Clinical trials: Submucosal Tumor of Gastrointestinal Tract
Early Gastric Cancer
Monitored Anesthesia Care With Propofol Plus Remifentanil During Endoscopic Submucosal Dissection: Evaluation of Bispectral Index Monitoring
There are clinical usefulness issues associated with bispectral index (BIS) for sedation of endoscopic submucosal dissection (ESD). However, the clinical usefulness of BIS for deep sedation is incompletely described.
- Trial name
- NCT01921283
- Testing
- BIS sensor attachment, no- BIS sensor attachment
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Yonsei University
Colorectal Neoplasm, Endoscopic Mucosal Resection
ESD for Colorectal LSL Using a Selective Strategy - a Prospective Cohort Study
Colonic Laterally spreading lesions (LSL) => 20mm are at high risk to progress to cancer. Overt stigmata of submucosal invasive cancer (SMIC) has been well characterized and includes ulceration and surface pit pattern changes as…
- Trial name
- COVERT (NCT04008407)
- Testing
- Endoscopic Submucosal Dissection, Endoscopic Mucosal Resection
- Where
- Australia
- Volunteers
- 391 people
- Sponsor
- Western Sydney Local Health District
Colorectal Tumor
Transanal Tube Drainage in Endoscopic Submucosal Dissection of the Colorectal Tumor
We design the clincal trial to investigate the efficacy of transanal tube drainage in colorectal ESD.
- Trial name
- NCT02973490
- Testing
- Transanal Tube Drainage
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Fudan University
Esophageal Cancer
Submucosal Saline Injection Followed by Endoscopic Ultrasound
Endoscopic ultrasound (EUS) is unsatisfactory in distinguishing between T1a and T1b stage esophageal squamous cell carcinoma (ESCC).
- Trial name
- EUS-SSI (NCT06022978)
- Testing
- Submucosal Saline Injection, Blue laser Imaging and Magnifying Endoscopy
- Where
- China
- Volunteers
- 432 people
- Sponsor
- Sun Yat-sen University
Esophageal Squamous Cell Carcinoma (ESCC), High-Grade Intraepithelial Neoplasia
Clinical Application of an AI-based Dissection Trajectory Prediction System (ADTPS) in Endoscopic Submucosal Dissection
In this prospective paired diagnostic study and single-center, randomized controlled trial, patients with early esophageal squamous neoplasia or high-grade intraepithelial neoplasia meeting the inclusion and exclusion criteria…
- Conditions
- Esophageal Squamous Cell Carcinoma (ESCC), High-Grade Intraepithelial Neoplasia, AI-Based Dissection Trajectory Prediction System
- Trial name
- NCT07757906
- Testing
- AI-based Dissection Trajectory Prediction System (ADTPS), Conventional ESD Procedure
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Qilu Hospital of Shandong University
Gastrointestinal Neoplasms, Achalasia
ConMed Beamer Study
This is a prospective registry of all patients who endoscopic submucosal dissection (ESD), per-oral endoscopic myotomy (POEM) and gastric per-oral endoscopic myotomy (G-POEM) using ConMed Electrosurgical unit for submucosal…
- Conditions
- Gastrointestinal Neoplasms, Achalasia, Gastroparesis
- Trial name
- NCT04752670
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Baylor College of Medicine
Colorectal Neoplasms, Colonic Polyps
A Novel Clinical Decision Support Tool to Predict Submucosal Invasive Cancer Within Large Non-Pedunculated Colorectal Polyps
Colorectal cancer can be effectively prevented by removal of pre-malignant polyps during colonoscopy. Large (>=20mm) non-pedunculated colorectal polyps (LNPCPs) require careful assessment before treatment.
- Trial name
- NCT07705880
- Where
- Belgium
- Volunteers
- 886 people
- Sponsor
- University Hospital, Ghent
Endoscopic Submucosal Dissection, Colorectal Neoplasms
Early Feeding Versus Delayed Feeding After Colorectal Endoscopic Submucosal Dissection
Currently, there are no clear guidelines regarding the optimal timing for dietary restart after gastrointestinal endoscopic submucosal dissection (ESD).
