Clinical trials: Subjective Cognitive Complaints, open to volunteers
Subjective Cognitive Decline (SCD), Subjective Cognitive Complaints (SCCs)
The Signature of Alzheimer's Disease in Subjective Cognitive Decline
This study focuses on improving early detection of Alzheimer's disease (AD) in patients with subjective cognitive decline (SCD), a preclinical stage of cognitive impairment, in the context of emerging disease-modifying therapies…
- Conditions
- Subjective Cognitive Decline (SCD), Subjective Cognitive Complaints (SCCs), Subjective Cognitive Impairment, Subjective Cognitive Concerns
- Trial name
- SIGN-AL (NCT07402161)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Policlinico S. Donato
Prodromal Alzheimer's Disease, Mild Cognitive Impairment
The Digital Memory Notebook
Compensatory aids (e.g., alarms, calendars) play an important supporting role when completing everyday tasks (e.g., appointments, medication management), and there is a growing body of scientific work suggesting that compensatory…
- Conditions
- Prodromal Alzheimer's Disease, Mild Cognitive Impairment, Subjective Cognitive Complaints
- Trial name
- DMN (NCT04240665)
- Testing
- Digital Memory Notebook (DMN) Application
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Davis
Mild Cognitive Impairment (MCI), Subjective Cognitive Complaints (SCCs)
EARLY-COGN^3 - Smart Digital Solutions for EARLY Treatment of COGnitive Disability: a Neuropsychological, Neurophysiological and Neurobiological Perspective in Chronic Neurological Diseases - PNRR-MCNT2-2023-12377069
The increase in life expectancy in recent decades has led to a large number of people living into old age and an increased risk of developing Chronic Neurological Diseases (CNDs) such as neurodegenerative diseases.
- Conditions
- Mild Cognitive Impairment (MCI), Subjective Cognitive Complaints (SCCs), Parkinson Disease
- Trial name
- EARLY-COGN^3 (NCT06657274)
- Testing
- RICORDO-DTx, Home-based unstructured cognitive stimulation
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Mild Cognitive Impairment (MCI), Subjective Memory Complaint
Validation of a Digital Intervention to Rehabilitate Cognitive Resources
The goal of this clinical trial is to learn if the use of a digital cognitive rehabilitation system named RICORDO, that is flexible and capable of adapting the rehabilitation pathway according to the needs and capacity of the…
- Conditions
- Mild Cognitive Impairment (MCI), Subjective Memory Complaint, Dementia Alzheimer Type
- Trial name
- MI-RICORDO (NCT07064226)
- Testing
- RICORDO, Treatment as Usual (TAU)
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Subjective Cognitive Impairment
A Study Evaluating the Impact of P-tau217 Blood Biomarker Testing on Early Evaluation and Management of Patients Presenting With Cognitive Complaint
The purpose of the study is to measure the difference in the proportion of participants with prespecified patient management actions between a tested interventional group and a control group.
- Trial name
- NCT07140744
- Testing
- P-tau217, Standard of Care
- Where
- United States
- Volunteers
- 7,000 people
- Sponsor
- Eli Lilly and Company
Perimenopause, Subjective Cognitive Complaints
Exercise in Perimenopause to Improve Cognitive Health
Perimenopause is now considered a possible risk factor for dementia and may contribute to the fact that 2/3 of those living with Alzheimer's disease are females.
- Trial name
- EPIC (NCT07272174)
- Testing
- Progressive Resistance Training, Balance, Flexibility, and Tone Exercises
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cognitive Decline
ADL+2.0: Intervention for Prevention of Cognitive Decline in Community-dwelling Older Adults
Singapore's rising dementia incidence with an ageing population presents an urgent need for effective interventions that delay or prevent cognitive decline.
- Trial name
- ADL+ 2 (NCT07141160)
- Testing
- Combined: Mobile app + 6WELLS, Remote mobile based app
- Where
- Singapore
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Mild Cognitive Impairment, Memory Disorders
Prospective Research on Identification of Dementia in Early Stages (P.R.I.D.E)
PRIDE Study - Brief Summary The PRIDE Study (Prospective Research on Identification of Dementia in Early Stages) is a multicenter, prospective, observational study designed to estimate the prevalence of Mild Cognitive Impairment…
- Conditions
- Mild Cognitive Impairment, Memory Disorders, Dementia
- Trial name
- PRIDE (NCT07918638)
- Volunteers
- 1,000 people
- Sponsor
- Don Mottola Medical Center
Hippocampal Hyperactivation, Prodromal Alzheimer Disease
Levetiracetam for Persons at Risk for Alzheimer's Disease
The goal of this clinical trial is to investigate whether very small doses of a drug called levetiracetam (LEV) may reduce elevated brain signaling in individuals who are at an increased risk for developing Alzheimer's Disease…
- Trial name
- ALEVIATE-2 (NCT07477431)
- Testing
- Levetiracetam (LEV)
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Sunnybrook Health Sciences Centre
Subjective Cognitive Complaints (SCCs), Sleep
Personalized Assessment of High-definition Slow-oscillatory Transcranial Direct Current Stimulation (So-tDCS) in Older Adults With Subjective Cognitive and Sleep Complaints
Background: Subjective cognitive decline (SCD) is considered to be the early risk stage of dementia. Untreated SCD comorbid with sleep disturbances may accelerate the progression of neurodegeneration (β-amyloid and tau) and lead…
- Trial name
- NCT07433738
- Testing
- so-tDCS
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Subjective Cognitive Complaints, Ehlers-Danlos Syndrome
COG+OT Telerehabilitation for Adults With Subjective Cognitive Complaints
This pilot study will evaluate a comprehensive cognitive assessment approach and personalized neurocognitive telerehabilitation intervention for adults with subjective cognitive complaints (SCC).
- Conditions
- Subjective Cognitive Complaints, Ehlers-Danlos Syndrome, Cognitive Dysfunction
- Trial name
- CogSCC (NCT07743229)
- Testing
- COG+OT Telerehabilitation
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Medical University of South Carolina
Parkinson Disease (PD)
Idiopathic Parkinson's Disease: Interest of an Early Group-Based Cognitive Rehabilitation Program (LIFECOG-PD)
Current pharmacological treatments have not demonstrated significant improvement in cognitive impairment in Parkinson's disease (PD).
- Trial name
- LIFECOG-PD (NCT07813156)
- Testing
- cognitive rehabilitation program
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand
Insomnia
Online COgnitive Behavioural Therapy for Sleep and Mental Health for Older Adults With Insomnia and Subjective Cognitive Complaints
The goal of this randomized controlled clinical trial is to assess a novel cognitive-behavioral program for sleep and mental health using a multidomain web platform (eCBTi+) in participants with insomnia and subjective cognitive…
- Trial name
- e-COSMOS (NCT06032377)
- Testing
- cognitive behavioral therapy for sleep, anxiety, and depression, education about healthy nutrition habits and communication in older age
- Where
- 2 sites in Canada
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Active Aging Individuals Aged 65 and Over, Aging
Italian Validation of the dNA Scale and Its Correlation With Neurocognitive Variables
The goal of this experimental multicentric intervention study is to validate, in Italian, the dynamic Neurocognitive Adaptation (dNA) Scale, which has already been validated in English, among a healthy elderly population (aged 65…
- Conditions
- Active Aging Individuals Aged 65 and Over, Aging, Mild Cognitive Impairment (MCI), Dementia
- Trial name
- NCT07533084
- Where
- 8 sites in Italy
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS