Clinical trials: Substance Dependency
Nicotine Dependence
Manipulating Tobacco Constituents in Female Menthol Smokers
This study examines the potential effect of reducing nicotine content or menthol or both in women of reproductive age, a vulnerable population identified by the FDA in need of further research.
- Trial name
- Menthol (NCT02048852)
- Testing
- Reduced Nicotine Content- Non Menthol, Reduced Nicotine Content- Menthol, Conventional Nicotine Content- Menthol
- Where
- 2 sites in United States
- Volunteers
- 381 people, healthy volunteers welcome
- Sponsor
- UConn Health
Smoking Cessation, Tobacco Dependence
Translating Extinction Research to Improve Pharmacotherapy for Tobacco Dependence
The purpose of this Pilot feasibility study is to find out the effect of different behavioral treatments along with different duration of a drug called varenicline, on smoking behavior and quitting smoking.
- Trial name
- NCT02202499
- Testing
- Varenicline, Counseling and Support Materials, Laboratory Assessments
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Nicotine Dependence
Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study
One of the most promising lines of investigation for the therapeutic use of hallucinogens in the 1960s and 1970s was in the treatment of drug dependence.
- Trial name
- NCT01943994
- Testing
- Psilocybin-assisted treatment, Nicotine Replacement Therapy (NRT)
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tobacco Dependence
Changing Thought and Action in Tobacco Dependence With Transcranial Magnetic Stimulation
This study will examine the effects of high frequency, repetitive Transcranial Magnetic Stimulation (rTMS) on decision-making and smoking behavior.
- Trial name
- rTMS (NCT00973622)
- Testing
- repetitive transcranial magnetic stimulation (rTMS) 10 Hertz (Hz), repetitive transcranial magnetic stimulation (rTMS) 20Hz
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Opioid-Related Disorders, Heroin Dependence
Depot Naltrexone Mechanism of Action in Heroin Dependent Patients Using fMRI and SPECT
The aim of this project is to study brain functions of 20 heroin addicts (compared to brain functions of 20 healthy controls) just before and during a three month extended release naltrexone treatment using functional MRI and…
- Trial name
- XRNT (NCT01471145)
- Testing
- Naltrexone
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cocaine-Related Disorders
Assessment of Potential Interactions Between GBR 12909 and Cocaine - 1
The purpose of this study is to assess potential interactions between intravenous (IV) cocaine and 3 doses of GBR 12909.
- Trial name
- NCT00100113
- Testing
- GBR 12909
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence, Nicotine Dependence, Cigarettes
Clinical Study Comparing 7 ENDS Products and 1 Combustible Cigarette Using 2 Delivery Methods.
A Randomized Study Comparing Nicotine Pharmacokinetics of Seven Electronic Cigarette Products and One Traditional Cigarette Across Two Delivery (10 puff and ad- libitum) Conditions, in Healthy Adult Smokers
- Conditions
- Nicotine Dependence, Nicotine Dependence, Cigarettes, Tobacco Use, Tobacco Smoking
- Trial name
- NCT03700112
- Testing
- JUUL Virginia Tobacco flavored 5.0% ENDS, PMI iQOS Heat sticks, Reynolds VUSE Solo ENDS - Original
- Where
- New Zealand
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Substance Dependence
GSK618334 Repeat Dose Study
The proposed study will evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of repeated oral doses of GSK618334 in healthy male and female volunteers.
- Trial name
- NCT01036061
- Testing
- GSK618334 Low Dose, GSK618334 PET subjects, GSK618334 Medium Dose
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cocaine Dependence
Impulsivity, Neural Deficits and Cocaine Addiction
The purpose of this study is to assess neurocognitive and associated neural regions/circuitry disruptions relevant to impulsive relapse in cocaine-addicted subjects, and the relationship of the cognitive and neural mechanisms of…
- Trial name
- NCT00744601
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Tobacco Use Disorder
Nicotine Lozenge to Reduce Smokeless Tobacco Use
Smokeless tobacco (ST), which includes both chewing tobacco and snuff, has as many health risks associated with its use as cigarettes.
