Clinical trials: Subclinical Atherosclerotic Cardiovascular Disease
Atherosclerosis, Chronic Kidney Diseases
The ILERVAS Project: Assessing the Prevalence of Subclinical Vascular Disease and Hidden Kidney Disease
BACKGROUND AND OBJECTIVES: Cardiovascular disease is the leading cause of death despite huge primary and secondary prevention policies with a strong economic burden.
- Conditions
- Atherosclerosis, Chronic Kidney Diseases, Metabolic Syndrome, PreDiabetes
- Trial name
- ILERVAS (NCT03228459)
- Testing
- Dried blood spot test, Urine test, Artery ultrasound
- Where
- 3 sites in Spain
- Volunteers
- 16,660 people
- Sponsor
- Institut de Recerca Biomèdica de Lleida
Type 2 Diabetes Mellitus, Coronary Atherosclerosis
Assessment With CCTA and MRI in Asymptomatic Patients With Type 2 Diabetes for Detection of Unrecognized Myocardial Scar in Subclinical Coronary Atherosclerosis
The study aimed to prospectively investigate the prevalence of myocardial scar on Dotarem-enhanced Cardiovascular Magnetic Resonance Imaging (MRI) in asymptomatic patients with type-2 Diabetes Mellitus and to assess its…
- Trial name
- ACCREDIT (NCT01254552)
- Testing
- iobitridol, gadoterate meglumine
- Where
- South Korea
- Volunteers
- 351 people
- Sponsor
- Guerbet
Atherosclerosis, Metabolic Syndrome
Cardiometabolic Risk Factors Registry
CARFARE (CARDIOMETABOLIC RISK FACTORS REGISTRY) is a registry done in the context of a cardiovascular primary prevention program of the Cardiometabolic Unit Officia of the Cardiology Department of the Austral University Hospital.
- Conditions
- Atherosclerosis, Metabolic Syndrome, Diabetes, Cardiovascular Risk Factor
- Trial name
- CARFARE (NCT04040777)
- Where
- Argentina
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Austral University, Argentina
Diabetes Mellitus, Type 1
Omega-3 Fatty Acids Supplementation Improves Early-stage Diabetic Nephropathy and Subclinical Atherosclerosis in Pediatric Patients With Type 1 Diabetes
The investigators conducted this randomized-controlled trial to assess the effect of oral omega-3 supplementation on glycemic control, lipid profile, albuminuria level, kidney injury molecule-1 (KIM-1) and carotid intima media…
- Trial name
- NCT05980026
- Testing
- oral omega-3 fatty acids supplementation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Coronary Artery Disease
Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- CloPidogREl for Primary preVENTION (HOST-PREVENTION)
The investigators will evaluate the efficacy and safety of clopidogrel for primary prevention in patients diagnosed with coronary atherosclerosis on imaging that did not require revascularization therapy.
- Trial name
- NCT05845489
- Testing
- Clopidogrel treatment group, No antiplatelet or anticoagulant group
- Where
- 61 sites in South Korea
- Volunteers
- 11,086 people
- Sponsor
- Seoul National University Hospital
Obesity, Postprandial Lipemia
Acute Effects of Dietary Proteins on Postprandial Lipemia, Incretin Responses and Subclinical Inflammation in Obese Subjects
The purpose of this study is to determine the effects of dietary protein on blood lipids and gut hormones after a fat-rich meal.
- Conditions
- Obesity, Postprandial Lipemia, Atherosclerosis, Inflammation
- Trial name
- NCT00863564
- Testing
- Caseine, Cod, Gluten
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Systemic Lupus Erthematosus (SLE), Lupus Nephritis (LN)
Non Invasive Assessment of Subclinical Atherosclerosis and Cardiovascular Risk Using TYG Index in Lupus Nephritis
Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease characterized by loss of immune tolerance, autoantibody production, immune complex deposition, and complement activation, resulting in widespread…
- Trial name
- NCT07719322
- Where
- Egypt
- Volunteers
- 156 people
- Sponsor
- Assiut University
Cardiovascular Diseases, Atherosclerosis
Serum Sex Hormone Levels and Subclinical Atherosclerosis - Ancillary to MESA
To assess the associations of serum sex hormones with the presence and progression of subclinical atherosclerosis.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Coronary Arteriosclerosis, Coronary Disease
- Trial name
- NCT00064532
- Volunteers
- 6,173 people
- Sponsor
- Northwestern University
Coronary Artery Disease
Predictor of Advanced Subclinical Atherosclerosis
Evaluation of skin cholesterol for cardiovascular risk assessment in asymptomatic individuals at low, intermediate, or high risk based on Framingham Global Risk estimates.
- Trial name
- NCT00245284
- Where
- 6 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- PreMD
Atherosclerosis, Coronary Artery Disease
Early Identification of Subclinical Atherosclerosis Using Non-Invasive Imaging Research (EISNER)
Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research (EISNER) is a multi-study research program being conducted at Cedars-Sinai Medical Center.
- Trial name
- EISNER (NCT00927693)
- Testing
- Coronary Artery Calcium (CAC) Scan
- Where
- United States
- Volunteers
- 2,137 people
- Sponsor
- Cedars-Sinai Medical Center
Hypothyroidism, Thyroid Diseases
Effect of L-Thyroxine on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism
Subclinical hypothyroidism (SCH) is a common condition affecting 3-10% of the general population, especially in women older than 50 years old.
- Conditions
- Hypothyroidism, Thyroid Diseases, Endocrine System Diseases
- Trial name
- NCT01831869
- Testing
- L-thyroxine
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shandong Provincial Hospital
Cardiovascular Diseases, Atherosclerosis
The AI-CAC Model for Subclinical Atherosclerosis Detection on Chest X-ray
The AI-CAC model is an artificial intelligence system capable of assessing the presence of subclinical atherosclerosis on a simple chest radiograph.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Coronary Artery Calcification
- Trial name
- AI-CAC-PVS (NCT06301009)
- Testing
- AI-CAC score
- Volunteers
- 500 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Coronary Artery Disease, Subclinical Atherosclerotic Cardiovascular Disease
Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Controlled Trial
In patients with subclinical coronary artery disease, the ASCAD-P study aims to assess the feasibility of a larger phase 3 pragmatic randomized controlled trial comparing prescription versus no prescription of low-dose aspirin in…
- Trial name
- ASCAD-P (NCT07524335)
- Testing
- Prescription of Aspirin, No prescription
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Montreal Heart Institute
Psoriasis, Atherosclerosis
The Early Detection and Progression of Subclinical Atherosclerosis in Psoriasis
The goal of this observational study is to identify new molecular and imaging markers associated with the presence of atherosclerosis and its progression in psoriasis.
- Trial name
- EDSAP (NCT05858099)
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Cardiovascular Disease
Better Adherence to Therapeutic Lifestyle Change Efforts Trial
The purpose of this study is to determine whether knowledge of abnormal results from a noninvasive test for detection of subclinical atherosclerosis (carotid intima media thickness [CIMT]), in addition to knowledge of…
- Trial name
- BATTLE (NCT00458874)
- Testing
- CIMT results
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Coronary Atherosclerosis
Subclinical COronary Atheroscleorosis Updated With Coronary cT Angiography (SCOUT Study)
The purpose of this study is to validate the usefulness of 64-slice multi-detecter computeted tomography as a screening tool in asymptomatic population.
- Trial name
- NCT00431860
- Testing
- Coronary computed tomographic angiography
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Seoul National University Bundang Hospital
Sleep Apnea, Snoring
Epigenetics Modifications in Obstructive Sleep Apnea
Changes in epigenetic regulation of genes involved in systemic inflammation and metabolic dysfunction in OSA are linked with accelerated cardiovascular morbidity.
- Trial name
- EPIOSA (NCT02131610)
- Where
- Spain
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Aragon Institute of Health Sciences
Cardiovascular Diseases, Fatty Liver
Ultrasound Assessment of Atherosclerotic Plaque Burden and Cardiovascular Risk: A 10-Year Prospective Study
The P-SONAR study is a large, observational, prospective cohort study. The overall aim of the study is to investigate whether plaque burden estimation by 2D ultrasound of the carotid and femoral arteries may enhance…
- Conditions
- Cardiovascular Diseases, Fatty Liver, Atherosclerosis of Femoral Artery, Carotid Artery Plaque
- Trial name
- P-SONAR (NCT06933745)
- Where
- Norway
- Volunteers
- 21,029 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Coronary Atherosclerosis, Diabetes Mellitus
Validation Study of Coronary CT Angiography as a Screening Tool in Asymptomatic Diabetes
The purpose of this study is to evaluate the prevalence and clinical predictors of subclinical coronary atherosclerosis and to validate the usefulness of coronary CT angiography as a screening tool in asymptomatic patients with…
- Trial name
- NCT00431977
- Testing
- coronary computed tomography angiography
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Seoul National University Bundang Hospital
Atherosclerosis
Women's Isoflavone Soy Health (WISH) Trial
The purpose of this study is to determine whether soy supplementation can reduce hardening of the arteries and cognitive decline in postmenopausal women.
- Trial name
- NCT00118846
- Testing
- 25 gm soy protein supplement
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Southern California