Clinical trials: Subarachnoid Block
Hypotension, Spinal Anesthesia
Prophylactic Ondansetron for Preventing Spinal Anesthesia-Induced Hypotension in Elective Cesarean Section
Spinal anesthesia is the preferred technique for elective cesarean section, but it frequently causes maternal hypotension due to sympathetic blockade and the Bezold-Jarisch reflex, which can threaten both mother and baby.
- Conditions
- Hypotension, Spinal Anesthesia, Cesarean Section
- Trial name
- NCT07886151
- Testing
- Ondansetron
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Spinal Anesthesia, Pregnancy
Ephedrine vs Phenylephrine - ECG Changes
ECG changes during caesarean section are common. Incidence of ST depression on the ECG is up to 81% in some studies. Although this may indicate inadequate oxygen supply to the heart muscle (myocardial ischaemia) many other…
- Trial name
- NCT01243970
- Testing
- Phenylephrine, Ephedrine
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Spinal Anesthesia, Total Knee Arthroplasty
Low Dose Spinal Bupivacaine for Total Knee Replacement and Recovery Room Wait Time
This study plans to investigate whether a reduced dose of bupivacaine (a local anesthetic numbing drug) injected into the spinal space for a total knee replacement will result in a shorter time to discharge from the recovery room…
- Trial name
- NCT00537472
- Testing
- Low dose bupivicaine in spinal anesthetic, Standard dose bupivacaine in spinal anesthetic
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Queen's University
Cesarean Section
Heart Rate Variability to Predict Hypotension Following Spinal Anesthesia in Cesarean Delivery
Based on the patient's heart rate variability, the analgesia nociception index (ANI) measures the activity of the autonomic nervous system and the sympathetic/parasympathetic nervous system and expresses it as a numerical value…
- Trial name
- NCT04979039
- Testing
- analgesia nociception index (ANI) monitoring
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Bundang Hospital
Geriatric Patient, Spinal Anesthesia
Comparison of Hemodynamic Effects of Hypobaric and Hyperbaric Bupivacaine in Spinal Anesthesia in Geriatric Patients
The frequency of hypotension is increased in geriatric patients due to physiological changes compared to the normal population. In this study, our aim is to compare the hemodynamic changes in geriatric patients undergoing hip…
- Conditions
- Geriatric Patient, Spinal Anesthesia, Hip Surgery
- Trial name
- NCT06972485
- Testing
- spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Eskisehir Osmangazi University
Cesarean Section, Anesthesia, Spinal
Intrathecal Dexmedetomidine vs Epinephrine
Several studies have shown that adding dexmedetomidine or epinephrine to single-dose spinal analgesia preparations improves the length and/or speed of onset of the sensory block and post-operative pain management without…
- Trial name
- NCT06418308
- Testing
- Dexmedetomidine, Epinephrine, Standardized Spinal Mixture
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ultrasound
Ultrasound Versus Palpation for Spinal Anesthesia Success
Aim is to investigate the difference in number of attempts to place neuraxial block comparing handheld ultrasound versus use of palpation alone for women with impalpable bony landmarks undergoing spinal anesthesia for elective…
- Trial name
- Accuro (NCT03679663)
- Testing
- Ultrasound
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Adverse Effect, Cerebral Perfusion
Investigation Of The Effects Of Unilateral And Bilateral Spinal Anesthesia On Cerebral Blood Flow
Spinal anesthesia is a widely used method in anesthesia practice. Unilateral spinal block refers to a neuroaxial technique that induces motor and sensory blockade on the surgical side.
- Trial name
- NCT06871449
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nuh Naci Yazgan University
Low Cardiac Output
Comparative Study of Haemodynamic Changes After Spinal Anaesthesia in Non-obese and Pregnant Women
Obesity has become one of the most common risk factors in obstetric practice with serious anaesthetic implications. Obese pregnants have limited physiological reserves and cardiovascular co- morbidities when compared to non-obese…
- Trial name
- NCT02599376
- Testing
- LiDCOrapid
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Hypotension During Surgery
Epinephrine Infusion for Prophylaxis Against Maternal Hypotension After Spinal Anesthesia for Cesarean Delivery
Subarachnoid block is the common route of anesthesia for cesarean delivery. Maternal hypotension after subarachnoid block is very common despite the vigorous methods for its prevention.
- Trial name
- NCT05881915
- Testing
- Phenylephrine, Epinephrine
- Where
- Egypt
- Volunteers
- 196 people
- Sponsor
- Cairo University
Coronary Artery Disease, Coronary Artery Bypass Surgery
Double-Blind Comparison of Combined General-Spinal Anesthesia to General Anesthesia for Coronary Artery Surgery
Use of neuraxial agents in anesthesia for cardiac surgery is expanding. We have used combined general-spinal anesthesia for cardiac surgery for 12 years.
