Clinical trials: Subarachnoid Block
Obstetric Anesthesia Problems, High-Risk Pregnancy
Effect of Intra-abdominal Pressure to the Level of the Sensory Block at Caesarean Section Under Spinal Anesthesia
It is known that an increase in intra-abdominal pressure (IAP) causes a decrease in the volume of cerebrospinal fluid in the lumbar and lower thoracic region, which may contribute to the development of more high spinal block.
- Trial name
- IAPSB (NCT02237092)
- Testing
- Measurement of IAP
- Where
- Russia
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Tver Regional Perinatal Center
Obstetric Anesthesia Problems, Bupivacaine Adverse Reaction
Thoraco Lumbar Vertebral Length and Bupivacaine Dosage in C-Section
Our hypothesis is that the bupivacaine dose determined according to the thoracolumbar vertebral body length (VBL) is more effective in achieving a lower hypotension rate during spinal anesthesia for cesarean delivery than the…
- Trial name
- bupivacaine (NCT06869434)
- Testing
- Group VBL (Thoracolumbal vertebral body length) received 0.2 mg x VBL cm of %0.5 hyperbaric bupivacaine, Group FD (fixed dose) received a volume of 0.5% hyperbaric bupivacaine based on a dose calculated according to the patient's height 0.065 mg/cm, Group AD (adjusted dosage) got intrathecal heavy bupivacaine (0.5%) tailored to the patient's height and weight.
- Where
- Turkey (Türkiye)
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Effects of; Anesthesia, in Labor and Delivery
Phenylephrine vs. Norepinephrine Infusion After Spinal Anesthesia for Cesarean Delivery
The purpose of the study is to determine if a medication called phenylephrine, which helps to control blood pressure, is more effective as a continuous intravenous (IV) infusion compared to continuous IV norepinephrine in…
- Trial name
- NCT02354833
- Testing
- Phenylephrine, Norepinephrine
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Effects of; Anesthesia, in Pregnancy
Carbetocin Versus Oxytocin and Hemodynamic Effects
A randomized double-blind trial of oxytocin 5 u, carbetocin 100 µg and placebo with hemodynamic response as a primary outcome measure.
- Trial name
- NCT00977769
- Testing
- carbetocin 100 µg, oxytocin 5 u
- Where
- 2 sites in Norway
- Volunteers
- 76 people
- Sponsor
- Oslo University Hospital
Preeclampsia, Hypotension
Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
Hypotension remains a common clinical problem after induction of spinal anesthesia for cesarean delivery. Maternal hypotension has been associated with considerable morbidity (maternal nausea and vomiting and fetal/neonatal…
- Trial name
- NCT00458003
- Testing
- Ephedrine, Phenylephrine
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Return of Motor and Sensory Blockade, Anesthesia, Spinal
1% Chloroprocaine(PF) vs. Bupivacaine Spinals
The use of 1% Chloroprocaine (PF) spinal anesthesia will reduce the recovery times and discharge time of patients undergoing hemorrhoidectomies as compared to 0.75% bupivacaine spinal.
- Conditions
- Return of Motor and Sensory Blockade, Anesthesia, Spinal, Decrease Discharge Time Status Post Hemorrhoidectomy
- Trial name
- NCT03324984
- Testing
- 1% chloroprocaine, 0.75% bupivacaine
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Montefiore Medical Center
Analgesia, Obstetrical, Cesarean Section
Intrathecal Opioids for Pain Control After Cesarean Delivery: Determining the Optimal Dose
Both hydromorphone and morphine are administered as part of spinal anesthesia to help improve pain control after cesarean delivery.
- Trial name
- NCT02009722
- Testing
- Morphine, Hydromorphone
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Mayo Clinic
Short Duration Lower Limb Surgery Via Spinal Anaesthesia
Spinal Anaesthesia With Chloroprocaine HCl 1% for Elective Lower Limb Procedures of Short Duration.
This study evaluate the effect of 3 doses of Chloroprocaine HCl 1% (30, 40 and 50 mg) for spinal anaesthesia in adult patients undergoing short duration elective surgery of the lower limb.
- Trial name
- NCT02481505
- Testing
- Chloroprocaine HCl 1%
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Sintetica SA
Nausea, Vomiting
Minimizing Nausea and Vomiting During Spinals for CS
In parturients undergoing Cesarean section under spinal anesthesia, co-loading of 1 liter of crystalloids, with placing the spinal, along with administering a phenylephrine infusion and glycopyrrolate, enables placing a spinal…
- Trial name
- NCT02872935
- Testing
- Glycopyrrolate, Normal Saline
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Kokila N Thenuwara
Hypotension and Shock, Excessive Amount of Blood / Fluid Infusion
Predict Fluid Responsiveness in Spinal Anesthesia
Spinal anesthesia is still the regional anesthesia technique most widely employed in everyday clinical practice. The most feared and common of its well known side effects consist in an abrupt reduction of systemic vascular…
- Trial name
- CERU-1401 (NCT02070276)
- Testing
- Trans-thoracic echocardiography, Passive Leg Raising Test
- Where
- Switzerland
- Volunteers
- 429 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Spinal Anaesthesia, Ultrasound
A Trial on Ultrasound-assisted Spinal Anaesthesia
A randomised controlled trial comparing the use of pre-procedural ultrasound scanning with manual palpation to identify landmarks for performance of spinal anaesthesia.
