Clinical trials: Subarachnoid Block
Decision Making , Cesarean Section
The Impact of a Shared Decision-Making Intervention on Intraoperative Patient Experience During Elective Cesarean Delivery Under Spinal Anesthesia
Caesarean delivery (CD) is a common surgical procedure performed when vaginal delivery poses risks to the mother or fetus, with global rates projected to reach 28.5% by 2030.
- Trial name
- NCT07476482
- Testing
- Proactive Plan: prophylactic IV ketamine 0.2 mg/kg or IV midazolam 1 mg given prior to incision. Reactive Plan: no prophylactic medication; rescue IV fentanyl 50 mcg administered only if NRS ≥4., Control Group (Standard Care)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Spinal Anesthesia, Machine Learning
Machine Learning for Predicting Spinal Anesthesia Duration
Spinal anesthesia provides significant advantages over general anesthesia in knee arthroplasty, including reduced blood loss, faster recovery, and fewer complications.
- Conditions
- Spinal Anesthesia, Machine Learning, Knee Arthroplasty, Total, Spinal Anesthesia Duration
- Trial name
- NCT07256548
- Testing
- Spinal Anesthesia (bupivacaine)
- Where
- Turkey (Türkiye)
- Volunteers
- 145 people
- Sponsor
- Kocaeli City Hospital
Procedural Sedation
Dexmedetomidine and Midazolam Nebulization as Sedation During Cesarean Delivery in Pre-eclampsia
Null hypothesis: There is no difference between the effects of nebulization of dexmedetomidine and midazolam as procedural sedation during cesarean delivery under spinal Anesthesia in pre-eclamptic parturients Alternative…
- Trial name
- NCT04873596
- Testing
- Nebulized dexmedetomidine, Nebulized midazolam
- Where
- Egypt
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Knee Surgery With Tourniquet
Effect of Spinal or Sevoflurane Anesthesia on Neutrophil Activation During Knee Surgery With Pneumatic Tourniquet
Aim of study : Assessement of neutrophil activation during ischemia reperfusion associated with tourniquet use for total knee arthroplasty.
- Trial name
- NCT03470363
- Testing
- Sevoflurane Volatile Liquid, Bupivacaine / SUFentanil
- Volunteers
- 40 people
- Sponsor
- University of Liege
Spinal Anesthesia Induced Hypotension, Geriatric
Internal Jugular Vein Ultrasound for Predicting Hypotension in Geriatric Patients Undergoing Spinal Anesthesia
Spinal anesthesia-induced hypotension is a common and clinically significant complication in geriatric patients. Accurate preoperative assessment of intravascular volume status may help identify patients at risk.
- Conditions
- Spinal Anesthesia Induced Hypotension, Geriatric, Internal Jugular Vein, Ultrasonography
- Trial name
- IJV-SPINAL (NCT07411313)
- Testing
- Not applicable- observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Shivering, Spinal Anesthesia
Prevention of Shivering Associated With Spinal Anesthesia
The aim of the study is to compare the effectiveness of prophylactic use of intravenous (IV) dexmedetomidine VS ketamine and meperidine(as a control group) in prevention of shivering associated with intrathecal anesthesia in…
- Trial name
- NCT06082076
- Testing
- Dexmedetomidine, Ketamine, Meperidine
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cesarean Section, Cardiac Output
Best Regimen for Phenylephrine Administration During Cesarean Section
During Cesarean delivery, phenylephrine is used to maintain the patient's blood pressure. Low blood pressure is the most common side effect of the spinal medication used to anesthetize the patient prior to the start of surgery.
- Conditions
- Cesarean Section, Cardiac Output, Hypotension
- Trial name
- NCT00996190
- Testing
- Phenylephrine
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Elective Cesarean Section, Spinal Anesthesia
Effect of Different Left Lateral Table Tilt for Elective Cesarean Delivery Under Spinal Anesthesia
The recommended position of the mother under caesarean section after spinal anesthesia is 15 degrees left. However, recent research has challenged the basic principles and practicality of the left-turn 15 degree position.
- Trial name
- NCT04083768
- Testing
- 15° and 30° wedge sponges
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Xuzhou Medical University
Hemondynamic Changes in Spinal Anesthesia
Comparison of Hemodynamic Effects of Bupivacaine in Spinal Anesthesia
To assess hemodynamic changes with hyperbaric bupivacaine with spinal anesthesia
- Trial name
- Nill (NCT07616882)
- Testing
- Spinal Anesthesia (bupivacaine)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Liaquat National Hospital & Medical College
Urologic Neoplasms, Benign Prostatic Hyperplasia
Spinal Versus General Anesthesia in Open Simple Prostatectomy
Open simple prostatectomy is still performed for selected patients with benign prostatic hyperplasia, particularly in cases with large prostate volume.
