Clinical trials: Substance Abuse Disorders
Drug-withdrawal., Drug Abuse
Clinical Studies on the Therapeutic Effects of Mirtazapine on Drug-craving in Cocaine Addicts.
INTRODUCTION. One of the main problems of the treatment of cocaine-dependent patients is the high rate of relapses occurs within the first months after detoxification.
- Conditions
- Drug-withdrawal., Drug Abuse, Drug-induced Depressive State, AOD Craving
- Trial name
- MADC (NCT01949571)
- Testing
- Mirtazapine (REMERON, Schering-Plough-Organon)
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Opioid Abuse, Prescription Opioid Abuse
Community Pharmacy-Based Prescription Drug Monitoring Program Opioid Risk Assessment Tool
This goal of this observational study is to develop and test the Opioid Risk Reduction Clinical Decision Support (ORRCDS) tool. The tool will be an opioid medication risk screener and decision support platform that will be used…
- Trial name
- PharmTool (NCT05706311)
- Testing
- Clinical Decision Support Tool (Moderate Risk), Clinical Decision Support Tool (High Risk), Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Utah
Autism, Autism Spectrum Disorder
NTI164 in Autism Spectrum Disorder
This is a double-blind, randomised, placebo-controlled study investigating the efficacy of a full-spectrum medicinal cannabis plant extract on core and associated ASD symptoms over placebo.
- Conditions
- Autism, Autism Spectrum Disorder, Autism Disorder
- Trial name
- Beyond Harmony (NCT07257939)
- Testing
- NTI164
- Where
- 3 sites in Australia
- Volunteers
- 200 people
- Sponsor
- Fenix Innovation Group
Cocaine Dependence
Striatal Effective Connectivity to Predict Treatment Response in Cocaine Misuse
This project proposes to investigate the role of brain connectivity in the mechanism of treatment response to dopaminergic medications in cocaine dependence.
- Trial name
- NCT02080819
- Testing
- levodopa/carbidopa 400/100 BID
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Alcoholism
Examination of Zinc, S-adenosylmethionine, and Combination Therapy Versus Placebo in Alcoholics
This is a randomized, placebo controlled trial of dietary zinc and S-adenosylmethionine (SAMe) in otherwise healthy alcoholic US Veterans.
- Trial name
- ExZACTO (NCT01899521)
- Testing
- Bronchoscopy, Zinc sulfate 220 mg once daily, S-adenosylmethionine 400 mg twice daily
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- VA Office of Research and Development
Alcohol Dependence, Alcohol Interaction
Clinical Trial to Evaluate the Safety of PT150 (Formerly ORG34517) When it is Taken Concurrently With Alcohol
The purpose of the clinical study is to compare pharmacodynamic and safety endpoints following an alcohol challenge prior to and concurrent with PT150 (study drug) treatment.
- Trial name
- NCT03548714
- Testing
- PT150, Beverage
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Pop Test Oncology LLC
Alcoholic Intoxication
Emergency Department (ED) Triage of Alcohol Abuse
Retrospective study of adult patients (> 16 y) admitted to Geneva University Hospitals with alcohol abuse. Triage criteria will be reviewed. Patients characteristics and patient flow in the ED will be described.
- Trial name
- NCT02449772
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 775 people
- Sponsor
- University Hospital, Geneva
Marijuana Abuse
Treatment for Adolescent Marijuana Abuse
Marijuana remains the most prevalent illicit substance used by adolescents and the number of adolescents receiving treatment for marijuana abuse more than tripled during the last decade.
- Trial name
- NCT00580671
- Testing
- MET/CBT, CM, BPT
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Drug Abuse, Genotoxicity
Effect of Folic Acid on the Presentation of Nuclear Abnormalities in People With a History Drug Abuse
Background: Multiple studies have pointed to the harmful potential of licit and illicit drugs. as agents associated with neoplastic processes and other non-communicable diseases, for which reason It has become a problem of global…
- Trial name
- NCT05712044
- Testing
- Folic Acid 5 MG
- Where
- Mexico
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centro Universitario de Tonalá
Cannabis Dependence
Fixed or Self-Titrated Dosages of Sativex on Cannabis Users
The purpose of this study is to to demonstrate the feasibility and tolerability of the use of Sativex in cannabis dependent individuals and to assess the effects of fixed or self titrated dosages of SATIVEX®…
- Trial name
- NCT01748799
- Testing
- Sativex
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Centre for Addiction and Mental Health
Opioid Sensitivity, Individual Difference
A118G SNP and OPRM1 Gene Opioid-Mediated Effects in Humans
Within-subject, double-blind, placebo-controlled examination of opioid abuse potential in healthy individuals as a function of A118G SNP on the OPRM1 gene.
