Clinical trials: Subcutaneous Fat
Craniosynostosis
Osteogenic Profiling of Tissue From Children With Craniosynostosis
The primary objectives of this study are to procure human temporalis muscle, subcutaneous adipose (fat), and bone tissue samples from children with craniosynostosis, to grow cells from these tissues in vitro, to evaluate the…
- Trial name
- NCT00773643
- Testing
- biopsy
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- University of Pittsburgh
Cardiac Amyloidosis
Mitochondrial Function in Transthyretin Amyloidosis
Hereditary (familial) amyloidosis arising from the misfolding of a mutated or variant transthyretin, is the most frequent form of amyloid cardiomyopathy in the Caribbean basin.
- Trial name
- MIT-Amylose (NCT03328338)
- Where
- Martinique
- Volunteers
- 12 people
- Sponsor
- University Hospital Center of Martinique
Knee Arthritis Osteoarthritis, Knee Replacement Arthroplasty
Is BMI Outdated in TKA Patient Selection? Assessment of the Impact of Pre-tubercular Subcutaneous Tissue Thickness and the Risk of Postoperative Infection Following Total Knee Arthroplasty
While Body Mass Index (BMI) is currently used as a primary tool for risk stratification in patients undergoing Total Knee Athroplasty(TKA), its limitations raise concerns regarding its accuracy and fairness in guiding surgical…
- Conditions
- Knee Arthritis Osteoarthritis, Knee Replacement Arthroplasty, BMI, Regional Body Composition
- Trial name
- BEYOND-BMI (NCT07763535)
- Volunteers
- 400 people
- Sponsor
- East Lancashire Hospitals NHS Trust
Subcutaneous Fat
A Study to Evaluate the Pharmacokinetic Profile of CBL-514 Injection in Healthy Volunteers
This Phase 2 study will be an open-label and single course study to assess the safety, tolerability, PK and metabolite profile of CBL-514.
- Trial name
- NCT05234736
- Testing
- CBL-514
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Caliway Biopharmaceuticals Co., Ltd.
Surgical Incision
Does Disinfection of the Subcutaneous Tissue Reduce Contamination of the Operating Field With P. Acnes?
Propionibacterium acnes is a pathogen commonly identified in postoperative shoulder infections. A recent study has shown that P.
- Trial name
- Elec_cautery (NCT04250649)
- Testing
- subcutaneous tissue disinfection
- Where
- Switzerland
- Volunteers
- 105 people
- Sponsor
- Hôpital du Valais
Lipedema
Diathermy Effectiveness in Reducing Subcutaneous Adipose Tissue Affected by Lipedema
Diathermy, a therapy that uses deep heat to reach deep tissue layers, is known to induce the breaking down of fatty cells and fibrotic tissue. In lipedema, patients develop fibrosis of their subcutaneous adipose tissue.
- Trial name
- EDRTASAL (NCT05944796)
- Testing
- Diathermy
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Camilo Jose Cela University
Wounds and Injuries, Wound Infection
Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
This study will evaluate the use of free autologous dermal fat grafting (also called free dermal fat autografting) to treat complex craniofacial wounds that have failed standard treatment and to understand how well these grafts…
- Conditions
- Wounds and Injuries, Wound Infection, Facial Bones Fracture, Soft Tissue Injuries
- Trial name
- FTFDT2 (NCT03880188)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dufresne, Craig, MD, PC
HIV Infections, Lipoatrophy
Clinical Trial to Assess the Effect of the Change of Efavirenz (EFV) for Lopinavir/Ritonavir (LPV/r) in Lipoatrophy in HIV-infected Patients
Eligible HIV-infected patients with clinically evident lipoatrophy despite treatment with efavirenz and fixed-dose combination of thymidine nucleoside analogues will be informed and asked to enroll in the study; will be…
- Trial name
- LIPOKAL (NCT00978237)
- Testing
- EFV, LPV/r
- Where
- 7 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Juan A. Arnaiz
Obesity, Type 2 Diabetes
Adaptive Mechanisms In GRown up ObeSity Study (AMIGROS)
The investigator recently showed that the glycan-binding adipokine galectin-1 increased during overfeeding and that galectin-1 independently could predict type 2 diabetes.
- Trial name
- AMIGROS (NCT06065930)
- Testing
- Subcutaneous microdialysis
- Where
- Sweden
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Subcutaneous Fat
A Study to Evaluate the Efficacy, Safety and Tolerability of CBL-514 Injection for Reducing Subcutaneous Fat (Stage 1)
The Stage 1 of this phase 2 study is an open-label single ascending dose (SAD) study. The primary objectives are to evaluate the safety and tolerability of injection lipolysis with CBL-514.
