Clinical trials: Study Recruitment
Atelectasis, Perioperative Oxygenation
Individualized vs Standard PEEP and Oxygen Reserve Index in Laparoscopic Hernia Surgery
During laparoscopic surgery under general anesthesia, lung function can be affected by increased abdominal pressure and patient positioning.
- Conditions
- Atelectasis, Perioperative Oxygenation, Laparoscopic Inguinal Hernia Repair, Mechanical Ventilation
- Trial name
- NCT07775573
- Testing
- Standard PEEP Ventilation, Individualized PEEP Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Postoperative Respiratory Complications
Individualized Intraoperative PEEP Following Alveolar Recruitment Maneuvres and Postoperative Respiratory Complications
Patients ASA I-III, undergoing laparoscopic abdominal surgery will be randomly assigned, into one of two groups, namely group C-PEEP , that will be the control group ; and group I-PEEP, where alveolar recruitment maneuvres will…
- Trial name
- NCT06600386
- Testing
- Alveolar recruitement, Standard PEEP
- Where
- Greece
- Volunteers
- 69 people
- Sponsor
- Asklepieion Voulas General Hospital
Mechanical Ventilation, Respiration, Artificial
Fluid Responsiveness Predicted by a Stepwise PEEP Elevation Recruitment Maneuver in Mechanically Ventilated Patients
Hemodynamic and fluid optimization during perioperative period can reduce postoperative morbidity. The assessment of preload and determination of whether the patient is fluid responsive is still challenging.
- Trial name
- STEP-PEEP (NCT04304521)
- Testing
- Lung recruitment maneuver
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Acute Respiratory Failure With Hypoxia
High-flow Oxygen Therapy vs Non-invasive Ventilation: Comparison of Alveolar Recruitment in Acute Respiratory Failure
This physiological study showed an increase in regional ventilation with NIV but no difference in alveolar recruitment as compared to HFNC in patients with hypoxemic ARF.
- Trial name
- IRAvista (NCT04664322)
- Testing
- non invasive ventilation and high flow nasal canulae oxygen therapy
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Rouen
Recruitment
Oxidative Stress Gene Polymorphism and Ovarian Reserve Functione
the relationship between FOXO3A-bim pathway gene polymorphisms and ovarian reserve function of paitients with ovarian endometrioma
- Trial name
- NCT03682341
- Testing
- endometriosis
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
COPD Exacerbation
Once Daily Long-Acting Muscarinic Antagonists Administered in the Evening for Prevention of Chronic Obstructive Pulmonary Disease Exacerbations Requiring Hospitalization or Death from Any Cause
To examine, among once-daily LAMA using COPD patients, whether evening administration of LAMA is superior with respect to the incidence of hospitalization requiring AECOPD or death from all causes than the more conventional…
- Trial name
- NCT05563675
- Testing
- Long acting muscarinic antagonists (LAMAs) in the evening
- Where
- Denmark
- Volunteers
- 10,011 people
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Complication of Surgical Procedure, Acute Respiratory Failure, Adult
Prospective Evaluation of a RIsk Score for Postoperative Pulmonary COmPlications in Europe
Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe (PERISCOPE) is a multi-centre, international observational study of a random-sample cohort of patients undergoing a nonobstetric…
- Conditions
- Complication of Surgical Procedure, Acute Respiratory Failure, Adult, Postoperative Respiratory Complications, Pulmonary Failure
- Trial name
- PERISCOPE (NCT01346709)
- Where
- 63 sites in Albania, Belgium and 19 more
- Volunteers
- 5,450 people
- Sponsor
- European Society of Anaesthesiology
Asthma
Study of the Inflammation and Airway Changes That Occur After Exposure to Allergen in Asthmatics
This protocol describes a single site mechanistic study to investigate microRNAs (miRNAs) that are differentially expressed in the airway epithelium of patients with asthma at baseline and in response to allergen challenge.
- Trial name
- ACE (NCT02230189)
- Testing
- Segmental airway allergen challenge, Bronchoscopy, Methacholine challenge test
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Prescott Woodruff
Heart Disease, Mental Health Outcomes
The Feasibility of an Intervention Targeting Sources of Meaning in Cardiac Rehabilitation
Being diagnosed with heart disease can be a life-changing experience, often sparking existential questions and concerns about meaning in life.