- Trial name
- NCT01699373
- Testing
- Ultrasound scan
- Where
- Singapore
- Volunteers
- 170 people
- Sponsor
- Changi General Hospital
Lower Limb Surgery
Spinal Anaesthesia With Levobupivacaine 0.5% and Ropivacaine 0.75% for Lower Limb Orthopaedic Surgery
The purpose of this study is to compare the effects of two intrathecally administered drugs:0.5% levobupivacaine and0.75%Ropivacaine in spinal anesthesia
- Trial name
- NCT02201784
- Testing
- Levobupivacaine, Ropivacaine
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Aligarh Muslim University
Postoperative Nausea and Vomiting
Dexamethasone for the Prevention of Post-operative Nausea and Vomiting in Patients Undergoing Cesarean Sections
Patients who present for scheduled (non-emergent) cesarean section will be given either intravenous dexamethasone or placebo prior to receiving a duramorph containing spinal anesthetic.
- Trial name
- NCT01734161
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Pain
Effect of Gabapentin Enacarbil on Opioid Consumption and Pain Scores
Opioids are effective analgesics, but cause side effects including sedation, respiratory depression, low blood pressure, nausea, and constipation.
- Trial name
- NCT02840240
- Testing
- Gabapentin enacarbil
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- The Cleveland Clinic
Sedation
Clinical Study to Investigate the Efficacy and the Safety of DA-9501 in Sedation During the Surgery With Epidural Anesthesia or Spinal Anesthesia Without Intubation
The purpose of this study is to examine the efficacy and safety of DA-9501 (Dexmedetomidine) in patients who require sedation during the surgery that requires epidural or spinal anesthesia without intubation under monitored…
- Trial name
- NCT01438957
- Testing
- Dexmedetomidine hydrochloride
- Where
- 12 sites in Japan
- Volunteers
- 119 people
- Sponsor
- Pfizer
Obesity, Morbid, Spinal Anesthesia
ED90 for Hyperbaric Bupivacaine in Super Obese Parturients
The aim of this study is to determine the ED90 of hyperbaric intrathecal bupivacaine for the super obese population undergoing cesarean section under a combined spinal epidural technique.
- Conditions
- Obesity, Morbid, Spinal Anesthesia, Cesarean Delivery
- Trial name
- NCT03781388
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Duke University
Anesthesia; Adverse Effect, Spinal and Epidural, Headache, Complications; Anesthesia, Spinal and Epidural, in Pregnancy
Comparison of Two Spinal Needles Regarding Postdural Puncture Headache
The aim of the study is to observe the rate of postdural puncture headache observed after spinal anesthesia in cesarean section patients. Two kind of spinal anesthesia needles will be used: 1.
- Trial name
- NCT01821807
- Where
- Turkey (Türkiye)
- Volunteers
- 256 people
- Sponsor
- Adiyaman University Research Hospital
Pain
Evaluation of the Safety and Efficacy of EXPAREL When Administered Into the TAP in Subjects Undergoing Cesarean Section
This is a Phase 4, multicenter, open-label study evaluating EXPAREL infiltration into the transversus abdominis plane (TAP) after bupivacaine hydrochloride (HCl) spinal anesthesia in subjects undergoing elective Cesarean section…
- Trial name
- NCT02353754
- Testing
- Intrathecal morphine injection, EXPAREL
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Pre-eclampsia
Phenylephrine Versus Ephedrine in Pre-eclampsia
Phenylephrine administration is associated with reductions in CO and SctO2 compared with ephedrine when used for blood pressure management in women with pre-eclampsia undergoing cesarean delivery under spinal anesthesia.
- Trial name
- NCT02025426
- Testing
- Phenylephrine, Ephedrine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Duke University
Nerve Block, General Anesthesia
Spinal Versus General Anesthesia With Popliteal and Adductor Canal Blocks for Ambulatory Foot and Ankle Surgery.
The purpose of this study is to determine if there is a difference in patient outcomes with general anesthesia versus spinal anesthesia when given in addition to popliteal and adductor canal nerve blocks for foot and ankle…
- Conditions
- Nerve Block, General Anesthesia, Spinal Anesthesia, Pain
- Trial name
- LMA vs Spinal (NCT02996591)
- Testing
- 25 mL of 0.25% bupivacaine plus 2 mg preservative-free (PF) dexamethasone / 30 ml for popliteal nerve block, 10 mL of 0.25% bupivacaine plus 2 mg preservative-free (PF) dexamethasone / 30 ml for adductor canal nerve block, Midazolam, 2-5 mg IV + Glycopyrrolate, 0.1 mg IV + Ketamine, 10-20 mg + propofol as needed
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Hospital for Special Surgery, New York