Clinical trials: Subclinical Atherosclerotic Cardiovascular Disease
Atherosclerosis, Heart Diseases
Cardiac MR of Subclinical CVD: Impact of Age
To use magnetic resonance imaging to identify subclinical atherosclerosis and left ventricular hypertrophy in the Framingham Heart Study cohort.
- Conditions
- Atherosclerosis, Heart Diseases, Cardiovascular Diseases, Hypertrophy, Left Ventricular
- Trial name
- NCT00041418
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Rheumatoid Arthritis
Comprehensive Assessment of Subclinical Atherosclerosis in Patients With Rheumatoid Arthritis
Cardiovascular disease is a leading cause for morbidity and mortality in general population. The incidence of cardiovascular disease and their poor outcome is well documented in a broad spectrum of connective tissue diseases…
- Conditions
- Cardiovascular Diseases, Rheumatoid Arthritis, Atherosclerosis, Coronary
- Trial name
- NCT03813017
- Volunteers
- 100 people
- Sponsor
- Ziv Hospital
Carotid Atherosclerosis, Carotid Intimal Medial Thickness 1
Effects of Lutein Supplementation on Subclinical Atherosclerosis
This study is to investigate the possible positive effects of lutein and lycopene supplementation on early atherosclerosis in Beijing.
- Trial name
- NCT01534533
- Testing
- Lutein group, Combination group, Normal lutein control group
- Where
- China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Peking University
CMV
Effect of Atorvastatin on Subclinical Atherosclerosis
Statin administration is supposed to reduce subclinical atherosclerosis by decreasing LDL cholesterol levels, possibly via lipid-independent anti-inflammatory effect.
- Trial name
- NCT04101136
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Atherosclerosis, Metabolic Syndrome
Cardiometabolic Risk Factors Registry
CARFARE (CARDIOMETABOLIC RISK FACTORS REGISTRY) is a registry done in the context of a cardiovascular primary prevention program of the Cardiometabolic Unit Officia of the Cardiology Department of the Austral University Hospital.
- Conditions
- Atherosclerosis, Metabolic Syndrome, Diabetes, Cardiovascular Risk Factor
- Trial name
- CARFARE (NCT04040777)
- Where
- Argentina
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Austral University, Argentina
Atherosclerosis
Effect of Enhanced External Counterpulsation (EECP) on Subclinical Atherosclerosis
Shear stress maybe the most crucial local factor affecting atherogenesis. The present study investigated the effect of exposure to increased shear stress promoted by Enhanced External Counterpulsation (EECP) on the progression of…
- Trial name
- SESA (NCT01106495)
- Testing
- Enhanced External Counterpulsation (EECP), Simvastatin
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-sen University
Prevention of Subclinical Atherosclerosis Progression, Prevention of Cognitive Decline
Nattokinase Atherothrombotic Prevention Study
The potential for nattokinase to "thin" blood and to reduce blood clotting by positive antithrombotic and fibrinolytic effects presents a unique opportunity to safely study such effects on cardiovascular disease and cognition.
- Trial name
- NAPS (NCT02080520)
- Testing
- Nattokinase
- Where
- United States
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Thyroid Dysfunction, Atherosclerosis
The TRUST Study - CardioVascular Imaging IMT
Coronary heart disease (CHD) are the leading causes of mortality and morbidity, particularly with the current context of an aging population.
- Conditions
- Thyroid Dysfunction, Atherosclerosis, Heart Failure
- Trial name
- NCT02832934
- Testing
- Levothyroxine
- Where
- 3 sites in Switzerland
- Volunteers
- 184 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Atherosclerosis, Diabetes Mellitus
Coronary Computed Tomography Angiography and SPECT in Asymptomatic Diabetes
The purpose of this study is to compare the difference of diagnostic efficiency between coronary CT angiography and myocardial perfusion single photon emission computerized tomography in asymptomatic patients with type 2 diabetes…
- Trial name
- NCT00431717
- Where
- South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Diabetes Mellitus, Type 1
Omega-3 Fatty Acids Supplementation Improves Early-stage Diabetic Nephropathy and Subclinical Atherosclerosis in Pediatric Patients With Type 1 Diabetes
The investigators conducted this randomized-controlled trial to assess the effect of oral omega-3 supplementation on glycemic control, lipid profile, albuminuria level, kidney injury molecule-1 (KIM-1) and carotid intima media…
- Trial name
- NCT05980026
- Testing
- oral omega-3 fatty acids supplementation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Coronary Atherosclerosis
Evaluation of Subclinical COronary Atherosclerosis for Risk Stratification Using Coronary Computed Tomography (CT) Angiography
To evaluate the prognostic value of coronary CT angiography (CCTA) for risk stratification in asymptomatic adults in comparison with conventional risk stratification (CRS) and coronary artery calcium scoring (CACS).
