Clinical trials: Subdural Hematoma, open to volunteers
Chronic Subdural Hematoma
Tranexamic Acid Therapy For The Treatment of Subdural Hematomas
This Phase II randomized, placebo-controlled, double-blinded trial is the first step in our endeavor to improve the clinical outcomes of patients with chronic subdural hematomas (cSDH).
- Trial name
- NCT06718751
- Testing
- Tranexamic Acid 650 MG
- Volunteers
- 240 people
- Sponsor
- Baylor College of Medicine
Chronic Subdural Hematoma, Surgical Procedures, Operative
A National Study Examining the Most Effective Drainage Method After Burr Hole Evacuation of Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a common disease. The main treatment is neurosurgical evacuation and subsequent hematoma drainage.
- Conditions
- Chronic Subdural Hematoma, Surgical Procedures, Operative, Recurrence, Mortality
- Trial name
- SUPERDURA (NCT06621407)
- Testing
- 24 hours active subperiostal drainage, 24 hours passive subdural drainage
- Where
- 4 sites in Denmark
- Volunteers
- 354 people
- Sponsor
- Aalborg University Hospital
Chronic Subdural Hematoma
Aspirin Continuation or Discontinuation in Conservative Treatment for Chronic Subdural Hematoma
This clinical study aims to learn about the efficacy and safety of aspirin continuation or discontinuation in conservative treatment for chronic subdural hematoma.
- Trial name
- NCT07240454
- Testing
- Aspirin Continuation, Aspirin Discontinuation
- Where
- 2 sites in China
- Volunteers
- 143 people
- Sponsor
- Tao Liu
Chronic Subdural Hematoma, Stroke
Comparative Study of Embolic Agents in Patients With Subdural Hemorrhage Undergoing Middle Meningeal Artery (MMA) Embolization
Single site, prospective, comparative effectiveness pilot trial comparing efficacy and safety outcomes of three embolic materials (particles, liquid embolics, and Wallaby Phenox coils) in MMA embolication for cSDH.
- Conditions
- Chronic Subdural Hematoma, Stroke, Middle Meningeal Artery Embolization
- Trial name
- NCT07757113
- Testing
- Particles (polyvinyl alcohol or similar microspheres), Liquid Embolics (Onyx, n-BCA, or equivalent), Phenox Coils (Avenir UNO Helical Coil)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sanford Health
Chronic Subdural Hematoma, Trendelenburg
Effect of the Postoperative Trendelenburg Position on Chronic Subdural Hematoma Recurrence
Objective: Determine the effect of the postoperative trendelenburg position on the recurrence of chronic subdural hematoma (CSH) in patients undergoing surgery.
- Conditions
- Chronic Subdural Hematoma, Trendelenburg, Recurrence, Mortality
- Trial name
- POTHeR (NCT06911736)
- Testing
- Trendelenburg position
- Where
- 3 sites in Colombia
- Volunteers
- 254 people
- Sponsor
- Universidad de Antioquia
Chronic Subdural Hemorrhage (cSDH)
Chronic Subdural Hematoma Embolization With Detachable Coils
This is a prospective, multi-center, post market registry study designed to evaluate the safety and efficacy of treatment with Balt coils in patients with chronic subdural hematoma (cSDH).
- Trial name
- SEED (NCT07291427)
- Testing
- Balt coils: (Balt USA, LLC), MMA embolization
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gastrointestinal Stromal Tumors
The Efficacy and Safety of Temozolomide in SDH-deficient GIST
The goal of this clinical trial is to investigate the efficacy and safety of temozolomide in SDH deficiency GIST patients.
- Trial name
- GIST (NCT05661643)
- Testing
- Temozolomide capsule
- Where
- South Korea
- Volunteers
- 29 people
- Sponsor
- Asan Medical Center
Chronic Subdural Hematoma, Subdural Hematoma
Non-Thermal Plasma to Reduce Recurrence in Chronic Subdural Hematoma
The goal of this randomized controlled trial is to evaluate whether the adjuvant application of non-thermal plasma (NTP) during standard surgical drainage of chronic subdural hematoma (cSDH) can reduce the recurrence rate at 6…
- Conditions
- Chronic Subdural Hematoma, Subdural Hematoma, Recurrence, Postoperative Complications
- Trial name
- NCT07656818
- Testing
- Standard Surgery Protocol, Non-Thermal Plasma
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Benjamín Gonzalo Rodríguez Méndez
Chronic Subdural Hematoma
Neuroendoscopy-assisted Drainage Versus Burr Hole Drainage for Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a frequent condition in neurosurgery, leading to fluid accumulation between the meninges, brain compression, neurological dysfunction, and potentially herniation.
