Clinical trials: Subjective Cognitive Impairment
Subjective Memory Complaint
Lifestyle Remodeling in Subjective Memory Complaint (SMC): Brain Imaging and Blood Biochemistry Study
The specific study aims: 1. To investigate whether the brain function is affected by the past life experiences, such as lifestyle and physiology-related factors in SMC. 2.
- Trial name
- NCT04162990
- Testing
- Lifestyle remodeling Intervention, Does Comparator: regular treatment
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Presbycusis, Tinnitus
Effects of Huperzine a on Presbycusis(Δ,kHz, DB,MMSE, AD)
To investigate the effects of huperzine A on tinnitus suppression, hearing and cognitive function protection in patients with presbycusis-related subjective tinnitus and cognitive impairment.
- Conditions
- Presbycusis, Tinnitus, Cognitive Impairment
- Trial name
- NCT03101722
- Testing
- BTHE and Huperzine A, BETH
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhijun Bao
Mild Cognitive Impairment (MCI), Subjective Cognitive Decrease (SCD)
A Graphene Far-infrared Intervention Study of Cognitive Status in Older Adults
This study is a 4-week group controlled trial to explore whether graphene far-infrared intervention can improve the cognitive status of older adults presenting with symptoms of Subjective Cognitive Decline (SCD), Mild Cognitive…
- Conditions
- Mild Cognitive Impairment (MCI), Subjective Cognitive Decrease (SCD), Alzheimer's Disease(AD), Depression/Anxiety Symptoms
- Trial name
- NCT06843824
- Testing
- a custom-made graphene therapy cap, A regular cap that generates heat
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Institute of Psychology, Chinese Academy of Sciences
Subjective Cognitive Decline
Effects of Individualized Theta-tACS on a Working Memory Training at SCD
The aim of the study is to investigate the effects and mechanisms of action of an individualized transcranial alternating current stimulation in the theta-range (ITF-tACS) on a three day spatial working memory training in healthy…
- Trial name
- tACOSenior (NCT06501755)
- Testing
- transcranial alternating current stimulation (tACS)
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Subjective Cognitive Decline (SCD), Subjective Cognitive Impairment
Testing the Cog-Fun Aging Program for Older Adults With Subjective Cognitive Decline
The goal of this clinical trial is to learn if the Cog-Fun Aging program helps older adults with Subjective Cognitive Decline (SCD) manage memory challenges and improve their daily lives.
- Conditions
- Subjective Cognitive Decline (SCD), Subjective Cognitive Impairment, Subjective Memory Complaints
- Trial name
- NCT06816797
- Testing
- Cog Fun Ageing intervention, Cog-Fun Aging Crossover
- Where
- 3 sites in Israel
- Volunteers
- 27 people
- Sponsor
- Hebrew University of Jerusalem
MCI, Subjective Cognitive Decline (SCD)
FACE Phase II (a Stage II Trial)
How to ensure adherence to computerized cognitive training in unsupervised circumstances (e.g., at-home, self-administered) in older adults at risk for Alzheimer's disease (AD) or AD related dementia (AD/ADRD) is understudied.
- Conditions
- MCI, Subjective Cognitive Decline (SCD), Mild Behavioral Impairment
- Trial name
- NCT07130669
- Testing
- Cognitive Remediation, Cognitive Remediation II
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stanford University
Mild Cognitive Impairment
Curcumin and Yoga Therapy for Those at Risk for Alzheimer's Disease
Physical exercise has proven to improve memory including in the elderly. Drugs developed to stop the underlying disease processes that cause Alzheimer's disease may succeed only with multimodal efforts to stimulate brain…
- Trial name
- NCT01811381
- Testing
- Curcumin, aerobic yoga, non aerobic yoga
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment, Randomized Controlled Trial
Effects of a Computerised Cognitive Stimulation Versus Stimulating Leisure Activities
The aim of the study is to evaluate, at the level of global cognition, cognitive neuroconstructs, memory, verbal fluency, ADLs, IADLs, symptoms of depression and anxiety, the effectiveness of a personalised and adapted…
- Conditions
- Mild Cognitive Impairment, Randomized Controlled Trial, Subjective Cognitive Impairment
- Trial name
- NCT06058611
- Testing
- Cognitive stimulation, Stimulating leisure activities
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Subjective Cognitive Decline
Gut-brain Health Effects of PREbiotics in Older Adults With Suspected COgnitive DEcline
As people around the world are living longer, the number of individuals with dementia, particularly Alzheimer's disease (AD), is expected to triple by 2050.
- Trial name
- PRECODE (NCT06433037)
- Testing
- Chicory inulin, Resistant dextrin, Seaweed polysaccharide
- Where
- Netherlands
- Volunteers
- 164 people
- Sponsor
- Wageningen University
Alzheimer Disease, Mild Cognitive Impairment
Blood Tests for Alzheimer's Disease: Can Plasma Biomarkers Diagnose and Predict Disease Progression
BLAD is a prospective, monocentric, observational epidemiological study with an additional procedure (annual blood draw) evaluating the diagnostic and prognostic performance of plasma biomarkers for Alzheimer's disease (AD) in a…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Subjective Cognitive Decline, Dementia
- Trial name
- BLAD (NCT07717567)
- Testing
- Annual blood draw for plasma biomarker measurement
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- IRCCS San Raffaele
Alzheimer Disease, Cognitive Impairment
Feasibility and Efficacy of Dietary Interventions for Older Adults With Subjective Cognitive Decline
This study aims to assess if/how dietary interventions (i.e., the Modified Atkins Diet (MAD) and/or the Mediterranean-Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND)) might prevent…
- Trial name
- NCT03585907
- Testing
- MAD, MIND
- Sponsor
- Johns Hopkins University
Cognitive Decline, Mild, Cognition Disorders in Old Age
Effects of Wearable Sensor-based Interactive Cognitive-motor Training in Older Adults.
