Clinical trials: Subdural Hematoma, Chronic
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for Treatment of Chronic Subdural Hematoma
Middle meningeal artery (MMA) embolization via a minimally invasive endovascular approach has been attempted with the goal of eliminating the arterial supply to the vascularized membrane.
- Trial name
- NCT03307395
- Testing
- Middel Meningeal Artery Embolization
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Weill Medical College of Cornell University
Chronic Subdural Hematoma
The Finnish Study of Intraoperative Irrigation Versus Drain Alone After Evacuation of Chronic Subdural Hematoma (FINISH)
FINISH-trial is a prospective, randomized, controlled, parallel group non-inferiority trial comparing single burr-hole evacuation of chronic subdural hematoma (CSDH) with intraoperative irrigation (IR) and evacuation of CSDH…
- Trial name
- FINISH (NCT04203550)
- Testing
- Intraoperative irrigation, No irrigation
- Where
- Finland
- Volunteers
- 587 people
- Sponsor
- Helsinki University Central Hospital
Chronic Subdural Hematoma
Spinal CSF Leaks in Chronic Subdural Hematoma
Background: Chronic subdural hematoma (cSDH) is a type of intracranial bleeding, predominantly affecting the elderly and males, with an estimated incidence of 8/100.000.
- Trial name
- SPICE (NCT06323434)
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- University of Freiburg
Chronic SDH and the Efficacy of Embolization
Endovascular Embolization for Chronic Subdural Hematomas Following Surgical Evacuation
This study is designed to evaluate the effectiveness of endovascular embolization of middle meningeal artery following evacuation of subdural hematomas (SDHs) to assess rate of recurrence.
- Trial name
- endovascular (NCT04272996)
- Testing
- Craniotomy only, Craniotomy + Endovascular embolization of the middle meningeal vessels
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Augusta University
Chronic Subdural Hemorrhage (cSDH)
Chronic Subdural Hematoma Embolization With Detachable Coils
This is a prospective, multi-center, post market registry study designed to evaluate the safety and efficacy of treatment with Balt coils in patients with chronic subdural hematoma (cSDH).
- Trial name
- SEED (NCT07291427)
- Testing
- Balt coils: (Balt USA, LLC), MMA embolization
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Subdural Hematoma
The CHALLENGER Registry
The study is a multi-center prospective, single-arm, post-market study evaluating the efficacy and radiologic and functional outcomes associated use of the Numen SILK coils for Middle Meningeal Artery (MMA) embolization following…
- Trial name
- CHALLENGER (NCT07197840)
- Testing
- Numen SILK coil embolization system
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Subdural Hematoma
Defining Core Outcomes and Data Elements (CODE) in Chronic Subdural Haematoma
This study is aimed at improving reporting in Chronic Subdural Haematoma (CSDH) research studies, through development of a standardised Core Outcome Set (COS), a unified CSDH Definition and set of Data Elements (DE) for…
- Trial name
- CODE-CSDH (NCT04850612)
- Testing
- Survey
- Where
- United Kingdom
- Volunteers
- 184 people
- Sponsor
- University Hospital Plymouth NHS Trust
Chronic Subdural Hematoma
Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma -2
Chronic subdural hematoma (CSDH), a common disease after minor head trauma, is characterized by blood collection in the subdural space, which can result in severe neurological impairment.
- Trial name
- TRACE-2 (NCT04898712)
- Testing
- Tranexamic Acid 500 MG
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Unity Health Toronto
Chronic Subdural Hematomas
Prospective MMA Embolization Registry
Chronic subdural hematoma (cSDH) is a common condition, particularly in older adults, that can substantially impair patients' quality of life, functional independence, and neurological well-being.
- Trial name
- PRO-EMMA (NCT07626671)
- Testing
- Middle Meningeal Artery Embolization
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Chronic Subdural Hematoma
Targeting Spreading Depolarization After Chronic Subdural Hematoma Surgery (TASD)
Chronic Subdural Hematoma (cSDH) is an extremely common problem, particularly in the aging population, where fluid like collections compress the brain, frequently requiring surgical drainage.
