Clinical trials: Submucosal Tumor of Gastrointestinal Tract
Early Gastric Cancer, Gastric Adenoma
Performance of Endoscopic Submucosal Dissection According to the Sedation Method
Although proper sedation is mandatory for endoscopic procedures such as endoscopic submucosal dissection, the effects of sedation on ESD performance and complications have not been fully evaluated.
- Trial name
- NCT01806753
- Testing
- Intermittent midazolam/propofol injection controlled by endoscopist, Continuous propofol infusion with opioid administration
- Where
- South Korea
- Volunteers
- 157 people
- Sponsor
- Yonsei University
Pancreatic Cyst, Pancreatic Neoplasms
Clinical Registry of nCLE in Masses and Cystic Tumors of the Pancreas, Lymph Nodes, Submucosal Lesions of the GI Tract
This study focuses on four different lesions: pancreatic cysts, lymph nodes near the gastrointestinal tract, pancreatic masses and GIST tumors.
- Conditions
- Pancreatic Cyst, Pancreatic Neoplasms, Pancreatic Adenoma, Pancreatic Cancer
- Trial name
- US-nCLE (NCT01770405)
- Testing
- Endoscopic ultrasound fine needle aspiration
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Mauna Kea Technologies
Early Rectal Cancer, Large Rectal Adenomas
Endoscopic Submucosal Dissection Versus Transanal Endoscopic Microsurgery For Early Rectal Neoplasms And Large Rectal Adenomas: Сomparison Of Treatment Efficacy And Safety.
Transanal endoscopic microsurgery is the main treatment option for rectal tumors such as large adenoma, early cancer because of lower complications and mortality rates and shorter hospital stays rather than conventional surgery.
- Trial name
- NCT03718351
- Testing
- transanal endoscopic microsurgery, endoscopic submucosal dissection
- Where
- Russia
- Volunteers
- 236 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Gastric Neoplasm
The Effect of Perioperative Intravenous Magnesium on Pain After Endoscopic Submucosal Dissection for Gastric Neoplasm: Prospective Randomized Double-blind Placebo Controlled Study
Endoscopic submucosal dissection (ESD) is an effective treatment for early gastric cancer or premalignant lesions in the stomach.
- Trial name
- NCT02235246
- Testing
- Magnesium Sulfate, Normal saline
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Early Gastric Cancer, Gastric Dysplasia
Esomeprazole Plus Sucralfate for Post-ESD Ulcer Healing
Endoscopic submucosal dissection (ESD) is an established treatment for early gastric cancer and precancerous lesions. Post-ESD artificial ulcers may lead to complications including delayed bleeding (3-15%) and prolonged healing.
- Conditions
- Early Gastric Cancer, Gastric Dysplasia, Gastric Neoplasms, Peptic Ulcer With Haemorrhage
- Trial name
- NCT07312370
- Testing
- Esomeprazole (Intravenous), Esomeprazole (Oral), Sucralfate Suspension
- Where
- China
- Volunteers
- 120 people
- Sponsor
- LanZhou University
Barrett's Esophagus, Intestinal Dysplasia
Endoscopic Sub-mucosal Dissection With the Nestis® Jet Injector System With a Bi-functional Catheter: First Prospective Trial
ESD (Endoscopic Sub-mucosal Dissection)is the first-intent method to treat superficial neoplasms of the digestive tract at it allows an en-bloc R0 resection.
- Conditions
- Barrett's Esophagus, Intestinal Dysplasia, Esophageal Dysplasia, Colorectal Neoplasms
- Trial name
- NESTIS (NCT01913223)
- Testing
- Nestis® jet injector system with a bi-functional catheter
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Hospices Civils de Lyon
Esophageal Carcinoma in Situ AJCC V7
A Comparative Study of Endoscopic Submucosal Dissection and Photodynamic Therapy for Early Esophageal Cancer
The purpose of this study was to compare the efficacy and safety of Photodynamic therapy (PDT) and Endoscopic submucosal (ESD) dissection in the treatment of early esophageal cancer.
- Trial name
- NCT05208775
- Testing
- PDT, ESD
- Volunteers
- 46 people
- Sponsor
- The First Affiliated Hospital of Henan University of Science and Technology
Duodenal Adenoma, Duodenal Carcinoma
Analysis of Long-term Outcomes of Endoscopic Resection of Duodenal and Ampullary Mucosal and Submucosal Lesions
Mucosal and submucosal lesions of the duodenum represent a diverse group of pathologies, ranging from benign adenomas to lesions with significant malignant potential.
- Conditions
- Duodenal Adenoma, Duodenal Carcinoma, Papillary Adenoma, Papillary Adenocarcinoma
- Trial name
- DuoP-ER (NCT07781137)
- Where
- Australia
- Volunteers
- 1,000 people
- Sponsor
- Western Sydney Local Health District
Esophageal Stricture, Endoscopic Submucosal Dissection
Local Triamcinolone Injection Combined With Fibrin Glue Spray in Preventing Esophageal Stricture After Big-range Endoscopic Submucosal Dissection for Esophageal Early Cancer
Endoscopic submucosal dissection (ESD) is the main treatment for esophageal early cancer. But post-ESD stricture has a serious impact on quality of life.When the lesion range reaches up to 3/4 circumferential mucosal defect or…
- Conditions
- Esophageal Stricture, Endoscopic Submucosal Dissection, Early Esophageal Cancer or Precancerous Lesions Treated With Endoscopic Resection
- Trial name
- NCT06840561
- Testing
- Local triamcinolone injection combined with fibrin glue spray
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-Sen University Cancer Center
Esophageal Cancer
Comparison of Esophagectomy and Chemoradiation for Patients With cN0-pT1b Stage Esophageal Squamous Cell Carcinoma
The ad-ESD trial is phase III randomized trial to compare adjuvant esophagectomy and chemoradiation for patients with clinical stage N0 and pathological stage T1b squamous cell carcinoma (after endoscopic submucosal dissection).