- Conditions
- Heart Disease, Mental Health Outcomes, Rehabilitation
- Trial name
- NCT07262580
- Testing
- Conversation on Sources of Meaning in life with heart disease, Group based session on Sources of Meaning in life with heart disease, Dyadic Conversation on Sources of Meaning in Life with heart disease
- Where
- 2 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- University of Southern Denmark
Postoperative Pulmonary Complications
Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients
Controversies remain concerning the best intraoperative mechanical ventilation regimen for major cardiac surgery. While the use of intra operative low tidal volumes is now standard practice, the optimal level of positive…
- Trial name
- VACARM (NCT04408495)
- Testing
- Intervention group_MRA, Control group
- Where
- 10 sites in France
- Volunteers
- 441 people
- Sponsor
- Rennes University Hospital
Clostridium Difficile Infection
A Screening and Recruitment Study in Adults Expressing Interest in the Emory Microbiota Enrichment Program
The goal of this study is to rapidly identify subjects who are eligible for the Microbiota Enrichment Program (MEP) at Emory in Atlanta, Georgia.
- Trial name
- MEP (NCT03350711)
- Testing
- Microbiota Enrichment Program (MEP)
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Emory University
Survey
Using Survey to Explore Perceptions of Adults With Low Socioeconomic Status Regarding the NutriQuébec Study
Populations with low socioeconomic status (SES) are more likely to develop diseases across lifespan and are frequently underrepresented in large cohort studies.
- Trial name
- NCT03847584
- Testing
- Survey
- Where
- Canada
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Laval University
Recruitment
Multicenter Quantitative and Qualitative Study of the Determinants of Participation in a Cytomegalovirus Preventive Vaccine Study in France in Women Aged 18 to 40 Years Old.
During a vaccine clinical trial of Cytomegalovirus (CMV) vaccine, one of the participants' motivations was to prevent an infection responsible for malformations in a future child.
- Trial name
- NCT06511635
- Testing
- Qualitative interview, Quantitative questionnaire
- Where
- France
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Hypoxemia, COPD
The Effectiveness of Two Distinct Ventilation Strategies Escalating Positive End Expiratory Pressure (PEEP) and Lung Recruitment Maneuvers in Improving Oxygenation
This study evaluates and compares the effectiveness of two distinct ventilation strategies-escalating PEEP and lung recruitment maneuvers-in improving oxygenation (i.e., managing hypoxemia) in COPD patients undergoing VATS.
- Trial name
- NCT06847412
- Testing
- Escalating PEEP, Sustained inflation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Nasal Allergy
Leukotriene Antagonism in Recruitment of CD49d Expressing Neutrophils in Atopic Subjects
The purpose of this study is to see if the recruitment of a certain cell type (the alpha 4 integrin (CD49d) expressing neutrophil) during a nasal allergen challenge can be inhibited by pretreatment with an FDA approved…
- Trial name
- NCT03039101
- Testing
- Nasal lavage, Nasal allergen challenge, Epicutaneous skin testing
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mitchell Grayson
Probable Alzheimer's Disease
Exploratory Open Label Study for Development of a Method To Detect Dendritic Cells
This is a proof-of-concept study designed to confirm that human phagocytic cells can be labeled with the near-infrared dye indocyanine green (ICG) and the presence of the labeled cells 48 hours later in cerebral cortex can be…
- Trial name
- NCT05482867
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- MindImmune Therapeutics, Inc.
Healthy
Qing'E Formula Therapy on Menopausal Symptoms (Healthy Volunteers Recruitment for Control Study)
This study will recruit 50 healthy women with normal menstrual cycles aged 40-50, to investigate the expression of their NEI network and urine metabolomics.
- Trial name
- NCT01920997
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Acute Respiratory Distress Syndrome (ARDS)
Validation of Digital Chest-X-ray (CXR) to Assess Lung Recruitment in ARDS
Lung recruitability is essential for optimal Positive end-expiratory pressure (PEEP) selection in ARDS patients. It is defined as the potential for the non aerated or poorly aerated lung mass to become aerated due to the increase…
- Trial name
- RECRUTEX (NCT02081105)
- Testing
- PEEP of 5 or 15 cm H2O
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Hospices Civils de Lyon
Respiratory System Mechanics, Pneumoperitoneum
Recruitment-to-inflation Ratio to Set Positive End-expiratory Pressure for Laparoscopic/Robotic Surgery: a Multicenter Study
The present investigation is focused to assess the effects of positive end-expiratory pressure (PEEP) on respiratory system compliance in obese patients invasive mechanical ventilation for laparoscopic or robotic surgery with…
- Trial name
- PEEP_LAP1 (NCT05702554)
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera di Perugia
Electric Impedance Tomography, Bronchoscopy
Bronchoscopy and Electric Impedance Tomography (EIT) Pilot Study
Electrical Impedance Tomography (EIT)is a technique based on the injection of small currents and voltage measurements using electrodes on the skin surface generating cross-sectional images representing impedance change in a slice…
- Conditions
- Electric Impedance Tomography, Bronchoscopy, Change in Lung Impedance Due to Ventilation, Recruitment
- Trial name
- Broncho-EIT (NCT01294813)
- Testing
- Electrical Impedance Tomography (EIT)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- RWTH Aachen University