- Trial name
- NCT00218283
- Testing
- Nicotine Lozenge, Behavioral Counseling
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Pain, Insomnia
Effect of Medical Marijuana on Neurocognition and Escalation of Use
This study will use a randomized controlled design to test whether patients who use medical marijuana, compared to a waitlist control group, experience a change in health outcomes (relief of symptoms, or adverse health outcomes…
- Conditions
- Pain, Insomnia, Depression, Anxiety
- Trial name
- MMNE (NCT03224468)
- Testing
- Medical Marijuana
- Where
- United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Tobacco Dependence, Tobacco Use Disorder
Chatbot for Online Support Groups to Treat Tobacco Addiction
Investigators will conduct a pilot RCT to test the efficacy of an intelligent chatbot to aid small, private, quit-smoking peer support groups.
- Trial name
- NCT06952725
- Testing
- online quit-smoking support group with intelligent chatbot, online quit-smoking support group with unintelligent bot
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Cardiovascular Risk Factor, Nicotine Dependence
Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH
This study will examine the short-term cardiovascular (CV) effects of e-liquid pH in a randomized, crossover clinical and behavioral pharmacology study of experienced adult e-cigarette users (N=21).
- Trial name
- TCORS-2 (NCT04449510)
- Testing
- Electronic Cigarette
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Marijuana Dependence
Ph1 Marinol Interaction Study - Part 2 - 1
This study will examine the effects of oral dronabinol tetrahydrocannabinol (THC) on withdrawal symptoms in marijuana dependent volunteers, and evaluate the safety, pharmacokinetics (PK), and cardiovascular effects of the…
- Trial name
- NCT00490269
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Healthy
Glutamate-Glutamine Cycling (VCYC) During Cocaine Abstinence Using 1H-MRS
This study is designed to look at the relationship between brain glucose utilization, neurotransmission (e.g., glutamate, also known as the main excitatory amino-acid neurotransmitter in the brain), and synaptic density.
- Trial name
- NCT02124941
- Testing
- N-acetyl cysteine, [18F]FDG PET scan, 1H MRS
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine-Related Disorders
Therapeutic Potential of Kappa-Opioids Against Cocaine - 1
The purpose of this study is to characterize the effects of enadoline compared to hydromorphone and butorphanol.
- Trial name
- NCT00000323
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking Cessation
Motivating Quitline Use Among Smokers in Treatment for Substance Use Disorders
The long-term goal of this program of research is to disseminate an effective, brief computer-based intervention that can be readily integrated into Substance Use Disorders (SUD) treatment programs to motivate tobacco quitline…
- Trial name
- MI-SUD (NCT01882673)
- Testing
- Brief Computer Motivational Interviewing for Smoking Cessation, Nutrition Control
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Smoking, Nicotine Dependence
E-Cigarettes: Dynamic Patterns of Use and Health Effects
The proposed research will provide in-depth, longitudinal data, based on real-time reports, which will address key priorities for the FDA including, increased understanding of the relations between electronic cigarette (e-cig)…
- Trial name
- NCT02527980
- Testing
- No intervention: observation only
- Where
- 2 sites in United States
- Volunteers
- 422 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Tobacco Use Disorder, Schizophrenia
Social Cognition,Attentional Network and Nicotine Drug Dependency - A Pharmacological Clinical Trail
In the present study, we investigate healthy subjects and schizophrenic patients who frequently show very low attentional capacity with functional magnetic resonance imaging (fMRI) and electrophysiology (EEG) during…
- Trial name
- NIKOGEN (NCT00618280)
- Testing
- nicotine nasal spray
- Where
- 2 sites in Germany
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Opioid-Related Disorders
Effects of Buprenorphine/Naloxone in Treating Opioid Dependent Individuals Who Are Maintained on Methadone
Buprenorphine is a drug that may be helpful in treating opioid dependent individuals who were previously maintained on methadone.
- Trial name
- NCT00000243
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)