- Trial name
- NCT04135664
- Testing
- esophagectomy, chemoradiation, active surveillance
- Where
- 6 sites in China
- Volunteers
- 176 people
- Sponsor
- Shanghai Chest Hospital
Gastrointestinal Neoplasms, Gastric Cancer
Endoscopic Submucosal Dissection Registry
The purpose of this study is to monitor the success rates and completion rates for endoscopic submucosal dissection (ESD) for gastrointestinal (GI) cancers.
- Trial name
- ESD Registry (NCT01415609)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Mayo Clinic
Stomach Cancer, Undifferentiated Type
Comparison of Endoscopic Resection and Surgery for Early Gastric Cancer With Undifferentiated Histological Type
This multi-center, randomized controlled trial is designed to evaluate clinical effectiveness and cost-effectiveness of ESD for undifferentiated type of EGC meeting the expanded indication compared with surgery.
- Conditions
- Stomach Cancer, Undifferentiated Type, Expanded Indication of Endoscopic Resection
- Trial name
- ERASE-GC (NCT04890171)
- Testing
- Endoscopic submucosal dissection, Surgery
- Where
- South Korea
- Volunteers
- 708 people
- Sponsor
- National Cancer Center, Korea
Endoscopic Submucosal Dissection, Gastric Neoplasm
Learning Curve for Gastric Endoscopic Submucosal Dissection
Endoscopic submucosal dissection (ESD) for early gastric cancer is a widely accepted treatment option of expanded indication worldwide.
- Trial name
- NCT05265221
- Testing
- Endoscopic submucosal dissection
- Where
- South Korea
- Volunteers
- 356 people
- Sponsor
- Soonchunhyang University Hospital
Gastrointestinal Neoplasms
EUS-Endodrill vs. EUS-FNA for Diagnosis of Submucosal Tumors in the Upper GI Tract
Endodrill is a new instrument for biopsy sampling in the GI-channel. The purpose of this study is as follows: Compare EUS-guided Endodrill biopsies with endoscopic ultrasound guided fine needle aspiration (EUS-FNA) in terms of…
- Trial name
- NCT02744651
- Testing
- EUS-FNA, EUS-Endodrill biopsy
- Where
- Sweden
- Volunteers
- 4 people
- Sponsor
- Region Skane
Esophagus Cancer, Radiotherapy
A Clinical Study of Non-curative Resection Plus Radiotherapy After Endoscopic ESD for Superficial Esophageal Squamous Cell Carcinoma
The goal of observational study is to learn about the outcomes of the participants. The main questions it aims to answer are: 1.
- Conditions
- Esophagus Cancer, Radiotherapy, Endoscopic Mucosal Resection
- Trial name
- NCT06160557
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xiaomeng Zheng
Gastrointestinal Neoplasm
Prospective Cohort Study on the Safety and Efficacy of Endorobotics for Endoscopic Submucosal Dissection (Endorobotics ESD)
This trial is a prospective, single arm study of 30 patients recruited to undergo endoscopic submucosal dissection (ESD) with a novel robotic assisted technology.
- Trial name
- NCT06726798
- Testing
- Endoscopic submucosal dissection with EndoRobotics traction device
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Early Gastric Cancer
Endoscopic Submucosal Dissection Versus Gastrectomy
Gastrectomy is curative treatment for early gastric cancer (EGC). Recently, endoscopic submucosal dissection (ESD) has been accepted as standard treatment in selected patients with negligible risk of lymph node metastasis.
- Trial name
- NCT02216110
- Testing
- Surgery
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Soonchunhyang University Hospital
Pancreatic Disease, Pancreatic Cancer
EUS Examination Using EndoSound Vision System vs. Standard Echoendoscope
This is a randomized trial to compare the standard echoendoscope with the newly developed EndoSound Visual System in the evaluation of lesions in the gastrointestinal tract.
- Conditions
- Pancreatic Disease, Pancreatic Cancer, Pancreatic Cyst, Gastrointestinal Tumor
- Trial name
- NCT06340620
- Testing
- Endoscopic ultrasound examination
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Orlando Health, Inc.
Gastric Adenoma, Gastric Cancer
Efficacy of Bispectral Index Monitoring for Midazolam and Meperidine Induced Sedation During Endoscopic Submucosal Dissection
Background: Endoscopic submucosal dissection (ESD) usually requires adequate level of sedation due to lengthy and uncomfortable procedure.
- Trial name
- NCT01157598
- Testing
- bispectral index monitoring
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Samsung Medical Center
Early Gastric Cancer
Monitored Anesthesia Care With Propofol Plus Remifentanil During Endoscopic Submucosal Dissection: Evaluation of Bispectral Index Monitoring
There are clinical usefulness issues associated with bispectral index (BIS) for sedation of endoscopic submucosal dissection (ESD). However, the clinical usefulness of BIS for deep sedation is incompletely described.
- Trial name
- NCT01921283
- Testing
- BIS sensor attachment, no- BIS sensor attachment
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Yonsei University