Clinical trials: Substance Dependence
Anxiety Disorders, Anxiety
Personalized Feedback for Smokers With Elevated Anxiety Sensitivity
This project will develop and refine a computer-delivered integrated Personalized Feedback Intervention (PFI) that directly addresses smoking and anxiety sensitivity (AS).
- Conditions
- Anxiety Disorders, Anxiety, Tobacco Dependence, Smoking, Cigarette
- Trial name
- NCT03382093
- Testing
- Personalized Feedback Intervention, Smoking Information Control
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Houston
HIV-1-infection, Hepatitis C, Chronic
Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy in Patients With HIV-HCV Co-Infected Subjects on Opioid Substitution Therapy
The study hypothesis is to determine the feasibility of switching HIV-HCV co-infected patients receiving methadone or buprenorphine/naloxone as opioid substitution therapy with suppressed HIV RNA viral load on current…
- Conditions
- HIV-1-infection, Hepatitis C, Chronic, Methadone Dependence, Opioid Dependence
- Trial name
- NCT03549312
- Testing
- Genvoya, Epclusa, Biktarvy
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder
Prevalence of smoking among individuals with opioid use disorder (OUD) is six-fold that of the general US adult population. The mortality rate of opioid-dependent smokers is four times that of opioid-dependent nonsmokers, and…
- Trial name
- NCT04092101
- Testing
- Cigarettes with varying nicotine content, E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Opioid Abuse (Disorder), Opioid Analgesia
Reducing Opioid Use After Upper Extremity Surgery: Testing Lower Prescriptions and Pill Quantity
The goal of this clinical trial is to evaluate strategies for optimizing postoperative multimodal pain regimens and reducing opioid dependency in patients undergoing upper extremity surgery.
- Conditions
- Opioid Abuse (Disorder), Opioid Analgesia, Opioid Analgesic Adverse Reaction, Opioid Consumption
- Trial name
- NCT07750639
- Testing
- Naproxen, Acetaminophen, oxycodone
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Tobacco Dependence
The Interplay Between Addiction to Tobacco Smoking and Sleep Quality Among Healthy Adults
Tobacco smoking is a major health problem, leading to considerable morbidity and mortality due to cancer, impaired pulmonary function, and cardiovascular diseases.
- Trial name
- NCT04265339
- Testing
- Smoking cessation
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Max Stern Academic College Of Emek Yezreel
Nicotine Dependence, Nicotine Withdrawal
Progesterone and Brain Imaging Study
Male and female smokers were recruited to undergo 2 phases of smoking cessation. Each phase was 4 days long and involved 3 brain-imaging scans, blood draws and an intervention involving progesterone or a matched placebo.
- Trial name
- NCT01954966
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tobacco Dependence, Tobacco Smoking
Smoke-free Home Study in Subsidized Housing
Comprehensive smoke-free policies have the potential to substantially reduce tobacco-related disparities among populations in subsidized housing.
- Trial name
- NCT06170437
- Testing
- Smoke-free home resident intervention, Lay Health Worker coaching
- Where
- United States
- Volunteers
- 544 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Dependence, Alcohol Abuse
Community Reinforcement and Family Training (CRAFT) for Treatment-resistant Individuals With Alcohol Use Disorders
The present study examines the efficacy of the Community Reinforcement and Family Training (CRAFT) for Concerned Significant Others (CSOs) of individuals with alcohol use disorders (AUDs) using a randomized waiting list (WL)…
- Trial name
- CRAFT (NCT02112396)
- Testing
- Community Reinforcement and Family Training
- Where
- Germany
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Luebeck
HIV Infections, Drug Abuse
Disulfiram Interactions With HIV Medications: Clinical Implications
The purpose of this study is to determine whether disulfiram might be a safe and effective treatment for cocaine and/or alcohol dependence in patients with HIV disease.
- Trial name
- NCT00878306
- Testing
- Disulfiram, Disulfiram + Efavirenz, Disulfiram + Atazanavir
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Dysfunctional Breathing, Physical Activity
Prevalence and Association of Dysfunctional Breathing With Nicotine Dependence and Physical Activity Among Young Smokers
We will structure the study's summary to provide a clear and accessible overview for patients, families, and healthcare providers.
