Clinical trials: Subarachnoid Block
Respiratory Depression
Respiratory Depression in Women With BMI≥30 Underwent Spinal Anesthesia With Intrathecal Morphine in Elective C-section
The study will examine whether there is a difference in the frequencies of respiratory depression among obese women receiving spinal anesthesia combined with opioids compared to women with normal BMI.
- Trial name
- NCT02819661
- Testing
- SOMNOTOUCH RESP, Caesarean section, Spinal anesthesia with intrathecal morphine
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Old Age
ED50 and ED95 of Intrathecal Hyperbaric Bupivacaine With Fentanyl for Transurethral Prostatectomy in Elderly Patients
As people age, the incidence of prostate hyperplasia increases. So patients under Transurethral Resection of Prostate(TURP) or Holmium Laser Ennucleation of Prostate(HoLEP) are mostly ole age people.
- Trial name
- NCT03704441
- Testing
- Bupivacaine
- Where
- South Korea
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Aortic Stenosis
The Effects of High Spinal Anesthesia on Heart Function, Stress Response and Pain Control in Aortic Valve Surgery
This study is looking at the effects of high spinal anesthesia (also known as total spinal anesthesia) combined with general anesthesia versus general anesthesia alone on the following: Stress response: Patients undergoing aortic…
- Trial name
- NCT00348920
- Testing
- High Spinal and General Anesthesia
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Manitoba
Hemodynamic Instability
Effect of Prilocaine vs Bupivacaine on Hemodynamics in Spinal Anesthesia for Geriatric Patients
Data comparing prilocaine vs bupivacaine in equipotent doses in the elderly are lacking; therefore, the study will compare the effect of prilocaine vs bupivacaine on hemodynamics in spinal anesthesia for geriatric patients…
- Trial name
- NCT06165679
- Testing
- Prilocaine, Bupivacaine
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Cairo University
Chronic Renal Failure, Hip Fracture
Effects of Dexmedetomidine Premedication on Geriatric Patients With Chronic Renal Failure Undergoing Hip Surgery
Geriatric patients (age ≥ 65 years) undergo surgery for hip fractures that develops due to osteoporosis and falls. Dialysis-dependent chronic kidney disease is associated with an increased risk of cardiovascular comorbidity.
- Trial name
- NCT01837290
- Testing
- dexmedetomidine infusion for premedication, Midazolam, saline infusion
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Baskent University
Complications; Cesarean Section, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Phenylephrine Dose and Mode of Administration for Spinal Anesthesia Induced Hypotension
Three different regimens of phenylephrine are being evaluated to see if one is superior over the other in the maintenance of cardiac output while keeping normotension and/or treating hypotension experienced when receiving spinal…
- Trial name
- NCT02101047
- Testing
- Phenylephrine
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Shivering
Prophylactic Mirtazapine or Dexamethasone for Post-spinal Anesthesia Shivering
This study was conducted to evaluate the effect of a prophylactic dose of oral mirtazapine on shivering compared with prophylactic intravenous infusion (IVI) dexamethasone in patients undergoing gynecological surgeries under…
- Trial name
- NCT03675555
- Testing
- Mirtazapine, Dexamethasone phosphate
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ain Shams University
Intrathecal Dexmedetomidine
This Study Aims to Determine Whether Lower Doses (4 µg) of Intrathecal Dexmedetomidine Can Provide Comparable Analgesic Benefits While Minimizing Adverse Hemodynamic Effects in Patients Encountered in Our Setup( Shifa International Hospital Islamabad).
This study aims to determine whether lower doses (4 µg) of intrathecal dexmedetomidine can provide comparable analgesic benefits while minimizing adverse hemodynamic effects in patients encountered in our setup( Shifa…
- Trial name
- NCT07807020
- Testing
- Intrathecal Dexmedetomidine
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shifa International Hospital
Low Back Biomechanical Dysfunctions
Pain Pressure Threshold Values Versus the Biomechanical-Viscoelastic Findings of L4-5 Supraspinous Ligament in Women Who Underwent Cesarean Delivery With Spinal Anaesthesia
Cesarean delivery is a major obstetric surgery that aims to save the lives of mothers and their neonates from complications that may be related to high-risk pregnancy and difficult delivery (Teguete et al., 2012).
- Trial name
- NCT05367323
- Testing
- Pressure algometry (Baseline 2.2-Pound Dolorimeter) and Myoton PRO device (MyotonPRO; Myoton AS, Tallinn, Estonia)
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- South Valley University
Spinal Anesthesia Duration
Comparison of Different Doses of Dexmedetomidine Effect in the Duration of Spinal Anesthesia
Small doses of dexmedetomidine1.5,3, 5µg used in combination with bupivacaine, in humans for spinal anesthesia has been shown to produce a more rapid onset of motor block, and a longer duration of motor and sensory block with…
- Trial name
- NCT03143010
- Testing
- intrathecal Dexmedetomidine, Dexmedetomidine 1.5 micrograms, Dexmedetomidine 3 micrograms
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University
Pain Relief After Arthroscopic Anterior Cruciate Ligament Reconstruction
Oral Melatonin With Intra Articular Analgesia on Pain After Arthroscopic Anterior Cruciate Ligament Reconstruction
Anterior Cruciate Ligament Reconstruction (ACLR) is a common orthopedic procedure that is accompanied by moderate to severe postoperative pain and is primarily performed on an outpatient basis.
