Clinical trials: Subarachnoid Block
Chronic Postoperative Pain
Pain Control Following Total Hip Arthroplasty
Total hip arthroplasty (THA) is one of the most common surgical procedures performed in elderly patients, with its main indication being end-stage osteoarthritis of the hip1.
- Trial name
- NCT05062356
- Testing
- Bupivacaine Hydrochloride 0.25% Injection Solution_#2, EPINEPHrine 1:200,000 / Prilocaine HCl 4 % 1.8 ML Cartridge, Bupivacaine Hydrochloride 0.5% Injection Solution_#2
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- St. Mary's Research Center, Canada
Arthropathy of Hip, Arthropathy of Knee
Evaluation of the Duration of Bupivacaine Spinal Block in Orthopedic Procedures With and Without Epinephrine Wash
Bupivacaine spinal is commonly performed as the primary anesthetic for orthopedic procedures. In some cases the duration of the block is inadequate. An epinephrine wash is sometimes performed to prolong the duration of the block.
- Trial name
- NCT02619409
- Testing
- Bupivacaine Only, EPI25, EPI50 group
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Prevention of Shivering With Spinal Anaesthesia
Could Ephedrine Replace Dexmedetomidine Fordexmedetomidine Prevention of Shivering in Women Undergoing Cesarean Section Under Spinal Anaesthesia
Could ephedrine replace dexamedetomidine for prevention of shivering in women undergoing Cesarean section Under spinal anaesthesia
- Trial name
- NCT06233032
- Testing
- Ephedrine, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Total Knee Replacement
The Effect of Abdominal Massage and Warm Application on Excretory Activity in Patients Undergoing Total Knee Replacement With Spinal Anesthesia
The aim of this study was to determine the effect of abdominal massage and warm application on the excretory activity (time of first bowel sounds, defecation time and the amount of laxative used until discharge) after total knee…
- Trial name
- Abdominal (NCT06578936)
- Testing
- abdominal massage andwarm application
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Ayşe Demirtaş
Hypotension
Hemodynamic Monitoring in Obstetrics
Spinal anesthesia has long been considered the first choice technique in caesarean section, but although it is a reliable and safe procedure, it is in some cases associated with undesirable effects.
- Trial name
- NCT03755271
- Where
- Italy
- Volunteers
- 148 people
- Sponsor
- University of Catania
Lung Edema, Hip Fractures
Ultrasound in Evaluation of Preoperative Fluid Management of Hip Fracture Surgery Patients
Goal directed fluid therapy is a new standard surgical procedure which is successful in patients undergoing hip revision arthroplasty, There has been a reduction of postoperative complications, most importantly surgery with a…
- Trial name
- NCT05916599
- Testing
- ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Postpartum Hemorrhage, Uterine Atony
Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-Inferiority Trial
Background: Carbetocin is an established single-dose uterotonic agent for postpartum hemorrhage prophylaxis at elective cesarean delivery.
- Conditions
- Postpartum Hemorrhage, Uterine Atony, Cesarean Section, Blood Loss, Surgical
- Trial name
- CARBOXY-RCT (NCT07636421)
- Testing
- Carbetocin, Oxytocin
- Where
- Saudi Arabia
- Volunteers
- 332 people
- Sponsor
- Mansoura University
Effect of Sedatives
Effect of Sedatives on Perioperative Electroencephalogram in Elderly Patients Undergoing Spinal Anesthesia
In the present study, we observe perioperative findings of electroencephalogram in sedated and non-sedated elderly patients undergoing total knee arthroplasty under spinal anesthesia.
- Trial name
- NCT04248075
- Testing
- Electroencephalogram
- Volunteers
- 120 people
- Sponsor
- SMG-SNU Boramae Medical Center
Neonatal Cerebral Oxygenation, Cesarean Section
Effects of Spinal Versus General Anesthesia on Neonatal Cerebral Oxygenation During Cesarean Section
This prospective observational study evaluates and compares the effects of spinal and general anesthesia techniques used during elective cesarean section on neonatal cerebral regional oxygen saturation (crSO₂) during the early…
- Trial name
- NEO-OXY-CS (NCT07477093)
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Akdeniz University Hospital
Pregnancy, Cesarean Section
RCT of Epinephrine (None, 100mcg, and 200mcg) in a Hyperbaric Bupivacaine, Fentanyl and Morphine Spinal in C-sections.
This is a prospective, randomized, double blind study of 75 patients (n=25 for each group) in which epinephrine (100mcg or 200mcg) or normal saline vehicle is added to intrathecal hyperbaric bupivacaine (0.75% bupivacaine…
- Trial name
- NCT03335293
- Testing
- 100 mcg Epinephrine, normal saline, 200 mcg Epinephrine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Anesthesia
Pre-procedural Ultrasound Techniques Versus Conventional Landmark Technique of Spinal Anesthesia in Elderly Patients
Traditionally, spinal anesthesia is performed using the palpation of bony landmark to identify the level and point of entry of the spinal needle.
