Clinical trials: Subarachnoid Hemorrhage
Aneurysmal Subarachnoid Hemorrhage
Application of Magnesium-rich Artificial Cerebrospinal Fluid in Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) is a common type of acute hemorrhagic stroke. One of its complications, cerebral vasospasm (CVS), is the main cause of death and disability, with an incidence of up to 30%-90%.
- Trial name
- NCT04358445
- Testing
- Magnesium-Rich Artificial Cerebrospinal Fluid
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Subarachnoid Hemorrhage, Myocardial Stunning
Serial Echocardiography After Subarachnoid Hemorrhage
There is increasing interest in myocardial abnormalities following central nervous system events, such as subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Myocardial Stunning, Takotsubo Cardiomyopathy
- Trial name
- SEAS (NCT00123695)
- Where
- 6 sites in Netherlands
- Volunteers
- 350 people
- Sponsor
- Amsterdam UMC, location VUmc
SAH (Subarachnoid Hemorrhage)
Neutrophil-to-Lymphocyte Ratio in Predicting Outcomes of Patients With Aneurysmal Subarachnoid Hemorrhage in a Tertiary Care Hospital in Nepal
This study uses Neutrophil-to-Lymphocyte Ratio to Predict Outcomes of Patients with Aneurysmal Subarachnoid Hemorrhage which will be beneficial in taking early decisions for surgery , patient counselling etc
- Trial name
- NCT06683469
- Where
- Nepal
- Volunteers
- 51 people
- Sponsor
- Sujan Paudel
Subarachnoid Hemorrhage
Ultra-early Tranexamic Acid After Subarachnoid Hemorrhage.
This is a multicenter, prospective, randomized, open-label trial with blinded endpoint (PROBE) assessment. Adult patients with the diagnosis of non-traumatic SAH, as proven by computed tomography (CT) within 24 hours after the…
- Trial name
- ULTRA (NCT02684812)
- Testing
- Tranexamic Acid
- Where
- Netherlands
- Volunteers
- 955 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Social Determinant of Health, Intracranial Aneurysms
Risk Analysis of Intracranial Aneurysm Rupture Through Social Determinants of Health
Intracranial aneurysms (IA) are arterial malformations affecting about 3% of the overall population. Rupture is the most severe complication, as it is associated with nearly 30% of death or severe disability.
- Conditions
- Social Determinant of Health, Intracranial Aneurysms, Subarachnoid Hemorrhage, Treatment Outcomes
- Trial name
- ARAMISS (NCT06866210)
- Where
- France
- Volunteers
- 1,800 people
- Sponsor
- Nantes University Hospital
Subarachnoid Hemorrhage, Aneurysmal, Mental Fatigue
Understanding Mental Fatigue After Subarachnoid Hemorrhage
Fatigue is among the most frequently reported sequelae in stroke survivors. For a specific stroke diagnosis, aneurysmal subarachnoid hemorrhage (aSAH), fatigue, in general, is reported to be present in 30 to 90% of the patients.
- Trial name
- NCT06239142
- Volunteers
- 64 people
- Sponsor
- Sahlgrenska University Hospital
Subarachnoid Hemorrhage, Aneurysmal, Poor Grade Subarachnoid Hemorrhage
Poor Grade Aneurysmal Subarachnoid Hemorrhage Study Group
Multicentric registry study in order to define outcome, predictors, treatment effects and their modifiers in poor grade aneurysmal subarachnoid haemorrhage patients.
- Trial name
- POGASH (NCT04945603)
- Testing
- Standard management according to international/national guidelines
- Where
- 10 sites in Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS San Raffaele
Acute, Non-traumatic Subarachnoid Hemorrhage, Intraparenchymal Hemorrhage
Normoglycemia and Neurological Outcome
Brain injury patients who meet defined criteria will be assigned to intensive insulin treatment (target blood glucose levels of 10-110 mg/dl) or conventional IV insulin treatment (target glucose of 150-170 mg/dl).
- Conditions
- Acute, Non-traumatic Subarachnoid Hemorrhage, Intraparenchymal Hemorrhage, Brain Injuries
- Trial name
- NCT01137773
- Testing
- Insulin, Conventional insulin treatment
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Louisville
Subarachnoid Hemorrhage, Aneurysmal
Mild Hypothermia During Intracranial Aneurysm Clipping
The purpose of this study is to determine whether mild hypothermia causes reduction of vasoconstriction in microcirculation after clipping of aneurysms, and affects the blood flow in small diameter arteries at operating site…
- Trial name
- NCT02544256
- Testing
- Mild hypothermia
- Where
- Czechia
- Sponsor
- University Hospital Hradec Kralove
Subarachnoid Hemorrhage, Intracerebral Hemorrhage
Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?
