Clinical trials: Subfertility
Obesity, Infertility
Reprometabolic Syndrome Mediates Subfertility in Obesity
Obesity plays an adverse role at every stage of conception and pregnancy and mounting evidence implicates relative hypogonadotropic hypogonadism, and reduced menstrual cycle hormone secretion as likely contributors to the…
- Conditions
- Obesity, Infertility, Hypogonadotropic Hypogonadotropism, Hyperinsulinemia
- Trial name
- NCT02653092
- Testing
- Insulin, Intralipid, Dextrose
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Environmental Exposure to Harmful Algae and Toxins, Female Subfertility
Analysis of Toxins in Follicle Fluid
Environmental pollutants might be jointly responsible for increase of infertility among women. Especially endocrin active substances seem to be of particular importance.
- Trial name
- NCT01385605
- Where
- Germany
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Infertility Treatment Center Dortmund
Intrauterine Abnormalities in Infertility
SIGnificance of Routine Hysteroscopy Prior to a First 'in Vitro Fertilization'(IVF) Treatment Cycle
BACKGROUND: Despite the numerous advances in the field of in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI), there still exists a maximum implantation rate per embryo transferred of about 30%.
- Trial name
- inSIGHT (NCT01242852)
- Testing
- Office hysteroscopy (in combination with a 'Saline Infusion Sonography'(SIS))
- Where
- Netherlands
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Subfertility, Infertility
Hysteroscopy Before in Vitro Fertilization - Does it Improve the Outcome?
By randomizing sub-fertile women to either control or office-hysteroscopy in the circle prior to IVF or ICSI (intracytoplasmatic sperm injection ) treatment, we aim to enlighten whether hysteroscopy with endometrial biopsy…
- Trial name
- NCT01743391
- Testing
- Office-hysteroscopy with biopsy
- Where
- Denmark
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Subfertility
Does Hormonal Luteal Support After Intra-uterine Insemination (IUI) Increase the Pregnancy Rate?
A randomized study to investigate if hormonal luteal support after intra-uterine insemination (IUI) in ovulation induction cycles with human menopausal gonadotropin increases the pregnancy rate
- Trial name
- NCT00700492
- Testing
- progesterone
- Where
- Belgium
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Subfertility
Predicting Ovarian Response in Artificial Insemination With Low Stimulation
This large prospective multi-center cohort study aims to identify patient's characteristics that significantly influence ovarian response to mild stimulation with a fixed dose of 75 IU recombinant FSH.
- Trial name
- NCT01662180
- Testing
- Follicle Stimulating Hormone
- Where
- 7 sites in Netherlands
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Isala
Subfertility
Hormonal Stimulation in IUI Treatment: Is Clomifen Combined With Ethinyl Estradiol Better, Worse or Equal to Menopur
What is the best medication for hormonal stimulation in cycles with high intra-uterine insemination: tablets of Clomifen (5 days) followed by tablets of Ethinyl Estradiol (5 days) or daily injections with Human Menopausal…
- Trial name
- NCT01569945
- Testing
- Clomifen, Ethinyl Estradiol, Menotropins
- Where
- Belgium
- Volunteers
- 371 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Infertility
What is the Best Preparation for Embryo Transfer in Cryo Cycles: a Natural Cycle or Light Hormonal Stimulation?
The study investigates if, among women with a regular cycle (between 25 and 45 days), the endometrium is better prepared for the transfer of an embryo that was cryopreserved and if the subsequent embryo implantation rate is…
- Trial name
- NCT00492934
- Testing
- human menopausal gonadotrophins
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Subfertility, Female
Effect of Sildenafil Citrate Compared to Estrogen as Adjuvant Therapy for Unexplained Infertility
. This study aimed to determine and compare the effect of vaginal sildenafil citrate and estradiol valerate on endometrial thickness, blood flow and pregnancy rates in infertile women.
- Trial name
- NCT05753098
- Testing
- estrogen therapy, Sildenafil, Clomiphene Citrate 50mg
- Where
- Egypt
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Infertility, Reproductive Sterility
Does in Vivo Culture of Pre-cleavage Stage Embryo Reduce the Incidence of Aneuploidy?
