Clinical trials: Sub-fertility
Subfertility, Asthenozoospermia
Fertility and the Microbiome
With this study, the investigators want to investigate the microbiome and human papilloma virus (HPV) status of couples with subfertility.
- Trial name
- NCT05328999
- Testing
- Probiotics (Omnibiotic (R))
- Where
- Austria
- Volunteers
- 300 people
- Sponsor
- Medical University of Graz
Subfertility
Effect of Endometrial Scratching on Assisted Reproduction Outcomes: a Randomized Controlled Trial
To examine whether endometrial scratching (or injury) using a Pipelle endometrial sampler, performed on the first seven days of the menstrual cycle, is able to improve pregnancy rates in women who will be submitted to a fresh…
- Trial name
- NCT02180256
- Testing
- Endometrial Scratching
- Where
- Brazil
- Volunteers
- 107 people
- Sponsor
- University of Sao Paulo
Subfertility
Stimulated Versus Un-stimulated Intrauterine Insemination Cycles in Women With Endometriosis
Four hundred and fifty women with endometriosis will be divided into 3 equal groups using computer generated random numbers: Group 1 will have up to 4 stimulated intrauterine insemination (IUI) cycles, group 2 will have up to 4…
- Trial name
- NCT02470169
- Testing
- Merional, IUI, Choriomon
- Where
- 2 sites in Egypt
- Volunteers
- 450 people
- Sponsor
- Cairo University
Subfertility
LH/HCG Receptor Expression and Retrieval Rates
The purpose of this study is to evaluate if there is an association between the serum LH receptor expression on the day of hCG administration or the day of oocyte retrieval and the retrieval rates at oocyte pick up
- Trial name
- NCT00438373
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Subfertility
Clinical Effectiveness of Frozen Thawed Embryo Transfer Compared to Fresh Embryo Transfer
The objective of the present randomized controlled study is to compare clinical effectiveness and safety of freezing all embryos followed by frozen-thawed embryo transfer (FET) compared to fresh embryo transfer, in women…
- Trial name
- NCT02570386
- Testing
- Fresh embryo transfer, Frozen embryo transfer
- Where
- China
- Volunteers
- 138 people
- Sponsor
- The University of Hong Kong
Septate Uterus, Recurrent Pregnancy Loss
Hysteroscopic Septoplasty by Different Modalities
The goal of this clinical trial is to compare in participant population ( women with uterine septum meeting the inclusion criteria) hysteroscopic septoplasty by resectoscope compared to hysteroscopic septoplasty with scissors.
- Conditions
- Septate Uterus, Recurrent Pregnancy Loss, Subfertility
- Trial name
- NCT05802784
- Testing
- Hysteroscopic septoplasty with scissors, Hysteroscopic septoplasty with resectoscope
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University Hospital
Subfertility
Corifollitropin Alfa Compared to Daily rFSH in Poor Responders Undergoing ICSI
Corifollitropin alfa has been shown to result in significantly more oocytes compared to daily recombinant follicle stimulating hormone (recFSH) (Devroey et al., 2009), probably due to the higher circulating FSH activity during…
- Trial name
- NCT02046655
- Testing
- Corifollitropin alfa, rFSH
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Aristotle University Of Thessaloniki
Infertility, Subfertility
The Accuracy of Endometrial Ultrasound to Predict Implantation
To measure the accuracy of different ultrasound endometrial patterns to predict successful embryo implantation during assisted conception; in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI).
- Trial name
- NCT03860636
- Testing
- Endometrial Pattern on Ultrasound at ET, Endometrial Pattern on Ultrasound at HCG, Endometrial Pattern on Ultrasound at TVOR
- Where
- United Kingdom
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Subfertility, Infertility
Hysteroscopy Before in Vitro Fertilization - Does it Improve the Outcome?
By randomizing sub-fertile women to either control or office-hysteroscopy in the circle prior to IVF or ICSI (intracytoplasmatic sperm injection ) treatment, we aim to enlighten whether hysteroscopy with endometrial biopsy…
- Trial name
- NCT01743391
- Testing
- Office-hysteroscopy with biopsy
- Where
- Denmark
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Subfertility, Female
Effect of Sildenafil Citrate Compared to Estrogen as Adjuvant Therapy for Unexplained Infertility
. This study aimed to determine and compare the effect of vaginal sildenafil citrate and estradiol valerate on endometrial thickness, blood flow and pregnancy rates in infertile women.
