Clinical trials: Subarachnoid Block
Post-Dural Puncture Headache
Trans-nasal Sphenopalatine Ganglion Block Versus Ultrasound-guided Bilateral Greater and Lesser Occipital Nerve Block for Management of Post-Dural Puncture Headache.
Post-Dural Puncture Headache (PDPH) is a complication associated with spinal anesthesia. While conventional treatments are available, the Epidural Blood Patch (EBP) is considered the gold standard.
- Trial name
- TNSPGB /GALONB (NCT06705244)
- Testing
- Trans-nasal sphenopalatine nerve block, Greater and lesser occipital nerve block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Post Operative Pain
Continuous Versus Single-Shot Spinal Anesthesia for Orthopedic Surgery
A study was conducted to compare the effectiveness of continuous spinal anesthesia (CSA), single-shot spinal anesthesia (SSSA), and general anesthesia (GA) in patients over 60 years of age undergoing elective surgical repair of a…
- Trial name
- NCT06625606
- Testing
- Bupivacaine 0.5% Injectable Solution, Isoflurane Inhalant Product
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Benha University
Femoral Fractures, Acute Pain
Comparison of Ultrasound-Guided Fascia Iliaca Compartment Block Versus Intravenous Tramadol for Positioning of Femur Fracture Patients Before Spinal Anaesthesia
This randomized clinical study compared two methods of pain relief used before spinal anaesthesia in patients undergoing surgery for a femur fracture.
- Trial name
- NCT07735884
- Testing
- Ultrasound-Guided Fascia Iliaca Compartment Block, Tramadol
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Mayo Hospital Lahore
Acute Pain
Clinical Efficacy of Prophylactic Intravenous Neostigmine and Atropine in Preventing Post-Dural Puncture Headache Among Parturient Undergoing Spinal Anesthesia for Cesarean Section: A Double-blind Randomized Placebo-controlled Trial
Post dural puncture headache is a distressing issue, many measures tried to treat symptoms but few delt with prevention.
- Trial name
- NCT06493838
- Testing
- intravenous 50 mL of saline injection of 0.9% after umbilical cord clamping., Neostigmine 20μg/kg (Neostigmine Methylsulphate 0.5 mg, Amriya Pharm.Ind.) and atropine 0.01 mg/kg (diluted in 50 ml saline; 0.9% for 10 min) following umbilical cord clamping.
- Volunteers
- 180 people
- Sponsor
- Minia University
Hypotension, Cesarean Section Complications
Norepinephrine to Prevent Hypotension in Ceasrean Delivery
This study will be conducted on 40 healthy women having spinal anesthesia for elective cesarean delivery in the operating rooms at Menoufia university hospital.
- Trial name
- NCT05248932
- Testing
- Norepinephrine bolus, cardiometry, Norepinephrine infusion
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Menoufia University
IV Ketamine With Spinal Block
Effect of Intravenous Ketamine Combined With Spinal Anesthesia on Sensory Block Duration Compared to Spinal Anesthesia Alone in Lower Limb Surgeries in Geriatrics.
Effect of Intravenous Ketamine combined with Spinal Anesthesia on Sensory Block Duration compared to Spinal Anesthesia alone in Lower Limb surgeries in geriatrics:
- Trial name
- NCT07520487
- Testing
- Patients will receive 0.2 mg/kg IV of ketamine diluted to 5 ml followed by infusion 0.1 mg/kg/hr as a 20 ml solution, Patients will receive 5 ml of saline followed by infusion 0.1 ml/kg/hr as a 20 ml solution as a control group
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Cairo University
Anesthesia, Spinal, Dexmedetomidine
Atropine or Ephedrine Pretreatment for Preventing Bradycardia in Elderly Patients
Spinal anesthesia is widely used for lower extremity surgery, and sedation is often required during surgery. For sedation, propofol, midazolam and dexmedetomidine are frequently used.
- Conditions
- Anesthesia, Spinal, Dexmedetomidine, Bradycardia
- Trial name
- NCT03984526
- Testing
- normal saline, atropine 0.5mg, ephedrine 8mg
- Where
- South Korea
- Volunteers
- 102 people
- Sponsor
- Ajou University School of Medicine
Vomiting, Postoperative, Postoperative Complications
The Effect of Intravenous Granisetron and Ondansetron in Patients Undergoing Cesarean Section
This study compared the effects of prophylactic intravenous (IV) infusion of ondansetron and granisetron before the spinal anesthesia on hemodynamic parameters in patients undergoing elective cesarean section.
- Conditions
- Vomiting, Postoperative, Postoperative Complications, Hypotension
- Trial name
- NCT04613726
- Testing
- ondansetron, Granisetron, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Femur Neck Fracture, Spinal Anesthesia
Comparison of Unilateral Spinal Anesthesia and Nerve Block in Hip Fractures
This randomized study aims to compare the efficacy and hemodynamic effects of hypobaric unilateral spinal anesthesia (HUSA) and lumbar plexus block (LP-SP) in patients undergoing femoral neck fracture surgery.