- Trial name
- NCT06805123
- Testing
- Early feeding, Late feeding
- Where
- 5 sites in South Korea
- Volunteers
- 204 people
- Sponsor
- Pusan National University Hospital
Colorectal Cancer
Personalized Medicine in Early Stage Colorectal Cancer: Organ Preservation and Immune Benefit
The overall aim of this study is to determine whether the Immunoscore associated with histopathological features of endoscopically resected stage T1 colorectal tumors is predictive of locoregional lymph node invasion, in order to…
- Trial name
- COLOSAVE (NCT06251726)
- Testing
- Immunoscore Colon Test
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastric Cancer
Magnetic Anchoring Guided Endoscopic Submucosal Dissection for Early Gastric Caner
This study uses magnetic anchored guidance system to treat early gastric cancer by endoscopic mucosal dissection to test the advantages of magnetically anchored guidance system for surgical field exposure during endoscopic…
- Trial name
- MAGESD (NCT04327050)
- Testing
- Magnetic anchored guided endoscopic submucosal dissection
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Early Gastric Cancer, Endoscopic Submucosal Dissection
The Relationship Between Scar Formation and ESD Depth in Therapy for Gastric Carcinoma
This study is a single-center, prospective, group-controlled clinical trial, aiming to clarify the relationship between the depth of dissection and scar formation in the treatment of early gastric cancer by ESD, and to provide…
- Trial name
- NCT05323929
- Testing
- ESD
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Esophageal Neoplasm, Esophageal Polyp
Monopolar and Bipolar in Esophageal ESD
The objective of this study is to prospectively document the efficacy and clinical outcomes of Endoscopic Submucosal Dissection procedure that utilize either a novel Bipolar-Current ESD device or the standard monopolar…
- Conditions
- Esophageal Neoplasm, Esophageal Polyp, Endoscopic Submucosal Dissection, Bipolar Electocautery
- Trial name
- NCT05736705
- Testing
- Endoscopic Submucosal Dissection, Bipolar electrocautery knife
- Where
- United States
- Sponsor
- Baylor College of Medicine
Esophageal Squamous Cell Neoplasm
RFA to Prevent Metachronous Squamous Neoplasia Recurrence After Complete Endoscopic Submucosal Dissection
Esophageal cancer is a highly lethal disease, and its incidence is still increasing in the world. Recent advances in image-enhanced techniques such as Lugol chromoendoscopy and narrow band imaging, the number of patients with…
- Trial name
- NCT03183115
- Testing
- Radiofrequency ablation, Endoscopy, Lugol's Solution (1.5%)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- E-DA Hospital
Gastrointestinal Neoplasia, Hirschsprung's Disease
Prospective Evaluation of the Efficacy and Safety of Submucosal Endoscopy
To test the idea that submucosal endoscopy is effective and safe for endoscopic myotomy, endoscopic submucosal dissection, and access for tissue acquisition and resection.
- Conditions
- Gastrointestinal Neoplasia, Hirschsprung's Disease, Esophageal Obstruction, Gastroparesis
- Trial name
- NCT03626350
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Colorado, Denver
Early Gastric Cancer
A Clinical Trial to Evaluate the Sensitivity and Specificity of "WAYMED Endo" Compared to the Endoscopists in Classifying Early Gastric Cancer (EGC) Based on the Depth of Invasion in Endoscopic Images
The purpose of this clinical trial is to prove that the prediction capability of 'WAYMED endo' is superior to that of the endoscopists in classifying EGC based on the depth of invasion categories in gastro-endoscopic images.
- Trial name
- NCT06317103
- Testing
- WADYMED endo, Control group (the endoscopists)
- Where
- South Korea
- Volunteers
- 653 people
- Sponsor
- WAYCEN Inc
Gastric Neoplasm
Use of Lidocaine in Endoscopic Submucosal Dissection
The primary purpose of this study is to investigate the effects of lidocaine on the total administered dose of fentanyl during sedation for endoscopic mucosal resection.
- Trial name
- NCT02543411
- Testing
- Lidocaine 1%, Normal saline
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Severance Hospital
Esophageal Cancer
Comparison of Esophagectomy and Chemoradiation for Patients With cN0-pT1b Stage Esophageal Squamous Cell Carcinoma
The ad-ESD trial is phase III randomized trial to compare adjuvant esophagectomy and chemoradiation for patients with clinical stage N0 and pathological stage T1b squamous cell carcinoma (after endoscopic submucosal dissection).
- Trial name
- NCT04135664
- Testing
- esophagectomy, chemoradiation, active surveillance
- Where
- 6 sites in China
- Volunteers
- 176 people
- Sponsor
- Shanghai Chest Hospital
Esophageal Squamous Cell Carcinoma
Cytosponge in Surveillance After Endoscopic Submucosal Dissection for Esophageal Squamous Cell Carcinoma
cytosponge has good diagnostic efficacy in the diagnosis of esophageal cancer, and is more safe, economic and comfortable. It is expected to replace gastroscope in the surveillance after endoscopic submucosal dissection to a…
- Trial name
- NCT06429865
- Testing
- cytosponge
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Changhai Hospital