Clinical trials: Subclinical Hypothyroidisms
Subclinical Hypothyroidism
The Effect of Levothyroxine on Arterial Stiffness and Lipid Profile in Patients With Subclinical Hypothyroidism
We evaluated the effect of levothyroxine in subclinical hypothyroidism (SCH) on arterial stiffness, lipid profile and inflammation. Thirty-four patients with SCH were included.
- Trial name
- NCT00498238
- Testing
- Levothyroxine
- Volunteers
- 34 people
- Sponsor
- Assaf-Harofeh Medical Center
Thyroid Gland Disease, Pregnancy Complications
Antithyroidal Antibodies With or Without Subclinical Hypothyroidism During Pregnancy in Infertile Women
One prospective observational study was carried out in 2009 aiming at identifying the fluctuations of the thyroid hormones in women with normal thyroid gland and in women with anti-TPO antibodies.
- Trial name
- Anti-TPO (NCT04249271)
- Testing
- serum sampling
- Where
- Switzerland
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Subclinical hypothyroïdism
Subclinical Hypothyroidism and Chronic Inflammation in PCOS
Chronic inflammation in polycystic ovary syndrome (PCOS) may be the result of dysregulation of cytokine production (due to insulin resistance, excess visceral fat and hyperandrogenemia), i.e., overproduction of pro-inflammatory…
- Conditions
- PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Subclinical hypothyroïdism, Hypothalamic-Pituitary-Gonadal Axis Dysfunction
- Trial name
- NCT05842096
- Testing
- Measurement and comparison of leucocytosis and concentrations of CRP, procalcitonin, fibrinogen, ferritin, IL-1, IL-6, IL-10, TNF-alpha in both study arms, Evaluation of the impact of subclinical hypothyroidism, with present/ absent antithyroid antibodies, on the balance between anti- and pro-inflammatory factors in women in both study arms, Assessment of the impact of imbalance between anti- and pro-inflammatory factors in women with different PCOS and HPOD phenotypes on ovarian reserve indices
- Where
- Poland
- Volunteers
- 158 people
- Sponsor
- Jagiellonian University
Levothyroxine, Cardiac Function
Levothyroxine Treatment on Cardiac Function in Children With Subclinical Hypothyroidism
This study aims to evaluate the effect of the treatment with levothyroxine on cardiac function in children with subclinical hypothyroidism.
- Conditions
- Levothyroxine, Cardiac Function, Children, Subclinical Hypothyroidism
- Trial name
- NCT07393165
- Testing
- L-thyroxine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Subclinical hypothyroïdism
Effects of Levothyroxine Treatment on Hemodynamic and Renal Functions in Subclinical Hypothyroidism
Renal and cardiovascular effects of subclinical hypothyroidism, defined by a high TSH and normal T4 are less known and the indications for treatment of subclinical hypothyroidism are subject to controversies.
- Trial name
- NCT02186405
- Testing
- LEVOTHYROXINE
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire de Nice
Recurrent Pregnancy Loss
Recurrent Pregnancy Loss and Thyroid Disease
The present study is divided into two groups ,one is the patients with subclinical hypothyroidism who has TPO antibody positive women with TSH concentrations > 2.5 mU/L and below the upper limit of the pregnancy specific…
- Trial name
- NCT03106935
- Testing
- Levothyroxine
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Soochow University
Subclinical Hypothyroidism
Subclinical Hypothyroidism and Mind in the Elderly
Some recommendations of expert consensus on subclinical hypothyroidism (SH) are controversial in those areas with not enough information to reach a conclusion, such as not recommending treatment with thyrotrophic hormone of 4-10…
- Trial name
- NCT00921050
- Testing
- levothyroxine sodium
- Where
- 2 sites in Mexico
- Volunteers
- 70 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Systolic Heart Failure, Sub-clinical Hypothyroidism
Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism
The purpose of this study is to determine whether levothyroxine supplementation is beneficial in patients with systolic heart failure and subclinical hypothyroidism on the functional class evaluated with a 6 minute walk test.
- Trial name
- NCT02316743
- Testing
- Levothyroxine supplementation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Université de Sherbrooke
Dyslipidemia, Subclinical hypothyroïdism
Thyroid Hormone Replacement for Subclinical Hypothyroidism and Dyslipidemia in ASCVD (ThyroHeart-Lipid Study)
In ASCVD patients complicated with subclinical hypothyroidism, the percentage of those who did not reach the target of lipid-lowering therapy (LDL-C>1.8mmol/L) is usually higher than that in population with normal thyroid…
- Conditions
- Dyslipidemia, Subclinical hypothyroïdism, Statin, ASCVD
- Trial name
- NCT03606824
- Testing
- Pitavastatin and levothyroxine
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Shaochun.Li
Subclinical hypothyroïdism, Acute Coronary Syndrome
Impact Of Subclinical Hypothyroidism On Short-Term Outcomes In Patients With Acute Coronary Syndrome In Sohag University Hospitals
Introduction: Subclinical hypothyroidism (SCH) is defined biochemically as a normal serum free thyroxine (T4) level in the presence of an increased serum thyroid stimulating hormone (TSH) concentration.(1) Its prevalence ranges…
- Trial name
- NCT06409520
- Testing
- thyroid function tests, cardiac enzymes, ECG
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University
Subclinical Hypothyroidism
Mechanistic Study of Subclinical Hypothyroidism In the Elderly
Subclinical hypothyroidism, defined as an elevated TSH in the setting of normal thyroid hormone levels, is a common diagnosis in the elderly.