- Conditions
- Femur Neck Fracture, Spinal Anesthesia, Lumbar Plexus Nerve Block
- Trial name
- NCT07272226
- Testing
- Hipobaric Unilateral Spinal Anesthesia Group, Lumbar Plexus Block (LP-SP)
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Post-Dural Puncture Headache
Pregabalin Versus Hydrocortisone for Postdural Puncture Headache After Spinal for Cesarean
Postdural puncture headache (PDPH) is a common complication after spinal anesthesia. The role of pregabalin and hydrocortisone in the treatment of PDPH is unclear.
- Trial name
- PDPH (NCT03910088)
- Testing
- Pregabalin 100Mg Oral Cap, Hydrocortisone, Acetaminophen
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Spinal Anesthesia, Epidural; Anesthesia
Bupivacaine With Epidural Volume Extension
In this study the investigator will address the efficacy of using low dose bupivacaine spinal anesthesia (SA) in combination with epidural volume extension (EVE) for patients undergoing short obstetric procedures.
- Trial name
- NCT03110003
- Testing
- 10 mg Bupivacaine, 5 mg Bupivacaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cesarean Section (MeSH: D002585), Anesthesia, Spinal (MeSH: D000775)
Ultrasound Versus Palpation for Determining Spinal Puncture Level in Cesarean Section
This study compares two methods of identifying the correct intervertebral level before performing spinal anesthesia in women undergoing elective cesarean delivery.
- Conditions
- Cesarean Section (MeSH: D002585), Anesthesia, Spinal (MeSH: D000775), Hypotension (MeSH: D007022)
- Trial name
- USG-SPINE (NCT07789756)
- Testing
- Preprocedural ultrasound level identification, Landmark palpation level identification
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Osteoarthritis, Hip
3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
Spinal anesthesia is commonly utilized for hip replacement surgery. Different medications used for spinal anesthesia work for different lengths of time.
- Trial name
- NCT03948386
- Testing
- isobaric bupivacaine, hyperbaric bupivacaine, isobaric mepivacaine
- Where
- 2 sites in United States
- Volunteers
- 159 people
- Sponsor
- Thomas Jefferson University
Hemodynamic Instability
Effect of Prilocaine vs Bupivacaine on Hemodynamics in Spinal Anesthesia for Geriatric Patients
Data comparing prilocaine vs bupivacaine in equipotent doses in the elderly are lacking; therefore, the study will compare the effect of prilocaine vs bupivacaine on hemodynamics in spinal anesthesia for geriatric patients…
- Trial name
- NCT06165679
- Testing
- Prilocaine, Bupivacaine
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Cairo University
Tissue Perfusion, Lower Extremity Surgery
Comparison of the Effects of General Anesthesia and Spinal Anesthesia on Tissue Perfusion in Patients Undergoing Lower Extremity Surgery
This prospective, single-center observational study compares the effects of general anesthesia and spinal anesthesia on tissue perfusion in patients undergoing lower extremity surgery with tourniquet use.
- Conditions
- Tissue Perfusion, Lower Extremity Surgery, Tourniquet-Induced Ischemia-Reperfusion Injury, General Anesthesia
- Trial name
- Perf-LEX (NCT07474480)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Cesarean Section
Dexmedetomidine Versus Magnesium Sulphate for Caesarean Delivery
Regional anesthesia has become more popular in cesarean deliveries because most of the parturients prefer being awake during the birth process. In addition, regional anesthesia may be a safer method than general.
- Trial name
- NCT03067896
- Testing
- Bupivacaine, Dexmedetomidine, Magnesium Sulfate
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cesarean Section, Spinal Anesthesia
Low Dose Hyperbaric Bupivacaine and Dexmedetomidine as an Adjuvant, Caesarean Section
The aim of this study is to evaluate the effectiveness of low dose scheme with dexmedetomidine as an adjuvant. Taking in consideration optimum intraoperative surgical conditions, best post-operative pain free experience, and more…
- Conditions
- Cesarean Section, Spinal Anesthesia, Dexmedetomidine
- Trial name
- NCT03775655
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Hypotension During Surgery
Epinephrine Infusion for Prophylaxis Against Maternal Hypotension After Spinal Anesthesia for Cesarean Delivery
Subarachnoid block is the common route of anesthesia for cesarean delivery. Maternal hypotension after subarachnoid block is very common despite the vigorous methods for its prevention.
- Trial name
- NCT05881915
- Testing
- Phenylephrine, Epinephrine
- Where
- Egypt
- Volunteers
- 196 people
- Sponsor
- Cairo University
Cardiac Arrythmias
Carbetocin on Myocardial Repolarization Dynamics in Obstetrics Study
Relationship between carbetocin dose on transmural dispersion of repolarization (TDR).
- Trial name
- CaRDIO (NCT03716076)
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Total Knee Arthroplasty (TKA)
Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty
The purpose of this study is to compare same-day discharge rates and recovery outcomes across an adult patient population undergoing elective Total Knee Arthroplasty (TKA), and randomized to receive either spinal block anesthesia…
- Trial name
- NCT07672301
- Testing
- Total IntraVenous Anesthesia (TIVA), Spinal-Block, Electroencephalogram (EEG)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Chicago
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