Clinical trials: Substance Addiction, open to volunteers
Nicotine Addiction, Craving
Advancing VR-based Attentional Bias as a Biomarker for Tobacco Use Disorder
The proposed project will include enrollment of 200 daily tobacco cigarette users, ages 22+, from the San Diego community. Participants will be assessed on the VR Nicotine Cue Exposure paradigm then randomized (stratified on age…
- Trial name
- VR (NCT06582888)
- Testing
- Varenicline Tartrate
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Diego
Addiction, Addiction Disorders
Can Selfcompassion Training Reduce Alcohol Consumption in Patients With Alcohol Use Disosrder ?
The objective of this interventional study is to evaluate the effectiveness of the Mindful Self-Compassion (MSC) program in reducing alcohol consumption in a population of individuals with Alcohol Use Disorder (AUD), six months…
- Conditions
- Addiction, Addiction Disorders, Alcohol Use Disorders, Alcohol Dependence
- Trial name
- COMPAL (NCT07131124)
- Testing
- Mindful Self-Compassion program, Treatment As Usual (TAU) program
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Etablissement Public de Santé Barthélemy Durand
Substance Use Disorder (SUD), mHealth
Connecting Loved Ones to Support and Empowering Recovery
Substance use disorders are highly prevalent. However, recovery from them is possible. The recovery process can benefit greatly from support from loved ones.
- Trial name
- Project Closer (NCT07740395)
- Testing
- KulaMind-Recovery
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Addiction, Addiction Disorders
Evaluation of the ADD'Pro Vocational Reintegration Program (ADD-PRO-EVAL)
The goal of this clinical trial is to evaluate whether an integrated medico-psychosocial vocational support program (ADD'Pro) can improve employment outcomes in adults with substance use disorders receiving care at a specialized…
- Conditions
- Addiction, Addiction Disorders, Substance Use Recovery, Return to Work
- Trial name
- ADD-PRO-EVAL (NCT07520617)
- Testing
- ADD'Pro Program, Standard Care (in control arm)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Substance-Related Disorders
The Road to Recovery Initiative (R2RI)
Despite substance use causing significant harms and cost to our health care system, British Columbia's (BC) current addiction treatment system remains under-resourced and fragmented.
- Trial name
- R2RI (NCT06639373)
- Testing
- Specialized clinical service access
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- BC Centre on Substance Use
Alcohol Use Disorder, Cognition Disorders
Influence of Individual Traits on Adaptation Processes in Individuals With Alcohol Use Disorder
Alcohol Use Disorder (AUD) is a chronic condition that affects behavior, decision-making, and the ability to adapt to changing situations.
- Trial name
- TIPA (NCT07468825)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Substance-Related Disorders, Treatment Adherence
Motivational Interviewing at Intake vs Intake as Usual on Client Engagement in Addiction Treatment
This K23 study is an effectiveness-implementation hybrid type I design to determine the effectiveness of Motivational Interviewing at Intake (MII), relative to intake-as-usual on client engagement and mechanisms of engagement…
- Trial name
- NCT05489068
- Testing
- Motivational Interviewing at Intake (MII), Intake as Usual (IAU)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of New Mexico
Alcohol Dependence
High-dose Accelerated Theta Burst Stimulation for the Treatment of Alcohol Addiction
This is a two-arm randomized placebo-controlled trial in which 72 patients with alcohol addiction are treated with high-dose accelerated intermittent theta burst stimulation (TBS).
- Trial name
- TBA (NCT05738174)
- Testing
- high-dose accelerated intermittent theta burst stimulation
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- Berthold Langguth, MD, Ph.D.
Tobacco Use Disorder
Increasing Smoking Cessation Success Through Sleep-amplified Memory Consolidation
The goal of this subproject is to examine the hypothesized improvement of treatment with chess-based training and sleep enhancement, both together and on their own, in smokers.
- Trial name
- NCT05726045
- Testing
- Standard smoking cessation program (SCP), Cognitive remediation treatment (CRT), High-intensity interval training (HIIT evening)
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Nicotine Addiction
Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches
The goal of this study is to assess the effects of nicotine concentration and its interplay with pH on sensory experience, product appeal, and abuse liability of NPs among young adults NP users.