- Trial name
- NCT02399475
- Testing
- Levothyroxine, Liothyronine, Thyrotropin-Releasing Hormone
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Pennsylvania
Metabolic Dysfunction-Associated Steatotic Liver Disease, Hypothyroidism
Hypothyroidism and Liver Fibrosis Severity in MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide, characterized by excess fat accumulation in the liver associated with metabolic risk factors such as obesity and…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Hypothyroidism, Liver Cirrhosis, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT07793279
- Volunteers
- 85 people
- Sponsor
- Assiut University
Subclinical Hypothyroidism, Sarcopenia
The Effect of Thyroid Hormone Therapy on Muscle Mass and Function in Older Adults With Subclinical Hypothyroidism
Subclinical hypothyroidism (SCH) is common among the elderly population and has been associated with neuromuscular impairment. Muscular symptoms such as weakness, myalgia and cramps are more often reported by SCH patients…
- Trial name
- NCT04354896
- Testing
- Levothyroxin
- Where
- 5 sites in Netherlands, Switzerland
- Volunteers
- 322 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Subclinical Hypothyroidisms
Thyroid Replacement Therapy in Patients With Subclinical Hypothyroidism
The purpose of this experiment is to compared the changes of thyroid function, anti-thyroid peroxidase antibody, anti-thyroglobulin antibody, thyroid magnetic resonance T1-mapping and various metabolic indexes from baseline to…
- Trial name
- NCT04953195
- Testing
- Levothyroxine Sodium Tablets
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Chao Yang Hospital
Thyroid Dysfunction, Atherosclerosis
The TRUST Study - CardioVascular Imaging IMT
Coronary heart disease (CHD) are the leading causes of mortality and morbidity, particularly with the current context of an aging population.
- Conditions
- Thyroid Dysfunction, Atherosclerosis, Heart Failure
- Trial name
- NCT02832934
- Testing
- Levothyroxine
- Where
- 3 sites in Switzerland
- Volunteers
- 184 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Subclinical Hypothyroidism
Thyroid Screening Protocol During Pregnancy: a Multi-center Prospective Controlled Study
Estimate the proper thyroid screening method during pregnancy. Evaluate if maternal subclinical hypothyroidism treatment during pregnancy result in improved pregnancy outcome and cognitive function in the children.
- Trial name
- NCT01838031
- Testing
- thyroid screening
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking Union Medical College Hospital
Rheumatoid Arthritis, Subclinical Hypothyroidism
Subclinical Hypothyroidism and Disease Activity in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that causes persistent joint inflammation and damage. Thyroid disorders, particularly subclinical hypothyroidism, are common co-existing conditions in…
- Conditions
- Rheumatoid Arthritis, Subclinical Hypothyroidism, Thyroid Dysfunction
- Trial name
- NCT07793786
- Volunteers
- 150 people
- Sponsor
- Assiut University
Subclinical Hypothyroidism
The Prevalence of Sub Clinical Hypothyroidism During Early Pregnancy in Pakistan
The Precious study is likely to help determine the frequency (percentage) of subclinical hypothyroidism among pregnant women in Pakistan It will also help to determine the risk factors for developing subclinical hypothyroidism…
- Trial name
- PRECIOUS (NCT03036956)
- Where
- 9 sites in Pakistan
- Volunteers
- 500 people
- Sponsor
- Abbott
Subclinical Hypothyroidism
Thyroid Hormone Replacement for Subclinical Hypothyroidism
Subclinical hypothyroidism (SCH) is a common condition among older men and women. Although by definition SCH comprises biochemically mild thyroid hormone deficiency without overt symptoms, it is a possible contributor to multiple…
- Trial name
- TRUST (NCT01660126)
- Testing
- Levothyroxine
- Where
- United Kingdom
- Volunteers
- 737 people
- Sponsor
- NHS Greater Glasgow and Clyde
Hypothyroidism
Discontinuation of Low-Dose Levothyroxine in Older Adults With Subclinical Hypothyroidism
The goal of this clinical trial is to learn whether low-dose levothyroxine can be safely discontinued in adults aged 65 years or older who are taking levothyroxine for subclinical hypothyroidism.
- Trial name
- NCT07787585
- Testing
- Levothyroxine Pill
- Where
- 3 sites in United States
- Volunteers
- 138 people
- Sponsor
- Spyridoula Maraka