- Trial name
- NCT05753098
- Testing
- estrogen therapy, Sildenafil, Clomiphene Citrate 50mg
- Where
- Egypt
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Male Infertility, Infertility
The Therapeutic Effects of Bu Shen Yi Jing Pill on Semen Quality in Sub Fertile Males: a Randomized Controlled Trial
This study aims to evaluate the safety and efficacy of Bu Shen Yi Jing (BSYJ) Pill , a type of traditional Chinese medicine, in improving male subfertility and semen parameters.
- Conditions
- Male Infertility, Infertility, Traditional Chinese Medication (TCM), Reproductive Issues
- Trial name
- NCT05290558
- Testing
- Bu Shen Yi Jing Pill
- Where
- Singapore
- Volunteers
- 59 people
- Sponsor
- KK Women's and Children's Hospital
Estradiol Receptor Polymorphism, Progesterone Receptor Polymorphism
Gene-polymorphisms Relating to Human Subfertility
Estradiol is synthesized by granulosa cells of ovaries under control of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). It is known that Estradiol plays a crucial role in maturation and fertilization of oocytes.
- Conditions
- Estradiol Receptor Polymorphism, Progesterone Receptor Polymorphism, IVF, Subfertility
- Trial name
- NCT01385618
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Infertility Treatment Center Dortmund
Subfertility
RCT on the Effect of Endometrial Injury on Ongoing Pregnancy Rate in Subfertile Women Undergoing IVF
Implantation failure remains one of the major factors limiting success in IVF treatment. It was postulated that the local injury to endometrium induces secretions of cytokines and growth factors such as leukemia inhibitory…
- Trial name
- NCT01977976
- Testing
- Endometrial aspiration by pipelle
- Where
- Hong Kong
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Subfertility
DHEA Versus Placebo in Women With Poor Ovarian Response
440 women with expected poor ovarian response undergoing IVF/ICSI (intracytoplasmic sperm injection) will be randomly divided into 2 groups using computer generated random numbers .
- Trial name
- DHEA (NCT02561793)
- Testing
- DHEA
- Where
- 2 sites in Egypt
- Volunteers
- 440 people
- Sponsor
- Cairo University
In Vitro Fertilization, Subfertility
Hyaluronan-enriched Embryo Transfer Medium for Frozen-thawed Embryo Transfer
This is a randomized-controlled trial evaluating the effect of the use of hyaluronan (HA)-enriched embryo transfer medium on the live birth rate in women undergoing frozen-thawed embryo transfer.
- Trial name
- NCT02725827
- Testing
- EmbryoGlue (Vitrolife), Control medium
- Where
- 2 sites in Hong Kong
- Volunteers
- 550 people
- Sponsor
- The University of Hong Kong
Subfertility, Infertility
Analgesia for Endometrial Scratching
The aim of this study is to evaluate whether Ibuprofen alone or combined with lorazepam reduce the pain associated with endometrial scratching/injury.
- Trial name
- NCT02863614
- Testing
- Ibuprofen 600 mg, Lorazepam 1 mg
- Volunteers
- 150 people
- Sponsor
- University of Sao Paulo
Subfertility
Fixed Versus Flexible Gonadotropin-releasing Hormone (GnRH) Antagonist Initiation
This is a comparison of pregnancy achievement between two GnRH antagonist protocols which differ in the timing of GnRH antagonist initiation.
- Trial name
- NCT01005784
- Testing
- Cetrorelix (Cetrotide)
- Where
- Greece
- Volunteers
- 146 people
- Sponsor
- Aristotle University Of Thessaloniki
Infertility, Reproductive Sterility
Does in Vivo Culture of Pre-cleavage Stage Embryo Reduce the Incidence of Aneuploidy?
This Clinical Study has been designed to assess and compare the impact of in vitro or in vivo culture conditions on the euploidy of sibling blastocysts.
- Trial name
- NCT02652143
- Testing
- AneVivo (Medical device for in vivo culture of embryos), comparator for embryo culture in vitro
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Anecova SA
Infertility, Female
Clinical Efficacy of Virtual Reality During Office Hysteroscopy and Endometrial Biopsy in Subfertility
This study is a comparison between the current standard practice of performing a diagnostic hysteroscopy and a relatively recently developed technology that is added to the standard diagnostic hysteroscopy.
- Trial name
- HYSVIR (NCT04438759)
- Testing
- Oncomfort, commercially available Virtual Reality headset
- Where
- Belgium
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Subfertility
Effect of Intralipid Infusion in Patients With Recurrent Implantation Failure
The aim of present study is to evaluate the effect of intralipid 20% infusion, once between days 4 and 9 of the ovarian stimulation, and again within 7 days of a positive pregnancy test on clinical pregnancy rates in women with…
- Trial name
- NCT02865785
- Testing
- Intralipid 20%
- Where
- Egypt
- Volunteers
- 320 people
- Sponsor
- Ain Shams University