Clinical trials: Sts
Soft Tissue Sarcoma (STS)
Preoperative Radiotherapy and Anlotinib With or Without Penpulimab for Soft Tissue Sarcoma
Soft tissue sarcoma is a rare cancer that often requires surgery combined with radiotherapy. Preoperative radiotherapy can improve the chance of complete tumor removal and limb preservation, but some patients still experience…
- Trial name
- SPARE-04 (NCT07612098)
- Testing
- Anlotinib, Penpulimab, Preoperative Radiotherapy
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Soft Tissue Sarcoma
Radiation Therapy and Intratumoral Autologous Dendritic Cells in Soft Tissue Sarcomas (STS)
The purpose of this study is to determine if injection of the participant's our own immune related white blood cells (called dendritic cells) into their tumor will strengthen their immune system to fight against their cancer.
- Trial name
- NCT01347034
- Testing
- External Beam Radiation Therapy (RT), Autologous Dendritic Cells
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Sarcoma, Sarcoma, Leiomyo-, Adult
Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients
This is a cohort study aimed at developing a stratified medicine approach for personalised neoadjuvant chemotherapy (NCT) in high-risk soft tissue sarcoma (STS) patients with dedifferentiated liposarcoma (DDLPS), leiomyosarcoma…
- Conditions
- Sarcoma, Sarcoma, Leiomyo-, Adult, Sarcoma, Synovial, Adult, Soft Tissue Sarcoma (STS)
- Trial name
- PANTHR-S (NCT07432932)
- Testing
- Observational Translational Study
- Where
- United Kingdom
- Volunteers
- 800 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Liver Cancer, Ototoxicity
Cisplatin With or Without Sodium Thiosulfate in Treating Young Patients With Stage I, II, or III Childhood Liver Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- SIOPEL6 (NCT00652132)
- Testing
- cisplatin, sodium thiosulfate
- Where
- 16 sites in United Kingdom
- Volunteers
- 116 people
- Sponsor
- University of Birmingham
Sodium Thiosulfate, Ectopic Ossification
Treatment of Ectopic Calcification / Ossification With Sodium Thiosulfate (CATSSO)
Ectopic calcification and ossification complicate many diseases, which are rare for the most part. These calcifications (or ossifications) are generally classified according to their apparent formation mechanism.
- Trial name
- NCT03979378
- Where
- 7 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Limoges
Soft Tissue Sarcoma (STS)
A Phase Ib/II Study to Evaluate Safety and Efficacy of Bexmarilimab in Combination With Doxorubicin in Metastatic Soft-tissue Sarcoma.
This trial will Study a type of sarcoma defined metastatic soft-tissue sarcoma (STS). Participants will be treated with bexmarilimab, a CLEVER-1 antibody plus doxorubicin, a chemotherapy.
- Trial name
- BEXAR (NCT07460986)
- Testing
- bexmarilimab, Doxorubicin
- Where
- 11 sites in Spain
- Volunteers
- 278 people
- Sponsor
- MedSIR
Soft Tissue Sarcoma
A Study of Olaratumab (LY3012207) Plus Pembrolizumab in Participants With Advanced or Metastatic Soft Tissue Sarcoma
The purpose of this study is to evaluate the safety of olaratumab plus pembrolizumab in participants with previously treated advanced or metastatic soft tissue sarcoma.
- Trial name
- NCT03126591
- Testing
- Olaratumab, Pembrolizumab (KEYTRUDA®)
- Where
- 6 sites in United States, Belgium and 2 more
- Volunteers
- 41 people
- Sponsor
- Eli Lilly and Company
Epithelial Ovarian Cancer, Gastro-esophageal Junction Cancer
EPITOME-1015-I: a Study to Investigate the Safety and Tolerability of MDG1015 in Patients with Epithelial Ovarian Cancer, Gastroesophageal Adenocarcinoma, Round Cell Liposarcoma And/or Synovial Sarcoma
MDG1015 is a third generation TCR-T therapy product targeting NY-ESO-1/LAGE-1a armored and enhanced by the PD1-41BB costimulatory switch protein (CSP).
- Conditions
- Epithelial Ovarian Cancer, Gastro-esophageal Junction Cancer, Soft Tissue Sarcoma (STS), Myxoid Liposarcoma
- Trial name
- EPITOME-1015-I (NCT06748872)
- Testing
- Lymphodepletion, TCR-T cells (MDG1015)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Medigene AG
Soft Tissue Sarcoma
PLD and IFO As First-line Treatment for Patients With Advanced or Metastatic STS
This study is designed to evaluate the efficacy and safety of pegylated liposomal doxorubicin (PLD) combined with ifosfamide (IFO) for the first-line treatment of patients with advanced or metastatic soft tissue sarcoma (STS).
- Trial name
- NCT03268772
- Testing
- PLD and IFO
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fudan University
Soft Tissue Sarcoma (STS)
OVV-01 Injection Combined With AK112 Injection for the Treatment of Patients With Advanced Soft Tissue Sarcoma (STS)
The efficacy of OVV-01 injection in combination with AK112 injection in subjects with advanced soft tissue sarcoma was evaluated using ORR as the primary endpoint.