- Trial name
- NCT07165808
- Testing
- Nicotine pouch: Low dose, Nicotine pouch: High dose, Low pH
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Emory University
Addiction
Efficacy of a Smartphone App. Designed to Manage Craving & Individual Predictors of Substance Use/Addictive Behavior
Test the Efficacy of a smartphone application designed to manage craving and individual predictors of substance use / addictive behavior among individuals with addictive disorders
- Trial name
- CRAVINGMANAGER (NCT04732676)
- Testing
- Smartphone application
- Where
- France
- Volunteers
- 274 people
- Sponsor
- Centre Hospitalier Charles Perrens, Bordeaux
Alcohol Use Disorder
Deep Brain Stimulation to Understand and Treat Addiction
This study is testing whether deep brain stimulation (DBS) can safely help people with severe alcohol use disorder who have not improved with standard treatments.
- Trial name
- Brain-PACER (NCT07341230)
- Testing
- Dual-Target Deep Brain Stimulation, Nucleus Accumbens Deep Brain Stimulation, Ventral Internal Capsule Deep Brain Stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Cambridge
Nicotine Dependance, Serious Mental Illness
Evaluation of Community Health Worker Support to Help People With Serious Mental Illness to Quit Smoking
The purpose of this study is to learn whether providing additional smoking cessation support through specially trained members of behavioral healthcare team helps people quit smoking and improve their health.
- Conditions
- Nicotine Dependance, Serious Mental Illness, Smoking (Tobacco) Addiction, Tobacco Cessation
- Trial name
- NCT07789132
- Testing
- Integrated CHW Support intervention, Enhanced usual care (EUC)
- Where
- United States
- Volunteers
- 937 people
- Sponsor
- Massachusetts General Hospital
Drug Addiction
The Health of Women Monitored in the Addiction Department of the Strasbourg University Hospitals
The health of women suffering from addiction is little known and little explored in the literature. Indeed, they represent only 20% of addicted patients in general and are encountered primarily during pregnancy or complex…
- Trial name
- Santé-Fem (NCT07033728)
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Strasbourg, France
Opioid-use Disorder
Smartphones for Opiate Addiction Recovery
Treatments for opioid addiction exist, but effectiveness is compromised when subjects use illicit opiates during treatment. Reuse rates during treatment can be high, and reducing illicit opiate use during treatment has thus…
- Trial name
- SOAR (NCT05033028)
- Testing
- Smartphone app
- Where
- 2 sites in United States
- Volunteers
- 225 people
- Sponsor
- NYU Langone Health
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Substance Use, Harm Reduction
A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students
The primary goal of this study is to test the effectiveness of the iDECIDE (Drug Education Curriculum: Intervention, Diversion, and Empowerment) curriculum, a novel drug education and diversion program, in approximately 300…
- Conditions
- Substance Use, Harm Reduction, Adolescent Behavior
- Trial name
- NCT06115746
- Testing
- iDECIDE
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Community Reinforcement And Family Training, Family Health
Phase II: Scalable Digital Delivery of CRAFT Training for Professionals to Maximize Treatment Rates of OUD in Families
The goal of this project is to demonstrate digital training efficacy at scale and commercial readiness. This pilot project will advance piloted digital training programs for CRAFT and maximize scalability.
- Conditions
- Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
- Trial name
- NCT06685003
- Testing
- Digital Tutorial overview, Digital Tutorial plus training Materials, Digital Tutorial plus training Materials plus feedback and Coaching
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- We The Village, Inc.
Opioid Use Disorder, Chronic Pain
Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine
Chronic pain is common in individuals with opioid use disorder (OUD) and the first-line treatment, Medication for OUD (MOUD), does not address the considerable functional impairments associated with chronic pain.
- Trial name
- NCT07361432
- Testing
- Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT), Enhanced Treatment as Usual (ETAU)
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- VA Office of Research and Development
Cannabis Use, Cannabis Dependence
Neuroimaging of Adolescent Cannabis Use Treatment
This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use.
- Conditions
- Cannabis Use, Cannabis Dependence, Cannabis Use Disorder, Cannabis Abuse
- Trial name
- ACT (NCT07340554)
- Testing
- Contingency Management, Elastic Net Regression
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Indiana University