Clinical trials: Submassive Pulmonary Embolism
Acute Pulmonary Embolism, Thromboembolism
SYMPHONY-PE Study for Treatment of Pulmonary Embolism
Evaluation of the Safety and Efficacy of the Symphony Thrombectomy System in the Treatment of Pulmonary Embolism
- Conditions
- Acute Pulmonary Embolism, Thromboembolism, Emboli, Pulmonary, Thrombosis
- Trial name
- NCT06062329
- Testing
- Symphony Thrombectomy System
- Where
- 19 sites in United States
- Volunteers
- 110 people
- Sponsor
- Imperative Care, Inc.
Pulmonary Embolism, Pulmonary Hypertension
Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE
To determine whether peripheral low dose systemic thrombolysis (PLST) is non-inferior to catheter directed acoustic pulse thrombolysis (ACDT) in improving RV function and reducing pulmonary artery pressures in submassive…
- Conditions
- Pulmonary Embolism, Pulmonary Hypertension, Thromboembolism, Right Ventricular Dysfunction
- Trial name
- NCT03581877
- Testing
- Alteplase, EKOS
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Northwell Health
Pulmonary Embolism, Acute Pulmonary Embolism
Submassive and Massive Pulmonary Embolism Treatment With Ultrasound Accelerated Thrombolysis Therapy
The purpose of this study is to determine if the EKOS EkoSonic® Endovascular Device when used in conjunction with recombinant tissue plasminogen activator (t-PA) as a treatment for acute PE will decrease the ratio of right…
- Conditions
- Pulmonary Embolism, Acute Pulmonary Embolism, Sub-massive Pulmonary Embolism, Massive Pulmonary Embolism
- Trial name
- SEATTLE II (NCT01513759)
- Testing
- recombinant tissue plasminogen activator, EKOS EkoSonic Endovascular System
- Where
- 22 sites in United States
- Volunteers
- 150 people
- Sponsor
- Boston Scientific Corporation
Pulmonary Embolism
Diclofenac for Submassive PE
The primary objective is to demonstrate the clinical benefits of diclofenac (added to standard anticoagulant therapy) over placebo in normotensive patients with acute symptomatic pulmonary embolism and right ventricular…
- Trial name
- AINEP-1 (NCT01590342)
- Testing
- Diclofenac
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Ministry of Health, Spain
Pulmonary Embolism, Pulmonary Thromboembolism
Recombinant Streptokinase Versus Urokinase in Pulmonary Embolism in China (RESUPEC)
Recombinant streptokinase (r-SK) is an effective thrombolytic agent developed with gene engineering. Its characteristics of high output and low production cost make it affordable in treating acute myocardial infarction (AMI) in…
- Trial name
- RESUPEC (NCT00968929)
- Testing
- Recombinant Streptokinase, Urokinase
- Where
- 8 sites in China
- Volunteers
- 83 people
- Sponsor
- Beijing Chao Yang Hospital
Submassive Pulmonary Embolism
ULTRAsound-assisted Catheter vs. STAndaRd Catheter Thrombolysis for Submassive Pulmonary Embolism
Acute pulmonary embolism (PE) accounts for 5-10% of in-hospital deaths. Systemic anticoagulation (AC) is the standard of care and thrombolysis is recommended for those at a higher mortality risk.
- Trial name
- UltraStar sPE (NCT03389971)
- Testing
- catheter-directed thrombolysis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Piedmont Healthcare
Pulmonary Embolism, Pulmonary Embolism Subacute Massive
Effect of iNO in Patients With Submassive and Massive PE
A single center study to evaluate the effect of inhaled nitric oxide (iNO) on pulmonary dynamics in patients presenting with imaging confirmed intermediate/submassive or massive pulmonary embolism (PE).
- Trial name
- NCT04996667
- Testing
- inhaled nitric oxide (iNO)
- Where
- United States
- Sponsor
- University of California, Los Angeles
Pulmonary Embolism
tPA by Endovascular Administration for the Treatment of Submassive PE Using CDT for the Reduction of Thrombus Burden
To demonstrate the efficacy and safety of the Bashir™ Endovascular Catheter for the administration of pharmaco-mechanical catheter directed therapy using low dose r-tPA for the treatment of acute submassive pulmonary embolism.
- Trial name
- RESCUE (NCT04248868)
- Testing
- The Bashir™ Endovascular Catheter, r-tPA
- Where
- 19 sites in United States
- Volunteers
- 109 people
- Sponsor
- Thrombolex, Inc.
Pulmonary Embolism and Thrombosis
Optimum Duration of Acoustic Pulse Thrombolysis Procedure in Acute Pulmonary Embolism
The objective is to determine the optimum dose of thrombolytic and duration of the ultrasound procedure (together defined as the APT Procedure) as a treatment for acute submassive pulmonary embolism (PE).
- Trial name
- OPTALYSE PE (NCT02396758)
- Testing
- Ekosonic® Endovascular Device ultrasonic infusion catheter, Recombinant tissue plasminogen activator
- Where
- 21 sites in United States, United Kingdom
- Volunteers
- 131 people
- Sponsor
- Boston Scientific Corporation
Pulmonary Embolism, Acute Pulmonary Embolism
FlowTriever Pulmonary Embolectomy Clinical Study
Evaluate the safety and effectiveness of the FlowTriever System for use in the removal of emboli from the pulmonary arteries in the treatment of acute pulmonary embolism.