- Trial name
- NCT02658058
- Testing
- Landmark technique, Ultrasound-guided paramedian technique, Ultrasound-guided midline technique
- Where
- Lebanon
- Volunteers
- 180 people
- Sponsor
- American University of Beirut Medical Center
Hypotension
Echocardiography Based Algorithm for Spinal Anaesthesia
The main aim of the study is to compare the proposed algorithm for preventing and treating spinal hypotension with normal anesthesia management of a spinal anesthesia.
- Trial name
- NCT03106649
- Testing
- Echocardiography, Treatment of spinal hypotension
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Postdural Puncture Headache
Effect of Intravenous Versus Intrathecal Dexamethazone on Postdural Puncture Headache
This study will be conducted at Ain Shams University Hospital in Operating Theatre after ethical committe approval number (MS 32/ 2020).
- Trial name
- NCT04709029
- Testing
- Dexamethasone intravenous, Dexamethasone intrathecal
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Ain Shams University
Pregnancy, Cesarean Section
Comparison of Remimazolam and Midazolam for Preventing Intraoperative Nausea and Vomiting During Cesarean Section Under Spinal Anesthesia
Spinal anesthesia is widely accepted as the anesthetic method of choice for Cesarean section. However, high-level blockage or hypotension induced by this technique may induce intraoperative nausea and vomiting (IONV), which is…
- Conditions
- Pregnancy, Cesarean Section, Spinal Anesthesia
- Trial name
- NCT05736341
- Testing
- Remimazolam besylate, Midazolam
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yonsei University
Spinal Anesthesia
Minimum Effective Dose of Ropivacaine for Spinal Anesthesia for Cesarean Delivery
Ropivacaine is one of commonly used anesthetics for spinal anesthesia. Usually L2-3 or L3-4 intervertebral space is chosen for spinal anesthesia.
- Trial name
- NCT02565303
- Testing
- Intervertebral space, Ropivacaine
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai 6th People's Hospital
Cesarean Section
Effect of Intravenous Dexamethasone Before Spinal Anesthesia on Post-cesarean Section Pain
*Aim of the Work This study aims to assess the efficacy of intravenous injection of dexamethasone prior to spinal anesthesia in reducing post-cesarean section pain in women undergoing cesarean section.
- Trial name
- NCT03122756
- Testing
- Dexamethasone, Normal Saline
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Cesarean Section
Dexmedetomidine Versus Magnesium Sulphate for Caesarean Delivery
Regional anesthesia has become more popular in cesarean deliveries because most of the parturients prefer being awake during the birth process. In addition, regional anesthesia may be a safer method than general.
- Trial name
- NCT03067896
- Testing
- Bupivacaine, Dexmedetomidine, Magnesium Sulfate
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Assiut University
Spinal Anesthesia Skill, Ultrasound Imaging of Anatomical Structures
Evaluation of a Perceptual Learning Module on Spinal Ultrasound Among Residents.
This medical education research project aims to evaluate the impact of a directed perceptual learning module (PLM) on spinal sonoanatomy.
- Conditions
- Spinal Anesthesia Skill, Ultrasound Imaging of Anatomical Structures, Medical Education
- Trial name
- MAP-Rachis (NCT06533488)
- Testing
- Perceptual learning module, Control
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maisonneuve-Rosemont Hospital
Hypothermia; Anesthesia, Perioperative Complication
Prevention of Perioperative Hypothermia in Transurethral Resection Under Spinal Anaesthesia
Perioperative hypothermia is one of the most common anaesthetic complications, increasing the morbidity/mortality of our patients.
- Conditions
- Hypothermia; Anesthesia, Perioperative Complication, Regional Anesthesia Morbidity, Temperature Change, Body
- Trial name
- NCT04252820
- Testing
- WarmTouch total body blanket, Covidien Ltd, Mansfield, USA
- Where
- Spain
- Volunteers
- 215 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Knee Osteoarthritis, Hip Osteoarthritis
General vs Spinal in Total Joint Arthroplasty (TJA)
The purpose of this research is to compare post-operative outcomes from patients undergoing TJA. The study team wants to learn about outcomes like length of hospital stay, post-operative pain scores, post-operative nausea, deep…
- Trial name
- NCT06747494
- Testing
- General Anesthesia, Spinal Anesthesia
- Where
- United States
- Volunteers
- 2,396 people
- Sponsor
- University of Miami
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