Clinical trials: Subclinical Hypothyroidisms
Child Development Disorders, Pregnancy
The Effect of Thyroid Hormone Levels in Pregnant Women on the Intelligence Quotient (IQ) of Their Children
This study is designed to test the hypothesis that the level of the thyroid hormone thyroxine (specifically, free thyroxine, FT4) circulating in the blood of pregnant women is the key thyroid-related factor to influence early…
- Conditions
- Child Development Disorders, Pregnancy, Subclinical Hypothyroidism
- Trial name
- NCT00147433
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Subclinical Hypothyroidism
Thyroid Hormone Replacement After Coronary Artery Bypass Grafting for Patients With Subclinical Hypothyroidism
The goal of this clinical trial is to find out whether levothyroxine reduces complications and improves the prognosis of patients with subclinical hypothyroidism (SCH) undergoing coronary artery bypass grafting (CABG).
- Trial name
- RepleniSH (NCT07380854)
- Testing
- levothyroxine
- Where
- South Korea
- Volunteers
- 338 people
- Sponsor
- Seoul National University Bundang Hospital
Subclinical Hypothyroidism, Hyperthyroidism
Color Flow Doppler Ultrasound in Subclinical Thyroid Dysfunction
Overt hyperthyroidism and hypothyroidism are associated with inverted hemodynamic changes.Regional blood flow disturbances (including intrathyroidal) were also reported in these thyroid disorders.
- Conditions
- Subclinical Hypothyroidism, Hyperthyroidism, Thyroid Dysfunction
- Trial name
- NCT00437931
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- HaEmek Medical Center, Israel
Polycystic Ovary Syndrome, Hypothalamic-Pituitary-Ovarian Axis Dysfunction (Disorder)
Subclinical Hypothyroidism and Normogonadotropic Anovulation
Thyroid hormones (TH) can modify the functioning of the hypothalamic-pituitary-ovarian axis, affecting the functions of granulosa cells and the development and apoptosis of preantral follicles.
- Trial name
- NCT05782725
- Testing
- Comparison of laboratory test results in women in the 4 study arms
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Jagiellonian University
Subclinical Hypothyroidism
Lipids Profile in Subclinical Hypothyroidism
Overt hypothyroidism is associated with increased risk for cardiovascular disease (CVD) as indicated by hypertension, hypercholesterolemia, and increased low-density lipoprotein cholesterol (LDL-C) levels.
- Trial name
- LPSH (NCT00962221)
- Testing
- laboratory analysis
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- HaEmek Medical Center, Israel
Subclinical Hypothyroidism
Dietary Intervention With Únicla Dairy Products (DANTIAN)
Dietary intervention with Únicla dairy products, naturally enriched with selenium and omega-3 fatty acids, may improve thyroid-stimulating hormone (TSH) levels in women with subclinical hypothyroidism
- Trial name
- DANTIAN (NCT05019118)
- Testing
- Experimental milk, Experimental yogur, Experimental fresh cheese
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Cooperativas Lacteas Unidas
Hypothyroidism, Thyroid Diseases
Effect of L-Thyroxine on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism
Subclinical hypothyroidism (SCH) is a common condition affecting 3-10% of the general population, especially in women older than 50 years old.
- Conditions
- Hypothyroidism, Thyroid Diseases, Endocrine System Diseases
- Trial name
- NCT01831869
- Testing
- L-thyroxine
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shandong Provincial Hospital
Subclinical Hypothyroidism, Hypothyroxinemia
Thyroid Therapy for Mild Thyroid Deficiency in Pregnancy
The purpose of this study is to determine whether treating women, who are diagnosed with a mild imbalance of thyroid hormones during pregnancy, with thyroid hormone replacement affects their children's intellectual development at…
- Conditions
- Subclinical Hypothyroidism, Hypothyroxinemia, Pregnancy
- Trial name
- TSH (NCT00388297)
- Testing
- Levothyroxine
- Where
- 14 sites in United States
- Volunteers
- 1,203 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Congenital Hypothyroidism, L-Thyroxine
Diagnosis and Follow-up of Patients With Subclinical Hypothyroidism
Long term follow-up of the patients with delayed TSH elevation or subclinical hypothyroidism has been seldom reported. The purpose of this study was to explore the diagnostic criteria for subclinical hypothyroidism and the…
- Conditions
- Congenital Hypothyroidism, L-Thyroxine, Follow-Up
- Trial name
- CHRO1 (NCT00497575)
- Sponsor
- Zhejiang University
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Subclinical Hypothyroidism
Best Treatment for Women With Both (Polycystic Ovary Syndrome) PCOS and Subclinical Hypothyroidism
The goal of this randomized controlled trial is to compare letrozole alone versus letrozole plus levothyroxine for ovulation induction in infertile women with both PCOS and subclinical hypothyroidism.