This Clinical Study has been designed to assess and compare the impact of in vitro or in vivo culture conditions on the euploidy of sibling blastocysts.
- Trial name
- NCT02652143
- Testing
- AneVivo (Medical device for in vivo culture of embryos), comparator for embryo culture in vitro
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Anecova SA
Subfertility
Why Subfertile Couples Drop Out
Dropout rates for fertility treatments are high. This study will examine the rate of patients that drop out during any type of subfertility work up or treatment.
- Trial name
- DOT (NCT02302781)
- Testing
- Questionnaires
- Where
- 7 sites in Netherlands
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Isala
Ovarian Failure, Thyroid Diseases
Thyroid Function and Autoimmunity in Subfertility Women and Assisted Reproductive Therapy
The assessment of ovarian reserve is well established based on the dosage of anti-Mullerian hormone (AMH). The clinical applicability of detecting thyroid autoantibodies levels has been discussed as a potential marker of…
- Trial name
- NCT06394466
- Testing
- Non Applicable
- Where
- Brazil
- Volunteers
- 453 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Male Subfertility
Role of Immunoglobulin in Male Infertility
to investigate the role of IVIG in male infertility and to determine its benefits in term of semen parameters and assisted reproduction outcome
- Trial name
- NCT06423989
- Testing
- IVIG
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Dr Salma kafeel Qureshi
Adenomyosis of Uterus
Association of Ultrasound Features of the Myometrium Suggestive of Adenomyosis and Clinical Symptoms
The goal of this study/research is to assess the relationship between ultrasound features of the myometrium suggestive of adenomyosis and clinical symptoms of adenomyosis and to establish a reporting system for adenomyosis…
- Trial name
- MUSA3 (NCT07397715)
- Where
- 5 sites in Belgium, Poland and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Swiss GO Trial Group
Endometritis; Chronic, Subfertility
The FLORA-project: in Search for the Microbial Cause of Chronic Endometritis and the Most Appropriate Treatment to Obtain a Successful Pregnancy IVF/ICSI
Chronic endometritis is an inflammatory condition of the endometrium. This inflammation can negatively affect fertility and pregnancy. The pathology is frequently (+-10%) observed in women with fertility problems.
- Trial name
- FLORA (NCT05337072)
- Testing
- Microbiome study
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Hyperprolactinemia, Subfertility
Hyperprolactinaemia Management in Reproductive Services at University Hospital of Coventry and Warwickshire
Hyperprolactinaemia and thyroid disorders can significantly reduce fertility by causing ovulatory dysfunction. There is no evidence to suggest treatment of hyperprolactinaemia in the presence of regular ovulatory menstruation…
- Conditions
- Hyperprolactinemia, Subfertility, Subclinical hypothyroïdism
- Trial name
- NCT03569787
- Testing
- MRI Pituitary
- Where
- United Kingdom
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Subfertility
Preimplantation Genetic Testing for Aneuploidy of Polar Bodies
This study intends to randomly group the patients with advanced maternal age and poor ovarian response, and the study group will undergo polar body biopsy, and the next-generation sequencing(NGS) technology will be used to…
- Trial name
- NCT04538560
- Testing
- polar body biopsy
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Fertility, Male, Sub-Fertility, Male
Study of the Consumer Use of a New Home Test to Measure Sperm Concentration
The objective of the study is to evaluate the agreement in measurement of sperm concentration in human semen between lay users with TRAK and a recognized reference method.
- Trial name
- NCT02475395
- Testing
- TRAK device
- Where
- 3 sites in United States
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Sandstone Diagnostics
Metabolic Syndrome X, Infertility
Female Subfertility: a Metabolic and Vascular Profile
Introduction: Overall, 10 - 15% of couples seek specialist help once in their lives when a spontaneous pregnancy does not occur.
- Trial name
- NCT02136472
- Where
- Netherlands
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Infertility, Subfertility
The Microbiome in Subfertility and Assisted Reproductive Technologies (ART)
To assess the impact of the female genital microbiome on ART outcome.
- Trial name
- NCT03105453
- Testing
- 3 Sampling points
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel