NCT02066675)
- Testing
- Trabectedin
- Where
- 16 sites in Italy
- Volunteers
- 24 people
- Sponsor
- Italian Sarcoma Group
COVID-19, Virus Diseases
STS Administration on Coronavirus Disease (COVID-19) Patients in Critical Care
The primary purpose is to describe the safety of administration of three doses of STS to critically ill patients with confirmed COVID-19.
- Conditions
- COVID-19, Virus Diseases, Corona Virus Infection
- Trial name
- H4COVID (NCT05277285)
- Testing
- Sodium Thiosulfate 25% Solution for Injection
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Tumors
A Multi-Center, Open-Label Study of Surufatinib (HMPL-012) in Patients With Advanced Solid Tumors
Primary Objective Dose Escalation: To evaluate the safety and tolerability of surufatinib in patients with advanced solid tumors and to determine the maximum tolerable dose (MTD) or recommended phase II dose (RP2D).
- Trial name
- NCT02549937
- Testing
- surufatinib
- Where
- 12 sites in United States, Italy
- Volunteers
- 130 people
- Sponsor
- Hutchmed
Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma
PBI-MST-01 (NCT04541108) Substudy MSD-03: Intratumoral Microdosing of Pembrolizumab Alone and With MK-0482 or MK-4830 in HNSCC or STS
This is a multi-center, open-label, Phase 0 substudy designed to evaluate the ability of pembrolizumab, alone and in combination with MK-0482 or MK-4830, to elicit pharmacodynamic changes suggestive of antitumor immune activation…
- Trial name
- NCT06413095
- Testing
- Pembrolizumab, MK-0482 + Pembrolizumab, MK-4830 + Pembrolizumab
- Where
- 11 sites in United States
- Volunteers
- 13 people
- Sponsor
- Presage Biosciences