Clinical trials: Subarachnoid Hemorrhage (SAH)
Subarachnoid Hemorrhage
Deferoxamine to Prevent Delayed Cerebral Ischemia After Subarachnoid Hemorrhage
The investigators will test the central hypothesis that DFO treatment after SAH may improve cerebrovascular regulation, mitigate ischemic neural injury, and serve as an effective neuroprotectant against delayed ischemic injury…
- Trial name
- NCT02216513
- Testing
- desferrioxamine (DFO)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brigham and Women's Hospital
Head Trauma, Subarachnoid Hemorrhage
Problems With Morphine Use in Patients With a Severe Brain Injury
Hypothesis: During severe brain trauma (injury, surgery) the ensuing inflammatory response in the central nervous system (CNS) results in a decrease in the expression of the transporter protein p-glycoprotein (PGP) in the blood…
- Conditions
- Head Trauma, Subarachnoid Hemorrhage, Close Head Injury
- Trial name
- NCT00196131
- Testing
- morphine
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Dalhousie University
Cerebral Vasospasm, SAH
Continuous Neurophysiological Monitoring Detection of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage Subjects
Aneurysmal subarachnoid hemorrhage (bleeding on the brain due to a ruptured aneurysm) is a serious condition with a high morbidity (incidence of having ill health) and mortality (death).
- Conditions
- Cerebral Vasospasm, SAH, Aneurysm
- Trial name
- NCT01343537
- Testing
- Neuro Monitoring
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- State University of New York - Upstate Medical University
Subarachnoid Hemorrhage
Statins and Cerebral Blood Flow in Subarachnoid Hemorrhage (SAH)
The primary objective of this project is to investigate the effect of statin therapy on cerebral blood flow in patients with aneurysmal SAH who are randomized to receive or not receive statins in a blinded design.
- Trial name
- NCT00795288
- Testing
- Simvastatin, 80 mg/day for 21 days
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Ruptured Aneurysm of Intracranial Artery, SAH (Subarachnoid Hemorrhage)
Efficacy of Daily IV Administration of Dornase Alfa up to 14 Days Post Subarachnoid Hemorrhage on Functional Independence at 6 Months
Subarachnoid hemorrhage due to aneurysm rupture (SAH) results in high mortality, while survivors frequently suffer reduced quality of life and even loss of autonomy, particularly in the active population.
- Conditions
- Ruptured Aneurysm of Intracranial Artery, SAH (Subarachnoid Hemorrhage), Delayed Cerebral Ischemia
- Trial name
- RESET (NCT06723717)
- Testing
- Daily infusion of dornase alfa
- Where
- 6 sites in France
- Volunteers
- 304 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Subarachnoid Hemorrhage, Pneumonia, Bacterial
Influence of Pneumonia on Delayed Cerebral Ischemia After Subarachnoid Hemorrhage . SAH-CIP (SubArrachnoid Hemorrhage - Cerebral Infarction Pneumonia)
Prognosis of subarachnoid hemorrhage (SAH) is scarce, indeed almost half patients die or become severely disable after SAH. Outcome is related to the severity of the initial bleeding and delayed cerebral infarction (DCI).
- Trial name
- SAH-CIP (NCT05094349)
- Where
- France
- Volunteers
- 224 people
- Sponsor
- University Hospital, Brest
Subarachnoid Hemorrhage, Aneurysmal
Induced Suppression of Platelets Activity in Aneurysmal SAH Management (iSPASM)
This is a phase 1/2a, randomized, double blind, single-center study comparing standard care alone to standard care with Aggrastat in patients diagnosed with aneurysmal subarachnoid hemorrhage.
- Trial name
- NCT03691727
- Testing
- tirofiban hydrochloride (AGGRASTAT®), MRI, Neurological Exam
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- David Hasan
Subarachnoid Hemorrhage in Adult Patients
Sphenopalatine Block in Headache in Patients With Non-traumatic Subarachnoid Hemorrhage
Non-traumatic SAH, linked in 85% of cases to the rupture of an intracranial aneurysm, is a serious stroke affecting young people. Half of all survivors suffer cognitive impairment.
- Trial name
- SATURN (NCT06735261)
- Testing
- Sphenopalatine Ganglion Block using 2% lidocaine
- Volunteers
- 70 people
- Sponsor
- University Hospital, Grenoble
Aneurysmal Subarachnoid Hemorrhage
EARLYdrain - Outcome After Early Lumbar CSF-drainage in Aneurysmal SAH
The intention of the study is to investigate whether drainage of cerebral spinal fluid via a lumbar route ("Tuohy-drain") will improve outcome after intracranial aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- EARLYDRAIN (NCT01258257)
- Testing
- Insertion of a lumbar drain
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Subarachnoid Hemorrhage of Aneurysmal Cause
Observational Study on Mortality and Outcome of Patients Hospitalized for Subarachnoid Hemorrhage of Aneurysmal Origin in Martinique Between 2013 and 2021
The aim of our study is to analyze mortality and sequelae of subarachnoid hemorrhage of aneurysmal origin in hospitalized patients in Martinique. Predictive factors of poor prognosis will also be analyzed.