- Conditions
- PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Subclinical Hypothyroidism, Female Infertility
- Trial name
- NCT06041204
- Testing
- Letrozole 2.5mg, Levothyroxine 25 Mcg (0.025 Mg) Oral Tablet
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Muhamed Ahmed Abdelmoaty Muhamed Alhagrasy
Hypothyroidism
The Impact of Subclinical Hypothyroidism on Cardiovascular System
This research aims to evaluate the relation between SCH and cardiovascular System by assessment of lipid profile and carotid intima-media thickness (CIMT), as a marker of atherosclerosis, and endothelial function.
- Trial name
- NCT04236232
- Testing
- Thyroid function
- Volunteers
- 100 people
- Sponsor
- Assiut University
Thyroid Dysfunction, Atherosclerosis
The TRUST Trial - CardioVascular Imaging ECHO
Coronary heart disease (CHD) and heart failure (HF) are the leading causes of mortality and morbidity, particularly with the current context of an aging population.
- Conditions
- Thyroid Dysfunction, Atherosclerosis, Heart Failure
- Trial name
- NCT02832960
- Testing
- Levothyroxine
- Where
- 3 sites in Switzerland
- Volunteers
- 185 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Subclinical Hypothyroidism
Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism
Hypothyroidism is risk factor in atherosclerotic cardiovascular diseases, but there is a controversy in effect of subclinical hypothyroidism on cardiovascular diseases.
- Trial name
- NCT02090907
- Testing
- Levothyroxine
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Isfahan University of Medical Sciences
Abortion, Spontaneous, Pregnancy Complications
Relation Between Subclinical Hypothyroidism and Outcome of Pregnancy
Studies have demonstrated a relationship between subclinical hypothyroidism and obstetrics complications like preterm delivery, pre-eclampsia, placental abruption and stillbirth.
- Conditions
- Abortion, Spontaneous, Pregnancy Complications, Subclinical Hypothyroidism
- Trial name
- GravThyr (NCT01335802)
- Where
- Denmark
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Naestved Hospital
Heart Injuries
Subclinical Hypothyroidism and Acute Anterior Myocardial Infarction: Is it Cardio-protective or Not?
The study plans to investigate whether recovery of the heart function after acute anterior myocardial infarction is dependent upon improvement in thyroid gland functioning.
- Trial name
- NCT03017157
- Testing
- Echo-cardiogram, Blood test
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hillel Yaffe Medical Center
Cardiovascular Diseases, Heart Diseases
Subclinical Thyroid Dysfunction and Risk of Myocardial Infarction and Stroke
To examine the association of subclinical hypothyroidism and risk of myocardial infarction and stroke in a large prospective cohort of post-menopausal women.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypothyroidism, Myocardial Infarction
- Trial name
- NCT00094237
- Volunteers
- 3,200 people
- Sponsor
- University of North Carolina, Chapel Hill
Thyroid Dysfunction, Mental Fatigue
Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism
Thyroid hormone is a key regulatory hormone for a range of physiological systems. An impaired function of the thyroid gland such as subclinical hypothyroidism (SCH) can affect quality of life.
- Conditions
- Thyroid Dysfunction, Mental Fatigue, Fatigue
- Trial name
- TRUST FATIGUE (NCT02500342)
- Testing
- Levothyroxine
- Where
- 3 sites in Ireland, Switzerland
- Volunteers
- 276 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Iodine Deficiency, Subclinical Hypothyroidism
Iodine Supplementation in Obesity
The study hypothesis is that iodine supplementation will lower serum TSH and leptin concentrations and thereby improve the lipid and glucose profile.
- Trial name
- NCT01985204
- Testing
- Iodine tablet
- Where
- 2 sites in Morocco
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Chronic Kidney Diseases, Subclinical Hypothyroidism
Supplementation of Thyroid Hormone for TSH Control in Patients With Chronic Kidney Disease Without TRR.
Study design: Phase II study, randomized, double-blind, unicentric, two-arm, placebo-controlled clinical trial. Methods and participants: Patients with Chronic Kidney Disease G2-G5 with proteinuria without renal replacement…
- Trial name
- TSHrenal (NCT03898622)
- Testing
- Levothyroxine
- Where
- Mexico
- Volunteers
- 32 people
- Sponsor
- Hospital Civil de Guadalajara
Subclinical hypothyroïdism
Relationship of Noninvasive Assessment of Central BP With 10 Years Atherosclerotic CVD in Subclinical Hypothyroidism
verify Relationship of noninvasive assessment of central arterial blood pressure with 10 years Atherosclerotic Cardiovascular disease (ASCVD) in Subclinical hypothyroidism
- Trial name
- NCT06607978
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University