- Trial name
- NCT04575467
- Testing
- CBL-514
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Caliway Biopharmaceuticals Co., Ltd.
Obesity, Metabolic Syndrome
Cellular Dynamics of Subcutaneous Fat Distribution in Obese Women
The body shape of obese women varies between having the majority of fat either above the waist ("apple" shape) or below the waist ("pear" shape).
- Trial name
- Apple/Pear (NCT01748994)
- Testing
- Pioglitazone
- Where
- 2 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Abscess of Skin and/or Subcutaneous Tissue
Loop Drainage Versus Incision and Drainage for Abscesses
This is a multicenter randomized controlled trial of loop drainage versus traditional incision and drainage in adult patients presenting to the emergency department.
- Trial name
- NCT03911518
- Testing
- Loop drainage, Incision and drainage
- Sponsor
- Gary Peksa
Vascular Access Complication, Skin and Subcutaneous Tissue Disorders
Effectiveness of a Zinc Oxide Adhesive Securement Device in the Fixation of Midline and Peripherally Inserted Central Catheters in Hospitalized Adult Patients
Study in which a zinc oxide fixation device (a product that can help protect the skin) for catheters (polyurethane tubes inserted into a vein) will be tested to reduce catheter-related complications: catheter displacement, skin…
- Conditions
- Vascular Access Complication, Skin and Subcutaneous Tissue Disorders, Phlebitis, Pain
- Trial name
- FIX-ETI (NCT06770374)
- Testing
- Control group: acrylic adhesive sutureless fixation device, Intervention Group: zinc oxide sutureless fixation device, PICC
- Where
- 2 sites in Spain
- Volunteers
- 400 people
- Sponsor
- Hospital Arnau de Vilanova
Healthy
Spot Reduction in Male Adults
Spot reduction, referring to local body fat reduction, pertains to subcutaneous adipose tissue utilization from specific body parts during exercise.
- Trial name
- NCT05794854
- Testing
- Abdominal aerobic endurance exercise, Control training intervention
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Molde University College
Skin and Subcutaneous Tissue Bacterial Infections
Delafloxacin Versus Vancomycin and Aztreonam for the Treatment of Acute Bacterial Skin and Skin Structure Infections
This study was designed to evaluate the efficacy of delafloxacin patients with acute bacterial skin and soft tissue infections (ABSSSI).
- Trial name
- NCT01811732
- Testing
- Delafloxacin, Vancomycin, Aztreonam
- Where
- 50 sites in United States, Croatia and 5 more
- Volunteers
- 660 people
- Sponsor
- Melinta Therapeutics, Inc.
Non-alcoholic Fatty Liver Disease, Obesity
Magnetic Resonance Imaging (MRI) Fat Quantification of the Liver
Fatty liver in the obese is a common finding; some cases develop steato-hepatosis which in the long-term can lead to liver cirrhosis.
- Trial name
- NCT02682173
- Testing
- MR Abdomen
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University Hospital, Basel, Switzerland
Subcutaneous Fat
A Study to Evaluate the Efficacy and Safety of CBL-514 Injection for Reducing Subcutaneous Fat
A phase 3, randomized, double-blinded, placebo-controlled study to evaluate the efficacy, safety, and tolerability of CBL-514 injection for reducing abdominal subcutaneous fat.
- Trial name
- SUPREME-01 (NCT07140939)
- Testing
- CBL-514 Injection, 0.9% Sodium Chloride
- Where
- 13 sites in United States, Canada
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Caliway Biopharmaceuticals Co., Ltd.
Hernia
Collagen Analysis and Genetic Analysis of Families With Tendency to Hernias
Analysis of collagen subtype subcutaneously and genetic analysis of patients from families with a tendency to hernias. Furthermore circulating biomarkers and biomarkers extracted from the subcutaneously tissue such as MMP's…
- Trial name
- NCT00991484
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Subcutaneous Adipose Tissue Reduction
An Evaluation of the Pharmacokinetics and Safety of LIPO-102 in Healthy Volunteers
An Evaluation of the PK and Safety of LIPO-102 in Healthy Volunteers.
- Trial name
- NCT00918606
- Testing
- LIPO-102
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Neothetics, Inc
Alopecia, Androgenetic
STYLE -- A Trial of Cell Enriched Adipose For Androgenetic Alopecia
The primary objective of this study is to evaluate the safety and feasibility of the Celution and Puregraft Systems in the processing and preparation of an autologous fat graft enriched with adipose-derived regenerative cells…
- Trial name
- STYLE (NCT02503852)
- Testing
- Puregraft System, Celution System, Kerastem Therapy
- Where
- 4 sites in United States
- Volunteers
- 71 people
- Sponsor
- Kerastem Technologies, LLC