- Conditions
- Urologic Neoplasms, Benign Prostatic Hyperplasia, Anesthesia
- Trial name
- NCT07643415
- Testing
- Spinal anesthesia, General anesthesia
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Hitit University
Post-operative Nausea and Vomiting
Effect of Using Azithromycin Versus Placebo With Dexamethasone in Prevention of Post-spinal Nausea and Vomiting.
Postoperative nausea and vomiting is defined as any nausea, retching, or vomiting occurring during the first 24-48 h after surgery in inpatients.
- Trial name
- NCT03165123
- Testing
- Oral Azithromycin tablet, Intravenous dexamethasone
- Volunteers
- 160 people
- Sponsor
- Assiut University
Pain
Evaluation of the Safety and Efficacy of EXPAREL When Administered Into the TAP in Subjects Undergoing Cesarean Section
This is a Phase 4, multicenter, open-label study evaluating EXPAREL infiltration into the transversus abdominis plane (TAP) after bupivacaine hydrochloride (HCl) spinal anesthesia in subjects undergoing elective Cesarean section…
- Trial name
- NCT02353754
- Testing
- Intrathecal morphine injection, EXPAREL
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Spinal Anesthesia, Epidural; Anesthesia
Bupivacaine With Epidural Volume Extension
In this study the investigator will address the efficacy of using low dose bupivacaine spinal anesthesia (SA) in combination with epidural volume extension (EVE) for patients undergoing short obstetric procedures.
- Trial name
- NCT03110003
- Testing
- 10 mg Bupivacaine, 5 mg Bupivacaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Fluid Overload
Fluid Absorption in Patients Undergoing Operative Hysteroscopy; Results From a Prospective Controlled Study
To determine if combining intravenous oxytocin infusion and spinal anesthesia will reduce the amount of glycine absorption in patients undergoing operative hysteroscopy
- Trial name
- NCT04328870
- Testing
- oxytocin and spinal anesthesia, General anesthsia
- Where
- Jordan
- Volunteers
- 88 people
- Sponsor
- University of Jordan
Postoperative Pain, Lower Limb Injury
Block Duration After Spinal Block and iv Dexamethasone.
It has been largely demonstrated that iv dexamethasone prolongs the duration of analgesia after peripheral nerve block. However, data are missing regarding the duration of analgesia after spinal block.
- Trial name
- NCT03527576
- Testing
- Dexamethasone, NaCl 0.0308 MEQ/ML Injectable Solution
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Eric Albrecht
Hypotension
Transcutaneous Electrical Acupoint Stimulation(TEAS) for Hypotension After Spinal Anesthesia in Parturients
The purpose of this study is to compare the effect of TEAS on hypotension after spinal anesthesia in patients undergoing cesarean section
- Trial name
- THSAP (NCT01930227)
- Testing
- TEAS, Non-acupoint stimulation
- Where
- 2 sites in China
- Volunteers
- 150 people
- Sponsor
- wangqiang
Hypotension
Interest of Intravenous Ondansetron in the Prevention of Spinal Anaesthesia-induced Hypotension in Caesarean Section
The intravenous injection of 8mg of ondansetron (a serotonin type 3 receptor antagonist) before spinal anaesthesia for caesarean section, leads to a smaller reduction in systolic arterial pressure (SAP).
- Trial name
- ZORA (NCT02862873)
- Testing
- Spinal anaesthesia, Ondansetron, saline solution
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Non-invasive Blood Pressure, Cesarean Delivery
Evaluation of Non-invasive Blood Pressure Measured at the Ankle During Cesarean Delivery Compared to the Arm
Spinal anesthesia-induced maternal hypotension during cesarean delivery is hazardous to the mother and the fetus. Prevention of the unfavorable outcomes of maternal hypotension includes various fluid and vasopressor protocols…
- Conditions
- Non-invasive Blood Pressure, Cesarean Delivery, Spinal Anesthesia
- Trial name
- NCT04199156
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Kasr El Aini Hospital
Postoperative Complications, Cardiovascular Diseases
General Versus Regional Anesthesia in Peripheral Arterial Surgery
This multicenter, prospective, randomized clinical trial aims to compare the effects of spinal (neuraxial) anesthesia with spontaneous ventilation versus general anesthesia with mechanical ventilation on the incidence of…
- Trial name
- GENERA (NCT06953128)
- Testing
- Spinal Anesthesia, General Anesthesia
- Where
- Brazil
- Volunteers
- 594 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Hypotension
A Novel Closed-loop Integrated System for the Maintenance of Haemodynamic Stability
Hypotension occurs commonly during spinal anaesthesia for caesarean section with maternal and fetal adverse effects. The investigators developed a double-vasopressor automated system incorporating continuous non-invasive…
- Trial name
- DIVA (NCT02277730)
- Testing
- vasopressor delivery automated system, phenylephrine, ephedrine
- Where
- Singapore
- Volunteers
- 252 people
- Sponsor
- KK Women's and Children's Hospital
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