- Conditions
- Dysfunctional Breathing, Physical Activity, Nicotine Dependence
- Trial name
- NCT07843524
- Testing
- Observational evaluation.
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Istinye University
Nicotine Dependence, Depression
Vigorous Exercise for Depressed Smokers
In this project the investigators will develop and pilot test a supervised, vigorous intensity exercise intervention for depressed female smokers.
- Trial name
- NCT01860924
- Testing
- exercise, health education
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tobacco Use Disorder
Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers
This study will examine extended exposure to cigarettes varying in nicotine content among adults with opioid use disorder. Those with opioid use disorder are at increased risk for smoking, nicotine dependence, and using high…
- Trial name
- P2S2 (NCT02250664)
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Heroin Dependence, Opioid-Related Disorders
Counseling Conditions for Buprenorphine in a Primary Care Clinic - 1
The purpose of this study is to compare the Standard Medical Management (SMM) vs. SMM enhanced with additional education about addiction and recovery (Enhanced Medical Management, EMM)
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
- Trial name
- NCT00023283
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Cigarette Smoking, Nicotine Dependence
Comparison of Internet Stop Smoking Intervention to Usual Care on Smoking Cessation at 6 Months
The primary goal of this project is to carry out a randomized controlled trial (RCT) comparing quit rates of a Spanish/English stop smoking Web site to those of a no-intervention or "quit on your own" control.
- Trial name
- TC5Redes (NCT01639079)
- Testing
- Internet Smoking Cessation Web Site
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nicotine Dependence, Nicotine Addiction
A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults
Almost one in ten young adults report current e-cigarette use, putting them at risk of developing nicotine addiction and long-term health effects of exposure to inhaled toxicants.
- Conditions
- Nicotine Dependence, Nicotine Addiction, Nicotine Use Disorder, Nicotine Vaping
- Trial name
- NCT05897242
- Testing
- Smartphone app, Text Message, Survey Administration
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Nicotine Dependence
Human Laboratory Study Of Varenicline in Smokers
The purpose of this study is to test the ways that a drug called varenicline helps smokers to quit smoking. Varenicline is also called Chantix® and is approved by the United States Food and Drug Administration (FDA) to help…
- Trial name
- NCT00709696
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Alcohol Use Disorder, Alcohol Dependence
The Impact of Heavy Alcohol Use on Saliva and Oral Health
Background: People with alcohol use disorder (AUD) have a higher rate of dental and gum disease. Poor oral health can increase the risk of other diseases, such as diabetes and stroke.
- Trial name
- NCT06684483
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Smoking Cessation, Acceptability of Health Care
Re-Connect Application for Smoking Cessation
This series of studies will explore the acceptability, feasibility, and preliminary efficacy of making access to smartphone applications contingent on objective evidence of smoking abstinence.
- Conditions
- Smoking Cessation, Acceptability of Health Care, Nicotine Dependence, Cigarettes
- Trial name
- NCT05224154
- Testing
- Abstinent Contingent (AC) Re-Connect
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Rowan University
Tobacco Dependence
Healing and Empowering Alaskan Lives Towards Healthy-Hearts Study
This study aims to identify effective and cost-effective interventions for tobacco use and other risk behaviors for cardiovascular disease among Alaska Native people in rural villages.
- Trial name
- HEALTHH (NCT02137902)
- Testing
- Tobacco/Physical Activity Intervention, Diet plus BP/CHOL Intervention
- Where
- 2 sites in United States
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Stanford University
Schizophrenia and Disorders With Psychotic Features, Tobacco Use Disorder
Nicotine and Cotinine Levels in Smokers With Schizophrenia and Schizoaffective Disorder - 2
Nicotine dependence is very common among individuals with schizophrenia and schizoaffective disorder. Cotinine is a chemical that is made by the body from nicotine.
- Trial name
- NCT00135772
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)