- Trial name
- NCT00242697
- Testing
- spinal analgesia and anesthesia for coronary artery surgery
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- University of Calgary
Anesthesia, Spinal [E03.155.086.331], Operating Tables [E07.325.662]
Effect of the Height of the Operating Table During Spinal Anesthesia
The purpose of this study is to analyze the accuracy of needle insertion and the discomfort during different ergonomic conditions faced by anesthesiologists during spinal anesthesia.
- Trial name
- NCT02373410
- Testing
- Umbilicus, Lowest rib margin, Xiphoid
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Neuromuscular Blockade
Popliteal Approach to Sciatic Nerve Block Is Not Inferior to Infragluteal Approach
Study Hypothesis The investigators approach to demonstrate noninferiority of analgesia provided by popliteal block in TKA surgery will be based on a hypothesis of absence of a clinically significant difference in pain visual…
- Trial name
- NCT03410888
- Testing
- Popliteal approach, Infragluteal approach
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University Health Network, Toronto
Spinal Anaesthesia, Magnetic Resonance Imaging (MRI)
MRI-Based Estimation of Lumbar CSF Volume and Its Clinical Impact on Spinal Anaesthesia
This prospective observational study aims to investigate the clinical impact of lumbar cerebrospinal fluid (CSF) volume on spinal anesthesia characteristics.
- Conditions
- Spinal Anaesthesia, Magnetic Resonance Imaging (MRI), Lumbosacral Spinal Stenosis, Anaesthesia
- Trial name
- NCT07333703
- Testing
- Distribution of spinal anesthetic agent
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Samsun University
Postoperative Pain
Clinical Comparative Study Aiming to Evaluate Postoperative Effect of Using Intrathecal Dexmedetomidine and Fentanyl as an Adjuvant to Heavy Bupivacaine in Lower Limb Vascular Surgeries on Pain Intensity, Analgesic Requirement and Shivering. Patients and Methods After Approval of Medical Institution
Spinal anaesthesia is an excellent choice of numerous operating procedures. This is due to its effectiveness, rapid onset of action, easy to implement, patient stayed awake, and minimal drug cost.(1) It is also beneficial for…
- Trial name
- NCT07035223
- Testing
- 4 µg dexmedetomidine in 0.5 mL of normal saline intrathecal (dexmedetomidine 100 µg/mL will be diluted in 12.5 ml preservative-fr, fentanyl
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Nashwa Ahmed
Inguinal Hernia
Ultrasound Guided Local Anesthetic Field Block (A Five Step Procedure) for Open Inguinal Hernia Repair
The aim of this study is to evaluate success, efficacy, feasibility and safety of a simple five step ultrasound guided local anesthetic infiltration technique for unilateral open inguinal hernia repair and to determine the…
- Trial name
- NCT03193723
- Testing
- US guided five step field block, Spinal anesthesia
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Eslam Ayman Mohamed Shawki
Postoperative Shivering, Postspinal Shivering
Comparison of Intravenous Ondansetron and Low Dose Ketamine in Preventing Post Spinal Shivering
This randomized controlled trial assessed whether intravenous ondansetron is more effective than low dose ketamine in preventing shivering after spinal anesthesia in adults undergoing elective surgery.
- Trial name
- NCT07334223
- Testing
- ondansetron, Ketamine (0.25 mg/kg)
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Mayo Hospital Lahore
Anesthesia, Spinal, Nonemergency Cesarean Section
Spinal Anaesthesia for Caesarean Section: Descriptive Multicentre Study
Most of caesarean sections can be performed under spinal anaesthesia. Its major advantages are reliability and fast onset. However, dose of hyperbaric bupivacaine used, combination with adjuvants, hemodynamic management, and…
- Trial name
- CesAR (NCT04719819)
- Testing
- Spinal anaesthesia for caesarean section
- Where
- 11 sites in France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Anxiety, Hypotension
Impact of Music on Satisfaction, Anxiety, and Hemodynamics During Spinal Anesthesia for Cesarean Delivery
The aim of this study is to evaluate the effect of perioperative music on maternal anxiety, hemodynamic response to spinal anesthesia, postoperative pain medication requirement, and overall maternal satisfaction.
- Trial name
- NCT02732964
- Testing
- Pandora Music, Mozart Music
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Postoperative Pain After Cesarean Section, Postoperative Pain
Abdominal Ice Application After Cesarean Section
Cesarean section is one of the most commonly performed surgical procedures worldwide, and effective postoperative pain control is important for maternal recovery and patient comfort.
- Conditions
- Postoperative Pain After Cesarean Section, Postoperative Pain, Cesarean Section
- Trial name
- ICE-CS (NCT07626138)
- Testing
- Abdominal Ice Application, Standard Postoperative Care
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Nigde Omer Halisdemir University
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