- Trial name
- HSA Rankin (NCT06525012)
- Testing
- Usual patient care for patients hospitalized for subarachnoid hemorrhage of aneurysmal origin
- Where
- Martinique
- Volunteers
- 122 people
- Sponsor
- University Hospital Center of Martinique
Subarachnoid Hemorrhage
The Mortality and Changes in Quality of Life of Patients Suffering From SAH With Different Hydration Strategies
Purpose: Vasospasm and secondary ischemia following subarachnoidal hemorrhage considerably affect the clinical outcome. The purpose of this study is to determine whether crystalloid (Lactated Ringer's solution) or colloid…
- Trial name
- NCT02064075
- Testing
- Lactated Ringer's solution, Hydroxyethyl starch
- Where
- Hungary
- Volunteers
- 96 people
- Sponsor
- University of Debrecen
Aneurysmal Subarachnoid Haemorrhage, SAH
Goal Directed Therapy After Aneurysmal Subarachnoid Haemorrhage
The objective of this study is to determine whether a goal-directed therapy can reduce the incidence of delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage.
- Trial name
- PiSAH (NCT01832389)
- Testing
- PiCCO
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- Technical University of Munich
Aneurysmal Subarachnoid Hemorrhage (aSAH), Headache Disorders
Efficacy of Scalp Block in Managing Post Subarachnoid Hemorrhage Headache in Critically Ill Patients. A Single Centre Randomized Controlled Trial
Subarachnoid hemorrhage (SAH) is a devastating neurological disorder associated with significant mortality and morbidity rates, arising not just from the hemorrhage itself but also because of the catastrophic multisystem sequelae…
- Trial name
- SAH-BLOCK (NCT07307508)
- Testing
- Levobupivacaine Scalp block, Conventional analgesic therapy
- Where
- Qatar
- Volunteers
- 22 people
- Sponsor
- Hamad Medical Corporation
Subarachnoid Haemorrhage (SAH), Delayed Cerebral Ischemia
Metabolomics in Subarachnoid Hemorrhage
The goal of this observational study is to learn whether blood and cerebrospinal fluid markers, combined with clinical, imaging and brain monitoring data, can help predict the outcome of adults with spontaneous subarachnoid…
- Trial name
- NeuroMetas (NCT07865182)
- Testing
- Blood and cerebrospinal fluid sampling
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Unidade Local de Saude Sao Jose
SAH (Subarachnoid Hemorrhage), Headache
Transnasal Sphenopalatine Ganglion Block for Treatment of Acute Subarachnoid Hemorrhage Associated Headache
The study titled \"Transnasal sphenopalatine ganglion block for treatment of acute subarachnoid hemorrhage associated headache\" is a randomized controlled pilot study aimed at evaluating the efficacy of a transnasal…
- Trial name
- NCT06621329
- Testing
- Transnasal sphenopalatine ganglion block
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Davis
Hyperthermia
Dantrolene for Treatment of Hyperthermia in Subarachnoidal Hemorrhage (SAH)
Dantrolene is used to prevent hyperthermia in intensive care patients suffering from subarachnoidal hemorrhage.
- Trial name
- DTH1 (NCT00796900)
- Testing
- Dantrolene
- Where
- Austria
- Volunteers
- 34 people
- Sponsor
- Medical University of Vienna
Subarachnoid Hemorrhage, Cerebral Aneurysm
Clevidipine for Vasospasm After Subarachnoid Hemorrhage (SAH)
Vasospasm occurs frequently after aneurysmal subarachnoid hemorrhage and can lead to strokes. The investigators will investigate if infusion of a novel drug, clevidipine, will decrease vasospasm during the infusion and post…
- Conditions
- Subarachnoid Hemorrhage, Cerebral Aneurysm, Vasospasm, Intracranial
- Trial name
- CLEVAS (NCT02011321)
- Testing
- clevidipine
- Where
- United States
- Sponsor
- Henry Ford Health System
Subarachnoid Hemorrhage (SAH)
Interest of Impedancemetry in Monitoring Hydration and Hyponatremia During Subarachnoid Hemorrhages
Subarachnoid hemorrhage (SAH) is a rare and serious form of stroke, mainly linked to the rupture of an intracranial aneurysm responsible for bleeding into the meningeal spaces.
- Trial name
- BIASHA (NCT06646484)
- Testing
- Impedancemetry evaluation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Subarachnoid Hemorrhage, Vasospasm, Intracranial
The Factors Cause Vasospasm After Aneurysmal Subarachnoid Hemorrhage
Extensive research has shown that the big event that leads to the initiation of vasospasm is the release of oxyhemoglobin (blood breakdown product).Depletion of NO synthase (19,20,21) was also noted after SAH.CSF is produced from…
- Trial name
- NCT00745758
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Aneurysmal Subarachnoid Haemorrhage
CytoSorb SAH Trial
In aSAH high levels of IL-6 (a pro-inflammatory cytokine) in the cerebrospinal fluid, as well as systemically have been linked to the severity grade and the occurrence of vasospasm and delayed cerebral ischemia caused by…
- Trial name
- NCT05259514
- Testing
- CytoSorb
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Emanuela Keller