- Conditions
- Opioid Sensitivity, Individual Difference, Abuse Opioids
- Trial name
- NCT02360371
- Testing
- Within-subject test of blinded study medication
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Attention Deficit Hyperactivity Disorder (ADHD)
Experimental Medicine in ADHD - Cannabinoids
Adult patients with ADHD commonly report an improvement in behavioural symptoms when using cannabis with some reporting a preference towards cannabis over their ADHD stimulant medication.
- Trial name
- EMA-C (NCT02249299)
- Testing
- Sativex Oromucosal Spray
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College London
Substance Dependency, Addiction
Working Memory Training for Substance Dependent Individuals
Background: Substance abusers show impaired working memory (WM) functioning. Promising findings show training WM results in an improved working memory capacity (WMC) and a decrease of clinical symptoms in a range of disorders…
- Conditions
- Substance Dependency, Addiction, Anxiety, Depression
- Trial name
- NCT02119949
- Testing
- Working memory training
- Where
- Netherlands
- Volunteers
- 180 people
- Sponsor
- Erasmus Medical Center
Substance Abuse, Intravenous, Prevention and Control
Break the Cycle: Prevention for Reducing Initiation Into Injection Drug Use
Break the Cycle is a two-session, one-on-one, in-person intervention study designed to reduce the role persons who inject drugs (PWID) play initiating non-PWID into injection drug use.
- Trial name
- NCT03502525
- Testing
- Break the Cycle Intervention, Bacterial Infection Prevention
- Where
- 2 sites in United States, Estonia
- Volunteers
- 402 people
- Sponsor
- New York University
Drug Abuse
A First Study in Healthy Volunteers of a New Mobile Phone Application Measuring the Eyes Before and After Medication
This is a pre-market, explorative, early feasibility, pilot, controlled clinical investigation designed to collect initial clinical data on the medical device Previct Drugs.
- Trial name
- NCT05731999
- Testing
- Previct Drugs
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Kontigo Care AB
Alcohol Abuse
Brief Intervention for Families of Teens Treated in the Emergency Department for an Alcohol-Related Event
The purpose of this study is to compare the effectiveness of a brief family intervention in reducing alcohol use and alcohol-related problems among families of underage drinkers (13-17 years old) who are treated in a hospital…
- Trial name
- NCT00247221
- Testing
- MI/Family Check-up, MI only
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Brown University
Depression, Substance-Related Disorders
Treatment of Comorbid Depression and Substance Abuse in Young People
This study aims to treat young people with an adjunctive integrated cognitive behavioral therapy (CBT) intervention and to examine the acceptability of this treatment approach within this population.
- Trial name
- NCT00232284
- Testing
- sertraline, Cognitive Behavioural Therapy
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Dan Lubman
Alcoholic Liver Disease, Alcoholic Fibrosis of Liver
Early Detection of Alcoholic Liver Disease
This is an observational study to identify the prevalence of advanced liver fibrosis among patients with excessive alcohol intake using a non-invasive method (FibroScan®) and to characterize the main environmental, genetic and…
- Conditions
- Alcoholic Liver Disease, Alcoholic Fibrosis of Liver, Alcoholic Cirrhosis, Excessive Drinking
- Trial name
- NCT04070508
- Sponsor
- University of Pittsburgh
Psychosis, Cannabis Use
Cannabis Potency Effects on Brain White Matter in Early Phase Psychosis
Canada reports some of the highest rates of cannabis use in our youth and young adult populations, among all the developed countries.
- Trial name
- NCT07001878
- Testing
- Metformin
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- Nova Scotia Health Authority
Drug Addiction
Importance of Drug User Detection
1. Identify the illicit drugs (morphine, cannabinoids, benzodiazepines, barbiturates, tramadol, cocaine, amphetamine, alcohol, synthetic cannabinoids). 2.
- Trial name
- NCT05803044
- Volunteers
- 200 people
- Sponsor
- Assiut University
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