Based on research showing that cognitive-motor training programs help improve cognition in older adults with mild cognitive impairment, this program uses an interactive system to combine cognitive training with exercise.
- Conditions
- Cognitive Decline, Mild, Cognition Disorders in Old Age, Subjective Memory Decline
- Trial name
- NCT05983913
- Testing
- cognitive-motor training, cognition training
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Sahmyook University
Non-Pharmacological Interventions
Applied Research on a Non-pharmacological Intervention Program for Older Adults With Subjective Cognitive Decline
This study aims to verify the short-term and long-term effects of a group-based non-pharmacological intervention program for community-dwelling older adults with subjective cognitive decline, and to evaluate its implementation…
- Trial name
- NCT07629531
- Testing
- non-pharmacological interventions, Waiting List
- Volunteers
- 218 people
- Sponsor
- China Medical University, China
Dementia, Alzheimer Dementia (AD)
Fuzhou Aging Brain Health Initiative
The goal of this observational study is to learn about the pathophysiological characterization and evolutionary patterns of Alzheimer's disease (AD) in older adults in Fujian Province, China.
- Conditions
- Dementia, Alzheimer Dementia (AD), Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
- Trial name
- FAITH (NCT07891429)
- Testing
- Fluids biomarker and neuroimaging of AD diagnosis
- Where
- 4 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Subjective Cognitive Decline
Effects of Online Training Aimed at Increasing Participation in Everyday Life During a Pandemic (SCD Online).
This study evaluates the efficacy of Real-World Strategy Training (RWST) compared to a psycho-education workshop for improving everyday life performance in older adults with subjective cognitive decline (SCD).
- Trial name
- NCT04439500
- Testing
- Real World Strategy Training, Brain Education
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Baycrest
Aging, Cognitive Decline
Evaluation of the Online Memory & Aging Program and Online Goal Management Training
The current study is designed to test the effectiveness of online programs for memory and executive functions in healthy aging. The investigators are testing online adaptations of two cognitive interventions that have been…
- Trial name
- NCT03602768
- Testing
- Goal Management Training, Memory & Aging Program, Cambridge Brain Sciences
- Where
- Canada
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Baycrest
Cognitive Enhancement, Subjective Cognitive Decline (SCD)
The Efficacy of an IADL-based Non-immersive Virtual Reality Training Program to Enhance ADL Performance and Cognitive Function for Persons at Risk of Dementia
The goal of this clinical trial is to learn if a touchscreen-based virtual reality (VR) training program that simulates everyday life tasks works to improve daily living skills and thinking abilities in adults aged 50 and older…
- Conditions
- Cognitive Enhancement, Subjective Cognitive Decline (SCD), Mild Cognitive Impairmen
- Trial name
- NCT07895979
- Testing
- Daily Life VR Training, Non-Conditional Game VR Training, Traditional Cognitive Training
- Where
- Taiwan
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Dementia
The Effects of Music on ANS and Anxiety in Healthy Elderly and Persons With SCD
Subjective cognition decline (SCD) is considered as a risk factor of dementia and associates not only with further cognition deterioration but with a higher anxiety level.
- Trial name
- NCT04177160
- Testing
- Music, White noise
- Where
- Taiwan
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Subjective Cognitive Decline
REducing the Risk of COgnitive DEcline ad Dementia in Patients With Subjective Cognitive Decline Through an Immersive Virtual Reality and Telemedicine-based Multi-component Intervention: the SCD-ReCODED Study
Older adults with subjective cognitive decline (SCD) are at high risk of developing dementia and frequently experience subclinical symptoms (e.g., anxiety, depression) which are themselves associated with dementia and cognitive…
- Trial name
- SCD-ReCODED (NCT06429215)
- Testing
- Multi-component Intervention (MC-I): VR Cognitive training and Psychoeducation on health and lifestyle, Cognitive-only intervention (CO-I): VR Cognitive training (+ Psychoeducation active control), Active control intervention (AC-I): VR Cognitive active control + Psychoeducation active control
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
MCI, SCD
Effects of the Fully Immersive VR Cognitive Training Based on Leisure Activities for the Elderly With MCI and SCD.
Mild cognitive impairment (MCI) and subjective cognitive decline (SCD) are risk groups for dementia, and thus appropriate interventions are required.
- Conditions
- MCI, SCD, Virtual Reality
- Trial name
- NCT04779671
- Testing
- VR cognitive training, Traditional cognitive training
- Where
- Taiwan
- Volunteers
- 190 people
- Sponsor
- Chang Gung Memorial Hospital