- Trial name
- URANUS (NCT07144423)
- Testing
- Endoscope-assisted hematoma drainage, Burr hole hematoma drainage
- Where
- 24 sites in China
- Volunteers
- 770 people
- Sponsor
- Beijing Tiantan Hospital
Intraventricular Hemorrhage, Subarachnoid Hemorrhage
AFFECT Study for Patients With Intraventricular Hemorrhage, Subarachnoid Hemorrhage, Subdural Hematoma, and Ventriculitis
The goal of this clinical trial is to evaluate efficacy and safety of evacuation of cerebrospinal fluid, blood, and harmful bacteria from the intraventricular, subdural and subarachnoid spaces by Active Controlled Irrigation and…
- Conditions
- Intraventricular Hemorrhage, Subarachnoid Hemorrhage, Subdural Hematoma, Ventriculitis
- Trial name
- AFFECT (NCT05649904)
- Testing
- IRRAflow with Active Fluid Exchange System, External Ventricular Drain
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Ohio State University
GIST
A Study of Olverembatinib in SDH-deficient GIST.
An international multicenter, open, single-arm pivotal registration phase III study to determine the efficacy and safety of olverembatinib in patients with SDH-deficient gastrointestinal stromal tumor (GIST) who have previously…
- Trial name
- NCT06640361
- Testing
- Olverembatinib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ascentage Pharma Group Inc.
Hemorrhage, Intracranial Hemorrhages
Restarting Anticoagulation After Traumatic Intracranial Hemorrhage
Primary Objective: To identify the optimal interval to restart oral anticoagulation after traumatic intracranial hemorrhage that will minimize thrombotic events and major bleeding by performing a response adaptive randomized…
- Conditions
- Hemorrhage, Intracranial Hemorrhages, Bleeding, Trauma
- Trial name
- Restart tICrH (NCT04229758)
- Testing
- Anticoagulants
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- University of Texas at Austin
Trauma
Acute Subdural Hematoma
This retrospective data repository will serve as a means to aggregate and analyze standard surgical interventions and Middle Meningeal Arteryembolization as suitable treatment options for Acute Subdural Hematoma.
- Trial name
- NCT07490197
- Testing
- Medical/Phenotype Data Collection Procedures & Data to be Collected
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Methodist Health System
Chronic Subdural Hematoma
Middle Meningeal Artery Embolisation in Chronic Subdural Hematoma
This international multicenter study evaluates the efficacy and safety of middle meningeal artery embolization (MMAE) using PVA particles or liquid embolic agents as a perioperative treatment to prevent the recurrence of chronic…
- Trial name
- EMMA-CS (NCT07751887)
- Testing
- Middle Meningeal Artery Embolisation
- Where
- 6 sites in Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital Hradec Kralove
Chronic Subdural Hematoma
Efficacy of a Minimally Invasive Therapy Adjuvant to the Standards of Care by Cyanoacrylate Embolization
Chronic subdural hematomas (CSH) are collections of blood in the subdural space. CSH are becoming the most common cranial neurosurgical condition among adults, and a significant public health problem, due to an increasing use of…
- Trial name
- LEADH (NCT05374681)
- Testing
- Medical treatment, Surgical treatment, embolization of the MMA
- Where
- 11 sites in France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Brest
Chronic Subdural Hematoma, cSDH
Prospective Multi-center Single Arm Study for Subjects With Chronic Subdural Hematoma Treated With i-ED COILs, Either Alone or in Combination With Burr-holes or Mini-craniotomy
All participants will be asked to have a minimally invasive procedure for the treatment of chronic subdural hematoma, a blood clot on the brain.
- Conditions
- Chronic Subdural Hematoma, cSDH, Chronic Subdural Hematomas
- Trial name
- iCURE cSDH (NCT07214623)
- Testing
- Neuro endovascular embolic coil
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Kaneka Medical America LLC
Chronic Subdural Hematoma, Registry
Registry of Chronic Subdural Hematoma
The goal of this observational study is to better understand how chronic subdural hematoma (CSDH) progresses and how patients are treated and cared for. The study focuses on three main questions: 1.
- Trial name
- CSDH Registry (NCT06759428)
- Where
- 2 sites in Netherlands
- Volunteers
- 1,500 people
- Sponsor
- Erasmus Medical Center
Chronic Non-Traumatic Intracranial Subdural Haemorrhage
Non Traumatic Chronic Subdural Haematoma in Paediatric Age Groups, Management and Outcome
1-Review the management strategies and outcomes in cases of non traumatic chronic subdural haematoma in paediatric age group. 2- Review the underlying causes and risk factors in cases of non traumatic chronic subdural haematoma…
- Trial name
- NCT06743893
- Testing
- Diagnosis and outcome of non traumatic chronic subdural haematoma in pediatric age groups
- Volunteers
- 30 people
- Sponsor
- Assiut University
Subdural Hematoma
Scalp Block Versus General Anesthesia in Patients Undergoing Evacuation of Subdural Hematoma Via Burr Hole
this study amis to compare between Scalp block versus general anesthesia in patients undergoing evacuation of subdural hematoma via burr hole.
- Trial name
- NCT07143799
- Testing
- Cisatracurium, scalp block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Sohag University
Gastric Cancer, Gastric Neoplasm
Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis
Objective: To follow people with GISTs and collect tumor tissue so that it can be studied in the lab. Eligibility: People age 6 and older who have a GIST.
- Conditions
- Gastric Cancer, Gastric Neoplasm, Gastrointestinal Stromal Sarcoma, Gastrointestinal Stromal Neoplasm
- Trial name
- NCT04557969
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Cancer Institute (NCI)