- Conditions
- Pulmonary Embolism, Acute Pulmonary Embolism, Submassive Pulmonary Embolism, Massive Pulmonary Embolism
- Trial name
- FLARE (NCT02692586)
- Testing
- FlowTriever System
- Where
- 18 sites in United States
- Volunteers
- 106 people
- Sponsor
- Inari Medical
Pulmonary Embolism, Thrombotic Disease
Study to Assess the Safety, Pharmacokinetics/Dynamics of DS-1040b in Subjects With Acute Submassive Pulmonary Embolism
This is a Phase 1b, double-blind (participants and Investigators), placebo-controlled, randomized, single-ascending dose, multi-center study to assess the safety, efficacy, tolerability, pharmacokinetics (PK), and…
- Trial name
- NCT02923115
- Testing
- DS-1040b, Enoxaparin
- Where
- 46 sites in United States, Austria and 6 more
- Volunteers
- 134 people
- Sponsor
- Daiichi Sankyo
Pulmonary Embolism
Standard vs. Ultrasound-assisted Catheter Thrombolysis for Submassive Pulmonary Embolism
The study will compare standard catheter directed thrombolysis to ultrasound accelerated thrombolysis for the treatment of acute submassive pulmonary embolism (PE).
- Trial name
- SUNSET sPE (NCT02758574)
- Testing
- CDT without ultrasound acceleration, CDT with ultrasound acceleration
- Where
- 4 sites in United States
- Volunteers
- 77 people
- Sponsor
- University of Pittsburgh
Pulmonary Embolism
Treatment of Low-Risk Submassive Pulmonary Embolism With FlowTriever
This study is focused on investigating the efficacy and safety of the FlowTriever device to treat low-risk submassive pulmonary embolism.
- Trial name
- NCT05273762
- Testing
- FlowTriever
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Submassive Pulmonary Embolism
Long Term Effects of Treating Submassive Pulmonary Embolism With Ultra-sound Accelerated Thrombolysis
Patients with Submassive Pulmonary Embolism treated with ultra-sound therapy will have an improved right ventricular function 72 hours post treatment.
- Trial name
- SPEAR (NCT01899339)
- Testing
- submassive PA treatment with Ekosonic endo device
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Corewell Health West
Thrombolytic Therapy, Thrombolysis
Submassive Pulmonary Embolism Experience With EKOS
This single site study evaluates the efficacy of ultrasound accelerated thrombolysis using EKOS Endovascular Device with a standard infusion of thrombolytics for treatment of PE
- Conditions
- Thrombolytic Therapy, Thrombolysis, Mechanical Thrombolysis, Pulmonary Embolism
- Trial name
- SPEEK (NCT02926742)
- Testing
- EkoSonic Endovascular System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Krishna Mannava, MD, FACS, RPVI
Cardiovascular Diseases
Standard vs Ultrasound-assisted Catheter Thrombolysis for Submassive Pulmonary Embolism
The study is an investigator-initiated trial comparing two different catheters (standard versus ultrasound assisted) for the treatment of acute high risk pulmonary embolism (blood clots in lung arteries with evidence or heart…
- Trial name
- NCT03086317
- Testing
- Standard Catheter-Directed Thrombolysis, Ultrasound-Accelerated Thrombolysis
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Emory University
Submassive Pulmonary Embolism
ULTrasound Accelerated ThrombolysIs of PulMonAry Embolism
The ULTIMA study is intended to prove that in patients with pulmonary embolism and a right ventricular end diastolic diameter to left ventricular end diastolic diameter ratio ≥1 (RV/LV ratio) will benefit from treatment with…
- Trial name
- ULTIMA (NCT01166997)
- Testing
- EkoSonic Endovascular System, Unfractionated heparin
- Where
- 10 sites in Germany, Switzerland
- Volunteers
- 59 people
- Sponsor
- Boston Scientific Corporation
Submassive Pulmonary Embolism
Adjuvant Treatment of Pulmonary Embolism With Drotrecogin Alfa (Activated): Phase II Exploratory Study
An exploratory, multicenter, randomized, placebo-controlled, double blind, dose escalation study comparing a standard therapy for submassive pulmonary embolism (Enoxaparin sodium) to a combined therapy of Drotrecogin alfa…
- Trial name
- NCT00191724
- Testing
- Drotrecogin Alfa (Activated), Enoxaparin
- Where
- Germany
- Volunteers
- 47 people
- Sponsor
- Eli Lilly and Company
Acute Submassive Pulmonary Embolism
The RESCUE II Study. The Bashir™ Endovascular Catheter (BEC),
To demonstrate the efficacy and safety of the Bashir™ Endovascular Catheter for the administration of pharmaco-mechanical catheter directed therapy using pulse spray of r-tPA for the treatment of acute submassive pulmonary…
- Trial name
- NCT06120179
- Testing
- The Bashir™ Endovascular Catheter (BEC
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Temple University
Pulmonary Embolism
Comparison of Thrombgolytic and Anticoagulation Therapy in Submassive Pulmonary Embolism
Currently there is no clear guidance for the treatment of moderate risk of pulmonary embolism. The aim of the study is to compare two different therapeutic modalities - standard anticoagulation versus thrombolytic treatment…
- Trial name
- CONTACT-SPE (NCT02132689)
- Testing
- Actilyse (Thrombolytic therapy), Heparine (Standard anticoagulation therapy)
- Where
- 2 sites in Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Ostrava