- Trial name
- ACLR (NCT07096635)
- Testing
- Melatonin, Starch tablets
- Volunteers
- 50 people
- Sponsor
- Assiut University
Time to First Void After Spinal Anaesthesia
Using Three Different Doses of Hyperbaric Prilocaine 2% Local Anaesthetic ( 40,50 and 60mg ),Through Spinal Anaesthesia in Knee Arthroscopy Patients to Compare Time to Void
The goal of this randomised trial is to use a short acting local anaesthetic drug (hyperbaric prilocaine 2%) which is beneficial in short operations which are performed as a day case surgery.
- Trial name
- Prilocaine (NCT06703580)
- Testing
- Hyperbaric prilocaine 2% 40 mg, hyperbaric prilocaine 2% 50 mg, hyperbaric prilocaine 2% 60 mg
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Cairo University
Neuropathic Pain, Phantom Limb Pain
Mechanisms and Treatment of Post-amputation Neuropathic Pain
Phantom and residual limb pain are types of peripheral neuropathic pain that are difficult to treat and where the underlying mechanisms are still not fully understood.
- Conditions
- Neuropathic Pain, Phantom Limb Pain, Amputation
- Trial name
- NCT04819503
- Testing
- Spinal anaesthesia (sub-study 1), Repetitive transcranial magnetic stimulation (sub-study 2)
- Where
- Norway
- Volunteers
- 1 people
- Sponsor
- Oslo University Hospital
Spinal Anesthesia Administration
Does Ultrasound Guidance Improve Time to Perform a Spinal or Number of Attempts in Obese Patients?
Spinal anesthesia depends on being able to locate physical landmarks on a patient's body. In obese patients, the commonly used landmarks may be difficult or even impossible to feel.
- Trial name
- NCT01680913
- Testing
- Ultrasound guidance, Palpation of Tuffier's line, Spinal anesthetic
- Where
- 2 sites in Canada
- Volunteers
- 67 people
- Sponsor
- University of Saskatchewan
Sepsis, Continuous Spinal Anesthesia
Continuous Spinal Anesthesia Versus General Anesthesia in Sepsis
The anesthetic efficacy and safety of continuous spinal anesthesia and comparing it with general anesthesia technique in sepsis diagnosed patient.
- Conditions
- Sepsis, Continuous Spinal Anesthesia, General Anesthesia
- Trial name
- NCT05897151
- Testing
- Continuous spinal anesthesia, General anesthesia
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Mahmoud Rashad Ahmed
Orthopedic Surgery of Lower Limb
Prophylactic Phenylephrine Infusion for Preventing Hypotension During Spinal Anesthesia
Lower limb orthopedic surgery is commonly realized under spinal anesthesia. This loco-regional anesthesia induces a peripheral vascular resistance decrease by vasodilatation resulting in hypotension.
- Trial name
- PPSA (NCT01533662)
- Testing
- phenylephrine infusion, patients receiving saline infusion
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Toulouse
Hemodynamics
Non-invasive vs Invasive Cardiac Output Monitoring During Cesarean Section
This study aims to evaluate the consistency of hemodynamic monitoring between NICAP and NICCO technologies (T20A; Chongqing, China) and the traditional pulse wave analysis method (EV1000; USA).
- Trial name
- NCT06473818
- Testing
- Non-invasive monitoring, Invasive monitoring
- Where
- China
- Volunteers
- 45 people
- Sponsor
- General Hospital of Ningxia Medical University
Hypotension Symptomatic, Obstetric Anesthesia Problems
Prevention of Hypotension During Cesarean Section
The aim of this double-blind randomized study will be to compare a fixed-rate prophylactic noradrenaline infusion to a fixed-rate prophylactic phenylephrine infusion during elective cesarean section under combined spinal-epidural…
- Conditions
- Hypotension Symptomatic, Obstetric Anesthesia Problems, Cesarean Section Complications, Vasoconstriction
- Trial name
- NOR-PHEN (NCT03842046)
- Testing
- phenylephrine infusion, norepinephrine infusion
- Where
- 2 sites in Greece
- Volunteers
- 82 people
- Sponsor
- Aretaieion University Hospital
Body Temperature Changes
Single Bolus Intravenous Ephedrine Attenuates Reduction of Core Body Temperature in Patients Undergoing Spinal Anesthesia for Arthroscopic Knee and Ankle Surgery
A prospective double-blinded randomized controlled study to determine efficacy of ephedrine in preserving core temperature in patients under neuraxial spinal anesthesia for knee and ankle arthroscopic surgery.
- Trial name
- NCT02948920
- Testing
- Ephedrine, NSS
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Ramathibodi Hospital
Virtual Reality, Spinal Anesthesia
Seniors' Intraoperative Management Under Locoregional Anesthesia Integrating Virtual Reality
This study aims to evaluate the acceptability of intraoperative virtual reality in elderly patients under spinal anesthesia.
- Trial name
- SILVR (NCT06515873)
- Testing
- Virtual Reality Headset
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
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