- Trial name
- NCT07650838
- Testing
- OVV-01，AK112
- Volunteers
- 40 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Calciphylaxis
A Phase 3 Clinical Trial of Intravenous Sodium Thiosulfate in Acute Calciphylaxis Patients
This multicenter, randomized, double-blind, placebo-controlled clinical trial will evaluate the efficacy and safety of intravenous Sodium Thiosulfate Injection for treatment of acute calciphylaxis-associated pain in chronic…
- Trial name
- CALISTA (NCT03150420)
- Testing
- Sodium Thiosulfate
- Where
- 21 sites in United States, Canada and 1 more
- Volunteers
- 29 people
- Sponsor
- Hope Pharmaceuticals
Darier Disease, Hailey-Hailey Disease
National Registry for Ichthyosis and Related Disorders
The ichthyoses are a family of genetic skin diseases characterized by dry, thickened, scaling skin. Dermatologists estimate that there are over twenty varieties of ichthyosis, with a wide range of severity and associated…
- Conditions
- Darier Disease, Hailey-Hailey Disease, Hyperkeratosis, Epidermolytic, Ichthyosis
- Trial name
- NCT00074685
- Where
- United States
- Volunteers
- 610 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Syncope, Presyncope
Abbott Brady 3T MRI PMCF
The objective of this post-market, clinical follow up (PMCF) study, is to confirm the long-term safety of the Tendril STS and Isoflex leads, implanted with the Assurity MRI™ or Endurity MRI™ pacemakers, in patients undergoing a…
- Conditions
- Syncope, Presyncope, Fatigue, Disorientation
- Trial name
- NCT03786640
- Testing
- 3T MRI scan
- Where
- 9 sites in Estonia, France and 3 more
- Volunteers
- 3 people
- Sponsor
- Abbott Medical Devices
Soft Tissue Sarcoma (STS)
Umbilical Cord Blood NK Cell Therapy for High-Risk Pediatric Soft Tissue Sarcoma: Efficacy and Safety Study
This is a single-arm, open-label, non-blind, phase I/II clinical trial evaluating the safety and efficacy of umbilical cord blood natural killer (NK) cell in children with high-risk and relapsed/refractory soft tissue sarcoma…
- Trial name
- NCT06848582
- Testing
- umbilical cord blood NK cells
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Sun Yat-sen University
Childhood Medulloblastoma
A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss
This phase III trial tests two hypotheses in patients with low-risk and average-risk medulloblastoma. Medulloblastoma is a type of cancer that occurs in the back of the brain.
- Trial name
- NCT05382338
- Testing
- Audiometric Test, Auditory Brainstem Response, Biospecimen Collection
- Where
- 111 sites in United States, Canada
- Volunteers
- 225 people
- Sponsor
- Children's Oncology Group
Malignant Glioma
Combination Chemotherapy With or Without Sodium Thiosulfate in Preventing Low Platelet Count While Treating Patients With Malignant Brain Tumors
This randomized phase II trial studies how well giving combination chemotherapy with or without sodium thiosulfate works in preventing low platelet count while treating patients with malignant brain tumors.
- Trial name
- NCT00075387
- Testing
- Carboplatin, Cyclophosphamide, Etoposide Phosphate
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- OHSU Knight Cancer Institute
Soft Tissue Sarcoma (STS), Utidelone
Utidelone Capsules Combined With Doxorubicin for Advanced Soft Tissue Sarcoma
This trial is an open, multicenter, phase II clinical trial evaluating the efficacy and safety of uterostatin capsules (UTD2) combined with doxorubicin and tislelizumab in the treatment of advanced soft tissue sarcoma.
- Conditions
- Soft Tissue Sarcoma (STS), Utidelone, Doxorubicin
- Trial name
- NCT07842276
- Testing
- UTD2 + tislelizumab + doxorubicin
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Beijing Biostar Pharmaceuticals Co., Ltd.
Sarcoma, Soft Tissue
Study of Pazopanib Versus Placebo as Maintenance Therapy for Advanced Soft Tissue Sarcoma
Pazopanib monotherapy is approved by the Food and Drug Administration (FDA), European Medicines Agency, and other regulatory authorities worldwide for the treatment of patients with advanced renal cell carcinoma and patients with…
- Trial name
- NCT02367651
- Testing
- Pazopanib 800 mg
- Sponsor
- GlaxoSmithKline
Ototoxicity, Drug-Induced
Sodium Thiosulfate Otoprotection During Salvage Cisplatin Therapy
This study will attempt to demonstrate the efficacy of Sodium Thiosulfate (STS) in preventing hearing loss in patients re-treated with cisplatin-based therapy according to regimens Cisplatin and STS (regimen CS) and Cisplatin…
- Trial name
- NCT05756660
- Testing
- Sodium Thiosulfate
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Advanced Soft-tissue Sarcoma, Metastatic Soft-tissue Sarcoma
Geriatric Assessmen of Elderly "Unsuited" Patients Receiving Trabectedin in First Line Treatment For Advanced Soft Tissue Sarcomas (STS)
The aim of the non-interventional study is to prospectively collect and analyze data on the geriatric assessment of patients undergoing systemic 1st line therapy with trabectedin with focus on patients who have been assessed by…
- Trial name
- E-TRAB (NCT03022448)
- Testing
- No Intervention
- Where
- 12 sites in Austria, Germany and 1 more
- Volunteers
- 72 people
- Sponsor
- GWT-TUD GmbH