- Trial name
- TASD (NCT04966546)
- Testing
- Memantine Hydrochloride
- Where
- United States
- Sponsor
- University of New Mexico
Chronic Subdural Hematoma
Middle Meningeal Artery (MMA) Embolization Compared to Traditional Surgical Strategies to Treat Chronic Subdural Hematomas (cSDH)
Chronic Subdural Hematoma (cSDH) is a common hematologic problem particularly in older patients. The purpose of this study is to evaluate the safety and efficacy of middle meningeal artery (MMA) embolization compared to…
- Trial name
- NCT04095819
- Testing
- Middle Meningeal Artery procedure, Traditional Surgery
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Atlantic Health System
Chronic Subdural Hematoma
Assessing Outcomes of Coil Embolization for Unilateral vs Bilateral Chronic Subdural Hematomas
This is a pragmatic, prospective, multicenter, randomized controlled trial with intention to treat analysis. In which subjects will receive either unilateral or bilateral middle meningeal artery (MMA) embolization using coils for…
- Trial name
- (COAST) (NCT07715656)
- Testing
- embolization therapy Bilateral, embolization therapy Unilateral
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Lahey Clinic
Subdural Hematoma
MMA Embolization With NeoCast for Subacute and Chronic Subdural Hematoma
The purpose of this study is to evaluate the safety and efficacy of embolization of the middle meningeal artery (MMA) using the NeoCast Embolic System for treatment of symptomatic subacute or chronic subdural hematoma (SDH)…
- Trial name
- RADIANT (NCT07541404)
- Testing
- NeoCast Embolic System, Onyx LES, an FDA-Approved Commercial Liquid Embolic
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- Arsenal Medical, Inc.
Subdural Hematoma
A Study on the Safety of Tranexamic Acid for the Chronic Subdural Hematoma Population
This is a single center single arm study of 50 patients to 1) determine the safety of tranexamic acid in the chronic subdural hematoma population following surgical drainage of chronic subdural hematomas and 2) determine if the…
- Trial name
- TXA in CSDH (NCT02618382)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Hematoma, Subdural, Chronic
The Role of Meningeal Lymphatic Vessels in the Absorption of Chronic Subdural Hematoma and Its Injury Mechanism
Chronic subdural hematoma (CSDH) is a very common hemorrhagic disease of the nervous system, accounting for about 10% of hemorrhagic strokes.
- Trial name
- NCT05426889
- Testing
- subdural hematoma burr hole drainage, drug conservative treatment
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pelvic Fracture, Prostate Cancer
A COhort Study on Factors Leading to Vulnerability in Adult Patients With Serious Medical cOnditionS: the COSMOS-I Trial
The objective of this prospective multicentre study that recruits altogether 1500 older patients from the university hospitals of Tampere, Kuopio, and Oulu is to explore the clinical significance and detection of causes of…
- Conditions
- Pelvic Fracture, Prostate Cancer, Lung Cancer, Brain Metastasis
- Trial name
- COSMOS-I (NCT07740239)
- Testing
- Test set to determine vulnerability
- Where
- Finland
- Volunteers
- 2,050 people
- Sponsor
- Tampere University Hospital
Chronic Subdural Hematoma
GET-UP Trial: Impact of an Early Out-of-bed Paradigm in Postoperative Outcomes of Chronic Subdural Hematomas
Compare rates of medical complications, recurrence and outcome in 2 randomized groups of patients with surgical chronic subdural hematomas.
- Trial name
- GET-UP (NCT03788005)
- Testing
- Early mobilization
- Where
- Portugal
- Volunteers
- 208 people
- Sponsor
- Centro Hospitalar do Porto
Chronic Subdural Hematoma
Swedish Trial on Embolization of Middle Meningeal Artery Versus Surgical Evacuation in Chronic Subdural Hematoma
The SWEMMA trial is an open, national, multi-center, prospective, randomized (1:1), superiority trial designed to assess impact on reoperation rates for chronic subdural hematoma with a head-to-head comparison of embolization of…
- Trial name
- SWEMMA (NCT05267184)
- Testing
- Endovascular treatment of the middle meningeal artery, Standard neurosurgical hematoma evacuation
- Where
- 4 sites in Sweden
- Volunteers
- 288 people
- Sponsor
- Region Skane
Chronic Subdural Hematoma, Epilepsy; Seizure
Generating Evidence on NonEpileptic, Stereotypical and Intermittent Symptoms (NESIS) in Chronic Subdural Hematomas
Some patients with chronic subdural hematomas and transient neurological symptoms do not respond to standard antiepileptic drugs.
- Conditions
- Chronic Subdural Hematoma, Epilepsy; Seizure, Cortical Depression; Cortical Depolarization, Nonepileptic, Stereotypical and Intermittent Symptoms
- Trial name
- GENESIS (NCT04759196)
- Testing
- Topamax, Levetiracetam
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Université de Sherbrooke
Chronic Subdural Hematoma, Stroke
Comparative Study of Embolic Agents in Patients With Subdural Hemorrhage Undergoing Middle Meningeal Artery (MMA) Embolization
Single site, prospective, comparative effectiveness pilot trial comparing efficacy and safety outcomes of three embolic materials (particles, liquid embolics, and Wallaby Phenox coils) in MMA embolication for cSDH.
- Conditions
- Chronic Subdural Hematoma, Stroke, Middle Meningeal Artery Embolization
- Trial name
- NCT07757113
- Testing
- Particles (polyvinyl alcohol or similar microspheres), Liquid Embolics (Onyx, n-BCA, or equivalent), Phenox Coils (Avenir UNO Helical Coil)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sanford Health