The principal objective of this study is to compare the incidence of ventriculostomy related infections (VRIs) in patients who receive twenty-four hours of antibiotics, beginning no more than sixty minutes prior to EVD placement…
- Conditions
- Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Ventriculitis, Cerebral, Hydrocephalus
- Trial name
- NCT05001750
- Testing
- Long term (continuous) prophylactic antibiotics, 24 hours antibiotics
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Montefiore Medical Center
Subarachnoid Hemorrhage, Vasospasm, Intracranial
The Factors Cause Vasospasm After Aneurysmal Subarachnoid Hemorrhage
Extensive research has shown that the big event that leads to the initiation of vasospasm is the release of oxyhemoglobin (blood breakdown product).Depletion of NO synthase (19,20,21) was also noted after SAH.CSF is produced from…
- Trial name
- NCT00745758
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Aneurysmal Subarachnoid Hemorrhage
FLudrocortisone Administration in Aneurysmal Subarachnoid Haemorrhage
A multi-centre, prospective, blinded, randomised clinical trial of fludrocortisone compared with placebo in patients presenting with aneurysmal subarachnoid haemorrhage.
- Trial name
- FLASH (NCT06409364)
- Testing
- Fludrocortisone
- Where
- 16 sites in Australia, New Zealand
- Volunteers
- 524 people
- Sponsor
- The George Institute
Subarachnoid Hemorrhage, Aneurysmal
Cerebral Nitrosative/Oxidative Stress in Aneurysmal Subarachnoid Haemorrhage
Aneurysmal subarachnoid haemorrhage (SAH) carries a high morbidity and mortality, which is in part due to the development of secondary brain injury.
- Trial name
- NOX2 (NCT05686265)
- Testing
- Oxygen
- Where
- Denmark
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Subarachnoid Hemorrhage, Cerebral Aneurysm
Hypothalamo-, Pituitary-, Adrenal Axis Dysfunction in Subarachnoid Hemorrhage
Subarachnoid haemorrhage (SAH) may cause damage to the hypotalamo-pituitary-adrenal axis (HPA) thus disturbing the hormonal response of these structures.
- Trial name
- SAHENDO (NCT00614887)
- Where
- Finland
- Volunteers
- 46 people
- Sponsor
- Kuopio University Hospital
Ruptured Cerebral Aneurysm, Subarachnoid Hemorrhage (SAH)
Barrow Ruptured Aneurysm Trial
With evolving endovascular technologies there is a growing debate centered on the relative safety and efficacy of the currently accepted alternatives for the treatment of ruptured cerebral aneurysms in the face of acute…
- Trial name
- BRAT (NCT01593267)
- Testing
- coil embolization, clip occlusion
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Subarachnoid Hemorrhage
Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid Hemorrhage
The purpose of this study is to evaluate the clinical effect of esmolol treatment on cardiac function and electrophysiology; to assess the effects of esmolol treatment on serum adrenergic and cardiac biomarkers; to explore the…
- Trial name
- ABASH (NCT01232400)
- Testing
- Esmolol
- Where
- United States
- Sponsor
- University of Michigan
Brain Infarction, Ischemic Stroke
Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome
BACKGROUND: In industrialized countries a considerable and increasing proportion of strokes occur at younger ages. Stroke at young age causes marked disability at worst and thus long-standing socioeconomic consequences and…
- Conditions
- Brain Infarction, Ischemic Stroke, Thrombosis, Foramen Ovale, Patent
- Trial name
- SECRETO (NCT01934725)
- Where
- 19 sites in Estonia, Finland and 11 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- SECRETO Study Consortium
Traumatic Brain Injury, Subarachnoid Hemorrhage
iNtrAcranial PreSsurE in Intensive Care (ICU) (SynapseICU)
Intracranial pressure (ICP) monitoring is the most common neuromonitoring modality used in neurocritical care units (NCCU) around the world.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage
- Trial name
- SynapseICU (NCT03257904)
- Testing
- intracranial pressure monitoring
- Where
- Italy
- Volunteers
- 2,395 people
- Sponsor
- University of Milano Bicocca
Aneurysmal Subarachnoid Hemorrhage
Induced Suppression of Platelet Activity in Aneurysmal Subarachnoid Hemorrhage Management-2 (iSPASM-2)
An exploratory, randomized, double-blinded, placebo-controlled, two-center clinical trial to determine the maximum tolerated dosage of intravenous tirofiban in patients with aneurysmal subarachnoid hemorrhage (aSAH)…
- Trial name
- iSPASM-2 (NCT07493577)
- Testing
- Tirofiban
- Where
- 2 sites in United States
- Volunteers
- 82 people
- Sponsor
- Dr David Hasan, M.D.
Head Injury, Intracerebral Hemorrhage
The Prediction of Intracranial Pressure and Clinical Outcome by Transcranial Doppler in Neurocritical Patients
The purpose of this study is to use transcranial Doppler (TCD) to predict intracranial pressure (ICP) and clinical outcome of neurocritical patients.
- Conditions
- Head Injury, Intracerebral Hemorrhage, Ischemic Stroke, Subarachnoid Hemorrhage
- Trial name
- NCT00886054
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital