Clinical trials: Subclinical Hypothyroidism
Subclinical Hypothyroidism, Hypothyroxinemia
Thyroid Therapy for Mild Thyroid Deficiency in Pregnancy
The purpose of this study is to determine whether treating women, who are diagnosed with a mild imbalance of thyroid hormones during pregnancy, with thyroid hormone replacement affects their children's intellectual development at…
- Conditions
- Subclinical Hypothyroidism, Hypothyroxinemia, Pregnancy
- Trial name
- TSH (NCT00388297)
- Testing
- Levothyroxine
- Where
- 14 sites in United States
- Volunteers
- 1,203 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Subclinical Hypothyroidism
The Prevalence of Sub Clinical Hypothyroidism During Early Pregnancy in Pakistan
The Precious study is likely to help determine the frequency (percentage) of subclinical hypothyroidism among pregnant women in Pakistan It will also help to determine the risk factors for developing subclinical hypothyroidism…
- Trial name
- PRECIOUS (NCT03036956)
- Where
- 9 sites in Pakistan
- Volunteers
- 500 people
- Sponsor
- Abbott
Subclinical hypothyroïdism
Can Levothyroxine Treatment Reduce the Development of Cardio-metabolic Disorder in Subclinical Hypothyroidism?
2. Aim/ Objectives The aim of this study is to evaluate the clinical, laboratory and echocardiographic findings in children with SCH.
- Trial name
- NCT04178928
- Testing
- Levothyroxine
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Iodine Deficiency, Subclinical Hypothyroidism
Iodine Supplementation in Obesity
The study hypothesis is that iodine supplementation will lower serum TSH and leptin concentrations and thereby improve the lipid and glucose profile.
- Trial name
- NCT01985204
- Testing
- Iodine tablet
- Where
- 2 sites in Morocco
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Sub Clinical Hypothyroidism, Pregnancy Loss
Thyroxin in Subclinical Hypothyroidism
Subclinical hypothyroidism(SCH) is the elevated thyroid stimulating hormone (TSH) with normal free Thyroxine levels and it is a mild or compensated form of primary hypothyroidism.
- Trial name
- NCT03712683
- Testing
- Thyroxine
- Volunteers
- 168 people
- Sponsor
- Hawler Medical University
Chronic Kidney Diseases, Subclinical Hypothyroidism
Supplementation of Thyroid Hormone for TSH Control in Patients With Chronic Kidney Disease Without TRR.
Study design: Phase II study, randomized, double-blind, unicentric, two-arm, placebo-controlled clinical trial. Methods and participants: Patients with Chronic Kidney Disease G2-G5 with proteinuria without renal replacement…
- Trial name
- TSHrenal (NCT03898622)
- Testing
- Levothyroxine
- Where
- Mexico
- Volunteers
- 32 people
- Sponsor
- Hospital Civil de Guadalajara
Subclinical Hypothyroidism
Impact of Subclinical Hypothyroidism on Liver Enzymes and Lipid Profile
the goal of the randomized controlled observational study is to observe the effect of subclinical hypothyroidism on liver enzymes and lipid profile
- Trial name
- NCT07236697
- Testing
- liver enzymes
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Subclinical Hypothyroidism, Autoimmune Thyroid Disease
NeoThyr - the Role of Mitochondria-dysfunction in Newborns of Mothers With Autoimmune Thyroid Disease
Previously, studies have shown that children of women with thyroid autoantibodies experience more birth complications and poorer health in their first days.
- Conditions
- Subclinical Hypothyroidism, Autoimmune Thyroid Disease, Alteration of Mitochondrial Membrane
- Trial name
- NCT02061111
- Where
- Denmark
- Volunteers
- 77 people
- Sponsor
- Naestved Hospital
Subclinical Hypothyroidism
Discontinuation of Levothyroxine Therapy for Patients With Subclinical Hypothyroidism
The investigators propose the following hypothesis: discontinuation of levothyroxine (LT4) for veterans with subclinical hypothyroidism (SCH) will be feasible, acceptable, and safe and will not negatively affect their Quality of…
- Trial name
- NCT04288115
- Testing
- Levothyroxine
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VA Office of Research and Development
Hypothyroidism
The Impact of Subclinical Hypothyroidism on Cardiovascular System
This research aims to evaluate the relation between SCH and cardiovascular System by assessment of lipid profile and carotid intima-media thickness (CIMT), as a marker of atherosclerosis, and endothelial function.