- Trial name
- ESCORT (NCT01416532)
- Where
- South Korea
- Volunteers
- 5,000 people
- Sponsor
- Seoul National University Bundang Hospital
Atherosclerosis
Subclinical Atherosclerosis in Juvenile Systemic Lupus Erythematosus
The aim of this study is to evaluate subclinical atherosclerosis in children and adolescents with juvenile SLE by measuring carotid intima-media thickness (CIMT), and to determine its associations with traditional cardiovascular…
- Trial name
- NCT07545408
- Volunteers
- 70 people
- Sponsor
- Assiut University
type1diabetes
Sexual Dimorphism in Cardiovascular Autonomic Neuropathy in Patients With Type 1 Diabetes
Sex might interact with cardioautonomic neuropathy (CAN) in the development of macrovascular disease in patients with type 1 diabetes (T1D).
- Trial name
- NCT04950634
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Subclinical Carotid Atherosclerosis
Autonomic Testing in Subclinical Carotid Atherosclerosis
Background: Atherosclerotic carotid intima-media thickness (IMT) may be associated with alterations in the sensitivity of carotid and subclavian baroreceptors.
- Trial name
- AtheroDetect (NCT02726321)
- Volunteers
- 101 people
- Sponsor
- Universidade Camilo Castelo Branco
Coronary Artery Disease
Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine
The goal of this double-blind randomized controlled trial is to determine how treatment with high intensity statin, low-dose colchicine, and their combination modulates progression and composition of coronary atherosclerosis in…
- Trial name
- PROACT 2 (NCT05850091)
- Testing
- Rosuvastatin, Colchicine
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Healthy
Study to Evaluate Subclinical Atherosclerosis (an Early Sign of Heart Disease) in Healthy Adult Immigrant Asian Indians
Previous research has shown that Asian Indians are at relatively high risk for developing diabetes, heart problems and high blood pressure.
- Trial name
- NCT01104597
- Testing
- Flow Mediated Doppler (FMD), Nitroglycerin 0.4 mg sublingual
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Hypercholesterolemia, Familial
Subclinical Atherosclerosis in Patients With Familial Hypercholesterolemia Treated With Evolocumab®
Protein convertase subtilisin kexin type 9 (PCSK-9) inhibitors demonstrated efficacy in cholesterol reduction and in the prevention of cardiovascular events.
- Trial name
- NCT04313270
- Testing
- Evolocumab
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Federico II University
Dyslipidemia, Subclinical hypothyroïdism
Thyroid Hormone Replacement for Subclinical Hypothyroidism and Dyslipidemia in ASCVD (ThyroHeart-Lipid Study)
In ASCVD patients complicated with subclinical hypothyroidism, the percentage of those who did not reach the target of lipid-lowering therapy (LDL-C>1.8mmol/L) is usually higher than that in population with normal thyroid…
- Conditions
- Dyslipidemia, Subclinical hypothyroïdism, Statin, ASCVD
- Trial name
- NCT03606824
- Testing
- Pitavastatin and levothyroxine
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Shaochun.Li
Subclinical Atherosclerosis
Adipose Visceral and Epicardial Risk Evaluation
The goal of this procedure-based interventional study without drugs or devices is to investigate the molecular mechanisms underlying metabolically unfavorable obesity and related clinical phenotypes, in order to identify…
- Trial name
- AVERE (NCT07504679)
- Testing
- Peripheral blood sampling
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Artery Disease
Predictor of Advanced Subclinical Atherosclerosis
Evaluation of skin cholesterol for cardiovascular risk assessment in asymptomatic individuals at low, intermediate, or high risk based on Framingham Global Risk estimates.
- Trial name
- NCT00245284
- Where
- 6 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- PreMD