- Trial name
- NCT04236232
- Testing
- Thyroid function
- Volunteers
- 100 people
- Sponsor
- Assiut University
Hypothyroidism, Neoplasms
Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery
Patients that require treatment for cancers of the head and neck often require a combination of surgery and/or radiation and chemotherapy.
- Conditions
- Hypothyroidism, Neoplasms, Postoperative Complications
- Trial name
- LSHT (NCT02548715)
- Testing
- Levothyroxine
- Sponsor
- University of Alberta
Subclinical Hypothyroidism, Depression
The TRUST Study - Depression Substudy
Mild thyroid failure is a common condition among older adults and has been associated with numerous adverse effects on health, such as cardiovascular disease, cognition disturbances and muscular problems.
- Trial name
- TRUST (NCT01853579)
- Testing
- Levothyroxine
- Where
- 3 sites in Netherlands, Switzerland
- Volunteers
- 426 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Subclinical hypothyroïdism
Subclinical Hypothyroidism and Chronic Inflammation in PCOS
Chronic inflammation in polycystic ovary syndrome (PCOS) may be the result of dysregulation of cytokine production (due to insulin resistance, excess visceral fat and hyperandrogenemia), i.e., overproduction of pro-inflammatory…
- Conditions
- PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Subclinical hypothyroïdism, Hypothalamic-Pituitary-Gonadal Axis Dysfunction
- Trial name
- NCT05842096
- Testing
- Measurement and comparison of leucocytosis and concentrations of CRP, procalcitonin, fibrinogen, ferritin, IL-1, IL-6, IL-10, TNF-alpha in both study arms, Evaluation of the impact of subclinical hypothyroidism, with present/ absent antithyroid antibodies, on the balance between anti- and pro-inflammatory factors in women in both study arms, Assessment of the impact of imbalance between anti- and pro-inflammatory factors in women with different PCOS and HPOD phenotypes on ovarian reserve indices
- Where
- Poland
- Volunteers
- 158 people
- Sponsor
- Jagiellonian University
Thyroid Dysfunction, Atherosclerosis
The TRUST Trial - CardioVascular Imaging ECHO
Coronary heart disease (CHD) and heart failure (HF) are the leading causes of mortality and morbidity, particularly with the current context of an aging population.
- Conditions
- Thyroid Dysfunction, Atherosclerosis, Heart Failure
- Trial name
- NCT02832960
- Testing
- Levothyroxine
- Where
- 3 sites in Switzerland
- Volunteers
- 185 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypothyroidism, Thyroid Diseases
Effect of L-Thyroxine on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism
Subclinical hypothyroidism (SCH) is a common condition affecting 3-10% of the general population, especially in women older than 50 years old.
- Conditions
- Hypothyroidism, Thyroid Diseases, Endocrine System Diseases
- Trial name
- NCT01831869
- Testing
- L-thyroxine
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shandong Provincial Hospital
Systolic Heart Failure, Sub-clinical Hypothyroidism
Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism
The purpose of this study is to determine whether levothyroxine supplementation is beneficial in patients with systolic heart failure and subclinical hypothyroidism on the functional class evaluated with a 6 minute walk test.
- Trial name
- NCT02316743
- Testing
- Levothyroxine supplementation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Université de Sherbrooke
Heart Injuries
Subclinical Hypothyroidism and Acute Anterior Myocardial Infarction: Is it Cardio-protective or Not?
The study plans to investigate whether recovery of the heart function after acute anterior myocardial infarction is dependent upon improvement in thyroid gland functioning.
- Trial name
- NCT03017157
- Testing
- Echo-cardiogram, Blood test
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hillel Yaffe Medical Center
Thyroid Dysfunction, Mental Fatigue
Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism
Thyroid hormone is a key regulatory hormone for a range of physiological systems. An impaired function of the thyroid gland such as subclinical hypothyroidism (SCH) can affect quality of life.
- Conditions
- Thyroid Dysfunction, Mental Fatigue, Fatigue
- Trial name
- TRUST FATIGUE (NCT02500342)
- Testing
- Levothyroxine
- Where
- 3 sites in Ireland, Switzerland
- Volunteers
- 276 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Metabolic Dysfunction-Associated Steatotic Liver Disease, Hypothyroidism
Hypothyroidism and Liver Fibrosis Severity in MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide, characterized by excess fat accumulation in the liver associated with metabolic risk factors such as obesity and…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Hypothyroidism, Liver Cirrhosis, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT07793279
- Volunteers
- 85 people
- Sponsor
- Assiut University